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- Increased dendritic cell density and altered morphology in allergic conjunctivitis
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- Retinal Disease and Clinical Imaging Research Group
- Optical Imaging and Visualisation
- Public Health and Health Systems Research Group
- Myopia Research Group
- Ocular Surface Research (Inc. Dry Eye and Contact Lenses)
- Centre for Eye Health Research Group (CFEH)
- Sensory Processes Research Laboratory
- Eye Research Group
- Vision Loss and Health Ageing Group
- Testing and developing new antimicrobials and overcoming antimicrobial resistance (TADOAR)
- Ocular Pathology Research Group
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Research excellence
- Validation of a novel non-invasive high throughput screening tool for peripheral neuropathy in type 2 diabetes
- Eye infection and contact lens
- Development of novel antimicrobial scaffolds
- Preventing injuries and promoting health, safety and mobility for older people with age-related eye disease
- Biomarkers in dry eye disease
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Research groups
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- Optometry clinic
- ORLAB
- About us
- Study areas
- Student life & resources
-
Research & impact
Research groups
- Retinal Disease and Clinical Imaging Research Group
- Optical Imaging and Visualisation
- Public Health and Health Systems Research Group
- Myopia Research Group
- Ocular Surface Research (Inc. Dry Eye and Contact Lenses)
- Centre for Eye Health Research Group (CFEH)
- Sensory Processes Research Laboratory
- Eye Research Group
- Vision Loss and Health Ageing Group
- Testing and developing new antimicrobials and overcoming antimicrobial resistance (TADOAR)
- Ocular Pathology Research Group
Research excellence
- Validation of a novel non-invasive high throughput screening tool for peripheral neuropathy in type 2 diabetes
- Eye infection and contact lens
- Development of novel antimicrobial scaffolds
- Preventing injuries and promoting health, safety and mobility for older people with age-related eye disease
- Biomarkers in dry eye disease
- Partner with us
- Optometry clinic
- ORLAB

Dendritic cells (DC) are the initiators of the allergic immune response, and their density increases in vernal keratoconjunctivitis. DC density and morphology in the more common and often milder forms of allergic conjunctivitis have not been investigated.
In this study for the first time, we assessed the density, morphology, and distribution of corneal and conjunctival DC as a marker of allergic eye disease in allergic conjunctivitis using in vivo confocal microscopy Higher DC density was established at the cornea and conjunctiva in subjects with allergic conjunctivitis compared with unaffected controls.
There was increased antigen-capture capacity of corneal DC, evidenced by larger cell bodies and a higher proportion of cells with long dendrites which was established using a novel repeatable morphology grading system.
The results of this study highlight the potential role of corneal and conjunctival DC in ocular allergy. Augmenting knowledge of DC function in ocular allergic inflammation may help develop new therapeutic approaches.
see the full article here: https://rdcu.be/c40k6