Dr Yizhou Huang

Books

Book Chapters

Edited Books

Journal Articles

Journal articles | 2024

Beck D; Cao H; Tian F; Huang Y; Jiang M; Zhao H; Tai X; Xu W; Kosasih HJ; Kealy DJ; Zhao W; Taylor SJ; Couttas TA; Song G; Chacon-Fajardo D; Walia Y; Wang M; Dowle AA; Holding AN; Bridge KS; Zhang C; Wang J; Mi JQ; Lock RB; de Bock CE; Jing D, 2024, 'PU.1 eviction at lymphocyte-specific chromatin domains mediates glucocorticoid response in acute lymphoblastic leukemia', Nature Communications, 15, pp. 9697, http://dx.doi.org/10.1038/s41467-024-54096-2

Journal articles | 2024

Huang Y; de Bock CE, 2024, 'Overcoming a T-ALL order: A comprehensive study linking genomics to clinical outcomes', HemaSphere, 8, pp. e70027, http://dx.doi.org/10.1002/hem3.70027

Journal articles | 2023

Germon ZP; Sillar JR; Mannan A; Duchatel RJ; Staudt D; Murray HC; Findlay IJ; Jackson ER; McEwen HP; Douglas AM; McLachlan T; Schjenken JE; Skerrett-Byrne DA; Huang H; Melo-Braga MN; Plank MW; Alvaro F; Chamberlain J; De Iuliis G; Aitken RJ; Nixon B; Wei AH; Enjeti AK; Huang Y; Lock RB; Larsen MR; Lee H; Vaghjiani V; Cain JE; de Bock CE; Verrills NM; Dun MD, 2023, 'Blockade of ROS production inhibits oncogenic signaling in acute myeloid leukemia and amplifies response to precision therapies', Science Signaling, 16, pp. 1 - 18, http://dx.doi.org/10.1126/scisignal.abp9586

Journal articles | 2023

Moles E; Howard CB; Huda P; Karsa M; McCalmont H; Kimpton K; Duly A; Chen Y; Huang Y; Tursky ML; Ma D; Bustamante S; Pickford R; Connerty P; Omari S; Jolly CJ; Joshi S; Shen S; Pimanda JE; Dolnikov A; Cheung LC; Kotecha RS; Norris MD; Haber M; de Bock CE; Somers K; Lock RB; Thurecht KJ; Kavallaris M; Moles Meler E, 2023, 'Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia', Science translational medicine, 15, pp. eabm1262 - eabm1262, http://dx.doi.org/10.1126/scitranslmed.abm1262

Journal articles | 2023

Roche CD; Lin H; Huang Y; de Bock CE; Beck D; Xue M; Gentile C, 2023, '3D bioprinted alginate-gelatin hydrogel patches containing cardiac spheroids recover heart function in a mouse model of myocardial infarction', Bioprinting, 30, pp. e00263 - e00263, http://dx.doi.org/10.1016/j.bprint.2023.e00263

Journal articles | 2023

Subramanian S; Thoms JAI; Huang Y; Cornejo-Páramo P; Koch FC; Jacquelin S; Shen S; Song E; Joshi S; Brownlee C; Woll PS; Chacon-Fajardo D; Beck D; Curtis DJ; Yehson K; Antonenas V; O'Brien T; Trickett A; Powell JA; Lewis ID; Pitson SM; Gandhi MK; Lane SW; Vafaee F; Wong ES; Göttgens B; Alinejad-Rokny H; Wong JWH; Pimanda JE, 2023, 'Genome-wide transcription factor–binding maps reveal cell-specific changes in the regulatory architecture of human HSPCs', Blood, 142, pp. 1448 - 1462, http://dx.doi.org/10.1182/blood.2023021120

Journal articles | 2023

Walia Y; de Bock CE; Huang Y, 2023, 'The landscape of alterations affecting epigenetic regulators in T-cell acute lymphoblastic leukemia: Roles in leukemogenesis and therapeutic opportunities', International Journal of Cancer, 154, pp. 1522 - 1536, http://dx.doi.org/10.1002/ijc.34819

Journal articles | 2022

Chandrakanthan V; Rorimpandey P; Zanini F; Chacon D; Olivier J; Joshi S; Kang YC; Knezevic K; Huang Y; Qiao Q; Oliver RA; Unnikrishnan A; Carter DR; Lee B; Brownlee C; Power C; Brink R; Mendez-Ferrer S; Enikolopov G; Walsh W; Göttgens B; Taoudi S; Beck D; Pimanda JE, 2022, 'Mesoderm-derived PDGFRA⁺ cells regulate the emergence of hematopoietic stem cells in the dorsal aorta', Nature Cell Biology, 24, pp. 1211 - 1225, http://dx.doi.org/10.1038/s41556-022-00955-3

Journal articles | 2021

Thoms JAI; Truong P; Subramanian S; Knezevic K; Harvey G; Huang Y; Seneviratne JA; Carter DR; Joshi S; Skhinas J; Chacon D; Shah A; de Jong I; Beck D; Göttgens B; Larsson J; Wong JWH; Zanini F; Pimanda JE, 2021, 'Disruption of a GATA2-TAL1-ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cells', Blood, 138, pp. 1441 - 1455, http://dx.doi.org/10.1182/blood.2020009707

Journal articles | 2020

Carmichael CL; Wang J; Nguyen T; Kolawole O; Benyoucef A; de Mazière C; Milne AR; Samuel S; Gillinder K; Hediyeh-Zadeh S; Vo ANQ; Huang Y; Knezevic K; McInnes WRL; Shields BJ; Mitchell H; Ritchie ME; Lammens T; Lintermans B; van Vlierberghe P; Wong NC; Haigh K; Thoms JAI; Toulmin E; Curtis DJ; Oxley EP; Dickins RA; Beck D; Perkins A; McCormack MP; Davis MJ; Berx G; Zuber J; Pimanda JE; Kile BT; Goossens S; Haigh JJ, 2020, 'The EMT modulator SNAI1 contributes to AML pathogenesis via its interaction with LSD1', Blood, 136, pp. 957 - 973, http://dx.doi.org/10.1182/blood.2019002548

Journal articles | 2020

Thoms J; Knezevic K; Harvey G; Huang Y; Seneviratne J; Carter D; Subramanian S; Skhinas J; Chacon D; Shah A; de Jong I; Beck D; Göttgens B; Larsson J; Wong J; Zanini F; Pimanda J, 2020, 'Disruption of a GATA2, TAL1, ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cells', , http://dx.doi.org/10.1101/2020.10.26.353797

Journal articles | 2019

Chiu SK; Orive SL; Moon MJ; Saw J; Ellis S; Kile BT; Huang Y; Chacon D; Pimanda JE; Beck D; Hamilton JR; Tremblay CS; Curtis DJ, 2019, 'Shared roles for Scl and Lyl1 in murine platelet production and function', Blood, 134, pp. 826 - 835, http://dx.doi.org/10.1182/blood.2019896175

Journal articles | 2018

Beck D; Thoms JAI; Palu C; Herold T; Shah A; Olivier J; Boelen L; Huang Y; Chacon D; Brown A; Babic M; Hahn C; Perugini M; Zhou X; Huntly BJ; Schwarzer A; Klusmann JH; Berdel WE; Wörmann B; Büchner T; Hiddemann W; Bohlander SK; To LB; Scott HS; Lewis ID; D'Andrea RJ; Wong JWH; Pimanda JE, 2018, 'A four-gene LincRNA expression signature predicts risk in multiple cohorts of acute myeloid leukemia patients', Leukemia, 32, pp. 263 - 272, http://dx.doi.org/10.1038/leu.2017.210

Journal articles | 2018

Chiu SK; Saw J; Huang Y; Sonderegger SE; Wong NC; Powell DR; Beck D; Pimanda JE; Tremblay CS; Curtis DJ, 2018, 'A novel role for Lyl1 in primitive erythropoiesis', Development (Cambridge), 145, http://dx.doi.org/10.1242/dev.162990

Journal articles | 2018

Jing D; Huang Y; Liu X; Sia KCS; Zhang JC; Tai X; Wang M; Toscan CE; McCalmont H; Evans K; Mayoh C; Poulos RC; Span M; Mi J; Zhang C; Wong JWH; Beck D; Pimanda JE; Lock RB, 2018, 'Lymphocyte-Specific Chromatin Accessibility Pre-determines Glucocorticoid Resistance in Acute Lymphoblastic Leukemia', Cancer Cell, 34, pp. 906 - 921.e8, http://dx.doi.org/10.1016/j.ccell.2018.11.002

Journal articles | 2018

Liu Q; Thoms JAI; Nunez AC; Huang Y; Knezevic K; Packham D; Poulos RC; Williams R; Beck D; Hawkins NJ; Ward RL; Wong JWH; Hesson LB; Sloane MA; Pimanda JE, 2018, 'Disruption of a 35 KB enhancer impairs CTCF binding and MLH1 expression in colorectal cells', Clinical Cancer Research, 24, pp. 4602 - 4611, http://dx.doi.org/10.1158/1078-0432.CCR-17-3678

Journal articles | 2017

Chiu SK; Saw J; Huang Y; Beck D; Powell D; Pimanda J; Tremblay C; Curtis D, 2017, 'Maintenance of primitive haematopoiesis is shared by SCL and LYL1', Experimental Hematology, 53, pp. S115 - S115, http://dx.doi.org/10.1016/j.exphem.2017.06.288

Journal articles | 2017

Schwarzer A; Emmrich S; Schmidt F; Beck D; Ng M; Reimer C; Adams FF; Grasedieck S; Witte D; Käbler S; Wong JWH; Shah A; Huang Y; Jammal R; Maroz A; Jongen-Lavrencic M; Schambach A; Kuchenbauer F; Pimanda JE; Reinhardt D; Heckl D; Klusmann JH, 2017, 'The non-coding RNA landscape of human hematopoiesis and leukemia', Nature Communications, 8, http://dx.doi.org/10.1038/s41467-017-00212-4

Journal articles | 2017

Unnikrishnan A; Papaemmanuil E; Beck D; Deshpande NP; Verma A; Kumari A; Woll PS; Richards LA; Knezevic K; Chandrakanthan V; Thoms JAI; Tursky ML; Huang Y; Ali Z; Olivier J; Galbraith S; Kulasekararaj AG; Tobiasson M; Karimi M; Pellagatti A; Wilson SR; Lindeman R; Young B; Ramakrishna R; Arthur C; Stark R; Crispin P; Curnow J; Warburton P; Roncolato F; Boultwood J; Lynch K; Jacobsen SEW; Mufti GJ; Hellstrom-Lindberg E; Wilkins MR; MacKenzie KL; Wong JWH; Campbell PJ; Pimanda JE, 2017, 'Integrative Genomics Identifies the Molecular Basis of Resistance to Azacitidine Therapy in Myelodysplastic Syndromes', Cell Reports, 20, pp. 572 - 585, http://dx.doi.org/10.1016/j.celrep.2017.06.067

Journal articles | 2016

Huang Y; Thoms JAI; Tursky ML; Knezevic K; Beck D; Chandrakanthan V; Suryani S; Olivier J; Boulton A; Glaros EN; Thomas SR; Lock RB; MacKenzie KL; Bushweller JH; Wong JWH; Pimanda JE, 2016, 'MAPK/ERK2 phosphorylates ERG at serine 283 in leukemic cells and promotes stem cell signatures and cell proliferation', Leukemia, 30, pp. 1552 - 1561, http://dx.doi.org/10.1038/leu.2016.55

Journal articles | 2016

Thoms JAI; Knezevic K; Liu JJ; Glaros EN; Thai T; Qiao Q; Campbell H; Packham D; Huang Y; Papathanasiou P; Tunningley R; Whittle B; Yeung AWS; Chandrakanthan V; Hesson L; Chen V; Wong JWH; Purton LE; Ward RL; Thomas SR; Pimanda JE, 2016, 'Arrested hematopoiesis and vascular relaxation defects in mice with a mutation in Dhfr', Molecular and Cellular Biology, 36, pp. 1222 - 1236, http://dx.doi.org/10.1128/MCB.01035-15

Journal articles | 2016

Unnikrishnan A; Guan YF; Huang Y; Beck D; Thoms JAI; Peirs S; Knezevic K; Ma S; De Walle IV; De Jong IDE; Ali Z; Zhong L; Raftery MJ; Taghon T; Larsson J; MacKenzie KL; Van Vlierberghe P; Wong JWH; Pimanda JE, 2016, 'A quantitative proteomics approach identifies ETV6 and IKZF1 as new regulators of an ERG-driven transcriptional network', Nucleic Acids Research, 44, pp. 10644 - 10661, http://dx.doi.org/10.1093/nar/gkw804

Journal articles | 2015

Tursky ML; Beck D; Thoms JAI; Huang Y; Kumari A; Unnikrishnan A; Knezevic K; Evans K; Richards LA; Lee E; Morris J; Goldberg L; Izraeli S; Wong JWH; Olivier J; Lock RB; MacKenzie KL; Pimanda JE, 2015, 'Overexpression of ERG in cord blood progenitors promotes expansion and recapitulates molecular signatures of high ERG leukemias', Leukemia, 29, pp. 819 - 827, http://dx.doi.org/10.1038/leu.2014.299

Journal articles | 2013

Wong JJL; Ritchie W; Ebner OA; Selbach M; Wong JWH; Huang Y; Gao D; Pinello N; Gonzalez M; Baidya K; Thoeng A; Khoo TL; Bailey CG; Holst J; Rasko JEJ, 2013, 'XOrchestrated intron retention regulates normal granulocyte differentiation', Cell, 154, http://dx.doi.org/10.1016/j.cell.2013.06.052

Working Papers

Other

Preprints | 2023

Subramanian S; Subramanian S; Thoms JAI; Huang Y; Cornejo P; Koch F; Jacquelin S; Shen S; Song E; Joshi S; Brownlee C; Woll P; Fajardo DC; Beck D; Curtis D; Yehson K; Antonenas V; Brien TO; Trickett A; Powell J; Lewis I; Pitson S; Gandhi M; Lane S; Vafaee F; Wong E; Göttgens B; Rokny HA; Wong JWH; Pimanda J, 2023, Cell Type-Specific Regulation by a Heptad of Transcription Factors in Human Hematopoietic Stem and Progenitor Cells, http://dx.doi.org/10.1101/2023.04.18.537282

Conference Papers | 2019

Carmichael C; Wang J; Nguyen T; De Maziere C; Milne A; Goossens S; Davis M; Zadeh S; Vo A; McCormack M; Shields B; Haigh K; Huang Y; Thoms J; Knezevic K; Ritchie M; Berx G; Pimanda J; Kile B; Haigh J, 2019, '2008 - ALTERED EXPRESSION OF EPITHELIAL TO MESENCHYMAL TRANSITION MODULATORS IN ACUTE MYELOID LEUKAEMIA - A MODEL OF LSD1 CORRUPTION', in Experimental Hematology, Elsevier BV, pp. S44 - S44, http://dx.doi.org/10.1016/j.exphem.2019.06.282

Conference Papers | 2019

Chacon D; Braytee A; Huang Y; Thoms J; Subramanian S; Sauerland MC; Bohlander SK; Braess J; Woermann BJ; Berdel WE; Hiddemann W; Gabrys B; Metzeler KH; Herold T; Pimanda J; Beck D, 2019, 'Prospective Identification of Acute Myeloid Leukemia Patients Who Benefit from Gene-Expression Based Risk Stratification', in BLOOD, AMER SOC HEMATOLOGY, FL, Orlando, presented at 61st Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), FL, Orlando, 07 December 2019 - 10 December 2019, http://dx.doi.org/10.1182/blood-2019-129519

Conference Papers | 2018

Jing D; Huang Y; Liu X; Sia K; Poulos RC; Span M; Zhang C; Mi J; Wong JWH; Beck D; Pimanda JE; Lock RB, 2018, 'Lymphocyte-specific chromatin accessibility predetermines glucocorticoid resistance in acute lymphoblastic leukemia', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, IL, Chicago, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), IL, Chicago, 14 April 2018 - 18 April 2018, http://dx.doi.org/10.1158/1538-7445.AM2018-3173

Conference Presentations | 2017

Chandrakanthan V; Kang YC; Knezevic K; Qiao Q; Oliver R; Unnikrishnan A; Huang Y; Walsh W; Lee B; Lee CB; Power C; Beck D; Taoudi S; Pimanda J, 2017, 'DECLINED PRESENTATION MESENCHYMAL STEM CELL-LIKE CELL MEDIATED HEMATOPOIETIC STEM CELL GENERATION FROM NON-HEMOGENIC ENDOTHELIAL CELLS', https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000972742900274&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2016

Beck D; Thoms J; Palu C; Herold T; Shah A; Olivier J; Boelen L; Huang Y; Chacon D; Brown A; Babic M; Hahn C; Perugini M; Zhou X; Huntly B; Berdel W; Woermann B; Buechner T; Hiddemann W; Bohlander S; Scott H; Lewis I; D'Andrea R; Wong J; Pimanda J, 2016, 'INTEGRATIVE ANALYSIS OF LINCRNA EXPRESSION IN 922 ACUTE MYELOID LEUKEMIA PATIENTS REVEALS MULTIPLE PROGNOSTIC GENE SIGNATURES', in HAEMATOLOGICA, FERRATA STORTI FOUNDATION, DENMARK, Copenhagen, Vol. 101, pp. 208 - 209, presented at 21st Congress of the European-Hematology-Association, DENMARK, Copenhagen, 09 June 2016 - 12 June 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000379484600457&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2016

Unnikrishnan A; Papaemmanuil E; Beck D; Verma A; Kumari A; Woll P; Richards L; Knezevic K; Chandrakanthan V; Thoms J; Tursky M; Huang Y; Ali Z; Olivier J; Galbraith S; Kulasekararaj A; Tobiasson M; Karimi M; Pellagatti A; Wilson S; Lindeman R; Young B; Ramakrishna R; Arthur C; Stark R; Crispin P; Curnow J; Warburton P; Roncolato F; Boultwood J; Lynch K; Jacobsen S; Mufti G; Hellstrom-Lindberg E; MacKenzie K; Wong J; Campbell P; Pimanda J, 2016, 'INTEGRATIVE GENOMICS IDENTIFIES THE MOLECULAR BASIS OF RESISTANCE TO AZACITIDINE THERAPY IN MYELODYSPLASTIC SYNDROMES', in HAEMATOLOGICA, FERRATA STORTI FOUNDATION, DENMARK, Copenhagen, Vol. 101, pp. 157 - 158, presented at 21st Congress of the European-Hematology-Association, DENMARK, Copenhagen, 09 June 2016 - 12 June 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000379484600349&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2015

Unnikrishnan A; Papaemmanuil E; Beck D; Kumari A, 2015, 'An Integrative Genomics Approach Uncovers the Basis of Resistance to AZA Therapy in MDS and CMML', in An Integrative Genomics Approach Uncovers the Basis of Resistance to, USA, presented at ASH Annual Meeting, USA, 05 December 2015 - 08 December 2015

Conference Papers | 2012

Rasko J; Wong J; Ritchie W; Olivia E; Matthias S; Wong JWH; Huang Y; Gao D; Gonzalez M; Baidya K; Theong A; Khoo T-L; Bailey CG; Holst J, 2012, 'Intron Retention Coupled with Nonsense-Mediated Decay Determines Protein Expression and Nuclear Morphology in Granulopoiesis', in BLOOD, AMER SOC HEMATOLOGY, GA, Atlanta, presented at 54th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), GA, Atlanta, 08 December 2012 - 11 December 2012, http://dx.doi.org/10.1182/blood.V120.21.112.112

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Dr Yizhou Huang