Back to

Dr Tom Peat

Adjunct Professor

PhD from Columbia University in Molecular Biophysics

Science
School of Biotech & Biomolecular Science

Dr Tom Peat received a BA in biophysics and biochemistry from the University of California at Berkeley, and obtained Masters and PhD degrees from Columbia University. Tom has been involved with early-stage biotech companies in the US and has founded two companies in Australia. He has contributed over 300 structures to the Protein Data Bank and has been actively involved in fragment screening and other tools for structure-based drug development. Two of the projects he has been involved with have progressed into phase 2 clinical trials for cancer treatments.

E-mail
t.peat@unsw.edu.au
  • Book Chapters | 2015
    Fazio VJ; Peat TS; Newman J, 2015, 'Crystallization: Digging into the past to learn lessons for the future', in , pp. 141 - 159, http://dx.doi.org/10.1007/978-1-4939-2230-7_8
    Book Chapters | 2012
    Hill RJ; Graham LD; Turner KA; Howell L; Tohidi-Esfahani D; Fernley R; Grusovin J; Ren B; Pilling P; Lu L; Phan T; Lovrecz GO; Pollard M; Pawlak-Skrzecz A; Streltsov VA; Peat TS; Winkler DA; Lawrence MC, 2012, 'Chapter Four Structure and Function of Ecdysone Receptors—Interactions with Ecdysteroids and Synthetic Agonists', in Insect Growth Disruptors, Elsevier, pp. 299 - 351, http://dx.doi.org/10.1016/b978-0-12-391500-9.00004-8
    Book Chapters | 2012
    Hill RJ; Graham LD; Turner KA; Howell L; Tohidi-Esfahani D; Fernley R; Grusovin J; Ren B; Pilling P; Lu L; Phan T; Lovrecz GO; Pollard M; Pawlak-Skrzecz A; Streltsov VA; Peat TS; Winkler DA; Lawrence MC, 2012, 'Structure and Function of Ecdysone Receptors-Interactions with Ecdysteroids and Synthetic Agonists', in Advances in Insect Physiology, pp. 299 - 351, http://dx.doi.org/10.1016/B978-0-12-391500-9.00004-8
  • Journal articles | 2024
    Eldehna WM; Fares M; Bonardi A; Avgenikos M; Baselious F; Schmidt M; Al-Warhi T; Abdel-Aziz HA; Rennert R; Peat TS; Supuran CT; Wessjohann LA; Ibrahim HS, 2024, '4-(Pyrazolyl)benzenesulfonamide Ureas as Carbonic Anhydrases Inhibitors and Hypoxia-Mediated Chemo-Sensitizing Agents in Colorectal Cancer Cells.', J Med Chem, http://dx.doi.org/10.1021/acs.jmedchem.4c01894
    Journal articles | 2024
    Esquirol L; Newman J; Nebl T; Scott C; Vickers C; Sainsbury F; Peat TS, 2024, 'Characterization of novel mevalonate kinases from the tardigrade Ramazzottius varieornatus and the psychrophilic archaeon Methanococcoides burtonii', Acta Crystallographica Section D: Structural Biology, 80, pp. 203 - 215, http://dx.doi.org/10.1107/S2059798324001360
    Journal articles | 2024
    Fulford TS; Soliman C; Castle RG; Rigau M; Ruan Z; Dolezal O; Seneviratna R; Brown HG; Hanssen E; Hammet A; Li S; Redmond SJ; Chung A; Gorman MA; Parker MW; Patel O; Peat TS; Newman J; Behren A; Gherardin NA; Godfrey DI; Uldrich AP, 2024, 'Vγ9Vδ2 T cells recognize butyrophilin 2A1 and 3A1 heteromers', Nature Immunology, 25, pp. 1355 - 1366, http://dx.doi.org/10.1038/s41590-024-01892-z
    Journal articles | 2024
    Joho Y; Royan S; Caputo AT; Newton S; Peat TS; Newman J; Jackson C; Ardevol A, 2024, 'Enhancing PET Degrading Enzymes: A Combinatory Approach', ChemBioChem, 25, http://dx.doi.org/10.1002/cbic.202400084
    Journal articles | 2024
    Yi X; Kleinbeck F; Ching C; Boghospor L; Gomes S; Alvizo O; Allmendinger T; Fell J; Subramanian N; Li M; Garcia R; Riggins J; Entwistle D; Richter Y; Gschwend D; Lauener L; Peat TS; Lebhar H; Schlama T; Ruch T, 2024, 'Enhancing the Imine Reductase Activity of a Promiscuous Glucose Dehydrogenase for Scalable Manufacturing of a Chiral Neprilysin Inhibitor Precursor', ACS Catalysis, 14, pp. 7087 - 7096, http://dx.doi.org/10.1021/acscatal.3c05615
    Journal articles | 2023
    Sharma S; Chung CY; Uryu S; Petrovic J; Cao J; Rickard A; Nady N; Greasley S; Johnson E; Brodsky O; Khan S; Wang H; Wang Z; Zhang Y; Tsaparikos K; Chen L; Mazurek A; Lapek J; Kung PP; Sutton S; Richardson PF; Greenwald EC; Yamazaki S; Jones R; Maegley KA; Bingham P; Lam H; Stupple AE; Kamal A; Chueh A; Cuzzupe A; Morrow BJ; Ren B; Carrasco-Pozo C; Tan CW; Bhuva DD; Allan E; Surgenor E; Vaillant F; Pehlivanoglu H; Falk H; Whittle JR; Newman J; Cursons J; Doherty JP; White KL; MacPherson L; Devlin M; Dennis ML; Hattarki MK; De Silva M; Camerino MA; Butler MS; Dolezal O; Pilling P; Foitzik R; Stupple PA; Lagiakos HR; Walker SR; Hediyeh-Zadeh S; Nuttall S; Spall SK; Charman SA; Connor T; Peat TS; Avery VM; Bozikis YE; Yang Y; Zhang M; Monahan BJ; Voss AK; Thomas T; Street IP; Dawson SJ; Dawson MA; Lindeman GJ; Davis MJ; Visvader JE; Paul TA, 2023, 'Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer', Cell Chemical Biology, 30, pp. 1191 - 1210.e20, http://dx.doi.org/10.1016/j.chembiol.2023.07.005
    Journal articles | 2022
    Ahmed FH; Caputo AT; French NG; Peat TS; Whitfield J; Warden AC; Newman J; Scott1 C, 2022, 'Over the rainbow: structural characterization of the chromoproteins gfasPurple, amilCP, spisPink and eforRed', Acta Crystallographica Section D: Structural Biology, 78, pp. 599 - 612, http://dx.doi.org/10.1107/S2059798322002625
    Journal articles | 2022
    Satta A; Esquirol L; Ebert BE; Newman J; Peat TS; Plan M; Schenk G; Vickers CE, 2022, 'Molecular characterization of cyanobacterial short-chain prenyltransferases and discovery of a novel GGPP phosphatase', FEBS Journal, 289, pp. 6672 - 6693, http://dx.doi.org/10.1111/febs.16556
    Journal articles | 2021
    Caputo AT; Eder OM; Bereznakova H; Pothuis H; Ardevol A; Newman J; Nuttall S; Peat TS; Adams TE, 2021, 'Structure-guided selection of puromycin N-acetyltransferase mutants with enhanced selection stringency for deriving mammalian cell lines expressing recombinant proteins', Scientific Reports, 11, http://dx.doi.org/10.1038/s41598-021-84551-9
    Journal articles | 2021
    Gumus A; Bozdag M; Angeli A; Peat TS; Carta F; Supuran CT; Selleri S, 2021, 'Privileged scaffolds in medicinal chemistry: Studies on pyrazolo[1,5-a]pyrimidines on sulfonamide containing Carbonic Anhydrase inhibitors', Bioorganic and Medicinal Chemistry Letters, 49, http://dx.doi.org/10.1016/j.bmcl.2021.128309
    Journal articles | 2021
    Guo Z; Smutok O; Johnston WA; Walden P; Ungerer JPJ; Peat TS; Newman J; Parker J; Nebl T; Hepburn C; Melman A; Suderman RJ; Katz E; Alexandrov K, 2021, 'Design of a methotrexate-controlled chemical dimerization system and its use in bio-electronic devices', Nature Communications, 12, http://dx.doi.org/10.1038/s41467-021-27184-w
    Journal articles | 2021
    Mueller SL; Chrysanthopoulos PK; Halili MA; Hepburn C; Nebl T; Supuran CT; Nocentini A; Peat TS; Poulsen SA, 2021, 'The glitazone class of drugs as carbonic anhydrase inhibitors—a spin-off discovery from fragment screening', Molecules, 26, http://dx.doi.org/10.3390/molecules26103010
    Journal articles | 2020
    Angeli A; Peat TS; Selleri S; Saleh Alfawaz Altamimi A; Supuran CT; Carta F, 2020, 'X-ray crystallography of Epacadostat in adduct with Carbonic Anhydrase IX', Bioorganic Chemistry, 97, http://dx.doi.org/10.1016/j.bioorg.2020.103669
    Journal articles | 2020
    Berrino E; Angeli A; Zhdanov DD; Kiryukhina AP; Milaneschi A; De Luca A; Bozdag M; Carradori S; Selleri S; Bartolucci G; Peat TS; Ferraroni M; Supuran CT; Carta F, 2020, 'Azidothymidine "clicked" into 1,2,3-Triazoles: First Report on Carbonic Anhydrase-Telomerase Dual-Hybrid Inhibitors', Journal of Medicinal Chemistry, 63, pp. 7392 - 7409, http://dx.doi.org/10.1021/acs.jmedchem.0c00636
    Journal articles | 2020
    Dennis ML; Newman J; Dolezal O; Hattarki M; Surjadi RN; Nuttall SD; Pham T; Nebl T; Camerino M; Khoo PS; Monahan BJ; Peat TS, 2020, 'Crystal structures of human ENPP1 in apo and bound forms', Acta Crystallographica Section D: Structural Biology, 76, pp. 889 - 898, http://dx.doi.org/10.1107/S2059798320010505
    Journal articles | 2020
    Esquirol L; Peat TS; Sugrue E; Balotra S; Rottet S; Warden AC; Wilding M; Hartley CJ; Jackson CJ; Newman J; Scott C, 2020, 'Bacterial catabolism of s-triazine herbicides: biochemistry, evolution and application', Advances in Microbial Physiology, 76, pp. 129 - 186, http://dx.doi.org/10.1016/bs.ampbs.2020.01.004
    Journal articles | 2020
    Fares M; Eldehna WM; Bua S; Lanzi C; Lucarini L; Masini E; Peat TS; Abdel-Aziz HA; Nocentini A; Keller PA; Supuran CT, 2020, 'Discovery of Potent Dual-Tailed Benzenesulfonamide Inhibitors of Human Carbonic Anhydrases Implicated in Glaucoma and in Vivo Profiling of Their Intraocular Pressure-Lowering Action', Journal of Medicinal Chemistry, 63, pp. 3317 - 3326, http://dx.doi.org/10.1021/acs.jmedchem.9b02090
    Journal articles | 2020
    MacPherson L; Anokye J; Yeung MM; Lam EYN; Chan YC; Weng CF; Yeh P; Knezevic K; Butler MS; Hoegl A; Chan KL; Burr ML; Gearing LJ; Willson T; Liu J; Choi J; Yang Y; Bilardi RA; Falk H; Nguyen N; Stupple PA; Peat TS; Zhang M; de Silva M; Carrasco-Pozo C; Avery VM; Khoo PS; Dolezal O; Dennis ML; Nuttall S; Surjadi R; Newman J; Ren B; Leaver DJ; Sun Y; Baell JB; Dovey O; Vassiliou GS; Grebien F; Dawson SJ; Street IP; Monahan BJ; Burns CJ; Choudhary C; Blewitt ME; Voss AK; Thomas T; Dawson MA, 2020, 'HBO1 is required for the maintenance of leukaemia stem cells', Nature, 577, pp. 266 - 270, http://dx.doi.org/10.1038/s41586-019-1835-6
    Journal articles | 2020
    Newman J; Nebl T; Van H; Peat TS, 2020, 'The X-ray crystal structure of the N-terminal domain of Ssr4, a Schizosaccharomyces pombe chromatin-remodelling protein', Acta Crystallographica Section F: Structural Biology Communications, 76, pp. 583 - 589, http://dx.doi.org/10.1107/S2053230X20015216
    Journal articles | 2019
    Angeli A; Di Cesare Mannelli L; Ghelardini C; Peat TS; Bartolucci G; Menicatti M; Carta F; Supuran CT, 2019, 'Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects', European Journal of Medicinal Chemistry, 177, pp. 188 - 197, http://dx.doi.org/10.1016/j.ejmech.2019.05.058
    Journal articles | 2019
    Dennis ML; Esquirol L; Nebl T; Newman J; Scott C; Peat TS, 2019, 'The evolving story of AtzT, a periplasmic binding protein', Acta Crystallographica Section D: Structural Biology, 75, pp. 995 - 1002, http://dx.doi.org/10.1107/S2059798319013883
    Journal articles | 2019
    Dennis ML; Morrow BJ; Dolezal O; Cuzzupe AN; Stupple AE; Newman J; Bentley J; Hattarki M; Nuttall SD; Foitzik RC; Street IP; Stupple PA; Monahan BJ; Peat TS, 2019, 'Fragment screening for a protein-protein interaction inhibitor to WDR5', Structural Dynamics, 6, http://dx.doi.org/10.1063/1.5122849
    Journal articles | 2019
    Kaczmarski JA; Hong NS; Mukherjee B; Wey LT; Rourke L; Förster B; Peat TS; Price GD; Jackson CJ, 2019, 'Structural Basis for the Allosteric Regulation of the SbtA Bicarbonate Transporter by the PII-like Protein, SbtB, from Cyanobium sp. PCC7001', Biochemistry, 58, pp. 5030 - 5039, http://dx.doi.org/10.1021/acs.biochem.9b00880
    Journal articles | 2019
    Newman J; Caron K; Nebl T; Peat TS, 2019, 'Structures of the transcriptional regulator BgaR, a lactose sensor', Acta Crystallographica Section D: Structural Biology, 75, pp. 639 - 646, http://dx.doi.org/10.1107/S2059798319008131
    Journal articles | 2019
    Tanini D; Ricci L; Capperucci A; Di Cesare Mannelli L; Ghelardini C; Peat TS; Carta F; Angeli A; Supuran CT, 2019, 'Synthesis of novel tellurides bearing benzensulfonamide moiety as carbonic anhydrase inhibitors with antitumor activity', European Journal of Medicinal Chemistry, 181, http://dx.doi.org/10.1016/j.ejmech.2019.111586
    Journal articles | 2018
    Angeli A; Di Cesare Mannelli L; Trallori E; Peat TS; Ghelardini C; Carta F; Supuran CT, 2018, 'Design, Synthesis, and X-ray of Selenides as New Class of Agents for Prevention of Diabetic Cerebrovascular Pathology', ACS Medicinal Chemistry Letters, 9, pp. 462 - 467, http://dx.doi.org/10.1021/acsmedchemlett.8b00076
    Journal articles | 2018
    Angeli A; di Cesare Mannelli L; Lucarini E; Peat TS; Ghelardini C; Supuran CT, 2018, 'Design, synthesis and X-ray crystallography of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects', European Journal of Medicinal Chemistry, 154, pp. 210 - 219, http://dx.doi.org/10.1016/j.ejmech.2018.05.026
    Journal articles | 2018
    Baell JB; Leaver DJ; Hermans SJ; Kelly GL; Brennan MS; Downer NL; Nguyen N; Wichmann J; McRae HM; Yang Y; Cleary B; Lagiakos HR; Mieruszynski S; Pacini G; Vanyai HK; Bergamasco MI; May RE; Davey BK; Morgan KJ; Sealey AJ; Wang B; Zamudio N; Wilcox S; Garnham AL; Sheikh BN; Aubrey BJ; Doggett K; Chung MC; de Silva M; Bentley J; Pilling P; Hattarki M; Dolezal O; Dennis ML; Falk H; Ren B; Charman SA; White KL; Rautela J; Newbold A; Hawkins ED; Johnstone RW; Huntington ND; Peat TS; Heath JK; Strasser A; Parker MW; Smyth GK; Street IP; Monahan BJ; Voss AK; Thomas T, 2018, 'Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth', Nature, 560, pp. 253 - 257, http://dx.doi.org/10.1038/s41586-018-0387-5
    Journal articles | 2018
    Dennis ML; Lee MD; Harjani JR; Ahmed M; DeBono AJ; Pitcher NP; Wang ZC; Chhabra S; Barlow N; Rahmani R; Cleary B; Dolezal O; Hattarki M; Aurelio L; Shonberg J; Graham B; Peat TS; Baell JB; Swarbrick JD, 2018, '8-Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase', Chemistry - A European Journal, 24, pp. 1922 - 1930, http://dx.doi.org/10.1002/chem.201704730
    Journal articles | 2018
    Esquirol L; Peat TS; Wilding M; Hartley CJ; Newman J; Scott C, 2018, 'A novel decarboxylating amidohydrolase involved in avoiding metabolic dead ends during cyanuric acid catabolism in Pseudomonas sp. Strain ADP', PLoS ONE, 13, http://dx.doi.org/10.1371/journal.pone.0206949
    Journal articles | 2018
    Esquirol L; Peat TS; Wilding M; Liu JW; French NG; Hartley CJ; Onagi H; Nebl T; Easton CJ; Newman J; Scott C, 2018, 'An unexpected vestigial protein complex reveals the evolutionary origins of an s-triazine catabolic enzyme', Journal of Biological Chemistry, 293, pp. 7880 - 7891, http://dx.doi.org/10.1074/jbc.RA118.001996
    Journal articles | 2018
    Esquirol L; Peat TS; Wilding M; Lucent D; French NG; Hartley CJ; Newman J; Scott C, 2018, 'Structural and biochemical characterization of the biuret hydrolase (BiuH) from the cyanuric acid catabolism pathway of Rhizobium leguminasorum bv. viciae 3841', PLoS ONE, 13, http://dx.doi.org/10.1371/journal.pone.0192736
    Journal articles | 2018
    Liang YL; Khoshouei M; Deganutti G; Glukhova A; Koole C; Peat TS; Radjainia M; Plitzko JM; Baumeister W; Miller LJ; Hay DL; Christopoulos A; Reynolds CA; Wootten D; Sexton PM, 2018, 'Cryo-EM structure of the active, G s -protein complexed, human CGRP receptor', Nature, 561, pp. 492 - 497, http://dx.doi.org/10.1038/s41586-018-0535-y
    Journal articles | 2018
    Mujumdar P; Bua S; Supuran CT; Peat TS; Poulsen SA, 2018, 'Synthesis, structure and bioactivity of primary sulfamate-containing natural products', Bioorganic and Medicinal Chemistry Letters, 28, pp. 3009 - 3013, http://dx.doi.org/10.1016/j.bmcl.2018.04.038
    Journal articles | 2018
    Newman J; Sharp JA; Enjapoori AK; Bentley J; Nicholas KR; Adams TE; Peat TS, 2018, 'Structural characterization of a novel monotreme-specific protein with antimicrobial activity from the milk of the platypus', Acta Crystallographica Section F: Structural Biology Communications, 74, pp. 39 - 45, http://dx.doi.org/10.1107/S2053230X17017708
    Journal articles | 2017
    Angeli A; Tanini D; Peat TS; Di Cesare Mannelli L; Bartolucci G; Capperucci A; Ghelardini C; Supuran CT; Carta F, 2017, 'Discovery of New Selenoureido Analogues of 4-(4-Fluorophenylureido)benzenesulfonamide as Carbonic Anhydrase Inhibitors', ACS Medicinal Chemistry Letters, 8, pp. 963 - 968, http://dx.doi.org/10.1021/acsmedchemlett.7b00280
    Journal articles | 2017
    Chrysanthopoulos PK; Mujumdar P; Woods LA; Dolezal O; Ren B; Peat TS; Poulsen SA, 2017, 'Identification of a New Zinc Binding Chemotype by Fragment Screening', Journal of Medicinal Chemistry, 60, pp. 7333 - 7349, http://dx.doi.org/10.1021/acs.jmedchem.7b00606
    Journal articles | 2017
    Davies C; Böttcher C; Boss PK; Peat T; Newman J, 2017, 'Understanding the control of grape berry ripening and developing opportunities for its manipulation', Acta Horticulturae, 1157, pp. 1 - 10, http://dx.doi.org/10.17660/ActaHortic.2017.1157.1
    Journal articles | 2017
    Fisher CR; Sutton HJ; Kaczmarski JA; McNamara HA; Clifton B; Mitchell J; Cai Y; Dups JN; D'Arcy NJ; Singh M; Chuah A; Peat TS; Jackson CJ; Cockburn IA, 2017, 'T-dependent B cell responses to Plasmodium induce antibodies that form a high-avidity multivalent complex with the circumsporozoite protein', PLoS Pathogens, 13, http://dx.doi.org/10.1371/journal.ppat.1006469
    Journal articles | 2017
    Peat TS; Balotra S; Wilding M; Hartley CJ; Newman J; Scott C, 2017, 'High-resolution X-ray structures of two functionally distinct members of the cyclic amide hydrolase family of Toblerone fold enzymes', Applied and Environmental Microbiology, 83, http://dx.doi.org/10.1128/AEM.03365-16
    Journal articles | 2017
    Wilding M; Peat TS; Kalyaanamoorthy S; Newman J; Scott C; Jermiin LS, 2017, 'Reverse engineering: Transaminase biocatalyst development using ancestral sequence reconstruction', Green Chemistry, 19, pp. 5375 - 5380, http://dx.doi.org/10.1039/c7gc02343j
    Journal articles | 2017
    Wilding M; Scott C; Newman J; Peat TS, 2017, 'Crystal structure of a putrescine aminotransferase from Pseudomonas sp. strain AAC', Acta Crystallographica Section:F Structural Biology Communications, 73, pp. 29 - 35, http://dx.doi.org/10.1107/S2053230X16019658
    Journal articles | 2017
    Wilding M; Scott C; Peat TS; Newman J, 2017, 'X-ray crystal structure of a malonate-semialdehyde dehydrogenase from Pseudomonas sp. strain AAC', Acta Crystallographica Section:F Structural Biology Communications, 73, pp. 24 - 28, http://dx.doi.org/10.1107/S2053230X16020008
    Journal articles | 2017
    Zabara A; Meikle TG; Newman J; Peat TS; Conn CE; Drummond CJ, 2017, 'The nanoscience behind the art of: In-meso crystallization of membrane proteins', Nanoscale, 9, pp. 754 - 763, http://dx.doi.org/10.1039/c6nr07634c
    Journal articles | 2017
    Zabara A; Meikle TG; Trenker R; Yao S; Newman J; Peat TS; Separovic F; Conn CE; Call MJ; Call ME; Landau EM; Drummond CJ, 2017, 'Lipidic Cubic Phase-Induced Membrane Protein Crystallization: Interplay between Lipid Molecular Structure, Mesophase Structure and Properties, and Crystallogenesis', Crystal Growth and Design, 17, pp. 5667 - 5674, http://dx.doi.org/10.1021/acs.cgd.7b00519
    Journal articles | 2016
    Angeli A; Peat TS; Bartolucci G; Nocentini A; Supuran CT; Carta F, 2016, 'Intramolecular oxidative deselenization of acylselenoureas: a facile synthesis of benzoxazole amides and carbonic anhydrase inhibitors', Organic and Biomolecular Chemistry, 14, pp. 11353 - 11356, http://dx.doi.org/10.1039/c6ob02299e
    Journal articles | 2016
    Brewster JL; McKellar JLO; Finn TJ; Newman J; Peat TS; Gerth ML, 2016, 'Structural basis for ligand recognition by a Cache chemosensory domain that mediates carboxylate sensing in Pseudomonas syringae', Scientific Reports, 6, http://dx.doi.org/10.1038/srep35198
    Journal articles | 2016
    Dennis ML; Pitcher NP; Lee MD; Debono AJ; Wang ZC; Harjani JR; Rahmani R; Cleary B; Peat TS; Baell JB; Swarbrick JD, 2016, 'Structural Basis for the Selective Binding of Inhibitors to 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase from Staphylococcus aureus and Escherichia coli', Journal of Medicinal Chemistry, 59, pp. 5248 - 5263, http://dx.doi.org/10.1021/acs.jmedchem.6b00002
    Journal articles | 2016
    Kryshtafovych A; Moult J; Baslé A; Burgin A; Craig TK; Edwards RA; Fass D; Hartmann MD; Korycinski M; Lewis RJ; Lorimer D; Lupas AN; Newman J; Peat TS; Piepenbrink KH; Prahlad J; van Raaij MJ; Rohwer F; Segall AM; Seguritan V; Sundberg EJ; Singh AK; Wilson MA; Schwede T, 2016, 'Some of the most interesting CASP11 targets through the eyes of their authors', Proteins: Structure, Function and Bioinformatics, 84, pp. 34 - 50, http://dx.doi.org/10.1002/prot.24942
    Journal articles | 2016
    Mujumdar P; Teruya K; Tonissen KF; Vullo D; Supuran CT; Peat TS; Poulsen SA, 2016, 'An Unusual Natural Product Primary Sulfonamide: Synthesis, Carbonic Anhydrase Inhibition, and Protein X-ray Structures of Psammaplin C', Journal of Medicinal Chemistry, 59, pp. 5462 - 5470, http://dx.doi.org/10.1021/acs.jmedchem.6b00443
    Journal articles | 2016
    Wilding M; Peat TS; Newman J; Scott C, 2016, 'A β-alanine catabolism pathway containing a highly promiscuous ω-transaminase in the 12-aminododecanate-degrading Pseudomonas sp. strain AAC', Applied and Environmental Microbiology, 82, pp. 3846 - 3856, http://dx.doi.org/10.1128/AEM.00665-16
    Journal articles | 2016
    Woods LA; Dolezal O; Ren B; Ryan JH; Peat TS; Poulsen SA, 2016, 'Native State Mass Spectrometry, Surface Plasmon Resonance, and X-ray Crystallography Correlate Strongly as a Fragment Screening Combination', Journal of Medicinal Chemistry, 59, pp. 2192 - 2204, http://dx.doi.org/10.1021/acs.jmedchem.5b01940
    Journal articles | 2015
    Balotra S; Newman J; Cowieson NP; French NG; Campbell PM; Briggs LJ; Warden AC; Easton CJ; Peat TS; Scott C, 2015, 'X-Ray structure of the amidase domain of AtzF, the allophanate hydrolase from the cyanuric acid-mineralizing multienzyme complex', Applied and Environmental Microbiology, 81, pp. 470 - 480, http://dx.doi.org/10.1128/AEM.02783-14
    Journal articles | 2015
    Balotra S; Warden AC; Newman J; Briggs LJ; Scott C; Peat TS, 2015, 'X-Ray structure and mutagenesis studies of the n-isopropylammelide isopropylaminohydrolase, AtzC', PLoS ONE, 10, http://dx.doi.org/10.1371/journal.pone.0137700
    Journal articles | 2015
    Basnet SKC; Diab S; Schmid R; Yu M; Yang Y; Gillam TA; Teo T; Li P; Peat T; Albrecht H; Wang S, 2015, 'Identification of a highly conserved allosteric binding site on Mnk1 and Mnk2 s', Molecular Pharmacology, 88, pp. 935 - 948, http://dx.doi.org/10.1124/mol.115.100131
    Journal articles | 2015
    Peat TS; Newman J; Balotra S; Lucent D; Warden AC; Scott C, 2015, 'The structure of the hexameric atrazine chlorohydrolase AtzA', Acta Crystallographica Section D: Biological Crystallography, 71, pp. 710 - 720, http://dx.doi.org/10.1107/S1399004715000619
    Journal articles | 2015
    Ryan JH; Jarvis KE; Mulder RJ; Francis CL; Savage GP; Dolezal O; Peat TS; Deadman JJ, 2015, 'Unexpected Isomerisation of a Fragment Analogue During Fragment-Based Screening of HIV Integrase Catalytic Core Domain', Australian Journal of Chemistry, 68, pp. 1871 - 1879, http://dx.doi.org/10.1071/CH15587
    Journal articles | 2015
    Suryadinata R; Seabrook SA; Adams TE; Nuttall SD; Peat TS, 2015, 'Structural and biochemical analyses of a Clostridium perfringens sortase D transpeptidase', Acta Crystallographica Section D: Biological Crystallography, 71, pp. 1505 - 1513, http://dx.doi.org/10.1107/S1399004715009219
    Journal articles | 2015
    Tanpure RP; Ren B; Peat TS; Bornaghi LF; Vullo D; Supuran CT; Poulsen SA, 2015, 'Carbonic anhydrase inhibitors with dual-tail moieties to match the hydrophobic and hydrophilic halves of the carbonic anhydrase active site', Journal of Medicinal Chemistry, 58, pp. 1494 - 1501, http://dx.doi.org/10.1021/jm501798g
    Journal articles | 2015
    Warden AC; Williams M; Peat TS; Seabrook SA; Newman J; Dojchinov G; Haritos VS, 2015, 'Rational engineering of a mesohalophilic carbonic anhydrase to an extreme halotolerant biocatalyst', Nature Communications, 6, http://dx.doi.org/10.1038/ncomms10278
    Journal articles | 2014
    Balotra S; Newman J; French NG; Briggs LJ; Peat TS; Scott C, 2014, 'Crystallization and preliminary X-ray diffraction analysis of the amidase domain of allophanate hydrolase from Pseudomonas sp. strain ADP', Acta Crystallographica Section F:Structural Biology Communications, 70, pp. 310 - 315, http://dx.doi.org/10.1107/S2053230X13034705
    Journal articles | 2014
    Boersma YL; Newman J; Adams TE; Cowieson N; Krippner G; Bozaoglu K; Peat TS, 2014, 'The structure of vanin 1: A key enzyme linking metabolic disease and inflammation', Acta Crystallographica Section D: Biological Crystallography, 70, pp. 3320 - 3329, http://dx.doi.org/10.1107/S1399004714022767
    Journal articles | 2014
    Dennis ML; Chhabra S; Wang ZC; Debono A; Dolezal O; Newman J; Pitcher NP; Rahmani R; Cleary B; Barlow N; Hattarki M; Graham B; Peat TS; Baell JB; Swarbrick JD, 2014, 'Structure-based design and development of functionalized mercaptoguanine derivatives as inhibitors of the folate biosynthesis pathway enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from staphylococcus aureus', Journal of Medicinal Chemistry, 57, pp. 9612 - 9626, http://dx.doi.org/10.1021/jm501417f
    Journal articles | 2014
    Fazio VJ; Peat TS; Newman J, 2014, 'A drunken search in crystallization space', Acta Crystallographica Section F: Structural Biology Communications, 70, pp. 1303 - 1311, http://dx.doi.org/10.1107/S2053230X1401841X
    Journal articles | 2014
    Jackson CJ; Coppin CW; Carr PD; Aleksandrov A; Wilding M; Sugrue E; Ubels J; Paks M; Newman J; Peat TS; Russell RJ; Field M; Weik M; Oakeshott JG; Scott C, 2014, '300-fold increase in production of the Zn2+-dependent dechlorinase trzN in soluble form via apoenzyme stabilization', Applied and Environmental Microbiology, 80, pp. 4003 - 4011, http://dx.doi.org/10.1128/AEM.00916-14
    Journal articles | 2014
    Kenny PW; Newman J; Peat TS, 2014, 'Nitrate in the active site of protein tyrosine phosphatase 1B is a putative mimetic of the transition state', Acta Crystallographica Section D: Biological Crystallography, 70, pp. 565 - 571, http://dx.doi.org/10.1107/S1399004713031052
    Journal articles | 2014
    Moeker J; Peat TS; Bornaghi LF; Vullo D; Supuran CT; Poulsen SA, 2014, 'Cyclic secondary sulfonamides: Unusually good inhibitors of cancer-related carbonic anhydrase enzymes', Journal of Medicinal Chemistry, 57, pp. 3522 - 3531, http://dx.doi.org/10.1021/jm500255y
    Journal articles | 2014
    Newman J; Peat TS; Paul Savage G, 2014, 'What's in a name? Moving towards a limited vocabulary for macromolecular crystallisation', Australian Journal of Chemistry, 67, pp. 1813 - 1817, http://dx.doi.org/10.1071/CH14199
    Journal articles | 2014
    Peat TS; Dolezal O; Newman J; Mobley D; Deadman JJ, 2014, 'Interrogating HIV integrase for compounds that bind - A SAMPL challenge', Journal of Computer-Aided Molecular Design, 28, pp. 347 - 362, http://dx.doi.org/10.1007/s10822-014-9721-7
    Journal articles | 2014
    Ren B; Peat TS; Streltsov VA; Pollard M; Fernley R; Grusovin J; Seabrook S; Pilling P; Phan T; Lu L; Lovrecz GO; Graham LD; Hill RJ, 2014, 'Unprecedented conformational flexibility revealed in the ligand-binding domains of the Bovicola ovis ecdysone receptor (EcR) and ultraspiracle (USP) subunits', Acta Crystallographica Section D: Biological Crystallography, 70, pp. 1954 - 1964, http://dx.doi.org/10.1107/S1399004714009626
    Journal articles | 2013
    Chhabra S; Barlow N; Dolezal O; Hattarki MK; Newman J; Peat TS; Graham B; Swarbrick JD, 2013, 'Exploring the Chemical Space around 8-Mercaptoguanine as a Route to New Inhibitors of the Folate Biosynthesis Enzyme HPPK', PLoS ONE, 8, http://dx.doi.org/10.1371/journal.pone.0059535
    Journal articles | 2013
    Chhabra S; Dolezal O; Hattarki M; Peat TS; Simpson JS; Swarbrick JD, 2013, 'Fragment screening on Staphylococcus aureus HPPK - A folate pathway target', Australian Journal of Chemistry, 66, pp. 1537 - 1543, http://dx.doi.org/10.1071/CH13298
    Journal articles | 2013
    Dolezal O; Doughty L; Hattarki MK; Fazio VJ; Caradoc-Davies TT; Newman J; Peat TS, 2013, 'Fragment screening for the modelling community: SPR, ITC, and crystallography', Australian Journal of Chemistry, 66, pp. 1507 - 1517, http://dx.doi.org/10.1071/CH13302
    Journal articles | 2013
    Francis CL; Kenny PW; Dolezal O; Saubern S; Kruger M; Savage GP; Peat TS; Ryan JH, 2013, 'Construction of the CSIRO fragment library', Australian Journal of Chemistry, 66, pp. 1473 - 1482, http://dx.doi.org/10.1071/CH13325
    Journal articles | 2013
    Newman J; Burton DR; Caria S; Desbois S; Gee CL; Fazio VJ; Kvansakul M; Marshall B; Mills G; Richter V; Seabrook SA; Wu M; Peat TS, 2013, 'Crystallization reports are the backbone of Acta Cryst. F, but do they have any spine?', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 69, pp. 712 - 718, http://dx.doi.org/10.1107/S1744309113014152
    Journal articles | 2013
    Newman J; Seabrook S; Surjadi R; Williams CC; Lucent D; Wilding M; Scott C; Peat TS, 2013, 'Determination of the Structure of the Catabolic N-Succinylornithine Transaminase (AstC) from Escherichia coli', PLoS ONE, 8, http://dx.doi.org/10.1371/journal.pone.0058298
    Journal articles | 2013
    Peat TS; Balotra S; Wilding M; French NG; Briggs LJ; Panjikar S; Cowieson N; Newman J; Scott C, 2013, 'Cyanuric acid hydrolase: Evolutionary innovation by structural concatenation', Molecular Microbiology, 88, pp. 1149 - 1163, http://dx.doi.org/10.1111/mmi.12249
    Journal articles | 2013
    Peat TS; Rhodes DI; Vandegraaff N; Le G; Smith JA; Clark LJ; Jones ED; Coates JAV; Thienthong N; Newman J; Dolezal O; Mulder R; Ryan JH; Paul Savage G; Francis CL; Deadman JJ, 2013, 'Correction: Small molecule inhibitors of the LEDGF site of human immunodeficiency virus integrase identified by fragment screening and structure based design (PLoS ONE)', PLoS ONE, 8, http://dx.doi.org/10.1371/annotation/eb238f0f-7582-4318-af95-64ac98d3b0be
    Journal articles | 2013
    Ren B; Pham TM; Surjadi R; Robinson CP; Le TK; Scott Chandry P; Peat TS; McKinstry WJ, 2013, 'Expression, purification, crystallization and preliminary X-ray diffraction analysis of a lactococcal bacteriophage small terminase subunit', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 69, pp. 275 - 279, http://dx.doi.org/10.1107/S174430911300184X
    Journal articles | 2013
    Wielens J; Headey SJ; Rhodes DI; Mulder RJ; Dolezal O; Deadman JJ; Newman J; Chalmers DK; Parker MW; Peat TS; Scanlon MJ, 2013, 'Parallel screening of low molecular weight fragment libraries: Do differences in methodology affect hit identification?', Journal of Biomolecular Screening, 18, pp. 147 - 159, http://dx.doi.org/10.1177/1087057112465979
    Journal articles | 2013
    Zhang L; Holmes IP; Hochgräfe F; Walker SR; Ali NA; Humphrey ES; Wu J; De Silva M; Kersten WJA; Connor T; Falk H; Allan L; Street IP; Bentley JD; Pilling PA; Monahan BJ; Peat TS; Daly RJ, 2013, 'Characterization of the novel broad-spectrum kinase inhibitor CTx-0294885 as an affinity reagent for mass spectrometry-based kinome profiling', Journal of Proteome Research, 12, pp. 3104 - 3116, http://dx.doi.org/10.1021/pr3008495
    Journal articles | 2012
    Chhabra S; Dolezal O; Collins BM; Newman J; Simpson JS; Macreadie IG; Fernley R; Peat TS; Swarbrick JD, 2012, 'Structure of S. aureus HPPK and the discovery of a new substrate site inhibitor', PLoS ONE, 7, http://dx.doi.org/10.1371/journal.pone.0029444
    Journal articles | 2012
    Newman J; Bolton EE; Müller-Dieckmann J; Fazio VJ; Gallagher DT; Lovell D; Luft JR; Peat TS; Ratcliffe D; Sayle RA; Snell EH; Taylor K; Vallotton P; Velanker S; Von Delft F, 2012, 'On the need for an international effort to capture, share and use crystallization screening data', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 68, pp. 253 - 258, http://dx.doi.org/10.1107/S1744309112002618
    Journal articles | 2012
    Newman J; Dolezal O; Fazio V; Caradoc-Davies T; Peat TS, 2012, 'The DINGO dataset: A comprehensive set of data for the SAMPL challenge', Journal of Computer-Aided Molecular Design, 26, pp. 497 - 503, http://dx.doi.org/10.1007/s10822-011-9521-2
    Journal articles | 2012
    Peat TS; Böttcher C; Newman J; Lucent D; Cowieson N; Davies C, 2012, 'Crystal structure of an indole-3-acetic acid amido synthetase from grapevine involved in auxin homeostasis', Plant Cell, 24, pp. 4525 - 4538, http://dx.doi.org/10.1105/tpc.112.102921
    Journal articles | 2012
    Peat TS; Rhodes DI; Vandegraaff N; Le G; Smith JA; Clark LJ; Jones ED; Coates JAV; Thienthong N; Newman J; Dolezal O; Mulder R; Ryan JH; Savage GP; Francis CL; Deadman JJ, 2012, 'Small molecule inhibitors of the LEDGF site of human immunodeficiency virus integrase identified by fragment screening and structure based design', PLoS ONE, 7, http://dx.doi.org/10.1371/journal.pone.0040147
    Journal articles | 2011
    Falk H; Connor T; Yang H; Loft KJ; Alcindor JL; Nikolakopoulos G; Surjadi RN; Bentley JD; Hattarki MK; Dolezal O; Murphy JM; Monahan BJ; Peat TS; Thomas T; Baell JB; Parisot JP; Street IP, 2011, 'An efficient high-throughput screening method for MYST family acetyltransferases, a new class of epigenetic drug targets', Journal of Biomolecular Screening, 16, pp. 1196 - 1205, http://dx.doi.org/10.1177/1087057111421631
    Journal articles | 2011
    Kennedy DF; Drummond CJ; Peat TS; Newman J, 2011, 'Evaluating protic ionic liquids as protein crystallization additives', Crystal Growth and Design, 11, pp. 1777 - 1785, http://dx.doi.org/10.1021/cg1017104
    Journal articles | 2011
    Newman J; Pearce L; Lesburg CA; Strickland C; Peat TS, 2011, 'Crystallization of an apo form of human arginase: Using all the tools in the toolbox simultaneously', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 67, pp. 90 - 93, http://dx.doi.org/10.1107/S1744309110046208
    Journal articles | 2011
    Rhodes DI; Peat TS; Vandegraaff N; Jeevarajah D; Le G; Jones ED; Smith JA; Coates JAV; Winfield LJ; Thienthong N; Newman J; Lucent D; Ryan JH; Savage GP; Francis CL; Deadman JJ, 2011, 'Structural basis for a new mechanism of inhibition of HIV-1 integrase identified by fragment screening and structure-based design', Antiviral Chemistry and Chemotherapy, 21, pp. 155 - 168, http://dx.doi.org/10.3851/IMP1716
    Journal articles | 2011
    Rhodes DI; Peat TS; Vandegraaff N; Jeevarajah D; Newman J; Martyn J; Coates JAV; Ede NJ; Rea P; Deadman JJ, 2011, 'Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site', ChemBioChem, 12, pp. 2311 - 2315, http://dx.doi.org/10.1002/cbic.201100350
    Journal articles | 2011
    Wu N; Courtois F; Surjadi R; Oakeshott J; Peat TS; Easton CJ; Abell C; Zhu Y, 2011, 'Enzyme synthesis and activity assay in microfluidic droplets on a chip', Engineering in Life Sciences, 11, pp. 157 - 164, http://dx.doi.org/10.1002/elsc.201000043
    Journal articles | 2011
    Wu N; Oakeshott JG; Easton CJ; Peat TS; Surjadi R; Zhu Y, 2011, 'A double-emulsion microfluidic platform for in vitro green fluorescent protein expression', Journal of Micromechanics and Microengineering, 21, http://dx.doi.org/10.1088/0960-1317/21/5/054032
    Journal articles | 2010
    Chhabra S; Newman J; Peat TS; Fernley RT; Caine J; Simpson JS; Swarbrick JD, 2010, 'Crystallization and preliminary X-ray analysis of 6 - Hydroxymethyl-7,8- dihydropterin pyrophosphokinase from Staphylococcus aureus', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 66, pp. 575 - 578, http://dx.doi.org/10.1107/S1744309110010857
    Journal articles | 2010
    Dransfield DT; Cohen EH; Chang Q; Sparrow LG; Bentley JD; Dolezal O; Xiao X; Peat TS; Newman J; Pilling PA; Phan T; Priebe I; Brierley GV; Kastrapeli N; Kopacz K; Martik D; Wassaf D; Rank D; Conley G; Huang Y; Adams TE; Cosgrove L, 2010, 'A human monoclonal antibody against insulin-like growth factor-II blocks the growth of human hepatocellular carcinoma cell lines in vitro and in vivo', Molecular Cancer Therapeutics, 9, pp. 1809 - 1819, http://dx.doi.org/10.1158/1535-7163.MCT-09-1134
    Journal articles | 2010
    Ernberg K; McGrath AP; Peat TS; Adams TE; Xiao X; Pham T; Newman J; McDonald IA; Collyer CA; Guss JM, 2010, 'A new crystal form of human vascular adhesion protein 1', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 66, pp. 1572 - 1578, http://dx.doi.org/10.1107/S1744309110041515
    Journal articles | 2010
    Newman J; Fazio VJ; Lawson B; Peat TS, 2010, 'The C6 Web Tool: A resource for the rational selection of crystallization conditions', Crystal Growth and Design, 10, pp. 2785 - 2792, http://dx.doi.org/10.1021/cg1004209
    Journal articles | 2010
    Oakley AJ; Barrett S; Peat TS; Newman J; Streltsov VA; Waddington L; Saito T; Tashiro M; McKimm-Breschkin JL, 2010, 'Structural and functional basis of resistance to neuraminidase inhibitors of influenza B viruses', Journal of Medicinal Chemistry, 53, pp. 6421 - 6431, http://dx.doi.org/10.1021/jm100621s
    Journal articles | 2010
    Taylor MC; Jackson CJ; Tattersall DB; French N; Peat TS; Newman J; Briggs LJ; Lapalikar GV; Campbell PM; Scott C; Russell RJ; Oakeshott JG, 2010, 'Identification and characterization of two families of F420H2-dependent reductases from Mycobacteria that catalyse aflatoxin degradation', Molecular Microbiology, 78, pp. 561 - 575, http://dx.doi.org/10.1111/j.1365-2958.2010.07356.x
    Journal articles | 2009
    Newman J; Cohen EH; Cosgrove L; Kopacz K; Dransfield DT; Adams TE; Peat TS, 2009, 'Crystallization and preliminary X-ray analysis of the complexes between a Fab and two forms of human insulin-like growth factor II', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 65, pp. 945 - 948, http://dx.doi.org/10.1107/S1744309109024932
    Journal articles | 2009
    Newman J; Fazio VJ; Caradoc-Davies TT; Branson K; Peat TS, 2009, 'Practical aspects of the SAMPL challenge: Providing an extensive experimental data set for the modeling community', Journal of Biomolecular Screening, 14, pp. 1245 - 1250, http://dx.doi.org/10.1177/1087057109348220
    Journal articles | 2009
    Wu N; Zhu Y; Brown S; Oakeshott J; Peat TS; Surjadi R; Easton C; Leech PW; Sexton BA, 2009, 'A PMMA microfluidic droplet platform for in vitro protein expression using crude E. coli S30 extract', Lab on a Chip, 9, pp. 3391 - 3398, http://dx.doi.org/10.1039/b911581a
    Journal articles | 2008
    Newman J; Pham TM; Peat TS, 2008, 'Phoenito experiments: Combining the strengths of commercial crystallization automation', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 64, pp. 991 - 996, http://dx.doi.org/10.1107/S1744309108029667
    Journal articles | 2005
    Badger J; Sauder JM; Adams JM; Antonysamy S; Bain K; Bergseid MG; Buchanan SG; Buchanan MD; Batiyenko Y; Christopher JA; Emtage S; Eroshkina A; Feil I; Furlong EB; Gajiwala KS; Gao X; He D; Hendle J; Huber A; Hoda K; Kearins P; Kissinger C; Laubert B; Lewis HA; Lin J; Loomis K; Lorimer D; Louie G; Maletic M; Marsh CD; Miller I; Molinari J; Muller-Dieckmann HJ; Newman JM; Noland BW; Pagarigan B; Park F; Peat TS; Post KW; Radojicic S; Ramos A; Romero R; Rutter ME; Sanderson WE; Schwinn KD; Tresser J; Winhoven J; Wright TA; Wu L; Xu J; Harris TJR, 2005, 'Structural analysis of a set of proteins resulting from a bacterial genomics project', Proteins: Structure, Function and Genetics, 60, pp. 787 - 796, http://dx.doi.org/10.1002/prot.20541
    Journal articles | 2005
    Peat TS; Christopher JA; Newman J, 2005, 'Tapping the Protein Data Bank for crystallization information', Acta Crystallographica Section D: Biological Crystallography, 61, pp. 1662 - 1669, http://dx.doi.org/10.1107/S0907444905033202
    Journal articles | 2004
    Park F; Gajiwala K; Eroshkina G; Furlong E; He D; Batiyenko Y; Romero R; Christopher J; Badger J; Hendle J; Lin J; Peat T; Buchanan S, 2004, 'Crystal Structure of YIGZ, a Conserved Hypothetical Protein from Escherichia coli K12 with a Novel Fold', Proteins: Structure, Function and Genetics, 55, pp. 775 - 777, http://dx.doi.org/10.1002/prot.20087
    Journal articles | 2004
    Park F; Gajiwala K; Noland B; Wu L; He D; Molinari J; Loomis K; Pagarigan B; Kearins P; Christopher J; Peat T; Badger J; Hendle J; Lin J; Buchanan S, 2004, 'The 1.59 Å Resolution Crystal Structure of TM0096, a Flavin Mononucleotide Binding Protein from Thermotoga maritima', Proteins: Structure, Function and Genetics, 55, pp. 772 - 774, http://dx.doi.org/10.1002/prot.20086
    Journal articles | 2002
    Peat T; De la Fortelle E; Culpepper J; Newman J, 2002, 'From information management to protein annotation: Preparing protein structures for drug discovery', Acta Crystallographica Section D: Biological Crystallography, 58, pp. 1968 - 1970, http://dx.doi.org/10.1107/S0907444902016852
    Journal articles | 2001
    Cort JR; Santhana Mariappan SV; Kim CY; Park MS; Peat TS; Waldo GS; Terwilliger TC; Kennedy MA, 2001, 'Solution structure of Pyrobaculum aerophilum DsrC, an archaeal homologue of the gamma subunit of dissimilatory sulfite reductase', European Journal of Biochemistry, 268, pp. 5842 - 5850, http://dx.doi.org/10.1046/j.0014-2956.2001.02529.x
    Journal articles | 2001
    Lewis HA; Furlong EB; Laubert B; Eroshkina GA; Batiyenko Y; Adams JM; Bergseid MG; Marsh CD; Peat TS; Sanderson WE; Sauder JM; Buchanan SG, 2001, 'A structural genomics approach to the study of quorum sensing: Crystal structures of three LuxS orthologs', Structure, 9, pp. 527 - 537, http://dx.doi.org/10.1016/S0969-2126(01)00613-X
    Journal articles | 2000
    Peat TS; Newman JM, 2000, 'Structural genomics in the post-genomics era: The shapes of things to come', Current Opinion in Drug Discovery and Development, 3, pp. 399 - 407
    Journal articles | 1999
    McDonald JP; Peat TS; Levine AS; Woodgate R, 1999, 'Intermolecular cleavage by UmuD-like enzymes: Identification of residues required for cleavage and substrate specificity', Journal of Molecular Biology, 285, pp. 2199 - 2209, http://dx.doi.org/10.1006/jmbi.1998.2433
    Journal articles | 1999
    Newman J; Peat TS; Richard R; Kan L; Swanson PE; Affholter JA; Holmes IH; Schindler JF; Unkefer CJ; Terwilliger TC, 1999, 'Haloalkane dehalogenases: Structure of a Rhodococcus enzyme', Biochemistry, 38, pp. 16105 - 16114, http://dx.doi.org/10.1021/bi9913855
    Journal articles | 1998
    McLenigan M; Peat TS; Frank EG; McDonald JP; Gonzalez M; Levine AS; Hendrickson WA; Woodgate R, 1998, 'Novel Escherichia coli umuD' mutants: Structure-function insights into SOS mutagenesis', Journal of Bacteriology, 180, pp. 4658 - 4666, http://dx.doi.org/10.1128/jb.180.17.4658-4666.1998
    Journal articles | 1998
    Peat TS; Newman J; Waldo GS; Berendzen J; Terwilliger TC, 1998, 'Structure of translation initiation factor 5A from Pyrobaculum aerophilum at 1.75 Å resolution', Structure, 6, pp. 1207 - 1214, http://dx.doi.org/10.1016/S0969-2126(98)00120-8
    Journal articles | 1998
    Ruscetti T; Newman J; Peat TS; Francis J; Nolan R; Terwilliger TC; Peterson SR; Lehnert BE, 1998, 'A nondenaturing purification scheme for the DNA-binding domain of poly(ADP-ribose) polymerase, a structure-specific DNA-binding protein', Protein Expression and Purification, 14, pp. 79 - 86, http://dx.doi.org/10.1006/prep.1998.0919
    Journal articles | 1998
    Terwilliger TC; Waldo G; Peat TS; Newman JM; Chu K; Berendzen J, 1998, 'Class-directed structure determination: Foundation for a protein structure initiative', Protein Science, 7, pp. 1851 - 1856, http://dx.doi.org/10.1002/pro.5560070901
    Journal articles | 1996
    Peat TS; Frank EG; McDonald JP; Levine AS; Woodgate R; Hendrickson WA, 1996, 'Structure of the UmuD′ protein and its regulation in response to DNA damage', Nature, 380, pp. 727 - 730, http://dx.doi.org/10.1038/380727a0
    Journal articles | 1996
    Peat TS; Frank EG; McDonald JP; Levine AS; Woodgate R; Hendrickson WA, 1996, 'The UmuD' protein filament and its potential role in damage induced mutagenesis', Structure, 4, pp. 1401 - 1412, http://dx.doi.org/10.1016/S0969-2126(96)00148-7
    Journal articles | 1996
    Peat TS; Frank EG; Woodgate R; Hendrickson WA, 1996, 'Production and crystallization of a selenomethionyl variant of UmuD', an Escherichia coli SOS response protein', Proteins: Structure, Function and Genetics, 25, pp. 506 - 509, http://dx.doi.org/10.1002/(SICI)1097-0134(199608)25:4<506::AID-PROT10>3.3.CO;2-Z
    Journal articles | 1995
    Urs UK; Sharkey DJ; Peat TS; Hendrickson WA; Krishna Murthy HM, 1995, 'Characterization of crystals of the thermostable DNA polymerase I from thermus aquaticus', Proteins: Structure, Function, and Bioinformatics, 23, pp. 111 - 114, http://dx.doi.org/10.1002/prot.340230112
    Journal articles | 1981
    BLITZ J; PEAT TS, 1981, 'THE APPLICATION OF MULTIFREQUENCY EDDY CURRENTS TO TESTING FERROMAGNETIC METALS', NDT INTERNATIONAL, 14, pp. 15 - 17, http://dx.doi.org/10.1016/0308-9126(81)90058-4
  • Conference Papers | 2021
    Sharma S; Chung J; Uryu S; Rickard A; Nady N; Khan S; Wang Z; Zhang Y; Zhang H; Kung P-P; Greenwald E; Maegley K; Bingham P; Lam H; Bozikis YE; Falk H; Allan E; Avery VM; Butler MS; Camerino MA; Carrasco-Pozo C; Charman SA; Davis MJ; Dawson MA; Sarah-Jane D; de Silva M; Dennis ML; Dolezal O; Lagiakos R; Lindeman GJ; MacPherson L; Nuttall S; Peat TS; Ren B; Stupple AE; Surgenor E; Tan CW; Thomas T; Visvader JE; Voss AK; Vaillant F; White KL; Whittle J; Yang Y; Hediyeh-Zadeh S; Stupple PA; Street IP; Monahan BJ; Paul T, 2021, 'First-in-class KAT6A/KAT6B inhibitor CTx-648 (PF-9363) demonstrates potent anti-tumor activity in ER plus breast cancer with KAT6A dysregulation.', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000680263503465&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Preprints | 2019
    Kaczmarski JA; Hong N-S; Mukherjee B; Wey LT; Rourke L; Förster B; Peat TS; Price GD; Jackson CJ, 2019, Structural basis for the allosteric regulation of the SbtA bicarbonate transporter by the PII-like protein, SbtB, fromCyanobiumsp. PCC7001, http://dx.doi.org/10.1101/762807
    Conference Papers | 2018
    Peat TS; Dennis M; Dolezal O; Newman J; Morrow B; Monahan B; Foitzik R; Khoo PS; Stupple P; Street I, 2018, 'Fragment screening for a protein-protein interaction inhibitor to WDR5', in ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, INT UNION CRYSTALLOGRAPHY, pp. A139 - A139, http://dx.doi.org/10.1107/S0108767318098604
    Conference Papers | 2015
    Falk H; Foitzik RC; Allan E; deSilva M; Yang H; Bozikis YE; Nikac M; Walker SR; Camerino MA; Morrow BJ; Stupple AE; Lagiakos R; Pinson J-A; Lessene R; Kersten WJA; Ganame DG; Holmes IP; Lunniss GE; Chung M; Hermans SJ; Parker MW; Thistlethwaite A; White K; Charman SA; Monahan BJ; Pilling P; Grusovin J; Peat TS; Sonderegger S; Toulmin E; Jane SM; Curtis DJ; Stupple PA; Street IP, 2015, 'PRMT5 inhibitors as novel treatment for cancers', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, PA, Philadelphia, presented at 106th Annual Meeting of the American-Association-for-Cancer-Research (AACR), PA, Philadelphia, 18 April 2015 - 22 April 2015, http://dx.doi.org/10.1158/1538-7445.AM2015-5371
    Conference Papers | 2013
    Lapierre F; Best M; Stewart R; Oakeshott J; Peat T; Zhu Y, 2013, 'Integrated microdroplet-based system for enzyme synthesis and sampling', in Proceedings of SPIE - The International Society for Optical Engineering, http://dx.doi.org/10.1117/12.2033569
    Conference Papers | 2013
    Lapierre F; Cameron NR; Oakeshott J; Peat T; Zhu Y, 2013, 'How to fabricate robust microfluidic systems for a dollar', in Proceedings of SPIE - The International Society for Optical Engineering, http://dx.doi.org/10.1117/12.2033508
    Conference Papers | 2011
    Peat TS; Deadman JJ; Rhodes DI; Newman J; Dolezal O; Vandegraaff N; Smith JA; Le G; Ryan JH; Francis CL; Savage GP, 2011, 'New HIV Integrase inhibitors discovered through fragment screening', in ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, INT UNION CRYSTALLOGRAPHY, pp. C291 - C291, http://dx.doi.org/10.1107/S0108767311092737
    Conference Papers | 2005
    Peat TS; Christopher J; Schmidt K, 2005, 'AFITT-Working with Good Chemistry', in ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, INT UNION CRYSTALLOGRAPHY, pp. C165 - C165, http://dx.doi.org/10.1107/S0108767305092974
    Conference Papers | 2002
    Lewis HA; Furlong EB; Laubert B; Eroshkina GA; Batiyenko Y; Adams JM; Bergseid MG; Winhoven J; Marsh CD; Peat TS; Sanderson WE; Sauder JM; Buchanan SG, 2002, 'THE QUORUM SENSING PROTEIN LuxS: FUNCTIONAL INSIGHTS FROM STRUCTURE', in ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, INT UNION CRYSTALLOGRAPHY, pp. C194 - C194, http://dx.doi.org/10.1107/S0108767302092784
    Conference Papers | 1999
    Peat TS; Newman J; Waldo G; Terwilliger TC, 1999, 'PROTEOMICS AND THE SHOTGUN APPROACH TO STRUCTURE.', in ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, INT UNION CRYSTALLOGRAPHY, pp. 317 - 317, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000475706303043&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1