Dr Tim Murphy

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Research Interests: Autoregulation of blood flow is the ability of tissues to control 'local' blood flow in response to changes in systemic blood pressure and the tissue's metabolic requirements. Our research focusses on the mechanisms of blood flow autoregulation; pressure-induced changes in the diameter of arterioles (myogenic mechanisms) and alteration of arteriolar diameter in response to metabolic products (metabolic mechanisms). We are also interested in the effect of metabolic diseases such as obesity and diabetes on small artery function.

Broad Research Areas:
Cardiology and Vascular Disease, Pharmacology, Physiology

Qualifications:
BSc (Hons), PhD

Society Memberships & Professional Activities:
Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT), Australia and New Zealand Microcirculation Society, Australian Physiology Society, British Pharmacological Society

Specific Research Keywords:
Vascular Biology, Microcirculation, Vascular remodeling, Obesity, Diabetes

Phone

+61 2 9385 3600

E-mail

tim.murphy@unsw.edu.au

Journal articles | 2022

Luque NM; Lowe SM; Leader LL; Horrowitz SD; Murphy TV; Sandow SL, 2022, 'Treatment of preeclamptic vessels with pravastatin enhances vessel function and alters caveolae form and distribution through removal of cellular cholesterol', FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 36, http://dx.doi.org/10.1096/fasebj.2022.36.S1.R4373

Journal articles | 2022

2022, 'Microvascular anatomy and physiology laboratory class using the Australian cane toad', FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 36, http://dx.doi.org/10.1096/fasebj.2022.36.S1.0R828

Journal articles | 2021

Saunders SL; Hutchinson DS; Britton FC; Liu L; Markus I; Sandow SL; Murphy TV, 2021, 'Effect of β1/β2‐adrenoceptor blockade on β3‐adrenoceptor activity in the rat cremaster muscle artery', British Journal of Pharmacology, 178, pp. 1789 - 1804, http://dx.doi.org/10.1111/bph.15398

Journal articles | 2020

Drimousis S; Markus I; Murphy TV; Shevy Perera D; Phan-Thien KC; Zhang L; Liu L, 2020, 'Gender-related differences of tachykinin NK2 receptor expression and activity in human colonic smooth muscle', Journal of Pharmacology and Experimental Therapeutics, 375, pp. 28 - 39, http://dx.doi.org/10.1124/JPET.120.265967

Journal articles | 2019

Murphy TV; Sandow SL, 2019, 'Agonist-evoked endothelial Ca ²⁺ signalling microdomains', Current Opinion in Pharmacology, 45, pp. 8 - 15, http://dx.doi.org/10.1016/j.coph.2019.03.005

Journal articles | 2017

Grayson TH; Murphy TV; Sandow SL, 2017, 'Transient receptor potential canonical type 3 channels: Interactions, role and relevance - a vascular focus.', Pharmacology and Therapeutics, 174, pp. 79 - 96, http://dx.doi.org/10.1016/j.pharmthera.2017.02.022

Journal articles | 2016

Murphy TV; Kanagarajah A; Toemoe S; Bertrand PP; Grayson TH; Britton FC; Leader L; Senadheera S; Sandow SL, 2016, 'TRPV3 expression and vasodilator function in isolated uterine radial arteries from non-pregnant and pregnant rats', Vascular Pharmacology, 83, pp. 66 - 77, http://dx.doi.org/10.1016/j.vph.2016.04.004

Journal articles | 2016

Quek KJ; Boyd R; Ameer OZ; Zangerl B; Butlin M; Murphy TV; Avolio AP; Phillips JK, 2016, 'Progressive vascular remodelling, endothelial dysfunction and stiffness in mesenteric resistance arteries in a rodent model of chronic kidney disease', Vascular Pharmacology, 81, pp. 42 - 52, http://dx.doi.org/10.1016/j.vph.2015.12.004

Journal articles | 2015

Holobotovskyy V; Chong YS; Burchell J; He B; Phillips M; Leader L; Murphy TV; Sandow SL; McKitrick DJ; Charles AK; Tare M; Arnolda LF; Ganss R, 2015, 'Regulator of G protein signaling 5 is a determinant of gestational hypertension and preeclampsia', Science Translational Medicine, 7, http://dx.doi.org/10.1126/scitranslmed.aaa5038

Journal articles | 2015

Kerr PM; Wei R; Tam R; Sandow SL; Murphy TV; Ondrusova K; Lunn SE; Tran CHT; Welsh DG; Plane F, 2015, 'Activation of endothelial IKCa channels underlies NO-dependent myoendothelial feedback', Vascular Pharmacology, 74, pp. 130 - 138, http://dx.doi.org/10.1016/j.vph.2015.09.001

Journal articles | 2014

Ellinsworth DC; Earley S; Murphy TV; Sandow SL, 2014, 'Endothelial control of vasodilation: Integration of myoendothelial microdomain signalling and modulation by epoxyeicosatrienoic acids', Pflugers Archiv European Journal of Physiology, 466, pp. 389 - 405, http://dx.doi.org/10.1007/s00424-013-1303-3

Journal articles | 2014

Howitt L; Morris MJ; Sandow SL; Murphy TV, 2014, 'Effect of diet-induced obesity on BKCa function in contraction and dilation of rat isolated middle cerebral artery', Vascular Pharmacology, 61, pp. 10 - 15, http://dx.doi.org/10.1016/j.vph.2014.02.002

Journal articles | 2014

Wang K; Bertrand RL; Senadheera S; Polglaze KE; Murphy TV; Sandow SL; Liu L; Bornstein JC; Bertrand PP, 2014, 'Motility changes induced by intraluminal FeSO4 in guinea pig jejunum', Neurogastroenterology and Motility, 26, pp. 385 - 396, http://dx.doi.org/10.1111/nmo.12276

Journal articles | 2013

Grayson TH; Chadha P; Bertrand PP; Chen H; Morris MJ; Senadheera S; Murphy TV; Sandow SL, 2013, 'Increased caveolae density and caveolin-1 expression accompany impaired NO-mediated vasorelaxation in diet-induced obesity', Histochemistry and Cell Biology, 139, pp. 309 - 321, http://dx.doi.org/10.1007/s00418-012-1032-2

Journal articles | 2013

Naser M; Januszeski AS; Brown BE; Jenkins AJ; Hill MA; Murphy TV, 2013, 'Advanced glycation end products acutely impair Ca2+ signaling in bovine aortic endothelial cells', Frontiers in Physiology, 4, pp. Article No. 38, http://dx.doi.org/10.3389/fphys.2013.00038

Journal articles | 2013

Senadheera S; Bertrand PP; Grayson TH; Leader L; Murphy TV; Sandow SL, 2013, 'Pregnancy-induced remodelling and enhanced endothelium-derived hyperpolarization-type vasodilator activity in rat uterine radial artery: transient receptor potential vanilloid type 4 channels, caveolae and myoendothelial gap junctions', Journal of Anatomy, 223, pp. 677 - 686, http://dx.doi.org/10.1111/joa.12127

Journal articles | 2013

Senadheera S; Bertrand PP; Grayson TH; Leader L; Tare M; Murphy TV; Sandow SL, 2013, 'Enhanced contractility in pregnancy is associated with augmented TRPC3, L-type, and T-type voltage-dependent calcium channel function in rat uterine radial artery', American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 305, pp. R917 - R926, http://dx.doi.org/10.1152/ajpregu.00225.2013

Journal articles | 2012

Bertrand R; Senadheera SN; Tanoto A; Tan K; Howitt L; Chen H; Murphy TV; Sandow S; Liu L; Bertrand PP, 2012, 'Serotonin availability in rat colon is reduced during a Western diet model of obesity', American Journal of Physiology - Gastrointestinal and Liver Physiology, 303, pp. G424 - G434, http://dx.doi.org/10.1152/ajpgi.00048.2012

Journal articles | 2012

Howitt L; Grayson TH; Morris MJ; Sandow SL; Murphy TV, 2012, 'Dietary obesity increases NO and inhibits BKCa-mediated, endothelium-dependent dilation in rat cremaster muscle artery: association with caveolins and caveolae', American Journal of Physiology - Heart and Circulatory Physiology, 302, pp. H2464 - H2476, http://dx.doi.org/10.1152/ajpheart.00965.2011

Journal articles | 2012

Sandow S; Senadheera S; Bertrand PP; Murphy TV; Tare M, 2012, 'Myoendothelial contacts, gap junctions and microdomains: anatomical links to function?', Microcirculation, 19, pp. 403 - 415, http://dx.doi.org/10.1111/j.1549-8719.2011.00146.x

Journal articles | 2012

Sandow SL; Senadheera S; Grayson TH; Welsh DG; Murphy TV, 2012, 'Calcium and endothelium-mediated vasodilator signaling', Advances in Experimental Medicine and Biology, 740, pp. 811 - 831, http://dx.doi.org/10.1007/978-94-007-2888-2_36

Journal articles | 2012

Senadheera S; Kim YS; Grayson TH; Toemoe S; Kochukov MY; Abramowitz J; Housley GD; Bertrand RL; Chadha PS; Bertrand PP; Murphy TV; Tare M; Birnbaumer L; Marrelli SP; Sandow SL, 2012, 'Transient receptor potential canonical type 3 channels facilitate endothelium-derived hyperpolarization-mediated resistance artery vasodilator activity', Cardiovascular Research, 95, pp. 439 - 447, http://dx.doi.org/10.1093/cvr/cvs208

Journal articles | 2011

Bertrand R; Senadheera SN; Markus I; Liu L; Howitt L; Chen H; Murphy TV; Sandow S; Bertrand PP, 2011, 'A western diet increases serotonin availability in rat small intestine', Endocrinology, 152, pp. 36 - 47, http://dx.doi.org/10.1210/en.2010-0377

Journal articles | 2011

Chadha PS; Liu L; Rikard-Bell MJ; Senadheera S; Howitt L; Bertrand RL; Grayson TH; Murphy TV; Sandow SL, 2011, 'Endothelium-dependent vasodilation in human mesenteric artery is primarily mediated by myoendothelial gap junctions intermediate conductance calcium-activated K+ channel and nitric oxide', Journal of Pharmacology and Experimental Therapeutics, 336, pp. 701 - 708, http://dx.doi.org/10.1124/jpet.110.165795

Journal articles | 2011

Howitt L; Sandow SL; Grayson TH; Ellis ZE; Morris MJ; Murphy TV, 2011, 'Differential effects of diet-induced obesity on BKCa β1-subunit expression and function in rat skeletal muscle arterioles and small cerebral arteries', American Journal of Physiology - Heart and Circulatory Physiology, 301, pp. H29 - H40, http://dx.doi.org/10.1152/ajpheart.00134.2011

Journal articles | 2010

Chadha PS; Haddock RE; Howitt L; Morris MJ; Murphy TV; Grayson TH; Sandow SL, 2010, 'Obesity up-regulates intermediate conductance calcium-activated potassium channels and myoendothelial gap junctions to maintain endothelial vasodilator function', Journal of Pharmacology and Experimental Therapeutics, 335, pp. 284 - 293, http://dx.doi.org/10.1124/jpet.110.167593

Journal articles | 2010

Murphy TV; Jenkins AJ; Hill MA; Naser N, 2010, 'Effect of advanced glycation end products on dilation of rat skeletal muscle arterioles', FASEB JOURNAL, 24, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208675507367&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Journal articles | 2010

Sandow S; Murphy TV, 2010, 'Under Pressure - Kv channels and myogenic control of cerebral blood flow', The Journal of Physiology, 588, pp. 3635 - 3636, http://dx.doi.org/10.1113/jphysiol.2010.197996

Journal articles | 2009

Potocnik S; McSherry I; Ding H; Murphy TV; Kotecha N; Dora K; Yuill KH; Triggle C; Hill M, 2009, 'Endothelium-dependent Vasodilation in Myogenically Active Mouse Skeletal Muscle Arterioles: Role of EDH and K+ Channels', Microcirculation, 16, pp. 377 - 390

Journal articles | 2009

Yang Y; Murphy TV; Ella SR; Grayson TH; Haddock R; Hwang YT; Braun AP; Peichun G; Korthuis RJ; Davis MJ; Hill MA, 2009, 'Heterogeneity in function of small artery smooth muscle BKCa: involvement of the β1-subunit', The Journal of Physiology, 587, pp. 3025 - 3044, http://dx.doi.org/10.1113/jphysiol.2009.169920

Journal articles | 2007

Hill MA; Murphy TV; Gui P; Hwang Y; Howitt L; Davis M; Sun ZQ; Howitt L, 2007, 'Properties of the large conductance K+ channel (BKCa) in skeletal muscle arterioles', Federation of American Societies for Experimantal Biology Journal, 21, pp. A846 - A846, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000245708700519&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Journal articles | 2007

Murphy TV; Kotecha N, 2007, 'Endothelium-independent constriction of isolated, pressurized arterioles by N-omega nitro-L-arginine methyl ester (L- NAME)', British Journal of Pharmacology, 151, pp. 602 - 609, http://dx.doi.org/10.1038/sj.bjp.0707262

Journal articles | 2007

Murphy TV, 2007, 'I don`t need this pressure on; src-farnily kinases, ERK 1/2 kinase and mechanotransduction in arteries', Journal of Hypertension, 25, pp. 1791 - 1793, http://dx.doi.org/10.1097/HJH.0b013e3282ef45f9

Journal articles | 2007

Potocnik S; Jenkins NA; Murphy TV; Hill MA, 2007, 'Membrane cholesterol depletion with beta-cyclodextrin impairs pressure-induced contraction and calcium signalling in isolated skeletal muscle arterioles', Journal of Vascular Research, 44, pp. 292 - 302, http://dx.doi.org/10.1159/000101451

Journal articles | 2006

Hill MA; Davis M; Meininger G; Potocnik S; Murphy TV, 2006, 'Arteriolar myogenic signalling mechanisms: Implications for local vascular function', Clinical Hemorheology and Microcirculation, 34, pp. 67 - 79

Journal articles | 2006

Murphy TV; Howitt L; Hill MA; Howitt L, 2006, 'Pharmacological characterization of potassium channels regulating arteriolar myogenic tone in vitro and in vivo', ACTA Pharmacologica Sinica, 27, pp. 183 - 183, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000239590001425&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Journal articles | 2006

de Dios ST; Murphy TV; Sandow SL; Meininger GA; Hill MA, 2006, 'Atomic force microscopy in the study of the endothelial cell cytoskeleton', Vascular Pharmacology, 45, pp. e25 - e25, http://dx.doi.org/10.1016/j.vph.2006.08.111

Journal articles | 2003

Richards K; Davis MJ; Potocnik SJ; Murphy TV; Bishara NB; Rajanayagam MAS; Darby IA; Hill MA, 2003, 'Approaches for introducing peptides into intact and functional arteriolar smooth muscle: Manipulation of protein kinase-based signalling', Clinical and Experimental Pharmacology and Physiology, 30, pp. 653 - 658, http://dx.doi.org/10.1046/j.1440-1681.2003.03892.x

Journal articles | 2003

Spurrell BE; Murphy TV; Hill MA, 2003, 'Intraluminal pressure stimulates MAPK phosphorylation in arterioles: Temporal dissociation from myogenic contractile response', American Journal of Physiology - Heart and Circulatory Physiology, 285, pp. H1764 - H1773, http://dx.doi.org/10.1152/ajpheart.00468.2003

Journal articles | 2002

Bishara NB; Dunlop ME; Murphy TV; Darby IA; Sharmini Rajanayagam MA; Hill MA, 2002, 'Matrix protein glycation impairs agonist-induced intracellular Ca²⁺ signaling in endothelial cells', Journal of Cellular Physiology, 193, pp. 80 - 92, http://dx.doi.org/10.1002/jcp.10153

Journal articles | 2002

Bishara NB; Murphy TV; Hill MA, 2002, 'Capacitative Ca²⁺ entry in vascular endothelial cells is mediated via pathways sensitive to 2 aminoethoxydiphenyl borate and xestospongin C', British Journal of Pharmacology, 135, pp. 119 - 128, http://dx.doi.org/10.1038/sj.bjp.0704465

Journal articles | 2002

Murphy TV; Spurrell BE; Hill MA, 2002, 'Cellular signalling in arteriolar myogenic constriction: Involvement of tyrosine phosphorylation pathways', Clinical and Experimental Pharmacology and Physiology, 29, pp. 612 - 619, http://dx.doi.org/10.1046/j.1440-1681.2002.03698.x

Journal articles | 2002

Murphy TV; Spurrell BE; Hill MA, 2002, 'Mechanisms underlying pervanadate-induced contraction of rat cremaster muscle arterioles', European Journal of Pharmacology, 442, pp. 107 - 114, http://dx.doi.org/10.1016/S0014-2999(02)01498-X

Journal articles | 2001

Murphy TV; Spurrell BE; Hill MA, 2001, 'Tyrosine phosphorylation following alterations in arteriolar intraluminal pressure and wall tension', American Journal of Physiology - Heart and Circulatory Physiology, 281, http://dx.doi.org/10.1152/ajpheart.2001.281.3.h1047

Journal articles | 2001

Murphy TV; Spurrell BE; Hill MA, 2001, 'Tyrosine phosphorylation following alterations in arteriolar intraluminal pressure and wall tension.', American Journal of Physiology - Heart and Circulatory Physiology, 281, pp. H1047 - H1056, http://ajpheart.physiology.org/content/281/3/H1047.long

Journal articles | 2000

Potocnik SJ; Murphy TV; Kotecha N; Hill MA, 2000, 'Effects of mibefradil and nifedipine on arteriolar myogenic responsiveness and intracellular Ca²⁺', British Journal of Pharmacology, 131, pp. 1065 - 1072, http://dx.doi.org/10.1038/sj.bjp.0703650

Journal articles | 2000

Spurrell BE; Murphy TV; Hill MA, 2000, 'Tyrosine phosphorylation modulates arteriolar tone but is not fundamental to myogenic response', American Journal of Physiology - Heart and Circulatory Physiology, 278, http://dx.doi.org/10.1152/ajpheart.2000.278.2.h373

Journal articles | 2000

Spurrell BE; Murphy TV; Hill MA, 2000, 'Tyrosine phosphorylation modulates arteriolar tone but is not fundamental to myogenic response.', American Journal of Physiology - Heart and Circulatory Physiology, 278, pp. H373 - H382, http://ajpheart.physiology.org/content/278/2/H373.long

Journal articles | 1999

Murphy TV; Prountzos C; Kotsonis P; Iannazzo L; Majewski H, 1999, 'Structural determinants of phorbol ester binding in synaptosomes: Pharmacokinetics and pharmacodynamics', European Journal of Pharmacology, 381, pp. 77 - 84, http://dx.doi.org/10.1016/S0014-2999(99)00540-3

Journal articles | 1998

Binko J; Murphy TV; Majewski H, 1998, '17β-Oestradiol enhances nitric oxide synthase activity in endothelium-denuded rat aorta', Clinical and Experimental Pharmacology and Physiology, 25, pp. 120 - 127, http://dx.doi.org/10.1111/j.1440-1681.1998.tb02188.x

Journal articles | 1997

Kotsonis P; Murphy T; Majewski H, 1997, 'Determinants of the biological effects of phorbol esters: Neurotransmitter release', Proceedings of the Western Pharmacology Society, 40, pp. 155

Journal articles | 1997

Majewski H; Kotsonis P; Iannazzo L; Murphy TV; Musgrave IF, 1997, 'Protein kinase C and transmitter release', Clinical and Experimental Pharmacology and Physiology, 24, pp. 619 - 623, http://dx.doi.org/10.1111/j.1440-1681.1997.tb02102.x

Journal articles | 1997

Majewski H; Kotsonis P; Murphy TV; Barrington M, 1997, 'Noradrenaline release and the effect of endogenous activation of the phospholipase C/protein kinase C signalling pathway in rat atria', British Journal of Pharmacology, 121, pp. 1196 - 1202, http://dx.doi.org/10.1038/sj.bjp.0701236

Journal articles | 1997

Majewski H; Murphy T; Binko J, 1997, 'Sex hormones and nitric oxide vasodilator pathways', Proceedings of the Western Pharmacology Society, 40, pp. 142 - 143

Journal articles | 1997

Stoyanovsky D; Murphy T; Anno PR; Kim YM; Salama G, 1997, 'Nitric oxide activates skeletal and cardiac ryanodine receptors', Cell Calcium, 21, pp. 19 - 29, http://dx.doi.org/10.1016/S0143-4160(97)90093-2

Journal articles | 1995

Murphy TV; Broad LM; Garland CJ, 1995, 'Characterisation of inositol 1,4,5-trisphosphate binding sites in rabbit aortic smooth muscle', European Journal of Pharmacology: Molecular Pharmacology, 290, pp. 145 - 150, http://dx.doi.org/10.1016/0922-4106(95)90027-6

Journal articles | 1995

Murphy TV; Garland CJ, 1995, 'Specific accumulation of inositol 1,4,5-trisphosphate in rabbit basilar artery in response to noradrenaline but not 5-hydroxytryptamine', European Journal of Pharmacology: Molecular Pharmacology, 290, pp. 141 - 144, http://dx.doi.org/10.1016/0922-4106(95)90026-8

Journal articles | 1994

Murphy TV; Cross KML; Dunning PM; Garland CJ, 1994, 'Phorbol esters impair endothelium-dependent and independent relaxation in rat aortic rings', General Pharmacology, 25, pp. 581 - 588, http://dx.doi.org/10.1016/0306-3623(94)90218-6

Journal articles | 1994

Seager JM; Murphy TV; Garland CJ, 1994, 'Importance of inositol (1,4,5)‐trisphosphate, intracellular Ca²⁺ release and myofilament Ca²⁺ sensitization in 5‐hydroxytryptamine‐evoked contraction of rabbit mesenteric artery', British Journal of Pharmacology, 111, pp. 525 - 532, http://dx.doi.org/10.1111/j.1476-5381.1994.tb14769.x

Journal articles | 1992

Murphy TV; Foucart S; Majewski H, 1992, 'Prejunctional α2‐adrenoceptors in mouse atria function through G‐proteins which are sensitive to N‐ethylmaleimide, but not pertussis toxin', British Journal of Pharmacology, 106, pp. 871 - 876, http://dx.doi.org/10.1111/j.1476-5381.1992.tb14427.x

Journal articles | 1990

Foucart S; Murphy TV; Majewski H, 1990, 'Prejunctional β-adrenoceptors, angiotensin II and neuropeptide Y receptors on sympathetic nerves in mouse atria are linked to N-ethylmaleimide-susceptible G-proteins', Journal of the Autonomic Nervous System, 30, pp. 221 - 232, http://dx.doi.org/10.1016/0165-1838(90)90253-F

Journal articles | 1990

MAJEWSKI H; COSTA M; FOUCART S; MURPHY TV; MUSGRAVE IF, 1990, 'Second Messengers Are Involved in Facilitatory but Not Inhibitory Receptor Actions at Sympathetic Nerve Endings', Annals of the New York Academy of Sciences, 604, pp. 266 - 275, http://dx.doi.org/10.1111/j.1749-6632.1990.tb31999.x

Journal articles | 1990

Murphy TV; Majewski H, 1990, 'PERTUSSIS TOXIN ATTENUATES ANGIOTENSIN II BUT NOT β‐ADRENOCEPTOR FACILITATION OF NORADRENALINE RELEASE FROM RAT KIDNEY CORTEX', Clinical and Experimental Pharmacology and Physiology, 17, pp. 521 - 526, http://dx.doi.org/10.1111/j.1440-1681.1990.tb01352.x

Journal articles | 1990

Murphy TV; Majewski H, 1990, 'Pertussis toxin differentiates between angiotensin II and β-adrenoceptor mediated facilitation of [³H]noradrenaline release from rat kidney slices', European Journal of Pharmacology, 183, pp. 1485 - 1486, http://dx.doi.org/10.1016/0014-2999(90)94632-8

Journal articles | 1990

Murphy TV; Majewski H, 1990, 'Pertussis toxin differentiates between α1- and α2-adrenoceptor-mediated inhibition of noradrenaline release from rat kidney cortex', European Journal of Pharmacology, 179, pp. 435 - 439, http://dx.doi.org/10.1016/0014-2999(90)90185-9

Journal articles | 1989

Majewski H; Murphy TV, 1989, 'Beta-adrenoceptor blockade and sympathetic neurotransmission in the pithed rat', Journal of Hypertension, 7, pp. 991 - 996, http://dx.doi.org/10.1097/00004872-198912000-00010

Journal articles | 1989

Murphy TV; Majewski H, 1989, 'Modulation of noradrenaline release in slices of rat kidney cortex through α1- and α2-adrenoceptors', European Journal of Pharmacology, 169, pp. 285 - 295, http://dx.doi.org/10.1016/0014-2999(89)90026-5
Conference Abstracts | 2022

Murphy TV; Perry MA; Ulman LG; Marden NA; Daniel B; Hanna G; Housley GD, 2022, 'Microvascular anatomy and physiology laboratory class using the Australian cane toad', in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, United States, Vol. 36, United States, http://dx.doi.org/10.1096/fasebj.2022.36.S1.0R828

Conference Abstracts | 2020

Murphy T; Wu L; Sandow S; Das A; Naim H, 2020, 'Effect of Dietary Nicotinamide Mononucleotide (NMN) on Function and Mechanics of Skeletal Muscle Arteries from Aged Mice', in FASEB JOURNAL, WILEY, CA, San Diego, Vol. 34, presented at Annual Meeting on Experimental Biology, CA, San Diego, 04 April 2020 - 07 April 2020, http://dx.doi.org/10.1096/fasebj.2020.34.s1.04752

Conference Papers | 2018

Drimousis S; Markus I; Murphy T; Liu L, 2018, 'Modulation of tachykinin NK2 receptor expression and activity by sex hormones in the colon', in NEUROGASTROENTEROLOGY AND MOTILITY, WILEY, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000440928700056&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2018

Murphy TV; Saunders SL; Britton FC; Sandow SL; Wright SE, 2018, 'Beta<sub>3</sub>-Adrenergic Receptors in the Rat Cremaster Muscle Artery', in Proceedings for Annual Meeting of The Japanese Pharmacological Society, Japanese Pharmacological Society, pp. po2-3-13, http://dx.doi.org/10.1254/jpssuppl.wcp2018.0_po2-3-13

Conference Papers | 2017

Kerr PM; Wei R; Lunn SE; Gust SL; Classen B; Murphy TV; Sandow SL; Plane F, 2017, 'The Functional Contribution Of Myoendothelial Feedback To Arterial Tone Is Determined By The Nature Of The Vasoconstricion', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, IL, Chicago, presented at Annual Meeting of the American-Society-for-Pharmacology-and-Experimental-Therapeutics (ASPET) at Experimental Biology Meeting, IL, Chicago, 22 April 2017 - 26 April 2017, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000405986505412&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2016

Murphy TV; Kanagarajah A; Toemoe S; Bertrand PP; Grayson TH; Britton FC; Leader L; Senadheera S; Sandow SL, 2016, 'TRPV3 control of uterine blood vessels', in ASCEPT-MPGPCR Book of Oral Abstracts, ASCEPT ASM, Melbourne, Vol. 413, pp. 70 - 70, presented at Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists and Molecular Pharmacology of GPCRs Joint Scientific Meeting, Melbourne, 27 November 2016 - 30 November 2016, http://www.asceptasm.com/wp-content/uploads/2016/11/ASCEPT-MPGPCR-Book-of-oral-abstracts-final-2.pdf

Conference Abstracts | 2016

Murphy TV; Nguyen HL; Grayson TH; Jones NM; Sandow SL, 2016, 'Effect of focal cerebral ischemia on BKCa and TRPV4 in rat middle cerebral artery', in The FASEB Journal, Federation of American Societies for Experimental Biology, San Diego, Vol. 40, pp. 1275.6 - 1275.6, presented at Experimental Biology 2016 Meeting, San Diego, 02 April 2016 - 06 April 2016, http://dx.doi.org/10.1096/fj.1530-6860

Conference Presentations | 2016

Sandow SL; Lucque N; Nguyen HL; Grayson TH; Russell FD; Hinkley V; Jones NM; Murphy TV, 2016, 'Ischemic stroke results in loss of cerebral artery endothelial and smooth muscle connexin (Cx) 37, and altered expression of Cx40, but not Cxs32 and 43', presented at Joint meeting of the Australian Vascular Biology and Atherosclerosis Societies and High Blood Pressure Research Council, Hobart, 07 December 2016 - 10 December 2016

Conference Presentations | 2016

Sandow SL; Nguyen HL; Ellinsworth DC; Grayson TH; Jones NM; Murphy TV, 2016, 'Increased BKCa and TRPV4 expression, and decreased caveolae density in distal middle cerebral artery endothelium and smooth muscle in focal cerebral ischemic stroke', presented at Joint meeting of the Australian Vascular Biology and Atherosclerosis Societies and High Blood Pressure Research Council, Hobart, 07 December 2016 - 10 December 2016

Conference Papers | 2015

Sandow SL; Hinkley V; Leader L; Grayson TH; Murphy TV, 2015, 'IKCa-IP3R myoendothelial microdomains in the uterine radial arteriole are present in normal, and absent in gestational and pre-eclamptic hypertensive pregnancies: Targets for therapy?', in Allen DG; Davey DF (ed.), Proceedings of the Australian Physiology Society, Australian Physiology Society, Hobart, pp. 122P - 122P, presented at Australian Physiology Society Conference 2015, Hobart, 29 November 2015 - 02 December 2015, http://aups.org.au/Proceedings/46/122P

Conference Papers | 2015

Sandow SL; Jones NM; Nguyen HL; Ellinsworth D; Grayson TH; Grimley R; Dettrick A; Murphy TV, 2015, 'Endothelial BKCa, but not TRPV4 activity is altered in focal cerebral ischemic stroke', in Allen DG; Davey DF (ed.), Proceedings of the Australian Physiology Society, Australian Physiology Society, Hobart, pp. 59P - 59P, presented at Australian Physiology Society Meeting 2015, Hobart, 29 November 2015 - 02 December 2015, http://aups.org.au/Proceedings/46/59P/

Conference Presentations | 2015

Sandow SL; Jones NM; Nguyen HL; Ellinsworth D; Grayson TH; Grimley R; Dettrick A; Murphy TV, 2015, 'Focal cerebral ischemic stroke results in endothelial BKCa expression and altered function, with no change in TRPV4 function, in middle cerebral artery', presented at Proceedings of the World Congress for Microcirculation, Kyoto, 25 September 2015 - 27 September 2015

Conference Papers | 2014

Murphy T; Ivanov G; Senadheera S; Sandow S, 2014, 'Insulin increases IKCa expression and function in rat cremaster muscle arteries', in JOURNAL OF VASCULAR RESEARCH, KARGER, CANADA, Banff, pp. 37 - 37, presented at 11th International Symposium on Resistance Arteries from Molecular Machinery to Clinical Challenges, CANADA, Banff, 07 September 2014 - 11 September 2014, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000346236200030&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2014

Phillips JK; Quek KJ; Boyd R; Ameer OZ; Murphy T, 2014, 'HIGH BLOOD PRESSURE AS A DRIVER OF STRUCTURAL AND BIOMECHANICAL CHANGES IN MESENTERIC RESISTANCE ARTERIES IN CHRONIC KIDNEY DISEASE', in HYPERTENSION, LIPPINCOTT WILLIAMS & WILKINS, AUSTRALIA, Adelaide, Vol. 65, pp. E39 - E40, presented at 36th Annual Scientific Meeting of the High-Blood-Pressure-Research-Council-of-Australia (HBPRCA), AUSTRALIA, Adelaide, 26 November 2014 - 28 November 2014, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000352490400059&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2014

Quek J; Boyd R; Ameer O; Murphy T; Phillips J, 2014, 'Altered structural and biomechanical properties of mesenteric resistance arteries in a rat model of cystic kidney disease', in JOURNAL OF VASCULAR RESEARCH, KARGER, CANADA, Banff, pp. 115 - 115, presented at 11th International Symposium on Resistance Arteries from Molecular Machinery to Clinical Challenges, CANADA, Banff, 07 September 2014 - 11 September 2014, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000346236200097&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2014

Sandow S; Jones NM; Nguyen HL; Grayson TH; Murphy T, 2014, 'Focal cerebral ischemia and acute hypoxia increase the expression of endothelial BKCa alpha and beta 1 protein in intact middle cerebral artery of the adult rat', in JOURNAL OF VASCULAR RESEARCH, KARGER, Banff, CANADA, pp. 122 - 122, presented at 11th International Symposium on Resistance Arteries from Molecular Machinery to Clinical Challenges, Banff, CANADA, 07 September 2014 - 11 September 2014, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000346236200104&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Conference Papers | 2014

Sandow SL; Jones NM; Nguyen HL; Grayson TH; Murphy TV, 2014, 'Acute hypoxia and focal cerebral ischemia result in endothelial BKCaα and β1 protein expression in intact adult rat middle cerebral artery endothelium', in Morris B (ed.), State of the Heart 2014, International Society of cardiovascular Pharmacotherapy, Adelaide, pp. 105 - 105, presented at Annual Scientific Meeting of the International Society of Cardiovascular Pharmacotherapy, Adelaide, 26 November 2014 - 28 November 2014, http://www.hbprca.com.au/wp-content/uploads/SoTH_Workbook_FINAL_lowRes.pdf

Conference Presentations | 2014

Sandow SL; Jones NM; Nguyen HL; Grayson TH; Murphy TV, 2014, 'Acute hypoxia and focal cerebral ischemia result in endothelial BKCaα and β1 protein expression in intact adult rat middle cerebral artery endothelium.', presented at Annual Scientific Meeting of the International Society of Cardiovascular Pharmacotherapy, Adelaide, 26 November 2014 - 28 November 2014, http://www.hbprca.com.au/wp-content/uploads/SoTH_Workbook_FINAL_lowRes.pdf

Conference Papers | 2013

Murphy TV; Kanagarajah A; Senadheera S; Sandow SL, 2013, 'TRPV4-mediated responses of the rat isolated cremaster muscle artery', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, MA, Boston, presented at Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB), MA, Boston, 20 April 2013 - 24 April 2013, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000319860504432&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2011

Senadheera S; Kim Y; Toemoe S; Bertrand P; Kochukov MY; Murphy TV; Marrelli SP; Tare M; Sandow SL, 2011, 'TRPC3 channels facilitate K-Ca-mediated endothelial vasodilator activity in rat mesenteric artery', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, DC, Washington, presented at Experimental Biology Meeting 2011, DC, Washington, 09 April 2011 - 13 April 2011, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000310708401110&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2010

Howitt L; Grayson TH; Morris MJ; Murphy TV, 2010, 'Increased NO-dependent dilation of rat arterioles in diet-induced obesity', in The FASEB Journal, Federation of American Societies for Experimental Biology, Anaheim, pp. lb537, presented at Experimental Biology 2010, Anaheim, 24 April 2010 - 28 April 2010, http://www.fasebj.org/cgi/content/meeting_abstract/24/1_MeetingAbstracts/lb537?sid=6b3bd795-96e3-4770-8453-f6e66991246f

Conference Papers | 2009

Howitt L; Sandow SL; Grayson TH; Morris MJ; Murphy TV; Howitt L, 2009, 'Diet-induced obesity does not alter BKCa-mediated responses in rat mid-cerebral arterioles', in Sandow SL; Wise L (ed.), Journal of Vascular Research, Karger, Basel, Switzerland, pp. 29 - 29, presented at 14th Australian and New Zealand Microcirculation Society Meeting, Queenstown, New Zealand, 25 August 2009 - 27 August 2009, http://www.karger.com/Article/Pdf/230992

Conference Papers | 2009

Howitt L; Sandow SL; Grayson TH; Morris MJ; Murphy TV, 2009, 'Increased NO-dependent dilation of rat arterioles in diet-induced obesity', in Hypertension, Lippincott Williams & Wilkins, Sydney, Australia, pp. 1499 - 1499, presented at 31st Annual Scientific Meeting of the High-Blood-Pressure-Research-Council-of-Australia, Sydney, Australia, 01 December 2009 - 03 December 2009, http://dx.doi.org/10.1161/HYP.0b013e3181df4279

Conference Papers | 2009

Murphy TV; Thiyagarajan L, 2009, 'INCREASED INTRA-LUMINAL PRESSURE ALTERS BETA-ADRENOCEPTOR SIGNALLING IN ISOLATED ARTERIOLES FROM THE RAT CREMASTER MUSCLE', in Proceedings of the 2nd Workshop on Isolation and Integration in Embedded Systems, IIES`09, KARGER, Queenstown, NEW ZEALAND, pp. 33 - 33, presented at 14th Meeting of the Australian-and-New-Zealand-Microcirculation-Society, Queenstown, NEW ZEALAND, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000268340300034&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Conference Papers | 2009

Yang Y; Ella SR; Murphy TV; Grayson TH; Hwang YT; Haddock R; Peichun G; Andrew BP; Korthuis RJ; Davis MJ; Hill MA, 2009, 'Relative lack of β1-subunit-mediated regulation of BKCa in cremaster arteriolar smooth muscle', in The FASEB Journal, The Federation of American Societies for Experimental Biology, New Orleans, pp. 627.10, presented at Experimental Biology 2009, New Orleans, 18 April 2009 - 22 April 2009, http://www.fasebj.org/cgi/content/meeting_abstract/23/1_MeetingAbstracts/627.10?sid=e377dc8b-cb5c-4279-a3b3-6e7539d14737

Conference Papers | 2008

Murphy TV; Ellis Z; Howitt L; Morris MJ; Howitt L, 2008, 'Effect of diet-induced obesity on myogenic responses of arterioles from the rat cremaster muscle', in Hypertension, pp. 44 - 45, presented at *, -

Conference Papers | 2006

Hill MA; Murphy TV; Sandow S; Triggle C, 2006, 'The microvasculature as a therapeutic target in diabetes: Possible influence of vascular heterogeneity', in ACTA Pharmacologica Sinica, ACTA Pharmacologica Sinica, Shanghai, Peoples R China, pp. 41 - 41, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000239590000238&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Conference Papers | 2005

Hill MR; Sandow S; Ding H; Kotecha N; Murphy TV, 2005, 'Endothelium-smooth muscle communication in arterioles: Effect of myogenic tone', in Drug Development Research, Wiley-Liss, Hoboken, NJ, USA, pp. 219 - 220, presented at International Symposium on Cardiac Remodeling, Ion Channelpathy, Arrhythmias and Drug Discovery, Shanghai, PEOPLES R CHINA, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000236442000016&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Conference Papers | 2002

Murphy TV; Kotecha N; Hill MA, 2002, 'Effect of increased myogenic tone on endothelium-dependent dilation of arterioles', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, pp. A79 - A79, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000174533600441&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2002

Murphy TV; Spurrell BE; Hill MA, 2002, 'Tyrosine phosphorylation pathways in myogenic constriction of arterioles', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, pp. A79 - A79, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000174533600442&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2001

Murphy TV; Spurrell BE; Hill MA, 2001, 'Effect of cSrc inhibition on arteriolar myogenic responses and phosphotyrosine formation', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, pp. A41 - A41, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000167438100227&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2001

Spurrell BE; Murphy TV; Hill MA, 2001, 'Tyrosine phosphorylation of MAP kinase following increased intraluminal pressure or epidermal growth factor in cannulated arterioles', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, pp. A43 - A43, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000167438100241&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 1990

MURPHY TV; FOUCART S; MAJEWSKI H, 1990, 'N-ETHYLMALEIMIDE (NEM) ATTENUATES ALPHA-2-ADRENOCEPTOR INHIBITION OF [H-3] NORADRENALINE RELEASE FROM MOUSE ATRIA', in BLOOD VESSELS, KARGER, pp. 50 - 50, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1990DY75800066&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

My Research Supervision

Nathan Luque

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Dr Tim Murphy