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Dr Therese Becker

Dr Therese Becker

Conjoint Senior Lecturer
Medicine & Health
School of Clinical Medicine
Phone
0287389033
E-mail
t.becker@unsw.edu.au
Location
Ingham Institute for Applied Medical Research
  • Book Chapters | 2021
    Po JW; Ma Y; Balakrishnar B; Brungs D; Azimi F; Cooper A; Saricilar E; Murthy V; de Souza P; Becker TM, 2021, 'PD-L1 Detection on Circulating Melanoma Cells', in Melanoma: Methods and Protocols, pp. 223 - 233, http://dx.doi.org/10.1007/978-1-0716-1205-7_17
    Book Chapters | 2021
    Po JW; Ma Y; Luk AWS; Lynch D; Balakrishnar B; Brungs D; Azimi F; Cooper A; Saricilar E; Murthy V; de Souza P; Becker TM, 2021, 'Single-Cell Analysis of BRAFV600E and NRASQ61R Mutation Status in Melanoma Cell Lines as Method Generation for Circulating Melanoma Cells', in Melanoma: Methods and Protocols, pp. 277 - 286, http://dx.doi.org/10.1007/978-1-0716-1205-7_21
    Book Chapters | 2016
    Po JW; Lynch D; de Souza P; Becker TM, 2016, 'Importance and Detection of Epithelial-to-Mesenchymal Transition (EMT) Phenotype in CTCs', in Xu K (ed.), TUMOR METASTASIS, INTECH EUROPE, pp. 241 - 256, http://dx.doi.org/10.5772/64342
    Book Chapters | 2013
    Becker T; Haferkamp S, 2013, 'Molecular Mechanisms of Cellular Senescence', in Senescence and Senescence-Related Disorders, InTech, http://dx.doi.org/10.5772/54120
    Book Chapters | 2003
    Becker TM; Rizos H, 2003, 'Regulation of Cellular Senescence by the Retinoblastoma Pathway', in Aging of Cells in and Outside the Body, Springer Netherlands, pp. 151 - 169, http://dx.doi.org/10.1007/978-94-017-0669-8_9
    Book Chapters | 2003
    Rizos H; Becker T; Holland E, 2003, 'Cell cycle regulation in the melanocyte', in Textbook of Melanoma, CRC Press, pp. 13 - 24, http://dx.doi.org/10.1201/b14732-3
  • Journal articles | 2024
    Chan WY; Chua W; Wilkinson K; Epitakaduwa C; Mandaliya H; Descallar J; Roberts TL; Becker TM; Ng W; Lee CS; Lim SHS, 2024, 'The Prognostic and Predictive Utility of CDX2 in Colorectal Cancer', International Journal of Molecular Sciences, 25, http://dx.doi.org/10.3390/ijms25168673
    Journal articles | 2024
    El-Kamand S; Quinn JMW; Sareen H; Becker TM; Wong-Erasmus M; Cowley MJ, 2024, 'CRUX, a platform for visualising, exploring and analysing cancer genome cohort data', NAR Genomics and Bioinformatics, 6, http://dx.doi.org/10.1093/nargab/lqae003
    Journal articles | 2024
    Hirani R; Ross B; Ma Y; Irish K; Chamberlain J; Becker T; Smalley A; Irving H; Irving DO, 2024, 'The incidence of donor white blood cell survival (transfusion-associated microchimerism) in Australian pediatric patients', Transfusion, 64, pp. 1830 - 1840, http://dx.doi.org/10.1111/trf.18010
    Journal articles | 2024
    Ho V; Chung L; Wilkinson K; Ma Y; Rutland T; Lea V; Lim SH; Abubakar A; Ng W; Lee M; Roberts TL; Becker TM; Mackenzie S; Chua W; Lee CS, 2024, 'Microsatellite Instability Testing and Prognostic Implications in Colorectal Cancer', Cancers, 16, http://dx.doi.org/10.3390/cancers16112005
    Journal articles | 2024
    Lea V; Lim SH-S; Chua W; Ng WL; Wang B; Wilkinson KJ; Farzin M; Habashy P; Roberts T; Becker T; Lee CS, 2024, 'Incidence and potential prognostic implications of fibroblast growth factor receptor gene alterations and coexisting mutations in colorectal cancer.', Journal of Clinical Oncology, 42, pp. e15558 - e15558, http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e15558
    Journal articles | 2024
    Nindra U; Lin P; Becker T; Roberts TL; Chua W, 2024, 'Current state of theranostics in metastatic castrate-resistant prostate cancer', Journal of Medical Imaging and Radiation Oncology, 68, pp. 412 - 420, http://dx.doi.org/10.1111/1754-9485.13658
    Journal articles | 2024
    Nindra U; Pal A; Bray V; Yip PY; Tognela A; Roberts TL; Becker TM; Williamson J; Farzin M; Li JJ; Lea V; Hagelamin A; Ng W; Wang B; Lee CS; Chua W, 2024, 'Utility of multigene panel next-generation sequencing in routine clinical practice for identifying genomic alterations in newly diagnosed metastatic nonsmall cell lung cancer', Internal Medicine Journal, 54, pp. 596 - 601, http://dx.doi.org/10.1111/imj.16224
    Journal articles | 2023
    Davoudi F; Moradi A; Becker TM; Lock JG; Abbey B; Fontanarosa D; Haworth A; Clements J; Ecker RC; Batra J, 2023, 'Genomic and Phenotypic Biomarkers for Precision Medicine Guidance in Advanced Prostate Cancer', Current Treatment Options in Oncology, 24, pp. 1451 - 1471, http://dx.doi.org/10.1007/s11864-023-01121-z
    Journal articles | 2023
    Grebstad Tune B; Sareen H; Powter B; Kahana-Edwin S; Cooper A; Koh ES; Lee CS; Po JW; McCowage G; Dexter M; Cain L; O’Neill G; Prior V; Karpelowsky J; Tsoli M; Baumbusch LO; Ziegler D; Roberts TL; DeSouza P; Becker TM; Ma Y, 2023, 'From Pediatric to Adult Brain Cancer: Exploring Histone H3 Mutations in Australian Brain Cancer Patients', Biomedicines, 11, http://dx.doi.org/10.3390/biomedicines11112907
    Journal articles | 2023
    Habashy P; Lea V; Wilkinson K; Wang B; Wu XJ; Roberts TL; Ng W; Rutland T; Po JW; Becker T; Descallar J; Lee M; Mackenzie S; Gupta R; Cooper W; Lim S; Chua W; Lee CS, 2023, 'KRAS and BRAF Mutation Rates and Survival Outcomes in Colorectal Cancer in an Ethnically Diverse Patient Cohort', International Journal of Molecular Sciences, 24, http://dx.doi.org/10.3390/ijms242417509
    Journal articles | 2023
    Marivel AMJ; Ma Y; Becker TM; Verma A; Trieu S; Roberts TL; Ling SCW, 2023, 'The use of cell free DNA (cfDNA) for mutational screening of multiple myeloma', Leukemia Research Reports, 20, pp. 100393, http://dx.doi.org/10.1016/j.lrr.2023.100393
    Journal articles | 2023
    Nindra U; Pal A; Lea V; Lim SHS; Wilkinson K; Asghari R; Roberts TL; Becker TM; Farzin M; Rutland T; Lee M; MacKenzie S; Ng W; Wang B; Soon Lee C; Chua W, 2023, 'Multigene panel next generation sequencing in metastatic colorectal cancer in an Australian population', PLoS ONE, 18, http://dx.doi.org/10.1371/journal.pone.0292087
    Journal articles | 2022
    Fatima S; Ma Y; Safrachi A; Haider S; Spring KJ; Vafaee F; Scott KF; Roberts TL; Becker TM; de Souza P, 2022, 'Harnessing Liquid Biopsies to Guide Immune Checkpoint Inhibitor Therapy', Cancers, 14, http://dx.doi.org/10.3390/cancers14071669
    Journal articles | 2022
    Jeffreys SA; Becker TM; Khan S; Soon P; Neubauer H; de Souza P; Powter B, 2022, 'Prognostic and Predictive Value of CCND1/Cyclin D1 Amplification in Breast Cancer With a Focus on Postmenopausal Patients: A Systematic Review and Meta-Analysis', Frontiers in Endocrinology, 13, http://dx.doi.org/10.3389/fendo.2022.895729
    Journal articles | 2022
    Khan T; Becker TM; Po JW; Chua W; Ma Y, 2022, 'Single-Circulating Tumor Cell Whole Genome Amplification to Unravel Cancer Heterogeneity and Actionable Biomarkers', International Journal of Molecular Sciences, 23, http://dx.doi.org/10.3390/ijms23158386
    Journal articles | 2022
    Khan T; Becker TM; Scott KF; Descallar J; de Souza P; Chua W; Ma Y, 2022, 'Prognostic and Predictive Value of Liquid Biopsy-Derived Androgen Receptor Variant 7 (AR-V7) in Prostate Cancer: A Systematic Review and Meta-Analysis', Frontiers in Oncology, 12, http://dx.doi.org/10.3389/fonc.2022.868031
    Journal articles | 2022
    Khan T; Lock JG; Ma Y; Harman DG; de Souza P; Chua W; Balakrishnar B; Scott KF; Becker TM, 2022, 'Choice of antibody is critical for specific and sensitive detection of androgen receptor splice variant-7 in circulating tumor cells', Scientific Reports, 12, http://dx.doi.org/10.1038/s41598-022-20079-w
    Journal articles | 2022
    Sareen H; Ma Y; Becker TM; Roberts TL; de Souza P; Powter B, 2022, 'Molecular Biomarkers in Glioblastoma: A Systematic Review and Meta-Analysis', International journal of molecular sciences, 23, http://dx.doi.org/10.3390/ijms23168835
    Journal articles | 2022
    Tincknell G; Naveed A; Nankervis J; Mukhtiar A; Piper AK; Becker TM; Chantrill L; Aghmesheh M; Vine KL; Ranson M; Brungs D, 2022, 'HER2-Positive Gastroesophageal Cancers Are Associated with a Higher Risk of Brain Metastasis', Cancers, 14, http://dx.doi.org/10.3390/cancers14235754
    Journal articles | 2022
    Woodford R; Brungs D; Leighton C; Grimison P; Sjoquist KM; Becker T; Robinson S; Gebski V; Wilson K; Chantrill L; Aghmesheh M, 2022, 'Combination chemotherapy with NAB®-paclitaxel and capecitabine for patients with advanced biliary tract cancer (NAP-CAPABIL Pilot Study)', Asia-Pacific Journal of Clinical Oncology, 18, pp. e220 - e226, http://dx.doi.org/10.1111/ajco.13599
    Journal articles | 2022
    Yeap I; Becker T; Azimi F; Kernohan M, 2022, 'The management of hereditary melanoma, FAMMM syndrome and germline CDKN2A mutations: a narrative review', Australasian Journal of Plastic Surgery, 5, pp. 12 - 22, http://dx.doi.org/10.34239/ajops.v5n2.324
    Journal articles | 2022
    Young FP; Becker TM; Nimir M; Opperman T; Chua W; Balakrishnar B; de Souza P; Ma Y, 2022, 'Biomarkers of Castrate Resistance in Prostate Cancer: Androgen Receptor Amplification and T877A Mutation Detection by Multiplex Droplet Digital PCR', Journal of Clinical Medicine, 11, http://dx.doi.org/10.3390/jcm11010257
    Journal articles | 2022
    2022, 'Towards Diagnostic ctDNA Testing in Multiple Myeloma: How does Automated Magnetic Bead-Based Cell-Free DNA Extraction Compare to the Leading Silica Membrane-Based Manual Extraction?', Biomarkers and Applications, 5, http://dx.doi.org/10.29011/2576-9588.100043
    Journal articles | 2021
    Adam T; Becker TM; Chua W; Bray V; Roberts TL, 2021, 'The multiple potential biomarkers for predicting immunotherapy response-finding the needle in the haystack', Cancers, 13, pp. 1 - 20, http://dx.doi.org/10.3390/cancers13020277
    Journal articles | 2021
    Ding PN; Roberts TL; Chua W; Becker TM; Caixeiro N; de Souza P; Gao B; Lee CK; Itchins M; Westman H; Clarke S; Blinman P; Kao S; John T; Leal JL; Bray VJ, 2021, 'Plasma pre-treatment T790M relative allelic frequency in patients with advanced EGFR-mutated non-small cell lung cancer predicts treatment response to subsequent-line osimertinib', Translational Lung Cancer Research, 10, pp. 1623 - 1634, http://dx.doi.org/10.21037/tlcr-20-1125
    Journal articles | 2021
    Garrett C; Becker TM; Lynch D; Po J; Xuan W; Scott KF; De Souza P, 2021, 'Comparison of neutrophil to lymphocyte ratio and prognostic nutritional index with other clinical and molecular biomarkers for prediction of glioblastoma multiforme outcome', PLoS ONE, 16, http://dx.doi.org/10.1371/journal.pone.0252614
    Journal articles | 2021
    Pang TCY; Po JW; Becker TM; Goldstein D; Pirola RC; Wilson JS; Apte MV, 2021, 'Circulating tumour cells in pancreatic cancer: A systematic review and meta-analysis of clinicopathological implications', Pancreatology, 21, pp. 103 - 114, http://dx.doi.org/10.1016/j.pan.2020.11.022
    Journal articles | 2021
    Pang TCY; Xu Z; Mekapogu AR; Pothula S; Becker T; Corley S; Wilkins MR; Goldstein D; Pirola R; Wilson J; Apte M, 2021, 'Hgf/c-met inhibition as adjuvant therapy improves outcomes in an orthotopic mouse model of pancreatic cancer', Cancers, 13, pp. 2763, http://dx.doi.org/10.3390/cancers13112763
    Journal articles | 2021
    Powter B; Jeffreys SA; Sareen H; Cooper A; Brungs D; Po J; Roberts T; Koh ES; Scott KF; Sajinovic M; Vessey JY; de Souza P; Becker TM, 2021, 'Human TERT promoter mutations as a prognostic biomarker in glioma', Journal of Cancer Research and Clinical Oncology, 147, pp. 1007 - 1017, http://dx.doi.org/10.1007/s00432-021-03536-3
    Journal articles | 2021
    Tincknell G; Piper AK; Aghmesheh M; Becker T; Vine KL; Brungs D; Ranson M, 2021, 'Experimental and clinical evidence supports the use of urokinase plasminogen activation system components as clinically relevant biomarkers in gastroesophageal adenocarcinoma', Cancers, 13, http://dx.doi.org/10.3390/cancers13164097
    Journal articles | 2021
    Wilkinson K; Ng W; Roberts TL; Becker TM; Lim SHS; Chua W; Lee CS, 2021, 'Tumour immune microenvironment biomarkers predicting cytotoxic chemotherapy efficacy in colorectal cancer', Journal of Clinical Pathology, 74, pp. 625 - 634, http://dx.doi.org/10.1136/jclinpath-2020-207309
    Journal articles | 2020
    Brungs D; Minaei E; Piper AK; Perry J; Splitt A; Carolan M; Ryan S; Wu XJ; Corde S; Tehei M; Aghmesheh M; Vine KL; Becker TM; Ranson M, 2020, 'Establishment of novel long-term cultures from EpCAM positive and negative circulating tumour cells from patients with metastatic gastroesophageal cancer', Scientific Reports, 10, http://dx.doi.org/10.1038/s41598-019-57164-6
    Journal articles | 2020
    Jeffreys SA; Powter B; Balakrishnar B; Mok K; Soon P; Franken A; Neubauer H; Souza PD; Becker TM, 2020, 'Endocrine resistance in breast cancer: The role of estrogen receptor stability', Cells, 9, pp. 1 - 23, http://dx.doi.org/10.3390/cells9092077
    Journal articles | 2020
    Khan T; Scott KF; Becker TM; Lock J; Nimir M; Ma Y; De Souza P, 2020, 'The Prospect of Identifying Resistance Mechanisms for Castrate-Resistant Prostate Cancer Using Circulating Tumor Cells: Is Epithelial-to-Mesenchymal Transition a Key Player?', Prostate Cancer, 2020, http://dx.doi.org/10.1155/2020/7938280
    Journal articles | 2020
    Lynch D; Powter B; Po JW; Cooper A; Garrett C; Koh ES; Sheridan M; van Gelder J; Darwish B; Mckechnie S; Bazina R; Jaeger M; Roberts TL; de Souza P; Becker TM, 2020, 'Isolation of circulating tumor cells from glioblastoma patients by direct immunomagnetic targeting', Applied Sciences (Switzerland), 10, http://dx.doi.org/10.3390/app10093338
    Journal articles | 2020
    Pang TCY; Xu Z; Mekapogu AR; Pothula S; Becker TM; Goldstein D; Pirola RC; Wilson JS; Apte MV, 2020, 'An Orthotopic Resectional Mouse Model of Pancreatic Cancer', Journal of Visualized Experiments, http://dx.doi.org/10.3791/61726-v
    Journal articles | 2020
    Pang TCY; Xu Z; Mekapogu AR; Pothula S; Becker TM; Goldstein D; Pirola RC; Wilson JS; Apte MV, 2020, 'An orthotopic resectional mouse model of pancreatic cancer', Journal of Visualized Experiments, 2020, pp. 1 - 13, http://dx.doi.org/10.3791/61726
    Journal articles | 2020
    Sareen H; Garrett C; Lynch D; Powter B; Brungs D; Cooper A; Po J; Koh ES; Vessey JY; McKechnie S; Bazina R; Sheridan M; van Gelder J; Darwish B; Jaeger M; Roberts TL; De Souza P; Becker TM, 2020, 'The role of liquid biopsies in detecting molecular tumor biomarkers in brain cancer patients', Cancers, 12, pp. 1 - 16, http://dx.doi.org/10.3390/cancers12071831
    Journal articles | 2019
    Brungs D; Lochhead A; Iyer A; Illemann M; Colligan P; Hirst NG; Splitt A; Liauw W; Vine KL; Pathmanandavel S; Carolan M; Becker TM; Aghmesheh M; Ranson M, 2019, 'Expression of cancer stem cell markers is prognostic in metastatic gastroesophageal adenocarcinoma', Pathology, 51, pp. 474 - 480, http://dx.doi.org/10.1016/j.pathol.2019.03.009
    Journal articles | 2019
    Ding PN; Becker T; Bray V; Chua W; Ma Y; Xu B; Lynch D; de Souza P; Roberts T, 2019, 'Plasma next generation sequencing and droplet digital PCR-based detection of epidermal growth factor receptor (EGFR) mutations in patients with advanced lung cancer treated with subsequent-line osimertinib', Thoracic Cancer, 10, pp. 1879 - 1884, http://dx.doi.org/10.1111/1759-7714.13154
    Journal articles | 2019
    Ding PN; Becker TM; Bray VJ; Chua W; Ma YF; Lynch D; Po J; Luk AWS; Caixeiro N; de Souza P; Roberts TL, 2019, 'The predictive and prognostic significance of liquid biopsy in advanced epidermal growth factor receptor-mutated non-small cell lung cancer: A prospective study', Lung Cancer, 134, pp. 187 - 193, http://dx.doi.org/10.1016/j.lungcan.2019.06.021
    Journal articles | 2019
    Nimir M; Ma Y; Jeffreys SA; Opperman T; Young F; Khan T; Ding P; Chua W; Balakrishnar B; Cooper A; Souza PD; Becker TM, 2019, 'Detection of AR-v7 in liquid biopsies of castrate resistant prostate cancer patients: A comparison of AR-v7 analysis in circulating tumor cells, circulating tumor RNA and exosomes', Cells, 8, http://dx.doi.org/10.3390/cells8070688
    Journal articles | 2019
    Po JW; Ma Y; Balakrishna B; Brungs D; Azimi F; De Souza P; Becker TM, 2019, 'Immunomagnetic isolation of circulating melanoma cells and detection of PD-L1 status', PLoS ONE, 14, http://dx.doi.org/10.1371/journal.pone.0211866
    Journal articles | 2019
    Singh P; de Souza P; Scott KF; Hall BM; Verma ND; Becker TM; Toh JWT; Sajinovic M; Spring KJ, 2019, 'Biomarkers in immune checkpoint inhibition therapy for cancer patients: what is the role of lymphocyte subsets and PD1/PD-L1?', Translational Medicine Communications, 4, http://dx.doi.org/10.1186/s41231-019-0032-9
    Journal articles | 2018
    Brungs D; Lynch D; Luk AWS; Minaei E; Ranson M; Aghmesheh M; Vine KL; Carolan M; Jaber M; De Souza P; Becker TM, 2018, 'Cryopreservation for delayed circulating tumor cell isolation is a valid strategy for prognostic association of circulating tumor cells in gastroesophageal cancer', World Journal of Gastroenterology, 24, pp. 810 - 818, http://dx.doi.org/10.3748/wjg.v24.i7.810
    Journal articles | 2018
    Ding PN; Ma YF; Roberts TJ; Chua W; Bray VJ; Lynch D; Burke D; Souza PD; Becker TM, 2018, 'Droplet Digital PCR Based Detection of EGFR Mutations in Advanced Lung Cancer Patient Liquid Biopsies: A Comparison of Circulating Tumour DNA Extraction Kits', Journal of Molecular Biomarkers & Diagnosis, 09, http://dx.doi.org/10.4172/2155-9929.1000397
    Journal articles | 2018
    Pang T; Xu Z; Pothula S; Yang MH; Becker T; Goldstein D; Heeschen C; Pirola R; Wilson J; Apte MV, 2018, '517 - World-First Identification of Circulating Pancreatic Stellate Cells in Metastatic Pancreatic Cancer', Gastroenterology, 154, pp. S - 114, http://dx.doi.org/10.1016/s0016-5085(18)30816-3
    Journal articles | 2018
    Po JW; Roohullah A; Lynch D; DeFazio A; Harrison M; Harnett PR; Kennedy C; Kennedy C; De Souza P; Becker TM, 2018, 'Improved ovarian cancer EMT-CTC isolation by immunomagnetic targeting of epithelial EpCAM and mesenchymal N-cadherin', Journal of Circulating Biomarkers, 7, http://dx.doi.org/10.33393/jcb.2018.2090
    Journal articles | 2018
    Po JW; Roohullah A; Lynch D; DeFazio A; Harrison M; Harnett PR; Kennedy C; de Souza P; Becker TM, 2018, 'Improved ovarian cancer EMT-CTC isolation by immunomagnetic targeting of epithelial EpCAM and mesenchymal N-cadherin', Journal of Circulating Biomarkers, 7, http://dx.doi.org/10.1177/1849454418782617
    Journal articles | 2017
    Brungs D; Chen J; Aghmesheh M; Vine KL; Becker TM; Carolan MG; Ranson M, 2017, 'The urokinase plasminogen activation system in gastroesophageal cancer: A systematic review and meta-analysis', Oncotarget, 8, pp. 23099 - 23109, http://dx.doi.org/10.18632/oncotarget.15485
    Journal articles | 2017
    Ding PN; Roberts TL; Chua W; Becker TM; Descallar J; Yip PY; Bray V, 2017, 'Clinical outcomes in patients with advanced epidermal growth factor receptor-mutated non-small-cell lung cancer in South Western Sydney Local Health District', Internal Medicine Journal, 47, pp. 1405 - 1411, http://dx.doi.org/10.1111/imj.13555
    Journal articles | 2017
    Luk AWS; Ma Y; Ding PN; Young FP; Chua W; Balakrishnar B; Dransfield DT; De Souza P; Becker TM, 2017, 'CTC-mRNA (AR-V7) analysis from blood samples—impact of blood collection tube and storage time', International Journal of Molecular Sciences, 18, http://dx.doi.org/10.3390/ijms18051047
    Journal articles | 2017
    Pang TCY; Xu Z; Pothula S; Becker T; Goldstein D; Pirola RC; Wilson JS; Apte MV, 2017, 'Circulating pancreatic stellate (stromal) cells in pancreatic cancer-a fertile area for novel research', Carcinogenesis, 38, pp. 588 - 591, http://dx.doi.org/10.1093/carcin/bgx030
    Journal articles | 2016
    Brungs D; Aghmesheh M; Vine KL; Becker TM; Carolan MG; Ranson M, 2016, 'Gastric cancer stem cells: evidence, potential markers, and clinical implications', Journal of Gastroenterology, http://dx.doi.org/10.1007/s00535-015-1125-5
    Journal articles | 2016
    Ma Y; Luk A; Young FP; Lynch D; Chua W; Balakrishnar B; de Souza P; Becker TM, 2016, 'Droplet digital PCR based androgen receptor variant 7 (AR-V7) detection from prostate cancer patient blood biopsies', International Journal of Molecular Sciences, 17, http://dx.doi.org/10.3390/ijms17081264
    Journal articles | 2015
    Tognela A; Spring KJ; Becker T; Caixeiro NJ; Bray VJ; Yip PY; Chua W; Lim SH; de Souza P, 2015, 'Predictive and prognostic value of circulating tumor cell detection in lung cancer: A clinician's perspective', Critical Reviews in Oncology/Hematology, 93, pp. 90 - 102, http://dx.doi.org/10.1016/j.critrevonc.2014.10.001
    Journal articles | 2014
    Becker TM; Boyd SC; Mijatov B; Gowrishankar K; Snoyman S; Pupo GM; Scolyer RA; Mann GJ; Kefford RF; Zhang XD; Rizos H, 2014, 'Mutant B-RAF-Mcl-1 survival signaling depends on the STAT3 transcription factor', ONCOGENE, 33, pp. 1158 - 1166, http://dx.doi.org/10.1038/onc.2013.45
    Journal articles | 2014
    Becker TM; Caixeiro NJ; Lim SH; Tognela A; Kienzle N; Scott KF; Spring KJ; De Souza P, 2014, 'New frontiers in circulating tumor cell analysis: A reference guide for biomolecular profiling toward translational clinical use', International Journal of Cancer, 134, pp. 2523 - 2533, http://dx.doi.org/10.1002/ijc.28516
    Journal articles | 2014
    Caixeiro NJ; Kienzle N; Lim SH; Spring KJ; Tognela A; Scott KF; De Souza P; Becker TM, 2014, 'Circulating tumour cells - A bona fide cause of metastatic cancer', Cancer and Metastasis Reviews, 33, pp. 747 - 756, http://dx.doi.org/10.1007/s10555-014-9502-8
    Journal articles | 2014
    Caixeiro NJ; Kienzle N; Lim SH; Spring KJ; Tognela A; Scott KF; de Souza P; Becker TM, 2014, 'Circulating tumour cells-a bona fide cause of metastatic cancer', Cancer and Metastasis Reviews, http://dx.doi.org/10.1007/s10555-014-9502-8
    Journal articles | 2014
    Lim SH; Becker TM; Chua W; Caixeiro NJ; Ng WL; Kienzle N; Tognela A; Lumba S; Rasko JEJ; De Souza P; Spring KJ, 2014, 'Circulating tumour cells and circulating free nucleic acid as prognostic and predictive biomarkers in colorectal cancer', Cancer Letters, 346, pp. 24 - 33, http://dx.doi.org/10.1016/j.canlet.2013.12.019
    Journal articles | 2014
    Lim SHS; Becker TM; Chua W; Ng WL; De Souza P; Spring KJ, 2014, 'Circulating tumour cells and the epithelial mesenchymal transition in colorectal cancer', Journal of Clinical Pathology, 67, pp. 848 - 853, http://dx.doi.org/10.1136/jclinpath-2014-202499
    Journal articles | 2014
    Rizos H; Menzies AM; Pupo GM; Carlino MS; Fung C; Hyman J; Haydu LE; Mijatov B; Becker TM; Boyd SC; Howle J; Saw R; Thompson JF; Kefford RF; Scolyer RA; Long GV, 2014, 'BRAF inhibitor resistance mechanisms in metastatic melanoma: Spectrum and clinical impact', Clinical Cancer Research, 20, pp. 1965 - 1977, http://dx.doi.org/10.1158/1078-0432.CCR-13-3122
    Journal articles | 2014
    Todd JR; Scurr LL; Becker TM; Kefford RF; Rizos H, 2014, 'The MAPK pathway functions as a redundant survival signal that reinforces the PI3K cascade in c-Kit mutant melanoma', ONCOGENE, 33, pp. 236 - 245, http://dx.doi.org/10.1038/onc.2012.562
    Journal articles | 2013
    Boyd SC; Mijatov B; Pupo GM; Tran SL; Gowrishankar K; Shaw HM; Goding CR; Scolyer RA; Mann GJ; Kefford RF; Rizos H; Becker TM, 2013, 'Oncogenic B-RAFV(600E) Signaling Induces the T-Box3 Transcriptional Repressor to Repress E-Cadherin and Enhance Melanoma Cell Invasion', JOURNAL OF INVESTIGATIVE DERMATOLOGY, 133, pp. 1269 - 1277, http://dx.doi.org/10.1038/jid.2012.421
    Journal articles | 2013
    Carlino MS; Gowrishankar K; Saunders CAB; Pupo GM; Snoyman S; Zhang XD; Saw R; Becker TM; Kefford RF; Long GV; Rizos H, 2013, 'Antiproliferative Effects of Continued Mitogen-Activated Protein Kinase Pathway Inhibition following Acquired Resistance to BRAF and/or MEK Inhibition in Melanoma', MOLECULAR CANCER THERAPEUTICS, 12, pp. 1332 - 1342, http://dx.doi.org/10.1158/1535-7163.MCT-13-0011
    Journal articles | 2013
    Gowrishankar K; Snoyman S; Pupo GM; Becker TM; Kefford RF; Rizos H, 2013, 'Acquired Resistance to BRAF Inhibition Can Confer Cross-Resistance to Combined BRAF/MEK Inhibition', Journal of Investigative Dermatology, 133, pp. 2493 - 2493, http://dx.doi.org/10.1038/jid.2013.125
    Journal articles | 2013
    Haferkamp S; Borst A; Adam C; Becker TM; Motschenbacher S; Windhoevel S; Hufnagel AL; Houben R; Meierjohann S, 2013, 'Vemurafenib Induces Senescence Features in Melanoma Cells', JOURNAL OF INVESTIGATIVE DERMATOLOGY, 133, pp. 1601 - 1609, http://dx.doi.org/10.1038/jid.2013.6
    Journal articles | 2013
    Todd JR; Becker TM; Kefford RF; Rizos H, 2013, 'Secondary c-Kit mutations confer acquired resistance to RTK inhibitors in c-Kit mutant melanoma cells', PIGMENT CELL & MELANOMA RESEARCH, 26, http://dx.doi.org/10.1111/pcmr.12107
    Journal articles | 2012
    Becker TM, 2012, 'Chromatin Remodeling in Carcinoma Cells', Reviews in Cell Biology and Molecular Medicine, http://dx.doi.org/10.1002/3527600906.mcb.201100031
    Journal articles | 2012
    Gowrishankar K; Snoyman S; Pupo GM; Becker TM; Kefford RF; Rizos H, 2012, 'Acquired Resistance to BRAF Inhibition Can Confer Cross-Resistance to Combined BRAF/MEK Inhibition', JOURNAL OF INVESTIGATIVE DERMATOLOGY, 132, pp. 1850 - 1859, http://dx.doi.org/10.1038/jid.2012.63
    Journal articles | 2012
    Tran SL; Haferkamp S; Scurr LL; Gowrishankar K; Becker TM; Desilva C; Thompson JF; Scolyer RA; Kefford RF; Rizos H, 2012, 'Absence of Distinguishing Senescence Traits in Human Melanocytic Nevi', JOURNAL OF INVESTIGATIVE DERMATOLOGY, 132, pp. 2226 - 2234, http://dx.doi.org/10.1038/jid.2012.126
    Journal articles | 2011
    Scurr LL; McKenzie HA; Becker TM; Irvine M; Lai K; Mann GJ; Scolyer RA; Kefford RF; Rizos H, 2011, 'Selective loss of wild-type p16 INK4a expression in human nevi', Journal of Investigative Dermatology, 131, pp. 2329 - 2332, http://dx.doi.org/10.1038/jid.2011.197
    Journal articles | 2010
    Becker TM; Philipsz S; Scurr LL; Fung C; Haferkamp S; Kefford RF; Rizos H, 2010, 'Oncogenic B-RAF(V600E) Promotes Anchorage-Independent Survival of Human Melanocytes', JOURNAL OF INVESTIGATIVE DERMATOLOGY, 130, pp. 2144 - 2147, http://dx.doi.org/10.1038/jid.2010.117
    Journal articles | 2010
    Irvine M; Philipsz S; Frausto M; Mijatov B; Gallagher SJ; Fung C; Becker TM; Kefford RF; Rizos H, 2010, 'Amino terminal hydrophobic import signals target the p14(ARF) tumor suppressor to the mitochondria', CELL CYCLE, 9, pp. 829 - 839, http://dx.doi.org/10.4161/cc.9.4.10785
    Journal articles | 2010
    Jiang CC; Lai F; Tay KH; Croft A; Rizos H; Becker TM; Yang F; Liu H; Thorne RF; Hersey P; Zhang XD, 2010, 'Apoptosis of human melanoma cells induced by inhibition of B-RAF V600E involves preferential splicing of bimS', Cell Death and Disease, 1, http://dx.doi.org/10.1038/cddis.2010.48
    Journal articles | 2010
    McKenzie HA; Fung C; Becker TM; Irvine M; Mann GJ; Kefford RF; Rizos H, 2010, 'Predicting Functional Significance of Cancer-Associated p16(INK4a) Mutations in CDKN2A', HUMAN MUTATION, 31, pp. 692 - 701, http://dx.doi.org/10.1002/humu.21245
    Journal articles | 2010
    Scurr LL; Pupo GM; Becker TM; Lai K; Schrama D; Haferkamp S; Irvine M; Scolyer RA; Mann GJ; Becker JC; Kefford RF; Rizos H, 2010, 'IGFBP7 Is Not Required for B-RAF-Induced Melanocyte Senescence', Cell, 141, pp. 717 - 727, http://dx.doi.org/10.1016/j.cell.2010.04.021
    Journal articles | 2010
    Zhang XD; Jiang CC; Lai F; Croft A; Tay KH; Thorne RF; Becker T; Rizos H; Hersey P, 2010, 'Abstract 1790: Apoptotic response of mutant B-RAF human melanoma cells to a B-RAF inhibitor involves increased splicing production of BimS', Cancer Research, 70, pp. 1790 - 1790, http://dx.doi.org/10.1158/1538-7445.am10-1790
    Journal articles | 2009
    Becker TM; Haferkamp S; Dijkstra MK; Scurr LL; Frausto M; Diefenbach E; Scolyer RA; Reisman DN; Mann GJ; Kefford RF; Rizos H, 2009, 'The chromatin remodelling factor BRG1 is a novel binding partner of the tumor suppressor p16(INK4a)', MOLECULAR CANCER, 8, http://dx.doi.org/10.1186/1476-4598-8-4
    Journal articles | 2009
    Haferkamp S; Scurr LL; Becker TM; Frausto M; Kefford RF; Rizos H, 2009, 'Oncogene-Induced Senescence Does Not Require the p16(INK4a) or p14ARF Melanoma Tumor Suppressors', JOURNAL OF INVESTIGATIVE DERMATOLOGY, 129, pp. 1983 - 1991, http://dx.doi.org/10.1038/jid.2009.5
    Journal articles | 2009
    Haferkamp S; Tran SL; Becker TM; Scurr LL; Kefford RF; Rizos H, 2009, 'The relative contributions of the p53 and pRb pathways in oncogene induced melanocyte senescence', AGING-US, 1, pp. 542 - 556, http://dx.doi.org/10.18632/aging.100051
    Journal articles | 2009
    McKenzie H; Becker TM; Scurr LL; Kefford RF; Rizos H, 2009, 'Wild type and melanoma-associated mutant p16(INK4a) proteins do not oligomerize in vivo', PIGMENT CELL & MELANOMA RESEARCH, 22, pp. 131 - 133, http://dx.doi.org/10.1111/j.1755-148X.2008.00530.x
    Journal articles | 2008
    Haferkamp S; Becker TM; Scurr LL; Kefford RF; Rizos H, 2008, 'p16(INK4a)-induced senescence is disabled by melanoma-associated mutations', AGING CELL, 7, pp. 733 - 745, http://dx.doi.org/10.1111/j.1474-9726.2008.00422.x
    Journal articles | 2006
    Rizos H; McKenzie HA; Ayub AL; Woodruff S; Becker TM; Scurr LL; Stahl J; Kefford RF, 2006, 'Physical and functional interaction of the p14(ARF) tumor suppressor with ribosomes', JOURNAL OF BIOLOGICAL CHEMISTRY, 281, pp. 38080 - 38088, http://dx.doi.org/10.1074/jbc.M609405200
    Journal articles | 2005
    Becker TM; Ayub AL; Kefford RF; Mann GJ; Rizos H, 2005, 'The melanoma-associated 24 base pair duplication in p16INK4a is functionally impaired', INTERNATIONAL JOURNAL OF CANCER, 117, pp. 569 - 573, http://dx.doi.org/10.1002/ijc.21265
    Journal articles | 2005
    Becker TM; Rizos H; de la Pena A; Leclercq IA; Woodruff S; Kefford RF; Mann GJ, 2005, 'Impaired inhibition of NF-kappa B activity by melanoma-associated p16INK4a mutations', BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 332, pp. 873 - 879, http://dx.doi.org/10.1016/j.bbrc.2005.05.032
    Journal articles | 2003
    Fung DCY; Holland EA; Becker TM; Hayward NK; Bressac-de Paillerets B; Mann GJ, 2003, 'eMelanoBase: an online locus-specific variant database for familial melanoma', Human Mutation, 21, pp. 2 - 7, http://dx.doi.org/10.1002/humu.10149
    Journal articles | 2003
    Rizos H; Diefenbach E; Badhwar P; Woodruff S; Becker TM; Rooney RJ; Kefford RF, 2003, 'Association of p14(ARF) with the p120(E4F) transcriptional repressor enhances cell cycle inhibition', JOURNAL OF BIOLOGICAL CHEMISTRY, 278, pp. 4981 - 4989, http://dx.doi.org/10.1074/jbc.M210978200
    Journal articles | 2001
    Becker TM; Rizos H; Kefford RF; Mann GJ, 2001, 'Functional impairment of melanoma-associated p16(INK4a) mutants in melanoma cells despite retention of cyclin-dependent kinase 4 binding', CLINICAL CANCER RESEARCH, 7, pp. 3282 - 3288, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000171574600046&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 1997
    Holland EA; Becker TM; Kefford RF; Mann GJ, 1997, 'Mutation analysis of CDKN2A and CDK4 in familial melanoma', Melanoma Research, 7, pp. S133 - S133, http://dx.doi.org/10.1097/00008390-199706001-00463
    Journal articles | 1997
    Rizos H; Becker TM; Holland EA; Kefford RF; Mann GJ, 1997, 'Differential expression of p16(INK4a) and p16 beta transcripts in B-lymphoblastoid cells from members of hereditary melanoma families without CDKN2A exon mutations', ONCOGENE, 15, pp. 515 - 523, http://dx.doi.org/10.1038/sj.onc.1201217
    Journal articles | 1995
    Holland EA; Beaton SC; Becker TM; Grulet OMC; Peters BA; Rizos H; Kefford RF; Mann GJ, 1995, 'Analysis of the p16 gene, CDKN2, in 17 Australian melanoma kindreds', Oncogene, 11, pp. 2288 - 2294, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1995TK70200012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
  • Preprints | 2024
    Chan WY; Chua W; Wilkinson K; Epitakaduwa C; Mandaliya H; Descallar J; Roberts TL; Becker TM; Ng W; Lee CS; Lim SH, 2024, The Prognostic and Predictive Utility of CDX2 in Colorectal Cancer, http://dx.doi.org/10.20944/preprints202407.1687.v1
    Preprints | 2023
    El-Kamand S; Quinn JMW; Sareen H; Becker T; Wong-Erasmus M; Cowley M, 2023, CRUX, a platform for visualising, exploring and analysing cancer genome cohort data, http://dx.doi.org/10.1101/2023.07.25.550585
    Conference Abstracts | 2023
    Marivel A-MJ; Roberts TL; Descallar J; Aung WPP; Cheng J; Becker TM; James A; Ma Y; Bryant A; Ling S, 2023, 'Multiple Myeloma in the Culturally and Linguistically Diverse Southwestern Sydney, Australia', in Blood, American Society of Hematology, Vol. 142, pp. 6642 - 6642, http://dx.doi.org/10.1182/blood-2023-185193
    Preprints | 2022
    Khan T; Lock J; Ma Y; Harman D; Souza P; Chua W; Balakrishnar B; Scott KF; Becker TM, 2022, Choice of antibody is critical for specific and sensitive detection of androgen receptor splice variant-7 in circulating tumor cells, http://dx.doi.org/10.21203/rs.3.rs-1602818/v1
    Preprints | 2022
    Khan T; Lock J; Ma Y; Harman D; Souza P; Chua W; Balakrishnar B; Scott KF; Becker TM, 2022, Choice of antibody is critical for specific and sensitive detection of androgen receptor splice variant-7 in circulating tumor cells, http://dx.doi.org/10.21203/rs.3.rs-1602818/v2
    Conference Papers | 2021
    Tincknell G; Piper A-K; Ma Y; Ranson M; Becker T; Brungs D, 2021, 'Tracking circulating tumour DNA in patients with resectable gastroesophageal cancer', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY, pp. 43 - 43, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000693805000079&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2020
    Collier N; Oar A; Ng W; Johnston ML; Ma Y; Becker T; Apte M; Pavey D; Arumugam S; Merrett N; Asghari R; Lee MT, 2020, 'An Australian Three-Centre Feasibility Study of Neoadjuvant Modified FOLFIRINOX and Stereotactic Body Radiotherapy for Locally Advanced Pancreatic Cancer with Collection of Baseline Circulating Tumor Cells', in INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, ELSEVIER SCIENCE INC, ELECTR NETWORK, Vol. 108, pp. E644 - E644, presented at 62nd Annual Meeting of the American-Society-for-Radiation-Oncology (ASTRO), ELECTR NETWORK, 25 October 2020 - 28 October 2020, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000582521502240&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2020
    Pang TCY; Mekapogu AR; Xu Z; Pothula S; Goldstein D; Pirola RC; Wilson JS; Becker TM; Apte MV, 2020, 'Characterization of Circulating Pancreatic Stellate Cells (Pscs) in Pancreatic Cancer, by Single Cell Transcriptomic Analysis', in PANCREAS, LIPPINCOTT WILLIAMS & WILKINS, Vol. 49, pp. 1423 - 1423, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000614149700122&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2018
    Ding PN; Becker T; Bray VJ; Chua W; Ma YF; Luk A; Po J; Lynch D; Caixeiro N; de Souza P; Roberts TL, 2018, 'Longitudinal analysis of circulating biomarkers to monitor advanced EGFR mutated (EGFR+) non-small cell lung cancer (NSCLC)', in Annals of oncology : official journal of the European Society for Medical Oncology, pp. viii660, http://dx.doi.org/10.1093/annonc/mdy303.033
    Conference Papers | 2018
    Pang T; Xu Z; Pothula S; Yang MH; Becker T; Goldstein D; Heeschen C; Pirola R; Wilson J; Apte MV, 2018, 'WORLD-FIRST IDENTIFICATION OF CIRCULATING PANCREATIC STELLATE CELLS IN METASTATIC PANCREATIC CANCER', in GASTROENTEROLOGY, W B SAUNDERS CO-ELSEVIER INC, DC, Washington, pp. S114 - S114, presented at Annual Meeting of the American-Society-for-Gastrointestinal-Endoscopy / Digestive Disease Week, DC, Washington, 02 June 2018 - 05 June 2018, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000450011100327&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2018
    Wilson J; Pang T; Xu Z; Mekapogu A; Pothula S; Goldstein D; Pirola R; Wilson J; Apte M, 2018, 'Establishment of a noval adjuvant model of orthotopic pancreatic cancer: effects of HGF-cMET inhibition on disease progression', Sydney, presented at Avner Cancer Symposium, Sydney
    Conference Abstracts | 2015
    Lim SH; Spring K; Chua W; Ng W; Descallar J; Ma Y; Becker TM; De Souza P, 2015, 'Circulating Tumor Cells in Locally Advanced Rectal Cancer Treated With Neoadjuvant Chemoradiation', in INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, ELSEVIER SCIENCE INC, TX, San Antonio, Vol. 93, pp. E522 - E523, presented at 57th Annual Meeting of the American-Society-for-Radiation-Oncology (ASTRO), TX, San Antonio, 18 October 2015 - 21 October 2015, http://dx.doi.org/10.1016/j.ijrobp.2015.07.1883

My Research Supervision

Through UNSW and other Universities I am currently main supervisor of three PhD students with projects into prostate, brain and breast cancer. I am also co-supervising three PhD projects into lung and pancreatic cancer. I have successfully supervised ILP an BSC (Med) Hon projects (2016, 2018,2019) and the students were awarded several best poster/oral presentation prizes at high profile conferences. All students have authored publications, in fact one ILP student just published a first author journal publication in an impact factor 5.7 journal, while Phd students will generally average 2-3 first author and several middle author journal publications.