Dr Simon Brayford

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Dr Simon Brayford is a researcher at the Children's Cancer Institute and UNSW Conjoint Lecturer. His research interests include cell-signalling, metastasis and understanding mechanisms contributing to chemotherapy resistance in tumours. The aim of this research is to develop novel, multi-targeted therapeutic strategies for a range of adult and childhood cancers.

E-mail

SBrayford@ccia.org.au

Location

Level 1, Lowy Cancer Research Centre

Publications

Book Chapters | 2015

Brayford S; Schevzov G; Vos J; Gunning P, 2015, 'The role of the actin cytoskeleton in cancer and its potential use as a therapeutic target', in The Cytoskeleton in Health and Disease, pp. 373 - 391, http://dx.doi.org/10.1007/978-1-4939-2904-7_16
Journal articles | 2023

Brayford S; Duly A; Teo WS; Dwarte T; Gonzales-Aloy E; Ma Z; McVeigh L; Failes TW; Arndt GM; McCarroll JA; Kavallaris M, 2023, 'βIII-tubulin suppression enhances the activity of Amuvatinib to inhibit cell proliferation in c-Met positive non-small cell lung cancer cells', Cancer Medicine, 12, pp. 4455 - 4471, http://dx.doi.org/10.1002/cam4.5128

Journal articles | 2022

Cagigas ML; Bryce NS; Ariotti N; Brayford S; Gunning PW; Hardeman EC, 2022, 'Correlative cryo-ET identifies actin/tropomyosin filaments that mediate cell–substrate adhesion in cancer cells and mechanosensitivity of cell proliferation', Nature Materials, 21, pp. 120 - 128, http://dx.doi.org/10.1038/s41563-021-01087-z

Journal articles | 2022

Parker AL; Teo WS; Brayford S; Moorthi UK; Arumugam S; Ferguson C; Parton RG; McCarroll JA; Kavallaris M, 2022, 'βIII-Tubulin Structural Domains Regulate Mitochondrial Network Architecture in an Isotype-Specific Manner', Cells, 11, http://dx.doi.org/10.3390/cells11050776

Journal articles | 2021

Law AL; Jalal S; Pallett T; Mosis F; Guni A; Brayford S; Yolland L; Marcotti S; Levitt JA; Poland SP; Rowe-Sampson M; Jandke A; Köchl R; Pula G; Ameer-Beg SM; Stramer BM; Krause M, 2021, 'Nance-Horan Syndrome-like 1 protein negatively regulates Scar/WAVE-Arp2/3 activity and inhibits lamellipodia stability and cell migration', Nature Communications, 12, http://dx.doi.org/10.1038/s41467-021-25916-6

Journal articles | 2019

Brayford S; Kenny FN; Hiratsuka T; Serna-Morales E; Yolland L; Luchici A; Stramer BM, 2019, 'Heterotypic contact inhibition of locomotion can drive cell sorting between epithelial and mesenchymal cell populations', Journal of Cell Science, vol. 132, http://dx.doi.org/10.1242/jcs.223974

Journal articles | 2016

Brayford S; Bryce NS; Schevzov G; Haynes EM; Bear JE; Hardeman EC; Gunning PW, 2016, 'Tropomyosin promotes lamellipodial persistence by collaborating with Arp2/3 at the leading edge', Current Biology, 26, pp. 1312 - 1318, http://dx.doi.org/10.1016/j.cub.2016.03.028
Conference Papers | 2020

Brayford S; Teo WS; Parker A; McVeigh L; McCarroll JA; Kavallaris M, 2020, 'Abstract 1442: Identifying the molecular basis by which βIII-tubulin promotes tumor cell survival and drug resistance in non-small cell lung cancer', in Cancer Research, American Association for Cancer Research (AACR), pp. 1442 - 1442, http://dx.doi.org/10.1158/1538-7445.am2020-1442

Preprints | 2020

Law A-L; Jalal S; Pallett T; Mosis F; Guni A; Brayford S; Yolland L; Marcotti S; Levitt JA; Poland SP; Rowe-Sampson M; Jandke A; Köchl R; Pula G; Ameer-Beg SM; Stramer BM; Krause M, 2020, Nance-Horan Syndrome-like 1 protein negatively regulates Scar/WAVE-Arp2/3 activity and inhibits lamellipodia stability and cell migration, http://dx.doi.org/10.1101/2020.05.11.083030

Preprints | 2018

Brayford S; Serna-Morales E; Luchici A; Hiratsuka T; Stramer BM, 2018, EphB2 and ERK signaling are required for heterotypic contact inhibition of locomotion to drive cell sorting, http://dx.doi.org/10.1101/373696

Conference Presentations | 2018

Brayford S, 2018, 'EphB2 acts via ERK signalling to promote active cell repulsion and cell sorting', presented at The Dynamic Cell III, Manchester Conference Centre, Manchester, UK, 19 March 2018 - 21 March 2018, https://www.eventsforce.net/biochemsoc/frontend/reg/absViewDocumentFE.csp?popup=1&documentID=298&eventID=17

Conference Presentations | 2014

Brayford S; Schevzov G; Hardeman EC; Bear JE; Gunning PW, 2014, 'Tropomyosin 5a/b actin filaments collaborate with arp2/3 actin filaments to regulate cell motility.', Vol. 25, presented at ASCB/IFCB Meeting, PA, Philadelphia, 06 December 2014 - 10 December 2014, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000352094100083&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

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