Dr Michael Johnson

Dr Michael Johnson

Manager
Medicine & Health
School of Biomedical Sciences

Dr Johnson has an extensive background cell biology that he has applied in diverse fields ranging from parasitology, microbiology through to microbial ecology, cyanobacteriology and mammalian cell biology.    He has a proven track record in isolation and culture of cyanobacteria with unique photosystems, including the Acaryochloris genus of cyanobacteria. These cells are capable of growing in near infrared (NIR) wavelengths of light in the absence of all other wavelengths and provide an insight into the evolution of photosynthesis. He has a deep understanding of cyanobacteria and their nuanced utilisation of visible and NIR light in niche environments through the production of unique metabolic components. In addition to his interests in environmental microbiology,  Dr Johnson also has  an interest in medical diagnostics for important pathogens, particularly in regards to the protozoan pathogen Toxoplasma gondii (a closely related cousin of the malaria parasite). He has developed diagnostic approaches with recombinant antigens and strain specific peptides for this parasite. He has experience in quantifying parasite transmission in wildlife and livestock and has employed various genotyping approaches to understand this in an Australian setting.  Dr Johnson is particularly interested in applying his knowledge of diverse cell types towards fluorescence based analysis methods, including volume imaging (confocal and deconvolution methods), Forster Resonance Energy Transfer (FRET), spectroscopy and hyperspectral confocal imaging, microscopy based excitation emission profiling and flow cytometry.

Phone
0413809670
Location
Wallace Wurth Building, Level 2 East, Room 228
  • Journal articles | 2024
    Ritchie RJ; Sma-Air S; Johnson MS; Murray SA; Nguyen A; Larkum AWD; Dummee V, 2024, 'Photosynthesis in a green alga (zoochlorella), Chlorella cf. vulgaris in the soft coral Sarcophyton sp.', Phycologia, 63, pp. 60 - 73, http://dx.doi.org/10.1080/00318884.2023.2292908
    Journal articles | 2023
    Duman MN; Angeloski A; Johnson MS; Rawling T, 2023, 'Aromatic long chain cations of amphiphilic ionic liquids permeabilise the inner mitochondrial membrane and induce mitochondrial dysfunction at cytotoxic concentrations', Green Chemistry, 25, pp. 6067 - 6076, http://dx.doi.org/10.1039/d3gc00151b
    Journal articles | 2022
    Johnson MS; Burns BP; Herdean A; Angeloski A; Ralph P; Morris T; Kindler G; Wong HL; Kuzhiumparambil U; Sedger LM; Larkum AWD, 2022, 'A Cyanobacteria Enriched Layer of Shark Bay Stromatolites Reveals a New Acaryochloris Strain Living in Near Infrared Light', Microorganisms, 10, http://dx.doi.org/10.3390/microorganisms10051035
    Journal articles | 2022
    Kindler GS; Wong HL; Larkum AWD; Johnson M; MacLeod FI; Burns BP, 2022, 'Genome-resolved metagenomics provides insights into the functional complexity of microbial mats in Blue Holes, Shark Bay', FEMS Microbiology Ecology, 98, http://dx.doi.org/10.1093/femsec/fiab158
    Journal articles | 2022
    Lao W; Zhao Y; Tan Y; Johnson M; Li Y; Xiao L; Cheng J; Lin Y; Qu X, 2022, 'Regulatory Effects and Mechanism of Action of Green Tea Polyphenols on Osteogenesis and Adipogenesis in Human Adipose Tissue-Derived Stem Cells', Current Issues in Molecular Biology, 44, pp. 6046 - 6058, http://dx.doi.org/10.3390/cimb44120412
    Journal articles | 2022
    Ni Z; Gale A; Johnson MS; Sedger LM, 2022, 'Analysis insights for three FRET pairs of chemically unlinked two-molecule FRET cytometry', Cytometry Part A, 101, pp. 387 - 399, http://dx.doi.org/10.1002/cyto.a.24527
    Journal articles | 2021
    Dey A; Ni Z; Johnson MS; Sedger LM, 2021, 'A multi-colour confocal microscopy method for identifying and enumerating macrophage subtypes and adherent cells in the stromal vascular fraction of human adipose', Journal of Immunological Methods, 491, http://dx.doi.org/10.1016/j.jim.2021.112988
    Journal articles | 2021
    Ellis J; Barratt J; Kaufer A; Pearn L; Armstrong B; Johnson M; Park Y; Downey L; Cao M; Neill L; Lee R; Ellis B; Tyler K; Lun ZR; Stark D, 2021, 'A new subspecies of Trypanosoma cyclops found in the Australian terrestrial leech Chtonobdella bilineata', Parasitology, 148, pp. 1125 - 1136, http://dx.doi.org/10.1017/S0031182021000639
    Journal articles | 2021
    Quinn AW; Phillips CR; Violi JP; Steele JR; Johnson MS; Westerhausen MT; Rodgers KJ, 2021, 'β-Methylamino-L-alanine-induced protein aggregation in vitro and protection by L-serine', Amino Acids, 53, pp. 1351 - 1359, http://dx.doi.org/10.1007/s00726-021-03049-w
    Journal articles | 2021
    Taylor J; Patio K; De Rubis G; Morris MB; Evenhuis C; Johnson M; Bebawy M, 2021, 'Membrane to cytosol redistribution of αII-spectrin drives extracellular vesicle biogenesis in malignant breast cells', Proteomics, 21, http://dx.doi.org/10.1002/pmic.202000091
    Journal articles | 2020
    Cheng J; Tan Y; Zhou J; Xiao L; Johnson M; Qu X, 2020, 'Green tea polyphenols ameliorate metabolic abnormalities and insulin resistance by enhancing insulin signalling in skeletal muscle of Zucker fatty rats', Clinical Science, 134, pp. 1167 - 1180, http://dx.doi.org/10.1042/CS20200107
    Journal articles | 2020
    Kühl M; Trampe E; Mosshammer M; Johnson M; Larkum AWD; Frigaard NU; Koren K, 2020, 'Substantial near-infrared radiation-driven photosynthesis of chlorophyll f-containing cyanobacteria in a natural habitat', eLife, 9, http://dx.doi.org/10.7554/eLife.50871
    Journal articles | 2020
    Tan Y; Johnson M; Zhou J; Zhao Y; Kamal MA; Qu X, 2020, 'Antrodia cinnamomea Inhibits Growth and Migration of Lung Cancer Cells through Regulating p53-Bcl2 and MMPs Pathways', American Journal of Chinese Medicine, 48, pp. 1941 - 1953, http://dx.doi.org/10.1142/S0192415X20500974
    Journal articles | 2019
    Espinoza-Vergara G; Noorian P; Silva-Valenzuela CA; Raymond BBA; Allen C; Hoque MM; Sun S; Johnson MS; Pernice M; Kjelleberg S; Djordjevic SP; Labbate M; Camilli A; McDougald D, 2019, 'Vibrio cholerae residing in food vacuoles expelled by protozoa are more infectious in vivo', Nature Microbiology, 4, pp. 2466 - 2474, http://dx.doi.org/10.1038/s41564-019-0563-x
    Journal articles | 2019
    Ong M; Cheng J; Jin X; Lao W; Johnson M; Tan Y; Qu X, 2019, 'Paeoniflorin extract reverses dexamethasone-induced testosterone over-secretion through downregulation of cytochrome P450 17A1 expression in primary murine theca cells', Journal of Ethnopharmacology, 229, pp. 97 - 103, http://dx.doi.org/10.1016/j.jep.2018.09.006
    Journal articles | 2018
    Fisher A; Wangpraseurt D; Larkum AWD; Johnson M; Kühl M; Chen M; Wong HL; Burns BP, 2018, 'Correlation of bio-optical properties with photosynthetic pigment and microorganism distribution in microbial mats from Hamelin Pool, Australia', FEMS Microbiology Ecology, 95, http://dx.doi.org/10.1093/femsec/fiy219
    Journal articles | 2017
    Donnelly S; Huston WM; Johnson M; Tiberti N; Saunders B; O'Brien B; Burke C; Labbate M; Combes V, 2017, 'Targeting the master regulator mTOR: A new approach to prevent the neurological of consequences of parasitic infections?', Parasites and Vectors, 10, http://dx.doi.org/10.1186/s13071-017-2528-3
    Journal articles | 2017
    Jaiswal R; Johnson MS; Pokharel D; Krishnan SR; Bebawy M, 2017, 'Microparticles shed from multidrug resistant breast cancer cells provide a parallel survival pathway through immune evasion', BMC Cancer, 17, http://dx.doi.org/10.1186/s12885-017-3102-2
    Journal articles | 2016
    Zhao Z; Johnson MS; Chen B; Grace M; Ukath J; Lee VS; McRobb LS; Sedger LM; Stoodley MA, 2016, 'Live-cell imaging to detect phosphatidylserine externalization in brain endothelial cells exposed to ionizing radiation: Implications for the treatment of brain arteriovenous malformations', Journal of Neurosurgery, 124, pp. 1780 - 1787, http://dx.doi.org/10.3171/2015.4.JNS142129
    Journal articles | 2015
    Chaiyadet S; Smout M; Johnson M; Whitchurch C; Turnbull L; Kaewkes S; Sotillo J; Loukas A; Sripa B, 2015, 'Excretory/secretory products of the carcinogenic liver fluke are endocytosed by human cholangiocytes and drive cell proliferation and IL6 production', International Journal for Parasitology, 45, pp. 773 - 781, http://dx.doi.org/10.1016/j.ijpara.2015.06.001
    Journal articles | 2015
    Chaiyadet S; Sotillo J; Smout M; Cantacessi C; Jones MK; Johnson MS; Turnbull L; Whitchurch CB; Potriquet J; Laohaviroj M; Mulvenna J; Brindley PJ; Bethony JM; Laha T; Sripa B; Loukas A, 2015, 'Carcinogenic liver fluke secretes extracellular vesicles that promote cholangiocytes to adopt a tumorigenic phenotype', Journal of Infectious Diseases, 212, pp. 1636 - 1645, http://dx.doi.org/10.1093/infdis/jiv291
    Journal articles | 2015
    Smout MJ; Sotillo J; Laha T; Papatpremsiri A; Rinaldi G; Pimenta RN; Chan LY; Johnson MS; Turnbull L; Whitchurch CB; Giacomin PR; Moran CS; Golledge J; Daly N; Sripa B; Mulvenna JP; Brindley PJ; Loukas A, 2015, 'Carcinogenic Parasite Secretes Growth Factor That Accelerates Wound Healing and Potentially Promotes Neoplasia', PLoS Pathogens, 11, http://dx.doi.org/10.1371/journal.ppat.1005209
    Journal articles | 2013
    Frölich S; Johnson M; Robinson M; Entzeroth R; Wallach M, 2013, 'The spatial organization and extraction of the wall-forming bodies of Eimeria maxima', Parasitology, 140, pp. 876 - 887, http://dx.doi.org/10.1017/S0031182012002247
    Journal articles | 2012
    Ivanov IE; Boyd CD; Newell PD; Schwartz ME; Turnbull L; Johnson MS; Whitchurch CB; O'Toole GA; Camesano TA, 2012, 'Atomic force and super-resolution microscopy support a role for LapA as a cell-surface biofilm adhesin of Pseudomonas fluorescens', Research in Microbiology, 163, pp. 685 - 691, http://dx.doi.org/10.1016/j.resmic.2012.10.001
    Journal articles | 2010
    Parameswaran N; Thompson RCA; Sundar N; Pan S; Johnson M; Smith NC; Grigg ME, 2010, 'Non-archetypal Type II-like and atypical strains of Toxoplasma gondii infecting marsupials of Australia', International Journal for Parasitology, 40, pp. 635 - 640, http://dx.doi.org/10.1016/j.ijpara.2010.02.008
    Journal articles | 2003
    Johnson M; Broady K; Angelici MC; Johnson A, 2003, 'The relationship between nucleoside triphosphate hydrolase (NTPase) isoform and Toxoplasma strain virulence in rat and human toxoplasmosis', Microbes and Infection, 5, pp. 797 - 806, http://dx.doi.org/10.1016/S1286-4579(03)00148-5
    Journal articles | 1999
    Johnson MS; Broady KW; Johnson AM, 1999, 'Differential recognition of Toxoplasma gondii recombinant nucleoside triphosphate hydrolase isoforms by naturally infected human sera', International Journal for Parasitology, 29, pp. 1893 - 1905, http://dx.doi.org/10.1016/S0020-7519(99)00139-3
    Journal articles | 1999
    Johnson MS; Broady KW; Johnson AM, 1999, 'Studies on epitope recognition of the toxoplasma nucleoside triphosphate hydrolase', Journal of Protozoology Research, 9, pp. 135 - 141
  • Preprints | 2022
    Johnson MS; Burns B; Herdean A; Angeloski A; Ralph P; Morris T; Kindler G; Wong HL; Kuzhiumparambil U; Sedger L; Larkum AWD, 2022, A Cyanobacteria Enriched Layer of Shark Bay Stromatolites Reveals a New Acaryochloris strain Living in near Infrared Light, http://dx.doi.org/10.20944/preprints202204.0112.v1
    Preprints | 2020
    Kindler GS; Wong HL; Larkum AWD; Johnson M; MacLeod FI; Burns BP, 2020, Metagenomic insights into ecosystem function in the microbial mats of Blue Holes, Shark Bay, http://dx.doi.org/10.1101/2020.09.18.304444
    Preprints | 2020
    Lao W; Tan Y; Johnson M; Li Y; Lin Y; Xiao L; Qu X, 2020, Combating Osteoporosis and Obesity With Green Tea Polyphenols: Molecular Switching of Osteogenesis Versus Adipogenesis During Early Differentiation of Human Adipose Tissue-Derived Stem Cells, http://dx.doi.org/10.21203/rs.3.rs-53339/v1
    Preprints | 2019
    Kühl M; Trampe E; Mosshammer M; Johnson M; Larkum AWD; Koren K, 2019, Substantial near-infrared radiation-driven photosynthesis of chlorophyllf-containing cyanobacteria in a natural habitat, http://dx.doi.org/10.1101/750174
    Conference Papers | 2014
    Zhao Z; Johnson M; Chen B; Grace M; Ukath J; Lee V; Stoodley M, 2014, 'Ionizing radiation induced phosphatidylserine externalization on endothelial cell surface - a potential target for vascular targeting', in EUROPEAN JOURNAL OF CANCER, ELSEVIER SCI LTD, SPAIN, European Org Res & Treatment Canc, Barcelona, pp. 66 - 66, presented at 26th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, SPAIN, European Org Res & Treatment Canc, Barcelona, 18 November 2014 - 21 November 2014, http://dx.doi.org/10.1016/S0959-8049(14)70329-6