Back to
Ms Martina Beretta

Ms Martina Beretta

Lecturer

PhD in Molecular Biomedicine, Friedrich-Schiller University (Jena, Germany) 2013-2018

Master of Science in Medical Biotechnologies, University of Turin (Torino, Italy) 2011-2013

Science
School of Biotech & Biomolecular Science

 

Postdoctoral Research Associate, UNSW 2018-current

Research Assistant, UNSW 2018

 
E-mail
m.beretta@unsw.edu.au
Location
UNSW Biological Sciences Building, D26 Level 4 WEST
  • Journal articles | 2024
    Beretta M; Dai Y; Olzomer EM; Vancuylenburg CS; Santiago-Rivera JA; Philp AM; Hargett SR; Li K; Shah DP; Chen SY; Alexopoulos SJ; Li C; Harris TE; Lee B; Wathier M; Cermak JM; Tucker SP; Turner N; Bayliss DA; Philp A; Byrne FL; Santos WL; Hoehn KL, 2024, 'Liver-Selective Imidazolopyrazine Mitochondrial Uncoupler SHD865 Reverses Adiposity and Glucose Intolerance in Mice', Diabetes, 73, pp. 374 - 384, http://dx.doi.org/10.2337/db23-0233
    Journal articles | 2024
    Chen SY; Beretta M; Olzomer EM; Alexopoulos SJ; Shah DP; Byrne FL; Salamoun JM; Garcia CJ; Smith GC; Larance M; Philp A; Turner N; Santos WL; Cantley J; Hoehn KL, 2024, 'Head-to-head comparison of BAM15, semaglutide, rosiglitazone, NEN, and calorie restriction on metabolic physiology in female db/db mice', Biochimica et Biophysica Acta - Molecular Basis of Disease, 1870, http://dx.doi.org/10.1016/j.bbadis.2023.166908
    Journal articles | 2024
    Chen SY; Telfser AJ; Olzomer EM; Vancuylenberg CS; Zhou M; Beretta M; Li C; Alexopoulos SJ; Turner N; Byrne FL; Santos WL; Hoehn KL, 2024, 'Beneficial effects of simultaneously targeting calorie intake and calorie efficiency in diet-induced obese mice', Clinical Science, 138, pp. 173 - 187, http://dx.doi.org/10.1042/CS20231016
    Journal articles | 2024
    Cheng Y; Jones JP; Yu TT; Olzomer EM; Su J; Katen A; Black DSC; Hart-Smith G; Childress ES; Beretta M; Wilkins MR; Mateos IA; Santos WL; Hoehn KL; Byrne FL; Kumar N, 2024, 'Corrigendum to “Design, synthesis and biological evaluation of glucose metabolism inhibitors as anticancer agents” [Bioorg. Chem. 151 (2024) 107665] (Bioorganic Chemistry (2024) 151, (S0045206824005704), (10.1016/j.bioorg.2024.107665))', Bioorganic Chemistry, 151, http://dx.doi.org/10.1016/j.bioorg.2024.107725
    Journal articles | 2024
    Clarke RA; Govindaraju H; Beretta M; Olzomer E; Lawther AJ; Walker AK; Fang Z; Eapen V; Hyams TC; Killingsworth M; Bridge W; Turner N; Siddiqui KS, 2024, 'Immp2l Enhances the Structure and Function of Mitochondrial Gpd2 Dehydrogenase', International Journal of Molecular Sciences, 25, http://dx.doi.org/10.3390/ijms25020990
    Journal articles | 2024
    Foutz MA; Krinos EL; Beretta M; Hargett SR; Shrestha R; Murray JH; Duerre E; Salamoun JM; McCarter K; Shah DP; Hoehn KL; Santos WL, 2024, 'Design, Synthesis, and Biological Evaluation of [1,2,5]Oxadiazolo[3,4-b]pyridin-7-ol as Mitochondrial Uncouplers for the Treatment of Obesity and Metabolic Dysfunction-Associated Steatohepatitis', Journal of Medicinal Chemistry, http://dx.doi.org/10.1021/acs.jmedchem.4c02366
    Journal articles | 2024
    Salamoun JM; Krinos EL; Foutz MA; Hargett SR; Beretta M; Shrestha R; Hoehn KL; Santos WL, 2024, 'Design, synthesis, and biological evaluation of imidazo[4,5-b]pyridine mitochondrial uncouplers for the treatment of metabolic dysfunction-associated steatohepatitis (MASH)', European Journal of Medicinal Chemistry, 280, http://dx.doi.org/10.1016/j.ejmech.2024.116916
    Journal articles | 2024
    Shrestha R; Vancuylenburg CS; Beretta M; Zhou M; Shah DP; Olzomer EM; Richards SL; Hoehn KL; Byrne FL, 2024, 'Complete inhibition of liver acetyl-CoA carboxylase activity is required to exacerbate liver tumorigenesis in mice treated with diethylnitrosamine.', Cancer Metab, 12, pp. 34, http://dx.doi.org/10.1186/s40170-024-00363-1
    Journal articles | 2023
    Chen SY; Beretta M; Olzomer EM; Shah DP; Wong DYH; Alexopoulos SJ; Aleksovska I; Salamoun JM; Garcia CJ; Cochran BJ; Rye KA; Smith GC; Byrne FL; Morris MJ; Santos WL; Cantley J; Hoehn KL, 2023, 'Targeting negative energy balance with calorie restriction and mitochondrial uncoupling in db/db mice', Molecular Metabolism, 69, http://dx.doi.org/10.1016/j.molmet.2023.101684
    Journal articles | 2023
    Murray JH; Burgio AL; Beretta M; Hargett SR; Harris TE; Olzomer E; Grams RJ; Garcia CJ; Li C; Salamoun JM; Hoehn KL; Santos WL, 2023, 'Oxadiazolopyridine Derivatives as Efficacious Mitochondrial Uncouplers in the Prevention of Diet-Induced Obesity', Journal of Medicinal Chemistry, 66, pp. 3876 - 3895, http://dx.doi.org/10.1021/acs.jmedchem.2c01573
    Journal articles | 2022
    Chen SY; Olzomer EM; Beretta M; Cantley J; Nunemaker CS; Hoehn KL; Byrne FL, 2022, 'Investigating the Expression and Function of the Glucose Transporter GLUT6 in Obesity', International Journal of Molecular Sciences, 23, pp. 9798, http://dx.doi.org/10.3390/ijms23179798
    Journal articles | 2021
    Chen SY; Beretta M; Alexopoulos SJ; Shah DP; Olzomer EM; Hargett SR; Childress ES; Salamoun JM; Aleksovska I; Roseblade A; Cranfield C; Rawling T; Quinlan KGR; Morris MJ; Tucker SP; Santos WL; Hoehn KL, 2021, 'Mitochondrial uncoupler SHC517 reverses obesity in mice without affecting food intake', Metabolism: Clinical and Experimental, 117, http://dx.doi.org/10.1016/j.metabol.2021.154724
    Journal articles | 2021
    Jentho E; Ruiz-Moreno C; Novakovic B; Kourtzelis I; Megchelenbrink WL; Martins R; Chavakis T; Soares MP; Kalafati L; Guerra J; Roestel F; Bohm P; Godmann M; Grinenko T; Eugster A; Beretta M; Joosten LAB; Netea MG; Bauer M; Stunnenberg HG; Weis S, 2021, 'Trained innate immunity, long-lasting epigenetic modulation, and skewed myelopoiesis by heme', Proceedings of the National Academy of Sciences of the United States of America, 118, http://dx.doi.org/10.1073/pnas.2102698118
    Journal articles | 2021
    Press AT; Babic P; Hoffmann B; Müller T; Foo W; Hauswald W; Benecke J; Beretta M; Cseresnyés Z; Hoeppener S; Nischang I; Coldewey SM; Gräler MH; Bauer R; Gonnert F; Gaßler N; Wetzker R; Figge MT; Schubert US; Bauer M, 2021, 'Targeted delivery of a phosphoinositide 3-kinase γ inhibitor to restore organ function in sepsis', EMBO Molecular Medicine, 13, http://dx.doi.org/10.15252/emmm.202114436
    Journal articles | 2021
    Zunica ERM; Axelrod CL; Cho E; Spielmann G; Davuluri G; Alexopoulos SJ; Beretta M; Hoehn KL; Dantas WS; Stadler K; King WT; Pergola K; Irving BA; Langohr IM; Yang S; Hoppel CL; Gilmore LA; Kirwan JP, 2021, 'Breast cancer growth and proliferation is suppressed by the mitochondrial targeted furazano[3,4-b]pyrazine BAM15', CANCER & METABOLISM, 9, http://dx.doi.org/10.1186/s40170-021-00274-5
    Journal articles | 2020
    Alexopoulos SJ; Chen SY; Brandon AE; Salamoun JM; Byrne FL; Garcia CJ; Beretta M; Olzomer EM; Shah DP; Philp AM; Hargett SR; Lawrence RT; Lee B; Sligar J; Carrive P; Tucker SP; Philp A; Lackner C; Turner N; Cooney GJ; Santos WL; Hoehn KL; Evans A, 2020, 'Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice', Nature Communications, 11, pp. 2397, http://dx.doi.org/10.1038/s41467-020-16298-2
    Journal articles | 2020
    Beer AJ; Hertz D; Seemann E; Beretta M; Westermann M; Bauer R; Bauer M; Kessels MM; Qualmann B, 2020, 'Reduced Mrp2 surface availability as PI3Kγ-mediated hepatocytic dysfunction reflecting a hallmark of cholestasis in sepsis', Scientific Reports, 10, http://dx.doi.org/10.1038/s41598-020-69901-3
    Journal articles | 2020
    Hahnefeld L; Gruber L; Schömel N; Fischer C; Mattjus P; Gurke R; Beretta M; Ferreirós N; Geisslinger G; Wegner MS, 2020, 'Ether lipid and sphingolipid expression patterns are estrogen receptor-dependently altered in breast cancer cells', International Journal of Biochemistry and Cell Biology, 127, http://dx.doi.org/10.1016/j.biocel.2020.105834
    Journal articles | 2020
    Salamoun JM; Garcia CJ; Hargett SR; Murray JH; Chen SY; Beretta M; Alexopoulos SJ; Shah DP; Olzomer EM; Tucker SP; Hoehn KL; Santos WL, 2020, '6-Amino[1,2,5]oxadiazolo[3,4- b]pyrazin-5-ol Derivatives as Efficacious Mitochondrial Uncouplers in STAM Mouse Model of Nonalcoholic Steatohepatitis', Journal of Medicinal Chemistry, 63, pp. 6203 - 6224, http://dx.doi.org/10.1021/acs.jmedchem.0c00542
    Journal articles | 2015
    Beretta M; Bauer M; Hirsch E, 2015, 'PI3K signaling in the pathogenesis of obesity: The cause and the cure', Advances in Biological Regulation, 58, pp. 1 - 15, http://dx.doi.org/10.1016/j.jbior.2014.11.004
    Journal articles | 2014
    Perino A; Beretta M; Kilić A; Ghigo A; Carnevale D; Repetto IE; Braccini L; Longo D; Liebig-Gonglach M; Zaglia T; Iacobucci R; Mongillo M; Wetzker R; Bauer M; Aime S; Vercelli A; Lembo G; Pfeifer A; Hirsch E, 2014, 'Combined inhibition of PI3Kβ and PI3Kγ reduces fat mass by enhancing α-MSH-dependent sympathetic drive', Science Signaling, 7, http://dx.doi.org/10.1126/scisignal.2005485
  • Preprints | 2023
    Clarke R; Govindaraju H; Beretta M; Olzomer E; Lawther A; Walker A; Fang Z; Eapen V; Cohen-Hyams T; Killingsworth M; Bridge W; Turner N; Siddiqui K, 2023, IMMP2L Peptidase Enhances the Structure and Function of Mitochondrial GPD2 Dehydrogenase., http://dx.doi.org/10.20944/preprints202312.0505.v1
    Preprints | 2021
    Press AT; Babic P; Hoffmann B; Müller T; Foo W; Hauswald W; Benecke J; Beretta M; Cseresnyés Z; Hoeppener S; Nischang I; Coldewey SM; Gräler MH; Bauer R; Gonnert F; Gaßler N; Wetzker R; Figge MT; Schubert US; Bauer M, 2021, Targeted delivery of a phosphoinositide 3-kinase γ inhibitor to restore organ function in sepsis through dye-functionalized lipid nanocarriers, http://dx.doi.org/10.1101/2021.01.20.427305
    Preprints | 2020
    Hahnefeld L; Gruber L; Schömel N; Fischer C; Mattjus P; Gurke R; Beretta M; Ferreirós N; Geisslinger G; Wegner M-S, 2020, Ether lipid and sphingolipid expression patterns are G-protein coupled estrogen receptor 1-dependently altered in breast cancer cells, http://dx.doi.org/10.1101/2020.07.20.212894
    Preprints | 2019
    Jentho E; Novakovic B; Ruiz-Moreno C; Kourtzelis I; Martins R; Chavakis T; Soares MP; Kalafati L; Guerra J; Roestel F; Bohm P; Godmann M; Grinenko T; Eugster A; Beretta M; Joosten LAB; Netea M; Stunnenberg H; Bauer M; Weis S, 2019, Heme induces innate immune memory, http://dx.doi.org/10.1101/2019.12.12.874578

 

 

UNSW GRIP award (AUD $15,000), 2025

UNSW Career Advancement Fund (AUD $10,000), 2024

UNSW Momentum Award (AUD 5,000), 2024

 

The focus of my research is on the screening and development of molecules that derive from BAM15, a protonophore mitochondrial uncoupler with powerful anti-obesity effects. I have a 5-year experience in contract research studies for Continuum Biosciences Inc. and have validated the in vivo efficacy of small molecule mitochondrial uncouplers for treating non-alcoholic steatohepatitis (NASH) and associated metabolic diseases. In recent years I have also investigated the role of acetyl-coA carboxylase enzymes in the development of fatty liver disease and hepatocellular carcinoma.