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Dr Kevin Wang

Conjoint Lecturer

PhD: Lens Research Lab, Department of Anatomy and Histology, University of Sydney, Australia.

MSc: Department of Biological Science, University of Wollongong, Australia.

BSc: Department of Biophysics and Physiology, Fudan University, China.

Medicine & Health

School of Clinical Medicine

Book Chapters | 2019

Tian M; Wang Q; Yuan C; Ye S, 2019, 'Structure and function studies of GPCRs by site-specific incorporation of unnatural amino acids', in Topics in Medicinal Chemistry, pp. 195 - 215, http://dx.doi.org/10.1007/7355_2017_20
Journal articles | 2024

Cheung BB; Mittra R; Murray J; Wang Q; Seneviratne JA; Raipuria M; Wong IPL; Restuccia D; Gifford A; Salib A; Sutton S; Huang L; Ferdowsi PV; Tsang J; Sekyere E; Mayoh C; Luo L; Brown DL; Stow JL; Zhu S; Young RJ; Solomon BJ; Chappaz S; Kile B; Kueh A; Herold MJ; Hilton DJ; Liu T; Norris MD; Haber M; Carter DR; Parker MW; Marshall GM, 2024, 'Golgi-localized Ring Finger Protein 121 is necessary for MYCN-driven neuroblastoma tumorigenesis', Communications Biology, 7, pp. 1322, http://dx.doi.org/10.1038/s42003-024-06899-8

Journal articles | 2022

Quek LE; van Geldermalsen M; Guan YF; Wahi K; Mayoh C; Balaban S; Pang A; Wang Q; Cowley MJ; Brown KK; Turner N; Hoy AJ; Holst J, 2022, 'Glutamine addiction promotes glucose oxidation in triple-negative breast cancer', Oncogene, 41, pp. 4066 - 4078, http://dx.doi.org/10.1038/s41388-022-02408-5

Journal articles | 2022

Seneviratne JA; Carter DR; Mittra R; Gifford A; Kim PY; Luo JS; Mayoh C; Salib A; Rahmanto AS; Murray J; Cheng NC; Nagy Z; Wang Q; Kleynhans A; Tan O; Sutton SK; Xue C; Chung SA; Zhang Y; Sun C; Zhang L; Haber M; Norris MD; Fletcher JI; Liu T; Dilda PJ; Hogg PJ; Cheung BB; Marshall GM, 2022, 'Inhibition of mitochondrial translocase SLC25A5 and histone deacetylation is an effective combination therapy in neuroblastoma', International Journal of Cancer, 152, pp. 1399 - 1413, http://dx.doi.org/10.1002/ijc.34349

Journal articles | 2021

Trapika IGMGSC; Liu XT; Chung LH; Lai F; Xie C; Zhao Y; Cui S; Chen J; Tran C; Wang Q; Zhang S; Don AS; Li GQ; Hanrahan JR; Qi Y, 2021, 'Ceramide Regulates Anti-Tumor Mechanisms of Erianin in Androgen-Sensitive and Castration-Resistant Prostate Cancers', Frontiers in Oncology, 11, http://dx.doi.org/10.3389/fonc.2021.738078

Journal articles | 2021

Wang Q; Guan YF; Hancock SE; Wahi K; van Geldermalsen M; Zhang BK; Pang A; Nagarajah R; Mak B; Freidman N; Horvath LG; Turner N; Holst J, 2021, 'Inhibition of guanosine monophosphate synthetase (GMPS) blocks glutamine metabolism and prostate cancer growth', Journal of Pathology, 254, pp. 135 - 146, http://dx.doi.org/10.1002/path.5665

Journal articles | 2020

Bi L; Xie C; Jiao L; Jin S; Hnit SST; Mu Y; Wang Y; Wang Q; Ge G; Wang Y; Zhao X; Shi X; Kang Y; De Souza P; Liu T; Zhou J; Xu L; Dong Q, 2020, 'CPF impedes cell cycle re-entry of quiescent lung cancer cells through transcriptional suppression of FACT and c-MYC', Journal of Cellular and Molecular Medicine, 24, pp. 2229 - 2239, http://dx.doi.org/10.1111/jcmm.14897

Journal articles | 2020

Huxley C; Wibowo M; Lum KY; Gordon S; D'Hyon S; Guan H; Wang X; Chen Y; Si M; Wang M; White JM; Wahi K; Wang Q; Holst J; Davis RA, 2020, 'Synthesis of bilocularin A carbamate derivatives and their evaluation as leucine transport inhibitors in prostate cancer cells', Phytochemistry, 179, pp. 112478, http://dx.doi.org/10.1016/j.phytochem.2020.112478

Journal articles | 2020

Wang Q; Guan Y; Hancock S; Wahi K; van Geldermalsen M; Zhang B; Pang A; Nagarajah R; Mak B; Horvath L; Turner N; Holst J, 2020, 'Inhibition of guanosine monophosphate synthetase (GMPS) blocks glutamine metabolism and prostate cancer growthin vitroandin vivo', , http://dx.doi.org/10.1101/2020.09.07.286997

Journal articles | 2019

Gordon S; Wibowo M; Wang Q; Holst J; Davis RA, 2019, 'Dihydro-β-agarofurans from the Australian rainforest plant Denhamia celastroides that inhibit leucine transport in prostate cancer cells', Magnetic Resonance in Chemistry, 57, pp. 101 - 109, http://dx.doi.org/10.1002/mrc.4801

Journal articles | 2019

Zhang BK; Moran AM; Bailey CG; Rasko JEJ; Holst J; Wang Q, 2019, 'EGF-activated PI3K/Akt signalling coordinates leucine uptake by regulating LAT3 expression in prostate cancer', Cell Communication and Signaling, 17, pp. 83, http://dx.doi.org/10.1186/s12964-019-0400-0

Journal articles | 2018

Bi L; Xie C; Yao M; Thae Hnit SS; Vignarajan S; Wang Y; Wang Q; Xi Z; Xu H; Li Z; de Souza P; Tee A; Wong M; Liu T; Zhao X; Zhou J; Xu L; Dong Q, 2018, 'The histone chaperone complex FACT promotes proliferative switch of G0 cancer cells', International Journal of Cancer, 145, pp. 164 - 178, http://dx.doi.org/10.1002/ijc.32065

Journal articles | 2018

Wibowo M; Wang Q; Holst J; White JM; Hofmann A; Davis RA, 2018, 'Dihydro-β-agarofurans from the roots of the Australian endemic rainforest tree Maytenus bilocularis act as leucine transport inhibitors', Phytochemistry, 148, pp. 71 - 77, http://dx.doi.org/10.1016/j.phytochem.2018.01.009

Journal articles | 2018

van Geldermalsen M; Quek LE; Turner N; Freidman N; Pang A; Guan YF; Krycer JR; Ryan R; Wang Q; Holst J, 2018, 'Benzylserine inhibits breast cancer cell growth by disrupting intracellular amino acid homeostasis and triggering amino acid response pathways', BMC Cancer, 18, pp. 689, http://dx.doi.org/10.1186/s12885-018-4599-8

Journal articles | 2017

Chen Y; Ma J; Lu W; Tian M; Thauvin M; Yuan C; Volovitch M; Wang Q; Holst J; Liu M; Vriz S; Ye S; Wang L; Li D, 2017, 'Heritable expansion of the genetic code in mouse and zebrafish', Cell Research, 27, pp. 294 - 297, http://dx.doi.org/10.1038/cr.2016.145

Journal articles | 2017

Marshall AD; van Geldermalsen M; Otte NJ; Lum T; Vellozzi M; Thoeng A; Pang A; Nagarajah R; Zhang B; Wang Q; Anderson L; Rasko JEJ; Holst J, 2017, 'ASCT2 regulates glutamine uptake and cell growth in endometrial carcinoma', Oncogenesis, 6, http://dx.doi.org/10.1038/oncsis.2017.70

Journal articles | 2017

Wibowo M; Wang Q; Holst J; White JM; Hofmann A; Davis RA, 2017, 'Celastrofurans A-G: Dihydro-β-Agarofurans from the Australian Rainforest Vine Celastrus subspicata and Their Inhibitory Effect on Leucine Transport in Prostate Cancer Cells', Journal of Natural Products, 80, pp. 1918 - 1925, http://dx.doi.org/10.1021/acs.jnatprod.7b00220

Journal articles | 2016

Marshall AD; van Geldermalsen M; Otte NJ; Anderson LA; Lum T; Vellozzi MA; Zhang BK; Thoeng A; Wang Q; Rasko JEJ; Holst J, 2016, 'LAT1 is a putative therapeutic target in endometrioid endometrial carcinoma', International Journal of Cancer, 139, pp. 2529 - 2539, http://dx.doi.org/10.1002/ijc.30371

Journal articles | 2016

Van Geldermalsen M; Wang Q; Nagarajah R; Marshall AD; Thoeng A; Gao D; Ritchie W; Feng Y; Bailey CG; Deng N; Harvey K; Beith JM; Selinger CI; O'Toole SA; Rasko JEJ; Holst J, 2016, 'ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer', Oncogene, 35, pp. 3201 - 3208, http://dx.doi.org/10.1038/onc.2015.381

Journal articles | 2016

Wibowo M; Levrier C; Sadowski MC; Nelson CC; Wang Q; Holst J; Healy PC; Hofmann A; Davis RA, 2016, 'Bioactive Dihydro-β-agarofuran Sesquiterpenoids from the Australian Rainforest Plant Maytenus bilocularis', Journal of Natural Products, 79, pp. 1445 - 1453, http://dx.doi.org/10.1021/acs.jnatprod.6b00190

Journal articles | 2016

Wibowo M; Wang Q; Holst J; White JM; Hofmann A; Davis RA, 2016, 'Dihydro-β-agarofurans from the Australian Endemic Rainforest Plant Denhamia pittosporoides Inhibit Leucine Transport in Prostate Cancer Cells', Asian Journal of Organic Chemistry, 5, pp. 1461 - 1466, http://dx.doi.org/10.1002/ajoc.201600462

Journal articles | 2016

Wibowo M; Wang Q; Holst J; White JM; Hofmann A; Davis RA, 2016, 'Inside Cover: Dihydro‐β‐agarofurans from the Australian Endemic Rainforest Plant Denhamia pittosporoides Inhibit Leucine Transport in Prostate Cancer Cells (Asian J. Org. Chem. 12/2016)', Asian Journal of Organic Chemistry, 5, pp. 1412 - 1412, http://dx.doi.org/10.1002/ajoc.201600548

Journal articles | 2015

Grkovic T; Pouwer RH; Wang Q; Guymer GP; Holst J; Quinn RJ, 2015, 'LAT Transport Inhibitors from Pittosporum venulosum Identified by NMR Fingerprint Analysis', Journal of Natural Products, 78, pp. 1215 - 1220, http://dx.doi.org/10.1021/np500968t

Journal articles | 2015

Shin EH; Zhao G; Wang Q; Lovicu FJ, 2015, 'Sprouty gain of function disrupts lens cellular processes and growth by restricting RTK signaling', Developmental Biology, 406, pp. 129 - 146, http://dx.doi.org/10.1016/j.ydbio.2015.09.005

Journal articles | 2015

Wang Q; Hardie RA; Hoy AJ; Van Geldermalsen M; Gao D; Fazli L; Sadowski MC; Balaban S; Schreuder M; Nagarajah R; Wong JJL; Metierre C; Pinello N; Otte NJ; Lehman ML; Gleave M; Nelson CC; Bailey CG; Ritchie W; Rasko JE; Holst J, 2015, 'Targeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour development', Journal of Pathology, 236, pp. 278 - 289, http://dx.doi.org/10.1002/path.4518

Journal articles | 2015

Wang Q; Holst J, 2015, 'L-type amino acid transport and cancer: Targeting the mTORC1 pathway to inhibit neoplasia', American Journal of Cancer Research, 5, pp. 1281 - 1294

Journal articles | 2015

Yao M; Xie C; Kiang MY; Teng Y; Harman D; Tiffen J; Wang Q; Sved P; Bao S; Witting P; Holst J; Dong Q, 2015, 'Targeting of cytosolic phospholipase A2a impedes cell cycle re-entry of quiescent prostate cancer cells', Oncotarget, 6, pp. 34458 - 34474, http://dx.doi.org/10.18632/oncotarget.5277

Journal articles | 2014

Wang Q; Beaumont KA; Otte NJ; Font J; Bailey CG; Van Geldermalsen M; Sharp DM; Tiffen JC; Ryan RM; Jormakka M; Haass NK; Rasko JEJ; Holst J, 2014, 'Targeting glutamine transport to suppress melanoma cell growth', International Journal of Cancer, 135, pp. 1060 - 1071, http://dx.doi.org/10.1002/ijc.28749

Journal articles | 2014

Wang Q; Grkovic T; Font J; Bonham S; Pouwer RH; Bailey CG; Moran AM; Ryan RM; Rasko JEJ; Jormakka M; Quinn RJ; Holst J, 2014, 'Monoterpene glycoside ESK246 from pittosporum targets LAT3 amino acid transport and prostate cancer cell growth', ACS Chemical Biology, 9, pp. 1369 - 1376, http://dx.doi.org/10.1021/cb500120x

Journal articles | 2013

Tiffen JC; Bailey CG; Marshall AD; Metierre C; Feng Y; Wang Q; Watson SL; Holst J; Rasko JEJ, 2013, 'The cancer-testis antigen BORIS phenocopies the tumor suppressor CTCF in normal and neoplastic cells', International Journal of Cancer, 133, pp. 1603 - 1613, http://dx.doi.org/10.1002/ijc.28184

Journal articles | 2013

Wang Q; Tiffen J; Bailey CG; Lehman ML; Ritchie W; Fazli L; Metierre C; Feng YJ; Li E; Gleave M; Buchanan G; Nelson CC; Rasko JEJ; Holst J, 2013, 'Targeting amino acid transport in metastatic castration-resistant prostate cancer: Effects on cell cycle, cell growth, and tumor development', Journal of the National Cancer Institute, 105, pp. 1463 - 1473, http://dx.doi.org/10.1093/jnci/djt241

Journal articles | 2011

Wang Q; Bailey CG; Ng C; Tiffen J; Thoeng A; Minhas V; Lehman ML; Hendy SC; Buchanan G; Nelson CC; Rasko JEJ; Holst J, 2011, 'Androgen receptor and nutrient signaling pathways coordinate the demand for increased amino acid transport during prostate cancer progression', Cancer Research, 71, pp. 7525 - 7536, http://dx.doi.org/10.1158/0008-5472.CAN-11-1821

Journal articles | 2010

Wang Q; Mcavoy JW; Lovicu FJ, 2010, 'Growth factor signaling in vitreous humor-induced lens fiber differentiation', Investigative Ophthalmology and Visual Science, 51, pp. 3599 - 3610, http://dx.doi.org/10.1167/iovs.09-4797

Journal articles | 2009

Wang Q; Stump R; McAvoy JW; Lovicu FJ, 2009, 'MAPK/ERK1/2 and PI3-kinase signalling pathways are required for vitreous-induced lens fibre cell differentiation', Experimental Eye Research, 88, pp. 293 - 306, http://dx.doi.org/10.1016/j.exer.2008.08.023

Journal articles | 2007

Iyengar L; Wang Q; Rasko JEJ; McAvoy JW; Lovicu FJ, 2007, 'Duration of ERK1/2 phosphorylation induced by FGF or ocular media determines lens cell fate', Differentiation, 75, pp. 662 - 668, http://dx.doi.org/10.1111/j.1432-0436.2007.00167.x

Journal articles | 2006

Boros J; Newitt P; Wang Q; McAvoy JW; Lovicu FJ, 2006, 'Sef and Sprouty expression in the developing ocular lens: Implications for regulating lens cell proliferation and differentiation', Seminars in Cell and Developmental Biology, 17, pp. 741 - 752, http://dx.doi.org/10.1016/j.semcdb.2006.10.007

Journal articles | 2004

Feng J; Wang Q; Wu YS; Ai XC; Zhang XJ; Huang YG; Zhang XK; Zhang JP, 2004, 'Triplet excitation transfer between carotenoids in the LH2 complex from photosynthetic bacterium Rhodopseudomonas palustris', PHOTOSYNTHESIS RESEARCH, 82, pp. 83 - 94, http://dx.doi.org/10.1023/B:PRES.0000040445.71124.96

Journal articles | 2004

Feng J; Wang Q; Zhang XJ; Huang YG; Al XC; Zhang XK; Zhang JP, 2004, 'Spectroscopic evidence for triplet excitation energy transfer among carotenoids in the LH2 complex from photosynthetic bacterium Rhodopseudomonas palustris', SCIENCE IN CHINA SERIES B-CHEMISTRY, 47, pp. 80 - 90, http://dx.doi.org/10.1360/03yb0104
Conference Abstracts | 2019

van Geldermalsen M; Quek L-E; Turner N; Balaban S; Hoy A; Pang A; Guan YF; Wahi K; Wang Q; Holst J, 2019, 'Vulnerabilities in glutamine metabolism define triple-negative from Luminal A breast cancer subsets', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, TX, San Antonio, Vol. 80, presented at 42nd Annual San Antonio Breast Cancer Symposium, TX, San Antonio, 09 December 2019 - 14 December 2019, http://dx.doi.org/10.1158/1538-7445.SABCS19-P3-02-09

Conference Papers | 2017

van Geldermalsen M; Quek L-E; Turner N; Balaban S; Hoy A; Wang Q; Holst J, 2017, 'Glutamine metabolic vulnerabilities define triple-negative from luminal A breast cancer subsets.', in MOLECULAR CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, CA, Hollywood, pp. 72 - 72, presented at AACR Special Conference on Advances in Breast Cancer Research, CA, Hollywood, 07 October 2017 - 10 October 2017, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000440602000103&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2016

van Geldermalsen M; Wang Q; Holst J, 2016, 'Targeting ASCT2-mediated glutamine uptake and metabolism in breast cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, LA, New Orleans, presented at AACR 107th Annual Meeting on Bioinformatics and Systems Biology, LA, New Orleans, 16 April 2016 - 20 April 2016, http://dx.doi.org/10.1158/1538-7445.AM2016-1043

Conference Papers | 2015

Hardie R-A; Wang Q; Otte N; Simmons M; Holst J, 2015, 'Targeting adaptive nutrient metabolism pathways as a therapy for prostate cancer', in BJU INTERNATIONAL, WILEY-BLACKWELL, AUSTRALIA, Cairns, pp. 47 - 47, presented at 2nd Prostate Cancer World Congress (PCWC), AUSTRALIA, Cairns, 17 August 2015 - 21 August 2015, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000359254200134&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2015

Wang Q; Hardie R-A; Hoy A; Fazli L; Bailey C; Rasko JEJ; Holst J, 2015, 'Targeting amino acid transport to block mTORC1 and cell cycle in prostate cancer', in MOLECULAR CANCER THERAPEUTICS, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/1538-8514.PI3K14-B14

Conference Papers | 2015

Wang Q; van Geldermalsen M; Otte NJ; Hardie R-A; Zhang K; Holst J, 2015, 'Regulation of amino acid uptake coordinates adaptive cancer cell metabolism', in AMINO ACIDS, SPRINGER WIEN, pp. 1625 - 1625, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000358175100050&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2015

Zhang K; Moran A; Holst J; Wang Q, 2015, 'PI3K/Akt signalling regulates leucine transport in prostate cancer', in BJU INTERNATIONAL, WILEY-BLACKWELL, AUSTRALIA, Cairns, pp. 34 - 35, presented at 2nd Prostate Cancer World Congress (PCWC), AUSTRALIA, Cairns, 17 August 2015 - 21 August 2015, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000359254200098&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

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