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Professor Kenneth Williams

Professor Kenneth Williams

Honorary Professor
Medicine & Health
School of Clinical Medicine

Research Interests:
Interests span the general area of conducting of clinical trials of new medicines (design, ethical issues, endpoints including surrogate outcomes), including complementary medicines complementary medicines. A particular focus is on arthritis, gout and diabetes. Drug metabolism and disposition and pharmacokinetics are also interests.

Broad Research Areas:
Clinical Research, Pharmacology, Metabolism, Inflammation, Diabetes

Society Memberships & Professional Activities:
Society memberships:, ASCEPT, ARA, DIA, ARCS, , Professional Activities/Appointments:, Module coordinator and tutor Postgraduate Studies in Drug Development, UNSW, Deputy Director Department of Clinical Pharmacology, St Vincent's Hospital

Specific Research Keywords:
Clinical Pharmacology, Drugs, Drug Safety, Gout, Diabetes and Endocrinology
Phone
+61 2 8382 2617
E-mail
ken.williams@unsw.edu.au
Location
Department of Clinical Pharmacology & Toxicology Therapeutics Centre, Level 2 Xavier Building St Vincent's Hospital Sydney UNSW
  • Book Chapters | 2016
    2016, 'Metabolism and pharmacokinetics of ibuprofen', in Aspirin and Related Drugs, pp. 157 - 180
    Book Chapters | 2016
    2016, 'Propionic Acid Derivative Drugs (Profens)', in Compendium of Inflammatory Diseases, Springer Basel, pp. 1106 - 1110, http://dx.doi.org/10.1007/978-3-7643-8550-7_58
    Book Chapters | 2016
    2016, 'Propionic Acid Derivative Drugs (Profens)', in Encyclopedia of Inflammatory Diseases, Springer Basel, pp. 1 - 6, http://dx.doi.org/10.1007/978-3-0348-0620-6_58-4
    Book Chapters | 2013
    Day RO; Graham GG; Williams KM, 2013, 'Propionic acid derivative drugs (Profens)', in Encyclopedia of Inflammatory Diseases, Springer-Verlag, Berlin Heidelberg, http://www.springerreference.com/
    Book Chapters | 2013
    Day RO; Williams KM; Graham GG, 2013, 'Urate-lowering therapy: Uricosurics', in Dalbeth N; Peresa-Ruiz F; Schlesinger N (ed.), Gout, Future Medicine Ltd, pp. 174 - 188, http://dx.doi.org/10.2217/ebo.13.104
    Book Chapters | 2005
    Bachmeier CJ; Brooks PM; Day RO; Graham GG; Littlejohn GO; Morand E; Pile K; Williams KM, 2005, 'Disease-modifying anti-rheumatic drugs (DMARD)', in Nijkamp FJ; Parnham MJ (ed.), Principles of Immunopharmacology (2nd Ed), edn. 2nd, Birkhauser Verlag, Basel, pp. 511 - 544
    Book Chapters | 2003
    Tegeder I; Williams K; Geisslinger G, 2003, 'Metabolic Chiral Inversion of 2-Arylpropionic Acids', in Handbook of Experimental Pharmacology, Springer Berlin Heidelberg, pp. 341 - 354, http://dx.doi.org/10.1007/978-3-642-55842-9_14
    Book Chapters | 2000
    Day RO; Quinn DI; March LM; Graham GG; Williams KM, 2000, 'Rheumatoid arthritis. New Frontiers in pathogenesis and treatment', in NSAIDs and analgesics, edn. Original, Oxford University Press, Oxford, England, pp. 307 - 328
    Book Chapters | 1999
    Bachmeier CJ; Handel ML; Conaghan PG; Williams KM; Graham GG; Brooks PM; Day RO, 1999, 'Disease-modifying antirheumatic drugs', in Nijkamp FP; Parnham MJ (ed.), Principles of Immunopharmacology, edn. 3, Birkhauser Verlag (Springer), Basel, Switzerland, pp. 379 - 403
    Book Chapters | 1998
    1998, 'Disease Modifying antirheumatic drugs', in Textbook of Immunopharmacology, edn. 3, Burkhauser, Basel, Switzerland, pp. 183 - 190, http://dx.doi.org/10.1097/00002281-199705000-00003
    Book Chapters | 1998
    1998, 'Therapeutic considerations from pharmacokinetics and metabolism: ibuprofen and paracetamol', in Rainsford KD; Powanda MC (ed.), Safety and Efficacy of non-prescription (OTC) analgesics and NSAIDs, Kluwer Academic Publishers, Dordrecht, pp. 77 - 92, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000081416000006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
    Book Chapters | 1997
    Graham GG; Milligan MK; Day RO; Williams KM; Zeig , 1997, 'Therapeutic considerations from pharmacokinetics and metabolism: ibuprofen and paracetamol', in In: `Safety and efficacy of non-prescription (OTC) analgesics, edn. Original, Kluwer Academic Publishers, Great Britain, pp. 77 - 92
    Book Chapters | 1995
    Vesey G; Ashbolt NJ; Wallner G; Dorsch R; Williams KM; Veal DA, 1995, 'Assessing cryptosporidium parvum oocyst viability with fluorescent in situ hybridization using ribosomal RNA probes and flow cytometry', in Protozoan parasites and water, edn. Original, Royal Society of Chemistry, Cambridge, pp. 133 - 138
  • Journal articles | 2022
    Kamel B; Abuhelwa AY; Foster D; Duong JK; Graham GG; Williams KM; Pile KD; Day RO, 2022, 'Population pharmacokinetic modelling of febuxostat in healthy subjects and people with gout', British Journal of Clinical Pharmacology, 88, pp. 5359 - 5368, http://dx.doi.org/10.1111/bcp.15462
    Journal articles | 2021
    Carland JE; Stocker SL; Baysari MT; Li C; Själin J; Moran MA; Tang S; Sandaradura I; Elhage T; Gilbey T; Williams KM; Marriott DJE; Day RO, 2021, 'Are vancomycin dosing guidelines followed? A mixed methods study of vancomycin prescribing practices', British Journal of Clinical Pharmacology, 87, pp. 4221 - 4229, http://dx.doi.org/10.1111/bcp.14834
    Journal articles | 2021
    2021, 'Honorary Professor Garry Graham', Inflammopharmacology, 29, pp. 1255 - 1259, http://dx.doi.org/10.1007/s10787-021-00872-1
    Journal articles | 2020
    Chaudhri K; Stocker SL; Williams KM; McLeay RC; Marriott DJE; Di Tanna GL; Day RO; Carland JE, 2020, 'Voriconazole: An audit of hospital-based dosing and monitoring and evaluation of the predictive performance of a dose-prediction software package', Journal of Antimicrobial Chemotherapy, 75, pp. 1981 - 1984, http://dx.doi.org/10.1093/jac/dkaa098
    Journal articles | 2020
    Kamel B; Graham GG; Stocker SL; Liu Z; Williams KM; Carland JE; Pile KD; Day RO, 2020, 'A pharmacokinetic-pharmacodynamic study of a single dose of febuxostat in healthy subjects', British Journal of Clinical Pharmacology, 86, pp. 2486 - 2496, http://dx.doi.org/10.1111/bcp.14357
    Journal articles | 2020
    Shingde RV; Reuter SE; Graham GG; Carland JE; Williams KM; Day RO; Stocker SL, 2020, 'Assessing the accuracy of two bayesian forecasting programs in estimating vancomycin drug exposure', Journal of Antimicrobial Chemotherapy, 75, pp. 3293 - 3302, http://dx.doi.org/10.1093/jac/dkaa320
    Journal articles | 2020
    Smith FC; Stocker SL; Danta M; Carland JE; Kumar SS; Liu Z; Greenfield JR; Braithwaite HE; Cheng TS; Graham GG; Williams KM; Day RO, 2020, 'The safety and pharmacokinetics of metformin in patients with chronic liver disease', Alimentary Pharmacology and Therapeutics, 51, pp. 565 - 575, http://dx.doi.org/10.1111/apt.15635
    Journal articles | 2019
    Abdel Shaheed C; Carland JE; Graham GG; Stocker SL; Smith G; Hicks M; Williams KM; Furlong T; Macdonald P; Greenfield JR; Smith FC; Chowdhury G; Day RO, 2019, 'Is the use of metformin in patients undergoing dialysis hazardous for life? A systematic review of the safety of metformin in patients undergoing dialysis', British Journal of Clinical Pharmacology, 85, pp. 2772 - 2783, http://dx.doi.org/10.1111/bcp.14107
    Journal articles | 2019
    Day RO; Lau W; Stocker SL; Aung E; Coleshill MJ; Schulz M; Bechara J; Carland JE; Graham GG; Williams KM; McLachlan AJ, 2019, 'Management of gout in older people', Journal of Pharmacy Practice and Research, 49, pp. 90 - 97, http://dx.doi.org/10.1002/jppr.1511
    Journal articles | 2019
    Kamel B; Williams KM; Graham GG; Norris RLG; Stocker SL; Carland JE; Pile KD; Day RO, 2019, 'Determination of febuxostat in human plasma by high performance liquid chromatography (HPLC) with fluorescence-detection', Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1126-1127, http://dx.doi.org/10.1016/j.jchromb.2019.121764
    Journal articles | 2018
    Kumar SS; McManus H; Radovich T; Greenfield JR; Viardot A; Williams KM; Cronin P; Day RO, 2018, 'Interrogation of a longitudinal, national pharmacy claims dataset to explore factors that predict the need for add-on therapy in older and socioeconomically disadvantaged Australians with type 2 diabetes mellitus patients (T2DM)', European Journal of Clinical Pharmacology, 74, pp. 1327 - 1332, http://dx.doi.org/10.1007/s00228-018-2506-5
    Journal articles | 2018
    2018, 'A Multicentre Open-Label Pharmacokinetic-Pharmacodynamic Study of Febuxostat in Patients with Chronic Gout', Proceedings for Annual Meeting of The Japanese Pharmacological Society, WCP2018, http://dx.doi.org/10.1254/jpssuppl.wcp2018.0_po1-11-12
    Journal articles | 2017
    Day RO; Frensham LJ; Nguyen AD; Baysari MT; Aung E; Lau AYS; Zwar N; Reath J; Laba T; Li L; McLachlan A; Runciman WB; Buchbinder R; Clay-Williams R; Coiera E; Braithwaite J; McNeil HP; Hunter DJ; Pile KJ; Portek I; Williams KM; Westbrook JI, 2017, 'Effectiveness of an electronic patient-centred self-management tool for gout sufferers: A cluster randomised controlled trail protocol', BMJ Open, 7, pp. e017281, http://dx.doi.org/10.1136/bmjopen-2017-017281
    Journal articles | 2017
    Day RO; Kannangara DRW; Stocker SL; Carland JE; Williams KM; Graham GG, 2017, 'Allopurinol: insights from studies of dose–response relationships', Expert Opinion on Drug Metabolism and Toxicology, 13, pp. 449 - 462, http://dx.doi.org/10.1080/17425255.2017.1269745
    Journal articles | 2017
    Duong JK; Kroonen MYAM; Kumar SS; Heerspink HL; Kirkpatrick CM; Graham GG; Williams KM; Day RO, 2017, 'A dosing algorithm for metformin based on the relationships between exposure and renal clearance of metformin in patients with varying degrees of kidney function', European Journal of Clinical Pharmacology, 73, pp. 981 - 990, http://dx.doi.org/10.1007/s00228-017-2251-1
    Journal articles | 2017
    Kamel B; Graham GG; Williams KM; Pile KD; Day RO, 2017, 'Clinical Pharmacokinetics and Pharmacodynamics of Febuxostat', Clinical Pharmacokinetics, 56, pp. 459 - 475, http://dx.doi.org/10.1007/s40262-016-0466-4
    Journal articles | 2017
    Kannangara DRW; Graham GG; Wright DFB; Stocker SL; Portek I; Pile KD; Barclay ML; Williams KM; Stamp LK; Day RO, 2017, 'Individualising the dose of allopurinol in patients with gout', British Journal of Clinical Pharmacology, 83, pp. 2015 - 2026, http://dx.doi.org/10.1111/bcp.13307
    Journal articles | 2016
    Day RO; Kamel B; Kannangara DRW; Williams KM; Graham GG, 2016, 'Xanthine oxidoreductase and its inhibitors: Relevance for gout', Clinical Science, 130, pp. 2167 - 2180, http://dx.doi.org/10.1042/CS20160010
    Journal articles | 2016
    Kannangara DRW; Graham GG; Williams KM; Day RO, 2016, 'Effect of xanthine oxidase inhibitors on the renal clearance of uric acid and creatinine', Clinical Rheumatology, 35, pp. 2375 - 2376, http://dx.doi.org/10.1007/s10067-015-3165-x
    Journal articles | 2016
    Kannangara DRW; Phipps-Green AJ; Dalbeth N; Stamp LK; Williams KM; Graham GG; Day RO; Merriman TR, 2016, 'Hyperuricaemia: Contributions of urate transporter ABCG2 and the fractional renal clearance of urate', Annals of the Rheumatic Diseases, 75, pp. 1363 - 1366, http://dx.doi.org/10.1136/annrheumdis-2015-208111
    Journal articles | 2016
    Martinello M; Schteinman A; Alavi M; Williams K; Dore GJ; Day R; Matthews GV, 2016, 'The impact of ribavirin plasma concentration on the efficacy of the interferon-sparing regimen, sofosbuvir and ribavirin', ANTIVIRAL THERAPY, 21, pp. 127 - 132, http://dx.doi.org/10.3851/IMP2984
    Journal articles | 2016
    Moon J; Kumar SS; Graham GG; Baysari MT; Williams KM; Chen W; Viardot A; Greenfield JR; Day RO, 2016, 'Trends in metformin utilisation and dose appropriateness in Australia', European Journal of Clinical Pharmacology, 72, pp. 1489 - 1496, http://dx.doi.org/10.1007/s00228-016-2117-y
    Journal articles | 2016
    Rasheed H; McKinney C; Stamp LK; Dalbeth N; Topless RK; Day R; Kannangara D; Williams K; Smith M; Janssen M; Jansen TL; Joosten LA; Radstake TR; Riches PL; Tausche AK; Lioté F; Lu L; Stahl EA; Choi HK; So A; Merriman TR, 2016, 'The toll-like receptor 4 (TLR4) variant rs2149356 and risk of gout in European and polynesian sample sets', PLoS ONE, 11, http://dx.doi.org/10.1371/journal.pone.0147939
    Journal articles | 2016
    Smith FC; Kumar SS; Furlong TJ; Gangaram SV; Greenfield JR; Stocker SL; Graham GG; Williams KM; Day RO, 2016, 'Pharmacokinetics of Metformin in Patients Receiving Regular Hemodiafiltration', American Journal of Kidney Diseases, 68, pp. 990 - 992, http://dx.doi.org/10.1053/j.ajkd.2016.08.017
    Journal articles | 2016
    Vaccher S; Kannangara DRW; Baysari MT; Reath J; Zwar N; Williams KM; Day RO, 2016, 'Barriers to care in gout: From prescriber to patient', Journal of Rheumatology, 43, pp. 144 - 149, http://dx.doi.org/10.3899/jrheum.150607
    Journal articles | 2015
    Chung WH; Chang WC; Stocker SL; Juo CG; Graham GG; Lee MHH; Williams KM; Tian YC; Juan KC; Wu YJJ; Yang CH; Chang CJ; Lin YJ; Day RO; Hung SI, 2015, 'Insights into the poor prognosis of allopurinol-induced severe cutaneous adverse reactions: The impact of renal insufficiency, high plasma levels of oxypurinol and granulysin', Annals of the Rheumatic Diseases, 74, pp. 2157 - 2164, http://dx.doi.org/10.1136/annrheumdis-2014-205577
    Journal articles | 2015
    Duong JK; Kumar SS; Furlong TJ; Kirkpatrick CM; Graham GG; Greenfield JR; Williams KM; Day RO, 2015, 'The pharmacokinetics of metformin and concentrations of haemoglobin A1C and lactate in Indigenous and non-Indigenous Australians with type 2 diabetes mellitus', British Journal of Clinical Pharmacology, 79, pp. 617 - 623, http://dx.doi.org/10.1111/bcp.12525
    Journal articles | 2015
    Hmar RC; Kannangara DRW; Ramasamy SN; Baysari MT; Williams KM; Day RO, 2015, 'Understanding and improving the use of allopurinol in a teaching hospital', Internal Medicine Journal, 45, pp. 383 - 390, http://dx.doi.org/10.1111/imj.12701
    Journal articles | 2015
    Merriman TR; Stamp LK; Dalbeth N; Topless R; Day R; Kannangara D; Williams K; Janssen M; Jansen T; Joosten LA; Radstake T; Riches PL; Tausche A-K; Liote F; So A; McKinney C, 2015, 'Epistatic Interaction of Functional Inflammasome Genetic Variants in Determining the Risk of Gout', ARTHRITIS & RHEUMATOLOGY, 67, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000370860204715&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2015
    2015, 'Multiplicative interaction of functional inflammasome genetic variants in determining the risk of gout', Arthritis Research and Therapy, 17, http://dx.doi.org/10.1186/s13075-015-0802-3
    Journal articles | 2014
    Ghosh D; Williams KM; Graham GG; Nair P; Buscher H; Day RO, 2014, 'Multiple episodes of aspirin overdose in an individual patient: A case report', Journal of Medical Case Reports, 8, http://dx.doi.org/10.1186/1752-1947-8-374
    Journal articles | 2014
    Kannangara DR W; Graham GG; Williams KM; Day RO, 2014, 'Hypouricemic effects of prednisone and allopurinol: An uneven playing field?', Canadian Journal of Cardiology, 30, pp. 376.e1, http://dx.doi.org/10.1016/j.cjca.2013.04.015
    Journal articles | 2014
    Rasheed H; Topless R; Day R; Kannangara D; Williams K; Bradbury L; Brown M; Hill C; Lester S; Rischmueller M; Smith M; Andres M; Bardin T; Doherty M; Janssen M; Jansen T; Joosten L; Perez-Ruiz F; Radstake T; Riches PL; Roddy E; Tausche A-K; Stamp LK; Dalbeth N; Liote F; So A; McKinney C; Merriman TR, 2014, 'Association of the Toll-like Receptor 4 (TLR4) Gene with Gout.', ARTHRITIS & RHEUMATOLOGY, 66, pp. S1294 - S1295, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000344384906196&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2013
    Brett J; Chong O; Graham GG; Ray J; Marriott D; Williams KM; Day RO, 2013, 'Antifungal Use and Therapeutic Monitoring of Plasma Concentrations of Itraconazole in Heart and Lung Transplantation Patients.', Therapeutic Drug Monitoring, 35, pp. 133 - 136, http://dx.doi.org/10.1097/FTD.0b013e318275fe69
    Journal articles | 2013
    Day R; Lee H; Graham G; Williams K, 2013, 'Benzbromarone: Availability for general prescribing in New Zealand (a response to letters by Dr Lance Gravatt on benzbromarone)', New Zealand Medical Journal, 126, pp. 124 - 126
    Journal articles | 2013
    Kannangara DR W; Ramasamy SN; Ray JE; Jones G; Graham GG; Williams KM; Day RO, 2013, 'An audit of a therapeutic drug monitoring service for allopurinol therapy', Therapeutic Drug Monitoring, 35, pp. 863 - 866, http://dx.doi.org/10.1097/FTD.0b013e318299920a
    Journal articles | 2013
    Lee M-H; Stocker S; Williams KM; Day RO, 2013, 'HLA-B*5801 should be used to screen for risk of Stevens-Johnson Syndrome (SJS) in family members of Han-Chinese patients commencing allopurinol therapy', Journal of Rheumatology, 40, pp. 96 - 97, http://dx.doi.org/10.3899/jrheum.120803
    Journal articles | 2013
    Ramasamy SN; Korb-Wells CS; Kannangara DRW; Smith MWH; Wang N; Roberts DM; Graham GG; Williams KM; Day RO, 2013, 'Allopurinol hypersensitivity: A systematic review of all published cases, 1950-2012', Drug Safety, 36, pp. 953 - 980, http://dx.doi.org/10.1007/s40264-013-0084-0
    Journal articles | 2013
    Wong C; Kumar SS; Graham GG; Begg EJ; Chin P; Brett J; Ray J; Marriott D; Williams KM; Day RO, 2013, 'Comparing dose prediction software used to manage gentamicin dosing', Internal Medicine Journal, 43, pp. 519 - 525, http://dx.doi.org/10.1111/imj.12067
    Journal articles | 2012
    Duong JK; Roberts DM; Furlong TJ; Kumar SS; Greenfield JR; Kirkpatrick CM; Graham GG; Williams KM; Day RO, 2012, 'Metformin therapy in patients with chronic kidney disease', Diabetes Obesity and Metabolism, 14, pp. 963 - 965, http://dx.doi.org/10.1111/j.1463-1326.2012.01617.x
    Journal articles | 2012
    Kannangara D; Roberts DM; Furlong TJ; Graham GG; Williams K; Day RO, 2012, 'Oxypurinol, allopurinol and allopurinol-1-riboside in plasma following an acute overdose of allopurinol in a patient with advanced chronic kidney disease', British Journal of Clinical Pharmacology, 73, pp. 828 - 829, http://dx.doi.org/10.1111/j.1365-2125.2011.04147.x
    Journal articles | 2012
    Kannangara DRW; Ramasamy SN; Indraratna P; Stocker S; Graham GG; Jones G; Portek I; Williams KM; Day RO, 2012, 'Fractional clearance of urate: Validation of measurement in spot urine samples in healthy subjects and gouty patients', Arthritis Research and Therapy, 14, pp. R189 - R197, http://dx.doi.org/10.1186/ar4020
    Journal articles | 2012
    Lee M-H; Stocker S; Anderson JM; Phillips EJ; Nolan DL; Williams KM; Graham GG; Sullivan JR; Day RO, 2012, 'Initiating allopurinol therapy: Do we need to know the patient's human leucocyte antigen status?', Internal Medicine Journal, 42, pp. 411 - 416, http://dx.doi.org/10.1111/j.1445-5994.2011.02567.x
    Journal articles | 2012
    Stocker S; Mclachlan AJ; Savic RM; Kirkpatrick CM; Graham GG; Williams KM; Day RO, 2012, 'The pharmacokinetics of oxypurinol in people with gout', British Journal of Clinical Pharacology, 74, pp. 477 - 489, http://dx.doi.org/10.1111/j.1365-2125.2012.04207.x
    Journal articles | 2011
    Graham GG; Punt J; Manit A; Day RO; Doogue MP; Duong JK; Furlong TJ; Greenfield JR; Greenup L; Carl m kirkpatrick CM; Ray J; Timmins P; Williams KM, 2011, 'Clinical pharmacokinetics of metformin', Clinical Pharmacokinetics, 50, pp. 81 - 98, http://dx.doi.org/10.2165/11534750-000000000-00000
    Journal articles | 2011
    Milder T; Lipworth WL; Williams KM; Ritchie JE; Day RO, 2011, '"It looks after me": how older patients make decisions about analgesics for osteoarthritis.', Arthritis Care and Research, 63, pp. 1280 - 1286, http://dx.doi.org/10.1002/acr.20514
    Journal articles | 2011
    Milder T; Williams K; Ritchie JE; Lipworth WL; Day RO, 2011, 'Use of NSAIDs for osteoarthritis amongst older-aged primary care patients: Engagement with information and perceptions of risk', Age and Ageing, 40, pp. 254 - 259, http://dx.doi.org/10.1093/ageing/afq160
    Journal articles | 2011
    Stocker SL; Graham GG; McLachlan AJ; Williams K; Day RO, 2011, 'Pharmacokinetic and Pharmacodynamic interaction between allopurinol and probenecid in patients with gout', Journal of Rheumatology, 38, pp. 904 - 910, http://dx.doi.org/10.3899/jrheum.101160
    Journal articles | 2011
    Wang N; Lipworth WL; Ritchie JE; Williams K; Day RO, 2011, 'Eliciting views of Australian pharmaceutical industry employees on collaboration and the concept of Quality Use of Medicines', Internal Medicine Journal, 41, pp. 314 - 320, http://dx.doi.org/10.1111/j.1445-5994.2010.02239.x
    Journal articles | 2011
    2011, 'Lack of effect of hydrochlorothiazide and low-dose aspirin on the renal clearance of urate and oxypurinol after a single dose of allopurinol in normal volunteers', European Journal of Clinical Pharmacology, 67, pp. 709 - 713, http://dx.doi.org/10.1007/s00228-010-0963-6
    Journal articles | 2010
    Abdul M; Jiang XM; Williams KM; Day RO; Roufogalis B; Liauw WS; Xu H; Matthias A; Lehmann RP; McLachlan AJ, 2010, 'Pharmacokinetic and pharmacodynamic interactions of echinacea and policosanol with warfarin in healthy subjects', British Journal of Clinical Pharmacology, 69, pp. 508 - 515
    Journal articles | 2010
    Day RO; Liauw WS; Tozer L; McElduff P; Beckett RJ; Williams K, 2010, 'A double-blind, placebo-controlled study of the short term effects of a spring water supplemented with magnesium bicarbonate on acid/base balance, bone metabolism and cardiovascular risk factors in postmenpausal women', BMC Research Notes, 3, pp. 1 - 8
    Journal articles | 2010
    Indraratna P; Stocker SL; Williams KM; Graham GG; Jones G; Day RO, 2010, 'A proposal for identifying the low renal uric acid clearance phenotype', Arthritis Research and Therapy, 12, pp. 149 - 151
    Journal articles | 2010
    Stocker S; Franklin M; Anderson JM; Pillans PI; Williams K; McLachlan AJ; Day RO; taylor P, 2010, 'Measurement of urinary oxypurinol by high performance liquid chromatography-tandem mass spectrometry', Journal of Chromatography, 878, pp. 2363 - 2368
    Journal articles | 2010
    Wallace H; Graham GG; Williams K; Day RO, 2010, 'A risk-benefit assessment of paracetamol (acetaminophen) combined with caffeine', Pain Medicine, 11, pp. 951 - 965
    Journal articles | 2009
    Indraratna P; Williams KM; Graham GG; Day RO, 2009, 'Hyperuricemia, Cardiovascular Disease and the Metabolic Syndrome', The Journal of Rheumatology, 36, pp. 2842 - 2843
    Journal articles | 2009
    Pett SL; Mccarthy M; Cooper DA; MacRae K; Tendolkar A; Norris R; Strizki J; Williams KM; Emery S, 2009, 'A Phase I study to explore the activity and safety of SCH532706, a small molecule chemokine receptor-5 antagonist in HIV type-1-infected patients', Antiviral Therapy, 14, pp. 111 - 115
    Journal articles | 2008
    Abdul M; Jiang XM; Day RO; Roufogalis B; Liauw WS; Xu H; Mclachlan AJ, 2008, 'Pharmacodynamic interaction of warfarin with cranberry but not with garlic in healthy subjects', British Journal of Pharmacology, 154, pp. 1691 - 1700
    Journal articles | 2008
    Burrell C; Booy R; Wood N; Egan AM; Taverner D; Williams K; Liauw W; Moskwa A; Pepin-Covatta S; Saville M, 2008, 'Immunogenicity of a reduced dose of A/H3N2 in the 2005 southern hemisphere formulation of inactivated split influenza vaccine', Influenza and other Respiratory Viruses, 2, pp. 93 - 98, http://dx.doi.org/10.1111/j.1750-2659.2008.00039.x
    Journal articles | 2008
    Lee M; Graham GG; Williams KM; Day RO, 2008, 'A benefit-risk assessment of benzbromarone in the treatment of gout - was its withdrawal from the market in the best interest of patients?', Drug Safety, 31, pp. 643 - 665
    Journal articles | 2008
    Lu CY; Macneill P; Williams K; Day R, 2008, 'Access to high cost medicines in Australia: Ethical perspectives', Australia and New Zealand Health Policy, 5, http://dx.doi.org/10.1186/1743-8462-5-4
    Journal articles | 2008
    Lu CY; Williams KM; Day RO, 2008, 'Access to biologic medicines for the treatment of rheumatic diseases: lessons from Australia', International Journal of Rheumatology, 11, pp. 11 - 14
    Journal articles | 2008
    Stocker S; Williams KM; Mclachlan AJ; Graham GG; Day RO, 2008, 'Pharmacokinetic and pharmacodynamic interaction between allopurinol and probenecid in healthy subjects', Clinical Pharmacokinetics, 47, pp. 111 - 118
    Journal articles | 2008
    Xu H; Liauw WS; Murray M; Day RO; Mclachlan AJ, 2008, 'Effects of St John's wort and CYP2C9 genotype on the pharmacokinetics and pharmacodynamics of gliclazide', British Journal of Pharmacology, 153, pp. 1579 - 1586, http://dx.doi.org/10.1038/sj.bjp.0707685
    Journal articles | 2008
    2008, 'Maximising gout therapy', Australian Journal of Pharmacy, 89, pp. 86 - 88
    Journal articles | 2007
    Day RO; Graham G; Williams K, 2007, 'Fenofibratewarfarin interaction [1]', Australian Prescriber, 30, pp. 32, http://dx.doi.org/10.18773/austprescr.2007.014
    Journal articles | 2007
    Day RO; Graham GG; Hicks M; Mclachlan AJ; Stocker S; Williams KM, 2007, 'Clinical pharmacokinetics and pharmacodynamics of allopurinol and oxypurinol', Clinical Pharmacokinetics, 46, pp. 623 - 644
    Journal articles | 2007
    Day RO; Williams KM, 2007, 'Open-label extension studies - Do they provide meaningful information on the safety of new drugs?', Drug Safety, 30, pp. 93 - 105
    Journal articles | 2007
    Lu C; Ritchie JE; Williams KM; Day RO, 2007, 'The views of stakeholders on controlled access schemes for high-cost antirheumatic biological medicines in Australia', Australia and New Zealand Health Policy, 4
    Journal articles | 2007
    Lu CY; Williams KM; Day RO, 2007, 'The funding and use of high-cost medicines in Australia: The example of anti-rheumatic biological medicines', Australia and New Zealand Health Policy, 4, http://dx.doi.org/10.1186/1743-8462-4-2
    Journal articles | 2007
    Winston A; Mallon PW; Satchell C; MacRae K; Williams KM; Schutz M; Law MG; Cooper DA; Emery S, 2007, 'The safety, efficacy, and pharmacokinetic profile of a switch in antiretroviral therapy to saquinavir, ritonavir, and atazanavir alone for 48 weeks and a switch in the saquinavir formulation', Clinical Infectious Diseases, 44, pp. 1475 - 1483
    Journal articles | 2007
    2007, 'Has the use of disease-modifying anti-rheumatic drugs changed as a consequence of controlled access to high-cost biological agents through the Pharmaceutical Benefits Scheme?', Internal Medicine Journal, 37, pp. 601 - 606, http://dx.doi.org/10.1111/j.1445-5994.2007.01396.x
    Journal articles | 2006
    Loboz K; Gross AS; Williams KM; Liauw WS; Day RO; Blievernicht J; Zanger U; McLachlan AJ, 2006, 'Cytochrome P450 2B6 activity as measured by bupropion hydroxylation: Effect of induction by rifampin and ethnicity', Clinical Pharmacology and Therapeutics, 80, pp. 75 - 84
    Journal articles | 2006
    Lu CY; Williams KM; Day RO, 2006, 'Access to tumour necrosis factor inhibitors for rheumatoid arthritis treatment under the Australian Pharmaceutical Benefits Scheme: are we on target?', Internal Medicine Journal, 36, pp. 19 - 27, http://dx.doi.org/10.1111/j.1445-5994.2005.00992.x
    Journal articles | 2006
    2006, 'Access to high-cost medicines for the treatment of rheumatoid arthritis under Australia's pharmaceutical benefits scheme', Pharmacoepidemiology and Drug Safety, 15, pp. S213 - S213, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000240281200458&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
    Journal articles | 2006
    2006, 'Accessing health outcome data on high-cost medicines in Australia', Medical Journal of Australia, 184, pp. 411 - 413
    Journal articles | 2006
    2006, 'Utilisation of anti-rheumatic drugs in Australia: Impact of introducing high-cost biologics under the pharmaceutical benefits scheme', Pharmacoepidemiology and Drug Safety, 15, pp. S213 - S213, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000240281200457&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
    Journal articles | 2005
    Jiang X; Williams KM; Liauw WS; Ammit A; Roufogalis B; Duke C; Day RO; McLachlan AJ, 2005, 'Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects', British Journal of Clinical Pharmacology, 59, pp. 425 - 432
    Journal articles | 2005
    Lu CY; Ritchie JE; Williams KM; Day RO, 2005, 'Recent developments in targeting access to high cost medicines in Australia', Australia and New Zealand Health Policy, 2, pp. 1 - 8
    Journal articles | 2005
    Mallon PW; Unemori P; Sedwell R; Morey AL; Rafferty M; Williams KM; Chisholm DJ; Samaras K; Emery S; Kelleher AD; Cooper DA; Carr AD, 2005, 'In vivo, nucleoside reverse-transcriptase inhibitors alter expression of both mitochondrial and lipid metabolism genes in the absence of depletion of mitochondrial DNA', Journal of Infectious Diseases, 191, pp. 1686 - 1696
    Journal articles | 2004
    Jiang X; Williams KM; Liauw WS; Ammit AJ; Roufogalis BD; Duke CC; Day RO; McLachlan AJ, 2004, 'Erratum: Effect of St John's wort and ginseng on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects (British Journal of Clinical Pharmacology (2004) 57 (592-599))', British Journal of Clinical Pharmacology, 58, pp. 102, http://dx.doi.org/10.1111/j.1365-2125.2004.02155.x
    Journal articles | 2004
    Jiang XM; Williams KM; Liauw WS; Ammit A; Roufogalis B; Duke C; Day RO; Mclachlan AJ, 2004, 'Effect of St John's wort and ginseng on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects', British Journal of Clinical Pharmacology, 57, pp. 592 - 599
    Journal articles | 2004
    Lee EJ; Williams KM; Day RO; Graham GG; Champion D, 2004, 'Stereoselective disposition of ibuprofen enantiomers in man (Reprintedfrom Br J Clin Pharmacol, vol 19, pg 669-674, 1985)', British Journal of Clinical Pharmacology, 58, pp. S759 - S764
    Journal articles | 2004
    Liauw WS; Williams KM; Day RO, 2004, 'Protocol Appraisal: A Study Site's Viewpoint', Applied Clinical Trials, 13, pp. 34 - 42
    Journal articles | 2004
    Lomas M; Liauw WS; Packham D; Williams KM; Kelleher AD; Zaunders J; Ward RL, 2004, 'Phase I clinical trial of a human idiotypic p53 vaccine in patients with advanced malignancy', Annals of Oncology, 15, pp. 324 - 329
    Journal articles | 2004
    Pett SL; Williams LA; Day RO; Lloyd AR; Carr AD; Clezy KR; Emery S; Kaplan E; Mcphee D; Mclachlan AJ; Gelder F; Lewin S; Liauw WS; Williams KM, 2004, 'A phase I study of the pharmacokinetics and safety of passive immunotherapy with caprine anti-HIV antibodies, (PE)HRG214, in HIV-1-infected individuals', HIV Clinical Trials, 5, pp. 91 - 98
    Journal articles | 2004
    Williams KM, 2004, 'Stereoselective disposition of ibuprofen enantiomers in man - Author's commentary', British Journal of Clinical Pharmacology, 58, pp. S765 - S766
    Journal articles | 2004
    2004, 'Access to high cost drugs in Australia', British Medical Journal: Clinical Research, 329, pp. 415 - 416
    Journal articles | 2004
    2004, 'Changes in nuclear gene expression resulting from NRTI-induced inhibition of mitochondrial transcription reveal links between mitochondrial dysfunction and lipid metabolism', Antiviral Therapy, 9, pp. L56 - L56, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000231616000125&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
    Journal articles | 2004
    2004, 'In vivo nucleoside reverse transcriptase inhibitors alter expression of both mitochondrial and lipid metabolism genes independent to HIV infection', Antiviral Therapy, 9, pp. L11 - L11, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000231616000044&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
    Journal articles | 2004
    2004, 'Nucleoside reverse transcriptase inhibitors (NRTI) decrease adipocyte and monocyte mitochondrial (mt) messenger RNA transcription in the absence of changes in mtDNA or cell morphology', Antiviral Therapy, 9, pp. L56 - L57, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000231616000126&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
    Journal articles | 2004
    2004, 'Pharmacokinetic-pharmacodynamic modelling to investigate herb-drug interactions with warfarin', Clinical and Experimental Pharmacology and Physiology, 31, pp. A227 - A227, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000225490400052&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
    Journal articles | 2004
    2004, 'Subsided access to TNF alpha inhibitors: is the rationale for exclusion of rheumatoid-factor-negative patients defensible?', Medical Journal of Australia, 181, pp. 457 - 457
    Journal articles | 2003
    2003, 'Human subcutaneous tissue distribution of fluconazole: comparison of microdialysis and suction blister techniques', British Journal of Pharmacology, 56, pp. 551 - 561, http://dx.doi.org/10.1046/j.1365-2125.2003.01930.x
    Journal articles | 2003
    2003, 'Pharmacokinetics of estradiol, progesterone, testosterone and dehydroepiandrosterone after transbuccal administration to postmenopausal women', Climacteric, 6, pp. 104 - 111, http://dx.doi.org/10.1080/cmt.6.2.104.111
    Journal articles | 2002
    Sasongko L; Ramzan I; Williams KM; McLachlan AJ, 2002, 'Muscle distribution of the neuromuscular blocker gallamine using microdialysis', Journal of Pharmaceutical Sciences, 91, pp. 769 - 775, http://dx.doi.org/10.1002/jps.10082
    Journal articles | 2001
    Williams KM; Cooper S; Parisis K; Handel M; Day RO, 2001, 'The skin suction blister: A human model of inflammation', Clinical Pharmacology and Therapeutics, 69
    Journal articles | 2001
    2001, 'Application of a high-performance liquid chromatographic assay for the neuromuscular blocker gallamine to analysis of rat plasma, muscle and microdialysate samples', Journal of Chromatography B, 754, pp. 467 - 475, http://dx.doi.org/10.1016/S0378-4347(01)00032-9
    Journal articles | 2000
    Davies NP; Mclachlan AJ; Day RO; Williams KM, 2000, 'Clinical pharmacokinetics and pharmacodynamics of celecoxib: A selective cyclo-oxygenase-2 inhibitor.', Clinical Pharmacokinetics, pp. 225 - 242
    Journal articles | 2000
    2000, 'Assessment of in vitro in vivo recovery of gallamine using microdialysis', Journal of Pharmacological and Toxicological Methods, 44, pp. 519 - 525, http://dx.doi.org/10.1016/S1056-8719(00)00117-9
    Journal articles | 1999
    Browne GS; Nelson CJ; Nguyen TM; Ellis B; Day RO; Williams KM, 1999, 'Stereoselective and substrate-dependent inhibition of hepatic mitochondrial B-oxidation and oxidative phosphorylation by the non-steroidal anti-inflammatory drugs ibuprofen, flurbiprofen and ketorolac', Biochemical Pharmacology, pp. 837 - 844
    Journal articles | 1999
    Erb K; Brugger R; Williams K; Geisslinger G, 1999, 'Stereoselective disposition of tiaprofenic acid enantiomers in rats.', Chirality, 11, pp. 103 - 108, http://dx.doi.org/10.1002/(SICI)1520-636X(1999)11:2<103::AID-CHIR4>3.0.CO;2-1
    Journal articles | 1999
    Erb K; Brugger R; Williams KM; Geisslinger G, 1999, 'Stereoselective disposition of tiaprofenic acid enantiomers in rats', Chirality, 11, pp. 103 - 108
    Journal articles | 1999
    Williams KM; Day RO; Roberts LK; Harbin JA, 1999, 'A comparison of the efficacy of α-ketobutyric acid (KBA), nordihidro-guaiaretic acid (NDGA), salicylic acid (SA), and placebo (P) in the accelerated removal of corns', Clinical Pharmacology and Therapeutics, 65, pp. 122, http://dx.doi.org/10.1016/S0009-9236(99)80022-8
    Journal articles | 1999
    1999, 'Pharmacokinetics of non-steroidal anti-inflammatory drugs in synovial fluid', Clinical Pharmacokinetics, 36, pp. 191 - 210, http://dx.doi.org/10.2165/00003088-199936030-00002
    Journal articles | 1998
    Campbell TJ; Williams KM, 1998, 'Therapeutic Drug monitoring of antiarrhythmic drugs', British Journal of Clinical Pharmacology, pp. 307 - 319
    Journal articles | 1998
    Campbell TJ; Williams KM, 1998, 'Therapeutic drug monitoring: Antiarrhythmic drugs', British Journal of Clinical Pharmacology, 46, pp. 307 - 319, http://dx.doi.org/10.1046/j.1365-2125.1998.t01-1-00768.x
    Journal articles | 1998
    Day RO; Williams KM; Campbell TJ, 1998, 'The death of a normal healthy volunteer in a human research project: implications for Australian clinical research', Medical Journal of Australia, 168, pp. 449 - 451, http://dx.doi.org/10.5694/j.1326-5377.1998.tb139026.x
    Journal articles | 1998
    1998, 'Effect of clofibrate on the chiral inversion of ibuprofen in healthy volunteers', Clinical Pharmacology and Therapeutics, 64, pp. 168 - 176, http://dx.doi.org/10.1016/S0009-9236(98)90150-3
    Journal articles | 1998
    1998, 'Effect of clofibrate on the chiral inversion of ibuprofen in rats', Journal of Pharmacology and Experimental Therapeutics, 284, pp. 1132 - 1138
    Journal articles | 1997
    Wang X; Liu Y; Nair UB; Armstrong DW; Ellis B; Williams KM, 1997, 'Enantiomeric composition of monoterpenes in conifer resins', Tetrahedron - Asymmetry, pp. 3977 - 3984
    Journal articles | 1997
    Williams KM; Turner J; Geisslinger G; Day RO, 1997, 'The suction blister as an in vivo model of inflammation: Interblister variability and preliminary studies of the disposition of methotrexate', CLINICAL PHARMACOLOGY & THERAPEUTICS, 61, pp. PI93 - PI93, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1997WJ68400093&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 1997
    Williams KM; Turner J; Geisslinger G; Day RO, 1997, 'The suction blister as an in vivo model of inflammation: Interblister variability and preliminary studies of the disposition of methotrexate', Clinical Pharmacology and Therapeutics, 61, pp. 160
    Journal articles | 1997
    1997, 'Disposition and effects of Flurbiprofen enantiomers in human serum and blister fluid', British Journal of Clinical Pharmacology, 43, pp. 145 - 153
    Journal articles | 1997
    1997, 'Effects of budesonide and fluticasoue on 24-hour plasma cortisol: A dose-response study.', American Journal of Respiratory and Critical Care Medicine, 156, pp. 1746 - 1751, http://dx.doi.org/10.1164/ajrccm.156.6.9703003
    Journal articles | 1996
    Day RO; Williams KM; Geisslinger G, 1996, 'Naproxen concentrations in plasma and synovial fluid and effects on prostanoid concentrations - Reply', JOURNAL OF RHEUMATOLOGY, 23, pp. 1827 - 1828, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1996VL78300035&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 1996
    Simkin PA; Bassett JE; Lapicque F; Bertin P; Netter P; Day RO; Williams KM; Geisslinger G, 1996, 'Naproxen concentration in plasma and synovial fluid and effects on prostanoid concentrations [1]', Journal of Rheumatology, 23, pp. 1826 - 1828
    Journal articles | 1996
    Soong R; Knowles S; Williams KM; Hammond IG; Wysocki SJ; Iacopetta BJ, 1996, 'Overexpression of p53 protein is an independent prognostic indicator in human endometrial carcinoma', British Journal of Cancer, pp. 562 - 567
    Journal articles | 1996
    1996, 'Effect of Flurbiprofen (FLU) Enantiomers on Prostaglandin E2 (PGE2) and Substance p (SP) Levels in Human Suction Blister', Clinical Pharmacology & Therapeutics, 59, pp. 208 - 208, http://dx.doi.org/10.1038/sj.clpt.1996.332
    Journal articles | 1996
    1996, 'Recombinant prespore-specific antigen from Dictyostelium discoideum is a B-sheet glycoprotein with a spacer peptide modified by O-linked N-acetyglucosamine', European Journal of Biochemistry, 238, pp. 511 - 518, http://dx.doi.org/10.1111/j.1432-1033.1996.0511z.x
    Journal articles | 1995
    Cordwell SJ; Wilkins MR; Poljak A; Gooley AA; Duncan MW; Williams KM; Humphery-Smith I, 1995, 'Cross-species identification of proteins separated by two-dimensional gel electrophoresis using MALDI-TOF mass spectrometry and amino acid composition', Electrophoresis, 16, pp. 438 - 443
    Journal articles | 1995
    Day RO; Francis H; Vial J; Geisslinger G; Williams KM, 1995, 'Naproxen concentrations in plasma and synovial fluid and effects on prostanoid concentrations', Journal of Rheumatology, 22, pp. 2295 - 2303
    Journal articles | 1995
    Day RO; Francis H; Vial JH; Geisslinger G; Williams KM, 1995, 'Pharmacokinetics and pharmacodynamics of naproxen in synovial fluid and plasma', Journal of Rheumatology, pp. 2295 - 2303
    Journal articles | 1995
    Wasinger VC; Cordwell SJ; Poljak A; Yan JX; Gooley AA; Wilkins MR; Duncan MW; Harris RI; Williams KM; Humphery-Smith I, 1995, 'Progress with gene-product mapping of the mollicutes: mycroplasma genitalium', Electrophoresis, 16, pp. 1090 - 1094
    Journal articles | 1995
    1995, 'Estimation of the rate and extent of chiral inversion using linear systems analysis', Chirality, 7, pp. 632 - 635, http://dx.doi.org/10.1002/chir.530070814
    Journal articles | 1995
    1995, 'Identification of macrophage activation associated proteins by two-dimensional gel electrophoresis and microsequencing', Journal of Leukocyte Biology, 57, pp. 507 - 512, http://dx.doi.org/10.1002/jlb.57.3.507
    Journal articles | 1995
    1995, 'The effect of tenoxicam on tolbutamide pharmacokinetics and glucose concentrations in healthy volunteers', International journal of clinical pharmacology, 33, pp. 308 - 310
    Journal articles | 1994
    Day R; Geisslinger G; Paull P; Williams K, 1994, 'Neither cimetidine nor probenecid affect the pharmacokinetics of tenoxicam in normal volunteers.', British Journal of Clinical Pharmacology, 37, pp. 79 - 81, http://dx.doi.org/10.1111/j.1365-2125.1994.tb04244.x
    Journal articles | 1994
    Sauernheimer C; Williams KM; Brune K; Geisslinger G, 1994, 'Application of microdialysis to the pharmacokinetics of analgesics: problems with reduction of dialysis efficiency in vivo.', J Pharmacol Toxicol Methods, 32, pp. 149 - 154, http://dx.doi.org/10.1016/1056-8719(94)90068-x
    Journal articles | 1994
    Seideman P; Lohrer F; Graham G; Duncan M; Williams K; Day R, 1994, 'The stereoselective disposition of the enantiomers of ibuprofen in blood, blister and synovial fluid.', British Journal of Clinical Pharmacology, 38, pp. 221 - 227, http://dx.doi.org/10.1111/j.1365-2125.1994.tb04345.x
    Journal articles | 1994
    1994, 'Stereoselective pharmacokinetics of methadone in beagle dogs.', Chirality, 6, pp. 492 - 495, http://dx.doi.org/10.1002/chir.530060608
    Journal articles | 1993
    Brooks PM; Day RO; Graham GG; Williams KM, 1993, 'Preface', Agents and Actions, 44
    Journal articles | 1993
    DAY RO; NGUYEN T; WILLIAMS KM, 1993, 'TENOXICAM DOSE CONCENTRATION RESPONSE RELATIONSHIP IN RHEUMATOID-ARTHRITIS (RA)', CLINICAL PHARMACOLOGY & THERAPEUTICS, 53, pp. 152 - 152, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1993KP26900067&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 1993
    Day RO; Brooks PM; Williams KM; Graham GG, 1993, 'Meeting report: Third world conference on variability in response to anti-rheumatic drugs, Singapore, July 22-24, 1992', Agents and Actions, 38
    Journal articles | 1993
    Day RO; Brooks PM; Williams KM; Graham GG, 1993, 'Third World conference on variability in response to anti-rheumatic drugs, Singapore, July 22-24, 1992.', Agents and actions, 38, http://dx.doi.org/10.1007/bf01976204
    Journal articles | 1993
    Williams KM; Day RO; Breit SN, 1993, 'Biochemical actions and clinical pharmacology of anti-inflammatory drugs', Advances in Drug Research, 24, pp. 121 - 198
    Journal articles | 1993
    Williams KM, 1993, 'Chiral NSAIDs: So what?', Agents and Actions, 44, pp. 15 - 22
    Journal articles | 1992
    Zhao B; Geisslinger G; Hall I; Day RO; Williams KM, 1992, 'The effect of the enantiomers of ibuprofen and flurbiprofen on the β‐oxidation of palmitate in the rat', Chirality, 4, pp. 137 - 141, http://dx.doi.org/10.1002/chir.530040302
    Journal articles | 1991
    Day RO; Williams KM; Graham S; Handel M, 1991, 'The pharmacokinetics of total and unbound concentrations of tenoxicam in synovial fluid and plasma', Arthritis & Rheumatism, 34, pp. 751 - 760, http://dx.doi.org/10.1002/art.1780340617
    Journal articles | 1991
    Knihinicki RD; Day RO; Williams KM, 1991, 'Chiral inversion of 2-arylpropionic acid non-steroidal anti-inflammatory drugs-II Racemization and hydrolysis of (R)- and (S)-ibuprofen-CoA thioesters', Biochemical Pharmacology, 42, pp. 1905 - 1911, http://dx.doi.org/10.1016/0006-2952(91)90588-V
    Journal articles | 1991
    Williams KM; Knihinicki RD; Day RO, 1991, 'Pharmacokinetics of the enantiomers of ibuprofen in the rabbit', Agents and Actions, 34, pp. 381 - 386, http://dx.doi.org/10.1007/BF01988732
    Journal articles | 1991
    Williams KM, 1991, 'Molecular Asymmetry and Its Pharmacological Consequences', Advances in Pharmacology, 22, pp. 57 - 135, http://dx.doi.org/10.1016/S1054-3589(08)60033-2
    Journal articles | 1990
    Knihinicki RD; Day RO; Graham GG; Williams KM, 1990, 'Stereoselective disposition of ibuprofen and flurbiprofen in rats', Chirality, 2, pp. 134 - 140, http://dx.doi.org/10.1002/chir.530020303
    Journal articles | 1990
    Lee EJD; Willia KM, 1990, 'Chirality Clinical Pharmacokinetic and Pharmacodynamic Considerations', Clinical Pharmacokinetics, 18, pp. 339 - 345, http://dx.doi.org/10.2165/00003088-199018050-00001
    Journal articles | 1990
    Nuernberg B; Knihinicki R; Williams K; Freeman GE; Dalton C; Brooks PM; Day RO, 1990, 'Anti-inflammatory effects and disposition of S- and R-flurbiprofen in the rat', European Journal of Pharmacology, 183, pp. 1591 - 1592, http://dx.doi.org/10.1016/0014-2999(90)94757-O
    Journal articles | 1990
    Williams KM, 1990, 'Enantiomers in arthritic disorders', Pharmacology and Therapeutics, 46, pp. 273 - 295, http://dx.doi.org/10.1016/0163-7258(90)90095-J
    Journal articles | 1989
    Knihinicki RD; Williams KM; Day RO, 1989, 'Chiral inversion of 2-arylpropionic acid non-steroidal anti-inflammatory drugs-1. In vitro studies of ibuprofen and flurbiprofen', Biochemical Pharmacology, 38, pp. 4389 - 4395, http://dx.doi.org/10.1016/0006-2952(89)90647-3
    Journal articles | 1989
    Williams KM, 1989, 'CHIRALITY: PHARMACOKINETICS AND PHARMACODYNAMICS IN 3 DIMENSIONS', Clinical and Experimental Pharmacology and Physiology, 16, pp. 465 - 470, http://dx.doi.org/10.1111/j.1440-1681.1989.tb01589.x
    Journal articles | 1988
    Day R; Paull P; Lam S; Swanson B; Williams K; Wade D, 1988, 'The effect of concurrent aspirin upon plasma concentrations of tenoxicam.', British Journal of Clinical Pharmacology, 26, pp. 455 - 462, http://dx.doi.org/10.1111/j.1365-2125.1988.tb03405.x
    Journal articles | 1988
    Day RO; Graham GG; Willia KM; Brooks PM, 1988, 'Variability in Response to NSAIDs: Fact or Fiction?', Drugs, 36, pp. 643 - 651, http://dx.doi.org/10.2165/00003495-198836060-00001
    Journal articles | 1988
    Day RO; Graham GG; Williams KM, 1988, 'Pharmacokinetics of non-steroidal anti-inflammatory drugs', Bailliere's Clinical Rheumatology, 2, pp. 363 - 393, http://dx.doi.org/10.1016/S0950-3579(88)80019-0
    Journal articles | 1988
    Day RO; Williams KM; Graham GG; Lee EJ; Knihinicki RD; Champion GD, 1988, 'Stereoselective disposition of ibuprofen enantiomers in synovial fluid', Clinical Pharmacology and Therapeutics, 43, pp. 480 - 487, http://dx.doi.org/10.1038/clpt.1988.62
    Journal articles | 1988
    Williams KM; Day RO, 1988, 'The contribution of enantiomers to variability in response to anti-inflammatory drugs.', Agents and actions. Supplements, 24, pp. 76 - 84, http://dx.doi.org/10.1007/978-3-0348-9160-8_7
    Journal articles | 1987
    Day RO; Graham GG; Williams KM; David Champion G; de Jager J, 1987, 'Clinical pharmacology of non-steroidal anti-inflammatory drugs', Pharmacology and Therapeutics, 33, pp. 383 - 433, http://dx.doi.org/10.1016/0163-7258(87)90072-6
    Journal articles | 1986
    WILLIAMS KM; DAY RO; KNIHINICKI RD; DUFFIELD AM, 1986, 'STEREOSELECTIVE INCORPORATION OF IBUPROFEN ENANTIOMERS INTO ADIPOSE-TISSUE IN RATS AND MAN', ACTA PHARMACOLOGICA ET TOXICOLOGICA, 59, pp. 192 - 192, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1986D896000552&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 1986
    Williams K; Day R; Knihinicki R; Duffield A, 1986, 'The stereoselective uptake of ibuprofen enantiomers into adipose tissue', Biochemical Pharmacology, 35, pp. 3403 - 3405, http://dx.doi.org/10.1016/0006-2952(86)90443-0
    Journal articles | 1985
    DAY RO; WILLIAMS KM; LEE EJ; KNIHINICKI R, 1985, 'DISPOSITION OF ENANTIOMERS OF IBUPROFEN IN PLASMA AND SYNOVIAL-FLUID IN ARTHRITIC DISEASE', CLINICAL AND INVESTIGATIVE MEDICINE-MEDECINE CLINIQUE ET EXPERIMENTALE, 8, pp. A58 - A58, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1985AQS8500134&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 1985
    Lee E; Williams K; Day R; Graham G; Champion D, 1985, 'Stereoselective disposition of ibuprofen enantiomers in man.', British Journal of Clinical Pharmacology, 19, pp. 669 - 674, http://dx.doi.org/10.1111/j.1365-2125.1985.tb02694.x
    Journal articles | 1985
    Williams K; Lee E, 1985, 'Importance of drug enantiomers in clinical pharmacology.', Drugs, 30, pp. 333 - 354, http://dx.doi.org/10.2165/00003495-198530040-00003
    Journal articles | 1985
    Williams KM; Day RO, 1985, 'Stereoselective disposition--basis for variability in response to NSAID's.', Agents and actions. Supplements, 17, pp. 119 - 126, http://dx.doi.org/10.1007/978-3-0348-7720-6_14
    Journal articles | 1984
    Lee EJD; Williams KM; Graham GG; Day RO; Champion GD, 1984, 'Liquid chromatographic determination and plasma concentration profile of optical isomers of ibuprofen in humans', Journal of Pharmaceutical Sciences, 73, pp. 1542 - 1544, http://dx.doi.org/10.1002/jps.2600731112
    Journal articles | 1984
    Williams KM, 1984, 'Kinetics of misonidazole enantiomers', Clinical Pharmacology and Therapeutics, 36, pp. 817 - 823, http://dx.doi.org/10.1038/clpt.1984.262
    Journal articles | 1983
    WILLIAMS KM; BEGG EJ; WADE DN; OSHEA K, 1983, 'THE EFFECT OF CIMETIDINE AND METOCLOPRAMIDE ON THE ELIMINATION OF MISONIDAZOLE (RO-07-0582) IN MAN', CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 10, pp. 718 - 719, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1983RW31100131&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 1983
    Williams K; Begg E; Wade D; O'Shea K, 1983, 'Effects of phenytoin, phenobarbital, and ascorbic acid on misonidazole elimination', Clinical Pharmacology and Therapeutics, 33, pp. 314 - 321, http://dx.doi.org/10.1038/clpt.1983.39
    Journal articles | 1983
    Williams K; Begg E; Wade D; O'Shea K, 1983, 'No significant effect of metoclopramide on misonidazole elimination in man.', British Journal of Clinical Pharmacology, 15, pp. 390 - 392, http://dx.doi.org/10.1111/j.1365-2125.1983.tb01519.x
    Journal articles | 1983
    1983, 'NO SIGNIFICANT EFFECT OF CIMETIDINE ON THE PHARMACOKINETICS OF MISONIDAZOLE IN MAN', BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 15, pp. 575 - 576, http://dx.doi.org/10.1111/j.1365-2125.1983.tb02096.x
    Journal articles | 1983
    1983, 'No significant effect of cimetidine on the pharmacokinetics of misonidazole in man.', British Journal of Clinical Pharmacology, 15, pp. 575 - 576, http://dx.doi.org/10.1111/j.1365-2125.1983.tb02096.x
    Journal articles | 1982
    CHINWAY PM; WILLIAMS KM; WADE DN, 1982, 'A STUDY OF THE DISTRIBUTION AND ELIMINATION OF HIGH-DOSES OF DPH IN RABBITS', CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 9, pp. 459 - 460, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1982PJ26400121&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 1982
    Tung C; Graham GG; Wade DN; Williams KM, 1982, 'The pharmacokinetics of chlorbutol in man', Biopharmaceutics & Drug Disposition, 3, pp. 371 - 378, http://dx.doi.org/10.1002/bdd.2510030410
    Journal articles | 1982
    Williams KM; Begg EJ; Wade DN; O'Shea K, 1982, 'The effect of phenytoin, phenobarbitone and ascorbic acid on the elimination of misonidazole (Ro 07-0582) in man', Clinical and Experimental Pharmacology and Physiology, 9, pp. 423
    Journal articles | 1981
    Williams KM; Duffield AM; Christopher RK; Finlayson PJ, 1981, 'Identification of minor metabolites of 5‐fluorocytosine in man by chemical ionization gas chromatography mass spectrometry', Biological Mass Spectrometry, 8, pp. 179 - 182, http://dx.doi.org/10.1002/bms.1200080410
    Journal articles | 1980
    WILLIAMS KM; DUFFIELD AM; CHRISTOPHER RK; FINLAYSON PJ, 1980, 'MINOR METABOLITES OF 5-FLUOROCYTOSINE IN MAN', CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 7, pp. 681 - 681, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1980KV12600077&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 1980
    1980, 'Comparison of enzyme immunoassay for gentamicin compared with other methods.', J Antimicrob Chemother, 6, pp. 561 - 562, http://dx.doi.org/10.1093/jac/6.4.561
    Journal articles | 1980
    1980, 'The pharmacokinetics of chlorbutol', Clinical and Experimental Pharmacology and Physiology, 7, pp. 672, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1980KV12600062&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 1979
    1979, 'Chlorbutol toxicity and dependence', Medical Journal of Australia, 1, pp. 288, http://dx.doi.org/10.5694/j.1326-5377.1979.tb112109.x
    Journal articles | 1979
    1979, 'Crystalluria during flucytosine therapy.', Med J Aust, 2, pp. 617, http://dx.doi.org/10.5694/j.1326-5377.1979.tb127231.x
  • Conference Papers | 2014
    Martinello M; Schteinman A; Alavi M; Williams K; Dore GJ; Day R; Matthews GV, 2014, 'The impact of ribavirin plasma concentration on the eficacy of the interferon-sparing regimen, sofosbuvir and ribavirin', in Antiviral Therapy, SAGE Publications, MA, Boston, pp. 127 - 132, presented at 65th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases, MA, Boston, 07 November 2014 - 11 November 2014, http://dx.doi.org/10.3851/IMP2984
    Conference Posters | 2014
    2014, 'Barriers to care in gout: A qualitative study of patients’ and prescribers’ understanding and management', Melbourne, Australia, presented at ASCEPT Scientific Meeting, Melbourne, Australia, 07 December 2014
    Conference Posters | 2013
    Matthews GV; Kaur A; Ray JE; Graham GG; Egan B; Williams KM; Day RO, 2013, 'USE OF A POPULATION PHARMACOKINETIC MODEL TO PREDICT WEEK 4 RIBAVIRIN LEVELS FROM EARLY CONCENTRATIONS', NETHERLANDS, Amsterdam, Vol. 58, pp. S357 - S357, presented at International Liver Congress / 48th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), NETHERLANDS, Amsterdam, 24 April 2013 - 28 April 2013, http://dx.doi.org/10.1016/S0168-8278(13)60872-7
    Conference Papers | 2009
    Franklin ME; Anderson JM; Stocker SL; Pillans PI; Williams KM; Day RO; Taylor PJ, 2009, 'Measurement of Oxypurinol Concentrations in Urine by HPLC-Tandem Mass Spectrometry', in THERAPEUTIC DRUG MONITORING, LIPPINCOTT WILLIAMS & WILKINS, CANADA, Montreal, pp. 640 - 640, presented at 11th International Congress of Therapeutic Drug Monitoring and Clinical Toxicology, CANADA, Montreal, 03 October 2009 - 08 October 2009, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000270484600142&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 1998
    1998, 'A comparative assessment of the safety of a new lignocaine suppository for the treatment of painful hemorrhoids', in Clinical Pharmacology and Therapeutics, Mosby, St Louis, MO, USA, pp. 147, presented at Clinical and Pharmacology Therapeutics, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000072420300042&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
    Conference Papers | 1998
    1998, 'Comparative pharmacokinetics of hepatitis B immuno-globulin after intramuscular administration in healthy subjects', in Naunyn - Schmiedebergs Archives of Pharmacology, Springer, New York, NY, USA, pp. 285, presented at Archives of Pharmacology 358, Munich, Germany, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000075207701061&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
    Conference Papers | 1998
    1998, 'Population pharmacokinetics (PK) and pharmacodynamics (PD) of tenoxicam (TN) in patients with rheumatoid arthritis (RA)', in Clinical Pharmacology and Therapeutics, Mosby, St Louis, MO, USA, pp. 168, presented at Clinical and Pharmacology Therapeutics, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000072420300125&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
    Conference Papers | 1997
    Ziegler JB; Graham GG; Day RO; Williams KM; Milligan MK, 1997, 'THERAPEUTIC CONSIDERATIONS FROM PHARMACOKINETICS AND METABOLISM: IBUPROFEN AND PARACETAMOL.', in Safety and Efficacy of non-prescription (OTC) analgesics and NSAIDs, Kluwer Academic Publishers, Dordrecht, presented at Safety and Efficacy of non-prescription analgesics and NSAIDS, San Francisco, California USA, 17 March 1997 -
    Conference Posters | 1990
    Day RO; Walker JS; Seideman P; Knihinicki RD; Williams K, 1990, 'A human model for evaluation of non-steroidal anti-inflammatory drug (NSAID) distribution into extracellular fluid', Vol. 183, pp. 1034, http://dx.doi.org/10.1016/0014-2999(90)92891-L