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Professor John Pimanda

Professor John Pimanda

Professor
Medicine & Health
School of Biomedical Sciences

We are a molecular and cell biology laboratory with a research focus in blood development and in leukemia. We study genome-wide changes in healthy and leukemic blood stem cells at single cell resolution. We use this knowledge to improve our understanding and management of blood stem disorders such as myelodysplasia (MDS) and acute myeloid leukaemia (AML). Our research interest lies in identifying critical components of the hematopoietic transcriptional network and how it governs stemness. We explore how this network is perturbed in mutant blood stem cells and the impact of mutations on clonal dominance and maintenance of leukaemia. We also investigate the role of stromal and immune cells in the development of blood stem cells in the embryo and the maintenance of leukemic cells in patients. 

 
Phone
0439241083
E-mail
jpimanda@unsw.edu.au
Location
University-Lowy Cancer Research Centre, UNSW,Sydney Hospital- Medical Professorial Unit, Edmund Blacket Building, The Prince of Wales Hospital, Randwick
  • Journal articles | 2024
    Thoms J; Hampton H; Yan F; Davidson S; Joshi S; Sarowar C; Lim XY; Nunez A; Kakadia P; Saw J; Bhuyan GS; Zou X; Ghodousi E; Jolly C; Koch F; Vafaee F; Pickford R; Raftery M; Hough S; Buckland G; Bailey M; Ghodke Y; Absar N; Vaughan L; Pasalic L; Fong C; Kenealy M; Hiwase D; Stoddart R; Mohammed S; Lee L; Passam F; Spring K; Skarratt K; Rebeiro P; Larsen S; Presgrave P; Stevenson W; Ling S; Tiley C; Fuller S; Roncolato F; Enjeti A; Hoenemann D; Lemech C; Curtis D; Bohlander S; Olivier J; Hertzberg M; Unnikrishnan A; Polizotto M; Pimanda J, 2024, '3178 – LONGITUDINAL DRUG INCORPORATION, CLONAL COMPOSITION, AND DNA METHYLATION DYNAMICS IN MDS/CMML PATIENTS TREATED WITH AZA', Experimental Hematology, 137, pp. 104498 - 104498, http://dx.doi.org/10.1016/j.exphem.2024.104498
    Journal articles | 2024
    Thoms JAI; Koch FC; Raei A; Subramanian S; Wong JWH; Vafaee F; Pimanda JE, 2024, 'BloodChIP Xtra: an expanded database of comparative genome-wide transcription factor binding and gene-expression profiles in healthy human stem/progenitor subsets and leukemic cells', Nucleic Acids Research, 52, pp. D1131 - D1137, http://dx.doi.org/10.1093/nar/gkad918
    Journal articles | 2024
    Truong P; Shen S; Joshi S; Islam MI; Zhong L; Raftery MJ; Afrasiabi A; Alinejad-Rokny H; Nguyen M; Zou X; Bhuyan GS; Sarowar CH; Ghodousi ES; Stonehouse O; Mohamed S; Toscan CE; Connerty P; Kakadia PM; Bohlander SK; Michie KA; Larsson J; Lock RB; Walkley CR; Thoms JAI; Jolly CJ; Pimanda JE, 2024, 'TOPORS E3 ligase mediates resistance to hypomethylating agent cytotoxicity in acute myeloid leukemia cells', Nature Communications, 15, pp. 7360, http://dx.doi.org/10.1038/s41467-024-51646-6
    Journal articles | 2024
    Vaughan L; Pimanda JE, 2024, 'Seeing MDS through the lens of genomics', Blood, 144, pp. 1552 - 1554, http://dx.doi.org/10.1182/blood.2024025676
    Journal articles | 2023
    Kugler E; Madiwale S; Yong D; Thoms JAI; Birger Y; Sykes DB; Schmoellerl J; Drakul A; Priebe V; Yassin M; Aqaqe N; Rein A; Fishman H; Geron I; Chen CW; Raught B; Liu Q; Ogana H; Liedke E; Bourquin JP; Zuber J; Milyavsky M; Pimanda J; Privé GG; Izraeli S, 2023, 'The NCOR-HDAC3 co-repressive complex modulates the leukemogenic potential of the transcription factor ERG', Nature Communications, 14, http://dx.doi.org/10.1038/s41467-023-41067-2
    Journal articles | 2023
    Moles E; Howard CB; Huda P; Karsa M; McCalmont H; Kimpton K; Duly A; Chen Y; Huang Y; Tursky ML; Ma D; Bustamante S; Pickford R; Connerty P; Omari S; Jolly CJ; Joshi S; Shen S; Pimanda JE; Dolnikov A; Cheung LC; Kotecha RS; Norris MD; Haber M; de Bock CE; Somers K; Lock RB; Thurecht KJ; Kavallaris M; Moles Meler E, 2023, 'Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia', Science translational medicine, 15, pp. eabm1262 - eabm1262, http://dx.doi.org/10.1126/scitranslmed.abm1262
    Journal articles | 2023
    Schnegg-Kaufmann AS; Thoms JAI; Bhuyan GS; Hampton HR; Vaughan L; Rutherford K; Kakadia PM; Lee HM; Johansson Beves EMV; Failes TW; Arndt GM; Koval J; Lindeman R; Warburton P; Rodriguez-Meira A; Mead AJ; Unnikrishnan A; Davidson S; Polizzotto MN; Hertzberg M; Papaemmanuil E; Bohlander SK; Faridani OR; Jolly CJ; Zanini F; Pimanda JE, 2023, 'Contribution of mutant HSC clones to immature and mature cells in MDS and CMML, and variations with AZA therapy', Blood, 141, pp. 1316 - 1321, http://dx.doi.org/10.1182/blood.2022018602
    Journal articles | 2023
    Srivastava P; Romanazzo S; Kopecky C; Nemec S; Ireland J; Molley TG; Lin K; Jayathilaka PB; Pandzic E; Yeola A; Chandrakanthan V; Pimanda J; Kilian K, 2023, 'Defined Microenvironments Trigger In Vitro Gastrulation in Human Pluripotent Stem Cells', Advanced Science, 10, http://dx.doi.org/10.1002/advs.202203614
    Journal articles | 2023
    Subramanian S; Thoms JAI; Huang Y; Cornejo-Páramo P; Koch FC; Jacquelin S; Shen S; Song E; Joshi S; Brownlee C; Woll PS; Chacon-Fajardo D; Beck D; Curtis DJ; Yehson K; Antonenas V; O'Brien T; Trickett A; Powell JA; Lewis ID; Pitson SM; Gandhi MK; Lane SW; Vafaee F; Wong ES; Göttgens B; Alinejad-Rokny H; Wong JWH; Pimanda JE, 2023, 'Genome-wide transcription factor–binding maps reveal cell-specific changes in the regulatory architecture of human HSPCs', Blood, 142, pp. 1448 - 1462, http://dx.doi.org/10.1182/blood.2023021120
    Journal articles | 2023
    Truong P; Pimanda JE, 2023, 'DDX41: the poster child for familial MDS/AML grows up', Blood, 141, pp. 447 - 449, http://dx.doi.org/10.1182/blood.2022018787
    Journal articles | 2022
    Chandrakanthan V; Rorimpandey P; Zanini F; Chacon D; Olivier J; Joshi S; Kang YC; Knezevic K; Huang Y; Qiao Q; Oliver RA; Unnikrishnan A; Carter DR; Lee B; Brownlee C; Power C; Brink R; Mendez-Ferrer S; Enikolopov G; Walsh W; Göttgens B; Taoudi S; Beck D; Pimanda JE, 2022, 'Mesoderm-derived PDGFRA+ cells regulate the emergence of hematopoietic stem cells in the dorsal aorta', Nature Cell Biology, 24, pp. 1211 - 1225, http://dx.doi.org/10.1038/s41556-022-00955-3
    Journal articles | 2022
    Kapeni C; Nitsche L; Kilpatrick AM; Wilson NK; Xia K; Mirshekar-Syahkal B; Chandrakanthan V; Malouf C; Pimanda JE; Göttgens B; Kirschner K; Tomlinson SR; Ottersbach K, 2022, 'p57Kip2 regulates embryonic blood stem cells by controlling sympathoadrenal progenitor expansion', Blood, 140, pp. 464 - 477, http://dx.doi.org/10.1182/blood.2021014853
    Journal articles | 2022
    Kugler E; Madiwale S; Yong D; Birger Y; Thoms JA; Sykes DB; Yassin M; Aqaqe N; Rein A; Fishman H; Geron I; Chen CW; Raught B; Liu Q; Milyavsky M; Pimanda J; Privé GG; Izraeli S, 2022, 'AML-131 ERG: From a Fortuitous Discovery to Potential Treatment for AML', Clinical Lymphoma, Myeloma and Leukemia, 22, pp. S215 - S216, http://dx.doi.org/10.1016/S2152-2650(22)01225-3
    Journal articles | 2022
    Kugler E; Madiwale S; Yong D; Birger Y; Thoms JAI; Sykes DB; Yassin M; Aqaqe N; Rein A; Fishman H; Geron I; Chen C-W; Raught B; Liu Q; Milyavsky M; Pimanda J; Privé GG; Izraeli S, 2022, 'P417: A SINGLE AMINO ACID AT THE PNT DOMAIN OF ERG MEDIATES ITS LEUKEMOGENIC ACTIVITY THROUGH INTERACTION WITH THE NCOR-HDAC3 CO-REPRESSOR COMPLEX.', HemaSphere, 6, pp. 317 - 318, http://dx.doi.org/10.1097/01.hs9.0000844556.94296.43
    Journal articles | 2022
    Kugler E; Madiwale S; Yong D; Birger Y; Thoms JAI; Sykes DB; Yassin M; Aqaqe N; Rein A; Fishman H; Geron I; Chen C-W; Raught B; Liu Q; Milyavsky M; Pimanda J; Privé GG; Izraeli S, 2022, 'Poster: AML-131 ERG: From a Fortuitous Discovery to Potential Treatment for AML', Clinical Lymphoma Myeloma and Leukemia, 22, pp. S129 - S129, http://dx.doi.org/10.1016/s2152-2650(22)00769-8
    Journal articles | 2022
    Liu YC; Kwon J; Fabiani E; Xiao Z; Liu YV; Follo MY; Liu J; Huang H; Gao C; Liu J; Falconi G; Valentini L; Gurnari C; Finelli C; Cocco L; Liu JH; Jones AI; Yang J; Yang H; Thoms JAI; Unnikrishnan A; Pimanda JE; Pan R; Bassal MA; Voso MT; Tenen DG; Chai L, 2022, 'Demethylation and Up-Regulation of an Oncogene after Hypomethylating Therapy', New England Journal of Medicine, 386, pp. 1998 - 2010, http://dx.doi.org/10.1056/NEJMoa2119771
    Journal articles | 2022
    Pimanda JE; Thoms JAI; Hampton HR; Davidson S; Joshi S; Sarowar CH; Lim XY; Nunez AC; Kakadia PM; Pickford R; Raftery M; Hough S; Buckland G; Bailey M; Ghodke Y; Absar N; Vaughan L; Pasalic L; Fong CY; Kenealy M; Hiwase D; Stoddart R; Mohammed S; Lee L; Passam FH; Spring K; Skarratt KK; Rebeiro P; Larsen SR; Presgrave P; Stevenson WS; Ling S; Tiley C; Fuller S; Roncolato F; Enjeti AK; Hoenemann D; Lemech C; Bohlander SK; Olivier J; Hertzberg M; Unnikrishnan A; Polizzotto MN, 2022, 'In Vivo Drug Incorporation and Intracellular Dynamics of Injectable Versus Oral Azacytidine: A Phase II Open Label Multicentre Trial', Blood, 140, pp. 6927 - 6929, http://dx.doi.org/10.1182/blood-2022-157634
    Journal articles | 2022
    Putri GH; Anders S; Pyl PT; Pimanda JE; Zanini F, 2022, 'Analysing high-throughput sequencing data in Python with HTSeq 2.0', Bioinformatics, 38, pp. 2943 - 2945, http://dx.doi.org/10.1093/bioinformatics/btac166
    Journal articles | 2022
    Putri GH; Anders S; Pyl PT; Pimanda JE; Zanini F, 2022, 'Analysing high-throughput sequencing data in Python with HTSeq 2.0.', Bioinformatics, 38, pp. 2943 - 2945, http://dx.doi.org/10.1093/bioinformatics/btac166
    Journal articles | 2022
    Saini SK; Holmberg-Thydén S; Bjerregaard AM; Unnikrishnan A; Dorfmüller S; Platzbecker U; Tirado-Gonzalez I; Bönig H; El Fassi D; Grønbæk K; Pimanda J; Medyouf H; Hadrup SR, 2022, 'Neoantigen reactive T cells correlate with the low mutational burden in hematological malignancies', Leukemia, 36, pp. 2734 - 2738, http://dx.doi.org/10.1038/s41375-022-01705-y
    Journal articles | 2022
    Schnegg-Kaufmann A; Thoms J; Bhuyan GS; Henry H; Vaughan L; Rutherford K; Kakadia P; Johansson E; Failes T; Greg A; Koval J; Lindeman R; Warburton P; Rodriguez-Meira A; Mead A; Unnikrishnan A; Bohlander S; Pappaemmanuil E; Faridani O; Jolly C; Zanini F; Pimanda J, 2022, 'P748: SINGLE CELL GENOTYPING OF MATCHED BONE MARROW AND PERIPHERAL BLOOD CELLS IN TREATMENT NAIVE AND AZA-TREATED MDS AND CMML', HemaSphere, 6, pp. 643 - 644, http://dx.doi.org/10.1097/01.hs9.0000845876.01682.15
    Journal articles | 2022
    Subramanian S; Thoms JA; Huang Y; Jacquelin S; Shen S; Song E; Joshi S; Brownlee C; Woll PS; Fajardo DC; Beck D; Curtis DJ; Yehson K; Antonenas V; O' Brien T; Trickett A; Powell J; Pitson SM; Gandhi MK; Cornejo P; Wong E; Lane SW; Gottgens B; Rokny HA; Wong JWH; Pimanda JE, 2022, 'Comparative Analysis of Genome-Scale Gene Regulatory Networks in Human Hematopoietic Stem and Myeloid Progenitor Fractions', BLOOD, 140, pp. 2846 - 2848, http://dx.doi.org/10.1182/blood-2022-165620
    Journal articles | 2022
    Thoms JAI; Schnegg-Kaufmann A; Bhuyan GS; Hampton HR; Vaughan L; Rutherford K; Kakadia PM; Lee HM; Johansson E; Failes TW; Arndt GM; Koval J; Davidson S; Lindeman R; Warburton P; Rodriguez-Meira A; Mead AJ; Unnikrishnan A; Hertzberg M; Polizzotto MN; Papaemmanuil E; Bohlander SK; Faridani O; Jolly CJ; Zanini F; Pimanda JE, 2022, 'Clinical Response to Azacytidine (AZA) Is Associated with Increased Contribution from Mutated Blood Progenitors: Insights from Single Cell Genotyping of Matched Stem/Progenitor and Mature Blood Cells from MDS/CMML Patients Pre- and Post-AZA Treatment', Blood, 140, pp. 9751 - 9752, http://dx.doi.org/10.1182/blood-2022-163158
    Journal articles | 2022
    Truong P; Shen S; Joshi S; Afrasiabi A; Zhong L; Raftery MJ; Larsson J; Lock RB; Walkley CR; Rokny HA; Thoms JAI; Jolly CJ; Pimanda JE, 2022, 'Genome-Wide CRISPR-Cas9 Screening Identifies a Synergy between Hypomethylating Agents and Sumoylation Blockade in Myelodysplastic Syndromes and Acute Myeloid Leukemia', BLOOD, 140, http://dx.doi.org/10.1182/blood-2022-165713
    Journal articles | 2021
    Chandrakanthan V; Rorimpandey P; Zanini F; Chacon D; Kang YC; Knezevic K; Huang Y; Qiao Q; Oliver R; Unnikrishnan A; Carter D; Lee B; Brownlee C; Power C; Mendez-Ferrer S; Enikolopov G; Walsh W; Göttgens B; Taoudi S; Beck D; Pimanda J, 2021, 'Mesoderm-Derived PDGFRA+Cells Regulate the Emergence of Hematopoietic Stem Cells in the Dorsal Aorta', , http://dx.doi.org/10.1101/2021.08.08.455592
    Journal articles | 2021
    Tavassoli H; Rorimpandey P; Kang YC; Carnell M; Brownlee C; Pimanda JE; Chan PPY; Chandrakanthan V, 2021, 'Heart on A Chip: Label‐Free Isolation and Single Cell Biophysical Phenotyping Analysis of Primary Cardiomyocytes Using Inertial Microfluidics (Small 8/2021)', Small, 17, http://dx.doi.org/10.1002/smll.202170034
    Journal articles | 2021
    Tavassoli H; Rorimpandey P; Kang YC; Carnell M; Brownlee C; Pimanda JE; Chan PPY; Chandrakanthan V, 2021, 'Label-Free Isolation and Single Cell Biophysical Phenotyping Analysis of Primary Cardiomyocytes Using Inertial Microfluidics', Small, 17, http://dx.doi.org/10.1002/smll.202006176
    Journal articles | 2021
    Thoms J; Truong P; Subramanian S; Knezevic K; Harvey G; Huang Y; Seneviratne J; Carter D; Joshi S; Skhinas J; Chacon D; Shah A; de Jong I; Beck D; Göttgens B; Larsson J; Wong J; Zanini F; Pimanda J, 2021, '3034 – DISRUPTION OF A GATA2, TAL1, ERG REGULATORY CIRCUIT PROMOTES ERYTHROID TRANSITION IN HEALTHY AND LEUKEMIC STEM CELLS', Experimental Hematology, 100, pp. S59 - S59, http://dx.doi.org/10.1016/j.exphem.2021.12.255
    Journal articles | 2021
    Thoms JAI; Pimanda JE; Heidenreich O, 2021, 'To switch or not to switch: PU.1 expression is the question', Blood, 138, pp. 1289 - 1291, http://dx.doi.org/10.1182/blood.2021012112
    Journal articles | 2021
    Thoms JAI; Truong P; Subramanian S; Knezevic K; Harvey G; Huang Y; Seneviratne JA; Carter DR; Joshi S; Skhinas J; Chacon D; Shah A; de Jong I; Beck D; Göttgens B; Larsson J; Wong JWH; Zanini F; Pimanda JE, 2021, 'Disruption of a GATA2-TAL1-ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cells', Blood, 138, pp. 1441 - 1455, http://dx.doi.org/10.1182/blood.2020009707
    Journal articles | 2021
    Yang J; Gao C; Liu M; Liu YC; Kwon J; Qi J; Tian X; Stein A; Liu YV; Kong NR; Wu Y; Yin S; Xi J; Chen Z; Kumari K; Wong H; Luo H; Silberstein LE; Thoms JAI; Unnikrishnan A; Pimanda JE; Tenen DG; Chai L, 2021, 'Targeting an Inducible SALL4-Mediated Cancer Vulnerability with Sequential Therapy', Cancer Research, 81, pp. 6018 - 6028, http://dx.doi.org/10.1158/0008-5472.CAN-21-0030
    Journal articles | 2021
    Yeola A; Subramanian S; Oliver RA; Lucas CA; Thoms JAI; Yan F; Olivier J; Chacon D; Tursky ML; Hung T; Power C; Hardy P; D D; McCarroll J; Kavallaris M; Hesson LB; Beck D; Curtis DJ; Wong JWH; Hardeman EC; Walsh WR; Mobbs R; Chandrakanthan V; Pimanda JE; Chacon Fajardo D, 2021, 'Induction of Muscle Regenerative Multipotent Stem Cells from Human Adipocytes by PDGF-AB and 5-Azacytidine', Science Advances, pp. 2020.06.04.130872 - 2020.06.04.130872, http://dx.doi.org/10.1126/sciadv.abd1929
    Journal articles | 2021
    Yeola A; Subramanian S; Oliver RA; Lucas CA; Thoms JAI; Yan F; Olivier J; Chacon D; Tursky ML; Srivastava P; Potas JR; Hung T; Power C; Hardy P; Ma DD; Kilian KA; McCarroll J; Kavallaris M; Hesson LB; Beck D; Curtis DJ; Wong JWH; Hardeman EC; Walsh WR; Mobbs R; Chandrakanthan V; Pimanda JE; Subramanian S, 2021, 'Induction of muscle-regenerative multipotent stem cells from human adipocytes by PDGF-AB and 5-azacytidine', Science Advances, 7, pp. eabd1929, http://dx.doi.org/10.1126/sciadv.abd1929
    Journal articles | 2020
    Anande G; Deshpande N; Mareschal S; Batcha A; Hampton H; Herold T; Lehmann S; Wilkins M; Wong JWH; Unnikrishnan A; Pimanda J, 2020, 'RNA splicing alterations induce a cellular stress response associated with poor prognosis in AML', , http://dx.doi.org/10.1101/2020.01.10.895714
    Journal articles | 2020
    Anande G; Deshpande NP; Mareschal S; Batcha AMN; Hampton HR; Herold T; Lehmann S; Wilkins MR; Wong JWH; Unnikrishnan A; Pimanda JE, 2020, 'RNA Splicing Alterations Induce a Cellular Stress Response Associated with Poor Prognosis in Acute Myeloid Leukemia', Clinical Cancer Research, 26, pp. 3597 - 3607, http://dx.doi.org/10.1158/1078-0432.CCR-20-0184
    Journal articles | 2020
    Carmichael CL; Wang J; Nguyen T; Kolawole O; Benyoucef A; de Mazière C; Milne AR; Samuel S; Gillinder K; Hediyeh-Zadeh S; Vo ANQ; Huang Y; Knezevic K; McInnes WRL; Shields BJ; Mitchell H; Ritchie ME; Lammens T; Lintermans B; van Vlierberghe P; Wong NC; Haigh K; Thoms JAI; Toulmin E; Curtis DJ; Oxley EP; Dickins RA; Beck D; Perkins A; McCormack MP; Davis MJ; Berx G; Zuber J; Pimanda JE; Kile BT; Goossens S; Haigh JJ, 2020, 'The EMT modulator SNAI1 contributes to AML pathogenesis via its interaction with LSD1', Blood, 136, pp. 957 - 973, http://dx.doi.org/10.1182/blood.2019002548
    Journal articles | 2020
    Jolly CJ; Pimanda JE, 2020, 'Titans awake: HMAs for virus-driven ATL', Blood, 136, pp. 777 - 779, http://dx.doi.org/10.1182/blood.2020006488
    Journal articles | 2020
    Khanna A; Thoms JAI; Stringer BW; Chung SA; Ensbey KS; Jue TR; Jahan Z; Subramanian S; Anande G; Shen H; Unnikrishnan A; McDonald KL; Day BW; Pimanda JE, 2020, 'Constitutive CHK1 Expression Drives a pSTAT3–CIP2A Circuit that Promotes Glioblastoma Cell Survival and Growth', Molecular Cancer Research, 18, pp. 709 - 722, http://dx.doi.org/10.1158/1541-7786.MCR-19-0934
    Journal articles | 2020
    Lee Q; Padula MP; Pinello N; Williams SH; O’Rourke MB; Fumagalli MJ; Orkin JD; Song R; Shaban B; Brenner O; Pimanda JE; Weninger W; de Souza WM; Melin AD; Wong JJL; Crim MJ; Monette S; Roediger B; Jolly CJ, 2020, 'Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys', PLoS Pathogens, 16, pp. e1008262, http://dx.doi.org/10.1371/journal.ppat.1008262
    Journal articles | 2020
    Richards LA; Kumari A; Knezevic K; Thoms JAI; von Jonquieres G; Napier CE; Ali Z; O'Brien R; Marks-Bluth J; Maritz MF; Pickett HA; Morris J; Pimanda JE; MacKenzie KL, 2020, 'DKC1 is a transcriptional target of GATA1 and drives upregulation of telomerase activity in normal human erythroblasts', Haematologica, 105, pp. 1517 - 1526, http://dx.doi.org/10.3324/haematol.2018.215699
    Journal articles | 2020
    Saini SK; Ørskov A; Bjerregaard A-M; Unnikrishnan A; Holmberg-Thydén S; Borch A; Anande G; Bentzen A; Marquard A; Tamhane T; Gang A; Defva I; Szallasi Z; Eklund A; Pimanda J; Grønbæk K; Hadrup S, 2020, 'Human endogenous retroviruses form a reservoir of T cell targets in hematological cancers with low mutational burden', The Journal of Immunology, 204, pp. 242.14 - 242.14, http://dx.doi.org/10.4049/jimmunol.204.supp.242.14
    Journal articles | 2020
    Saini SK; Ørskov AD; Bjerregaard AM; Unnikrishnan A; Holmberg-Thydén S; Borch A; Jensen KV; Anande G; Bentzen AK; Marquard AM; Tamhane T; Treppendahl MB; Gang AO; Dufva IH; Szallasi Z; Ternette N; Pedersen AG; Eklund AC; Pimanda J; Grønbæk K; Hadrup SR, 2020, 'Human endogenous retroviruses form a reservoir of T cell targets in hematological cancers', Nature Communications, 11, pp. 5660, http://dx.doi.org/10.1038/s41467-020-19464-8
    Journal articles | 2020
    Tavassoli H; Kang YC; Rorimpandey P; Pimanda J; Chandrakanthan V; Chan PPY, 2020, 'Capturing Neonatal Cardiomyocyte – Endothelial interactions on-a-Chip', , http://dx.doi.org/10.1101/2020.08.10.243600
    Journal articles | 2020
    Tavassoli H; Rorimpandey P; Kang YC; Carnell M; Brownlee C; Pimanda J; Chan PPY; Chandrakanthan V, 2020, 'Label-free Isolation and Single Cell Biophysical Phenotyping Analysis of Primary Cardiomyocytes Using Inertial Microfluidics', , http://dx.doi.org/10.1101/2020.08.31.243592
    Journal articles | 2020
    Thoms J; Knezevic K; Harvey G; Huang Y; Seneviratne J; Carter D; Subramanian S; Skhinas J; Chacon D; Shah A; de Jong I; Beck D; Göttgens B; Larsson J; Wong J; Zanini F; Pimanda J, 2020, 'Disruption of a GATA2, TAL1, ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cells', , http://dx.doi.org/10.1101/2020.10.26.353797
    Journal articles | 2019
    Chiu SK; Orive SL; Moon MJ; Saw J; Ellis S; Kile BT; Huang Y; Chacon D; Pimanda JE; Beck D; Hamilton JR; Tremblay CS; Curtis DJ, 2019, 'Shared roles for Scl and Lyl1 in murine platelet production and function', Blood, 134, pp. 826 - 835, http://dx.doi.org/10.1182/blood.2019896175
    Journal articles | 2019
    Krivtsov AV; Evans K; Gadrey JY; Eschle BK; Hatton C; Uckelmann HJ; Ross KN; Perner F; Olsen SN; Pritchard T; McDermott L; Jones CD; Jing D; Braytee A; Chacon D; Earley E; McKeever BM; Claremon D; Gifford AJ; Lee HJ; Teicher BA; Pimanda JE; Beck D; Perry JA; Smith MA; McGeehan GM; Lock RB; Armstrong SA; Chacon Fajardo D, 2019, 'A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia', Cancer Cell, 36, pp. 660 - 673.e11, http://dx.doi.org/10.1016/j.ccell.2019.11.001
    Journal articles | 2019
    Kumar P; Beck D; Galeev R; Thoms JAI; Talkhoncheh MS; de Jong I; Unnikrishnan A; Baudet A; Subramaniam A; Pimanda JE; Larsson J, 2019, 'HMGA2 promotes long-term engraftment and myeloerythroid differentiation of human hematopoietic stem and progenitor cells', Blood Advances, 3, pp. 681 - 691, http://dx.doi.org/10.1182/bloodadvances.2018023986
    Journal articles | 2019
    Poulos RC; Perera D; Packham D; Shah A; Janitz C; Pimanda JE; Hawkins N; Ward RL; Hesson LB; Wong JWH, 2019, 'Scarcity of Recurrent Regulatory Driver Mutations in Colorectal Cancer Revealed by Targeted Deep Sequencing', JNCI CANCER SPECTRUM, 3, http://dx.doi.org/10.1093/jncics/pkz012
    Journal articles | 2019
    Thoms JAI; Beck D; Pimanda JE, 2019, 'Transcriptional networks in acute myeloid leukemia', Genes Chromosomes and Cancer, 58, pp. 859 - 874, http://dx.doi.org/10.1002/gcc.22794
    Journal articles | 2018
    Ali A; Penneroux J; Dal Bello R; Massé A; Quentin S; Unnikrishnan A; Hernandez L; Raffoux E; Ben Abdelali R; Renneville A; Preudhomme C; Pimanda J; Dombret H; Soulier J; Fenaux P; Clappier E; Adès L; Puissant A; Itzykson R, 2018, 'Granulomonocytic progenitors are key target cells of azacytidine in higher risk myelodysplastic syndromes and acute myeloid leukemia', Leukemia, 32, pp. 1856 - 1860, http://dx.doi.org/10.1038/s41375-018-0076-2
    Journal articles | 2018
    Beck D; Thoms JAI; Palu C; Herold T; Shah A; Olivier J; Boelen L; Huang Y; Chacon D; Brown A; Babic M; Hahn C; Perugini M; Zhou X; Huntly BJ; Schwarzer A; Klusmann JH; Berdel WE; Wörmann B; Büchner T; Hiddemann W; Bohlander SK; To LB; Scott HS; Lewis ID; D'Andrea RJ; Wong JWH; Pimanda JE, 2018, 'A four-gene LincRNA expression signature predicts risk in multiple cohorts of acute myeloid leukemia patients', Leukemia, 32, pp. 263 - 272, http://dx.doi.org/10.1038/leu.2017.210
    Journal articles | 2018
    Chiu SK; Saw J; Huang Y; Sonderegger SE; Wong NC; Powell DR; Beck D; Pimanda JE; Tremblay CS; Curtis DJ, 2018, 'A novel role for Lyl1 in primitive erythropoiesis', Development (Cambridge), 145, http://dx.doi.org/10.1242/dev.162990
    Journal articles | 2018
    Jacquelin S; Straube J; Cooper L; Vu T; Song A; Bywater M; Baxter E; Heidecker M; Wackrow B; Porter A; Ling V; Green J; Austin R; Kazakoff S; Waddell N; Hesson LB; Pimanda JE; Stegelmann F; Bullinger L; Döhner K; Rampal RK; Heckl D; Hill GR; Lane SW, 2018, 'Jak2V617F and Dnmt3a loss cooperate to induce myelofibrosis through activated enhancer-driven inflammation', Blood, 132, pp. 2707 - 2721, http://dx.doi.org/10.1182/blood-2018-04-846220
    Journal articles | 2018
    Jing D; Huang Y; Liu X; Sia KCS; Zhang JC; Tai X; Wang M; Toscan CE; McCalmont H; Evans K; Mayoh C; Poulos RC; Span M; Mi J; Zhang C; Wong JWH; Beck D; Pimanda JE; Lock RB, 2018, 'Lymphocyte-Specific Chromatin Accessibility Pre-determines Glucocorticoid Resistance in Acute Lymphoblastic Leukemia', Cancer Cell, 34, pp. 906 - 921.e8, http://dx.doi.org/10.1016/j.ccell.2018.11.002
    Journal articles | 2018
    Liu Q; Thoms JAI; Nunez AC; Huang Y; Knezevic K; Packham D; Poulos RC; Williams R; Beck D; Hawkins NJ; Ward RL; Wong JWH; Hesson LB; Sloane MA; Pimanda JE, 2018, 'Disruption of a 35 KB enhancer impairs CTCF binding and MLH1 expression in colorectal cells', Clinical Cancer Research, 24, pp. 4602 - 4611, http://dx.doi.org/10.1158/1078-0432.CCR-17-3678
    Journal articles | 2018
    Pimanda J, 2018, 'GENERATING MULTIPOTENT STEM CELLS FROM PRIMARY HUMAN ADIPOCYTES FOR TISSUE REPAIR', EXPERIMENTAL HEMATOLOGY, 64, pp. S94 - S94, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000975534800199&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2018
    Pimanda J, 2018, 'MESODERM-DERIVED PDGFRA plus CELLS REGULATE EMERGENCE OF HEMATOPOIETIC STEM CELLS IN THE DORSALAORTA', EXPERIMENTAL HEMATOLOGY, 64, pp. S45 - S45, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000975534800043&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2018
    Smeets MF; Tan SY; Xu JJ; Anande G; Unnikrishnan A; Chalk AM; Taylor SR; Pimanda JE; Wall M; Purton LE; Walkley CR, 2018, 'Srsf2P95H initiates myeloid bias and myelodysplastic/ myeloproliferative syndrome from hemopoietic stem cells', Blood, 132, pp. 608 - 621, http://dx.doi.org/10.1182/blood-2018-04-845602
    Journal articles | 2018
    Unnikrishnan A; Vo ANQ; Pickford R; Raftery MJ; Nunez AC; Verma A; Hesson LB; Pimanda JE, 2018, 'AZA-MS: A novel multiparameter mass spectrometry method to determine the intracellular dynamics of azacitidine therapy in vivo', Leukemia, 32, pp. 900 - 910, http://dx.doi.org/10.1038/leu.2017.340
    Journal articles | 2017
    Chandrakanthan V; Qiao Q; Kang YC; Knezevic K; Oliver R; Loo C; Anande G; Lee B; Walsh W; Power C; Wong J; Pimanda J, 2017, 'DECLINED PRESENTATION CHARACTERISATION OF STROMAL CELL POPULATIONS IN THE FOETAL LIVER AND THEIR CONTRIBUTIONS TO EMBRYONIC HAEMATOPOIETIC AND VASCULAR DEVELOPMENT', EXPERIMENTAL HEMATOLOGY, 53, pp. S118 - S118, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000972742900273&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2017
    Chiu SK; Saw J; Huang Y; Beck D; Powell D; Pimanda J; Tremblay C; Curtis D, 2017, 'Maintenance of primitive haematopoiesis is shared by SCL and LYL1', Experimental Hematology, 53, pp. S115 - S115, http://dx.doi.org/10.1016/j.exphem.2017.06.288
    Journal articles | 2017
    Jacquelin S; Straube J; Song A; Cooper L; Vu T; Heidecker M; Pimanda J; Hesson L; Hill G; Cloonan N; Heckl D; Lane S, 2017, 'IN VIVO CRISPR EDITING OF DNMT3A IN JAK2V617F HEMATOPOIETIC STEM CELLS INDUCES MYELOFIBROSIS', EXPERIMENTAL HEMATOLOGY, 53, pp. S95 - S95, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000972742900206&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2017
    Liu K; Beck D; Thoms JAI; Liu L; Zhao W; Pimanda JE; Zhou X, 2017, 'Annotating function to differentially expressed LincRNAs in myelodysplastic syndrome using a network-based method', Bioinformatics, 33, pp. 2622 - 2630, http://dx.doi.org/10.1093/bioinformatics/btx280
    Journal articles | 2017
    Schwarzer A; Emmrich S; Schmidt F; Beck D; Ng M; Reimer C; Adams FF; Grasedieck S; Witte D; Käbler S; Wong JWH; Shah A; Huang Y; Jammal R; Maroz A; Jongen-Lavrencic M; Schambach A; Kuchenbauer F; Pimanda JE; Reinhardt D; Heckl D; Klusmann JH, 2017, 'The non-coding RNA landscape of human hematopoiesis and leukemia', Nature Communications, 8, http://dx.doi.org/10.1038/s41467-017-00212-4
    Journal articles | 2017
    Unnikrishnan A; Papaemmanuil E; Beck D; Deshpande NP; Verma A; Kumari A; Woll PS; Richards LA; Knezevic K; Chandrakanthan V; Thoms JAI; Tursky ML; Huang Y; Ali Z; Olivier J; Galbraith S; Kulasekararaj AG; Tobiasson M; Karimi M; Pellagatti A; Wilson SR; Lindeman R; Young B; Ramakrishna R; Arthur C; Stark R; Crispin P; Curnow J; Warburton P; Roncolato F; Boultwood J; Lynch K; Jacobsen SEW; Mufti GJ; Hellstrom-Lindberg E; Wilkins MR; MacKenzie KL; Wong JWH; Campbell PJ; Pimanda JE, 2017, 'Integrative Genomics Identifies the Molecular Basis of Resistance to Azacitidine Therapy in Myelodysplastic Syndromes', Cell Reports, 20, pp. 572 - 585, http://dx.doi.org/10.1016/j.celrep.2017.06.067
    Journal articles | 2016
    Avellino R; Havermans M; Erpelinck C; Sanders MA; Hoogenboezem R; Van De Werken HJG; Rombouts E; Van Lom K; Van Strien PMH; Gebhard C; Rehli M; Pimanda J; Beck D; Erkeland S; Kuiken T; De Looper H; Gröschel S; Touw I; Bindels E; Delwel R, 2016, 'An autonomous CEBPA enhancer specific for myeloid-lineage priming and neutrophilic differentiation', Blood, 127, pp. 2991 - 3003, http://dx.doi.org/10.1182/blood-2016-01-695759
    Journal articles | 2016
    Botezatu L; Michel LC; Makishima H; Schroeder T; Germing U; Haas R; Van der Reijden B; Marneth AE; Bergevoet SM; Jansen JH; Przychodzen B; Wlodarski M; Niemeyer C; Platzbecker U; Ehninger G; Unnikrishnan A; Beck D; Pimanda J; Hellström-Lindberg E; Malcovati L; Boultwood J; Pellagatti A; Papaemmanuil E; Le Coutre P; Kaeda J; Opalka B; Möröy T; Dührsen U; Maciejewski J; Khandanpour C, 2016, 'GFI136N as a therapeutic and prognostic marker for myelodysplastic syndrome', Experimental Hematology, 44, pp. 590 - 595.e1, http://dx.doi.org/10.1016/j.exphem.2016.04.001
    Journal articles | 2016
    Chandrakanthan V; Yeola A; Kwan JC; Oliver RA; Qiao Q; Kang YC; Zarzour P; Beck D; Boelen L; Unnikrishnan A; Villanueva JE; Nunez AC; Knezevic K; Palu C; Nasrallah R; Carnell M; Macmillan A; Whan R; Yu Y; Hardy P; Grey ST; Gladbach A; Delerue F; Ittner L; Mobbs R; Walkley CR; Purton LE; Ward RL; Wong JWH; Hesson LB; Walsh W; Pimanda JE, 2016, 'Pdgf-ab and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells', Proceedings of the National Academy of Sciences of the United States of America, 113, pp. E2306 - E2315, http://dx.doi.org/10.1073/pnas.1518244113
    Journal articles | 2016
    Hesson LB; Ng B; Zarzour P; Srivastava S; Kwok CT; Packham D; Nunez AC; Beck D; Ryan R; Dower A; Ford CE; Pimanda JE; Sloane MA; Hawkins NJ; Bourke MJ; Wong JWH; Ward RL, 2016, 'Integrated genetic, epigenetic, and transcriptional profiling identifies molecular pathways in the development of laterally spreading tumors', Molecular Cancer Research, 14, pp. 1217 - 1228, http://dx.doi.org/10.1158/1541-7786.MCR-16-0175
    Journal articles | 2016
    Huang Y; Thoms JAI; Tursky ML; Knezevic K; Beck D; Chandrakanthan V; Suryani S; Olivier J; Boulton A; Glaros EN; Thomas SR; Lock RB; MacKenzie KL; Bushweller JH; Wong JWH; Pimanda JE, 2016, 'MAPK/ERK2 phosphorylates ERG at serine 283 in leukemic cells and promotes stem cell signatures and cell proliferation', Leukemia, 30, pp. 1552 - 1561, http://dx.doi.org/10.1038/leu.2016.55
    Journal articles | 2016
    Khanna A; Pimanda JE, 2016, 'Clinical significance of cancerous inhibitor of protein phosphatase 2A in human cancers', International Journal of Cancer, 138, pp. 525 - 532, http://dx.doi.org/10.1002/ijc.29431
    Journal articles | 2016
    Nasrallah R; Fast EM; Solaimani P; Knezevic K; Eliades A; Patel R; Thambyrajah R; Unnikrishnan A; Thoms J; Beck D; Vink CS; Smith A; Wong J; Shepherd M; Kent D; Roychoudhuri R; Paul F; Klippert J; Hammes A; Willnow T; Göttgens B; Dzierzak E; Zon LI; Lacaud G; Kouskoff V; Pimanda JE, 2016, 'Identification of novel regulators of developmental hematopoiesis using Endoglin regulatory elements as molecular probes', Blood, 128, pp. 1928 - 1939, http://dx.doi.org/10.1182/blood-2016-02-697870
    Journal articles | 2016
    Perera D; Poulos RC; Shah A; Beck D; Pimanda JE; Wong JWH, 2016, 'Differential DNA repair underlies mutation hotspots at active promoters in cancer genomes', Nature, 532, pp. 259 - 263, http://dx.doi.org/10.1038/nature17437
    Journal articles | 2016
    Poulos RC; Thoms JAI; Guan YF; Unnikrishnan A; Pimanda JE; Wong JWH, 2016, 'Functional Mutations Form at CTCF-Cohesin Binding Sites in Melanoma Due to Uneven Nucleotide Excision Repair across the Motif', Cell Reports, 17, pp. 2865 - 2872, http://dx.doi.org/10.1016/j.celrep.2016.11.055
    Journal articles | 2016
    Richmond J; Robbins A; Evans K; Beck D; Kurmasheva RT; Billups CA; Carol H; Heatley S; Sutton R; Marshall GM; White D; Pimanda J; Houghton PJ; Smith MA; Lock RB, 2016, 'Acute sensitivity of Ph-like acute lymphoblastic leukemia to the SMAC-mimetic birinapant', Cancer Research, 76, pp. 4579 - 4591, http://dx.doi.org/10.1158/0008-5472.CAN-16-0523
    Journal articles | 2016
    Shields BJ; Jackson JT; Metcalf D; Shi W; Huang Q; Garnham AL; Glaser SP; Beck D; Pimanda JE; Bogue CW; Smyth GK; Alexander WS; McCormack MP, 2016, 'Acute myeloid leukemia requires Hhex to enable PRC2-mediated epigenetic repression of Cdkn2a', Genes and Development, 30, pp. 78 - 91, http://dx.doi.org/10.1101/gad.268425.115
    Journal articles | 2016
    Thoms JAI; Knezevic K; Liu JJ; Glaros EN; Thai T; Qiao Q; Campbell H; Packham D; Huang Y; Papathanasiou P; Tunningley R; Whittle B; Yeung AWS; Chandrakanthan V; Hesson L; Chen V; Wong JWH; Purton LE; Ward RL; Thomas SR; Pimanda JE, 2016, 'Arrested hematopoiesis and vascular relaxation defects in mice with a mutation in Dhfr', Molecular and Cellular Biology, 36, pp. 1222 - 1236, http://dx.doi.org/10.1128/MCB.01035-15
    Journal articles | 2016
    Unnikrishnan A; Guan YF; Huang Y; Beck D; Thoms JAI; Peirs S; Knezevic K; Ma S; De Walle IV; De Jong IDE; Ali Z; Zhong L; Raftery MJ; Taghon T; Larsson J; MacKenzie KL; Van Vlierberghe P; Wong JWH; Pimanda JE, 2016, 'A quantitative proteomics approach identifies ETV6 and IKZF1 as new regulators of an ERG-driven transcriptional network', Nucleic Acids Research, 44, pp. 10644 - 10661, http://dx.doi.org/10.1093/nar/gkw804
    Journal articles | 2015
    Giotopoulos G; van der Weyden L; Osaki H; Rust AG; Gallipoli P; Meduri E; Horton SJ; Chan WI; Foster D; Prinjha RK; Pimanda JE; Tenen DG; Vassiliou GS; Koschmieder S; Adams DJ; Huntly BJP, 2015, 'A novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression', Journal of Experimental Medicine, 212, pp. 1551 - 1569, http://dx.doi.org/10.1084/jem.20141661
    Journal articles | 2015
    Jing RBAB; Thoms J; Pimanda J; Wong J; Beck D; Lock R; Knezevic K; Jing D; Bhadri V; Yakob N, 2015, 'Opposing regulation of BIM and BCL2 controls glucocorticoid-induced apoptosis of pediatric acute lymphoblastic leukemia cells', Blood, 125, pp. 273 - 283, http://dx.doi.org/10.1182/blood-2014-05-576470
    Journal articles | 2015
    Kartalaei PS; Yamada-Inagawa T; Vink CS; de Pater E; van der Linden R; Marks-Bluth J; van der Sloot A; van den Hout M; Yokomizo T; Lucila van Schaick-Solernó M; Delwel R; Pimanda JE; van IJcken WFJ; Dzierzak E, 2015, 'Whole-transcriptome analysis of endothelial to hematopoietic stem cell transition reveals a requirement for Gpr56 in HSC generation', Journal of Experimental Medicine, 212, pp. 93 - 106, http://dx.doi.org/10.1084/jem.20140767
    Journal articles | 2015
    Khanna A; Rane JK; Kivinummi KK; Urbanucci A; Helenius MA; Tolonen TT; Saramäki OR; Latonen L; Manni V; Pimanda JE; Maitland NJ; Westermarck J; Visakorpi T, 2015, 'CIP2A is a candidate therapeutic target in clinically challenging prostate cancer cell populations', Oncotarget, 6, pp. 19661 - 19670, http://dx.doi.org/10.18632/oncotarget.3875
    Journal articles | 2015
    Khanna A; Stringer B; Ensbey K; Jahaan Z; Boyd A; McDonald K; Day B; Pimanda J, 2015, '117PD Clinical relevance of DNA damage modulator checkpoint kinase 1 (CHK1) and cancerous inhibitor of protein phosphatase 2A (CIP2A) in human gliomas', Annals of Oncology, 26, pp. ix34 - ix34, http://dx.doi.org/10.1093/annonc/mdv520.01
    Journal articles | 2015
    Lacramioara B; Makishima H; Michel L; Hoenes J; Marneth A; van der Reijden B; Radiovoyevich T; Germing U; Haas R; Schroeder T; Vadnais C; Helness A; Pimanda J; Jansen J; Unnikrishnan A; Platzbecker U; Papaemmanuil E; Ehninger G; Moroy T; Duhrsen U; Maciejewski J; Khandanpour C, 2015, '72 PERSONALIZED TREATMENT APPROACH FOR GFI136N HETEROZYGOUS OR HOMOZYGOUS MDS PATIENTS', Leukemia Research, 39, pp. S35 - S35, http://dx.doi.org/10.1016/s0145-2126(15)30073-4
    Journal articles | 2015
    Marks-Bluth J; Khanna A; Chandrakanthan V; Thoms J; Bee T; Eich C; Kang YC; Knezevic K; Qiao Q; Fitch S; Oxburgh L; Ottersbach K; Dzierzak E; de Bruijn MFTR; Pimanda JE, 2015, 'SMAD1 and SMAD5 expression is coordinately regulated by FLI1 and GATA2 during endothelial development', Molecular and Cellular Biology, 35, pp. 2165 - 2172, http://dx.doi.org/10.1128/MCB.00239-15
    Journal articles | 2015
    Nasrallah R; Knezevic K; Thai T; Thomas SR; Göttgens B; Lacaud G; Kouskoff V; Pimanda JE, 2015, 'Endoglin potentiates nitric oxide synthesis to enhance definitive hematopoiesis', Biology Open, 4, pp. 819 - 829, http://dx.doi.org/10.1242/bio.011494
    Journal articles | 2015
    Poulos RC; Thoms JAI; Shah A; Beck D; Pimanda JE; Wong JWH, 2015, 'Systematic screening of promoter regions pinpoints functional cis-regulatory mutations in a cutaneous melanoma genome', Molecular Cancer Research, 13, pp. 1218 - 1226, http://dx.doi.org/10.1158/1541-7786.MCR-15-0146
    Journal articles | 2015
    Rao TN; Marks-Bluth J; Sullivan J; Gupta MK; Chandrakanthan V; Fitch SR; Ottersbach K; Jang YC; Piao X; Kulkarni RN; Serwold T; Pimanda JE; Wagers AJ, 2015, 'High-level Gpr56 expression is dispensable for the maintenance and function of hematopoietic stem and progenitor cells in mice', Stem Cell Research, 14, pp. 307 - 322, http://dx.doi.org/10.1016/j.scr.2015.02.001
    Journal articles | 2015
    Tursky ML; Beck D; Thoms JAI; Huang Y; Kumari A; Unnikrishnan A; Knezevic K; Evans K; Richards LA; Lee E; Morris J; Goldberg L; Izraeli S; Wong JWH; Olivier J; Lock RB; MacKenzie KL; Pimanda JE, 2015, 'Overexpression of ERG in cord blood progenitors promotes expansion and recapitulates molecular signatures of high ERG leukemias', Leukemia, 29, pp. 819 - 827, http://dx.doi.org/10.1038/leu.2014.299
    Journal articles | 2015
    Woll PS; Kjaellquist U; Chowdhury O; Doolittle H; Wedge DC; Thongjuea S; Erlandsson R; Ngara M; Anderson K; Deng Q; Mead AJ; Stenson L; Giustacchini A; Duarte S; Giannoulatou E; Taylor S; Karimi M; Scharenberg C; Mortera-Blanco T; Macaulay IC; Clark S-A; Dybedal I; Josefsen D; Fenaux P; Hokland P; Holm MS; Cazzola M; Malcovati L; Tauro S; Bowen D; Boultwood J; Pellagatti A; Pimanda JE; Unnikrishnan A; Vyas P; Goehring G; Schlegelberger B; Tobiasson M; Kvalheim G; Constantinescu SN; Nerlov C; Nilsson L; Campbell PJ; Sandberg R; Papaemmanuil E; Hellstroem-Lindberg E; Linnarsson S; Jacobsen SEW, 2015, 'Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo (vol 25, pg 794, 2014)', CANCER CELL, 27, pp. 603 - 605, http://dx.doi.org/10.1016/j.ccell.2015.03.003
    Journal articles | 2015
    Woll PS; Kjällquist U; Chowdhury O; Doolittle H; Wedge DC; Thongjuea S; Erlandsson R; Ngara M; Anderson K; Deng Q; Mead AJ; Stenson L; Giustacchini A; Duarte S; Giannoulatou E; Taylor S; Karimi M; Scharenberg C; Mortera-Blanco T; Macaulay IC; Clark SA; Dybedal I; Josefsen D; Fenaux P; Hokland P; Holm MS; Cazzola M; Malcovati L; Tauro S; Bowen D; Boultwood J; Pellagatti A; Pimanda JE; Unnikrishnan A; Vyas P; Göhring G; Schlegelberger B; Tobiasson M; Kvalheim G; Constantinescu SN; Nerlov C; Nilsson L; Campbell PJ; Sandberg R; Papaemmanuil E; Hellström-Lindberg E; Linnarsson S; Jacobsen SEW, 2015, 'Erratum to Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo, [Cancer Cell, 25, 2014, 794-808]', Cancer Cell, 27, pp. 603 - 605, http://dx.doi.org/10.1016/j.ccell.2015.03.003
    Journal articles | 2014
    Chacon D; Beck D; Perera D; Wong JWH; Pimanda JE, 2014, 'BloodChIP: A database of comparative genome-wide transcription factor binding profiles in human blood cells', Nucleic Acids Research, 42, http://dx.doi.org/10.1093/nar/gkt1036
    Journal articles | 2014
    Diffner E; Beck D; Gudgin E; Thoms JAI; Knezevic K; Pridans C; Foster S; Goode D; Khong Lim W; Boelen L; Metzeler KH; Micklem G; Bohlander SK; Buske C; Burnett A; Ottersbach K; Vassiliou GS; Olivier J; Wong JWH; Gottgens B; Huntly BJ; Pimanda JE, 2014, 'Erratum: Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia (Blood (2013) 121:12 (2289-2300))', Blood, 123, pp. 2901, http://dx.doi.org/10.1182/blood-2014-03-564831
    Journal articles | 2014
    Ju YSE; Alexandrov LB; Gerstung M; Martincorena I; Nik-Zainal S; Ramakrishna M; Davies HR; Papaemmanuil E; Gundem G; Shlien A; Bolli N; Behjati S; Tarpey PS; Nangalia J; Massie CE; Butler AP; Teague JW; Vassiliou GS; Green AR; Du MQ; Unnikrishnan A; Pimanda JE; Teh BTE; Munshi N; Greaves M; Vyas P; El-Naggar AK; Santarius T; Collins VP; Grundy R; Taylor JA; Hayes DN; Malkin D; Foster CS; Warren AY; Whitaker HC; Brewer D; Eeles R; Cooper C; Neal D; Visakorpi T; Isaacs WB; Bova GS; Flanagan AM; Futreal PA; Lynch AG; Chinnery PF; McDermott U; Stratton MR; Campbell PJ, 2014, 'Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer', eLife, 3, pp. e02935, http://dx.doi.org/10.7554/eLife.02935
    Journal articles | 2014
    Khanna A; Stringer B; Day B; Ensbey K; Shen H; Boyd A; McDonald KL; Pimanda J, 2014, 'Keeping GBM in check by targeting CHK1-CIP2A axis.', Journal of Clinical Oncology, 32, pp. 2036 - 2036, http://dx.doi.org/10.1200/jco.2014.32.15_suppl.2036
    Journal articles | 2014
    Nasrallah R; Knezevic K; Gottgens B; Lacaud G; Kouskoff V; Pimanda J, 2014, 'ENDOGLIN MODULATES STAGE SPECIFIC CELL RESPONSES DURING LINEAGE COMMITMENT FROM EMBRYONIC STEM CELLS TO BLOOD AND ENDOTHELIUM', EXPERIMENTAL HEMATOLOGY, 42, pp. S54 - S54, http://dx.doi.org/10.1016/j.exphem.2014.07.203
    Journal articles | 2014
    Perera D; Chacon D; Thoms JA; Poulos RC; Shlien A; Beck D; Campbell PJ; Pimanda JE; Wong JW, 2014, 'Oncocis: Annotation of cis-regulatory mutations in cancer', Genome Biology, 15, http://dx.doi.org/10.1186/s13059-014-0485-0
    Journal articles | 2014
    Sloane MA; Wong JWH; Perera D; Nunez AC; Pimanda JE; Hawkins NJ; Sieber OM; Bourke MJ; Hesson LB; Ward RL, 2014, 'Epigenetic inactivation of the candidate tumor suppressor USP44 is a frequent and early event in colorectal neoplasia', Epigenetics, 9, pp. 1092 - 1100, http://dx.doi.org/10.4161/epi.29222
    Journal articles | 2014
    Tobiasson M; Karimi M; Dimitriou M; Qu Y; Lennartsson A; Ali HA; Unnikrishnan A; Jadersten M; Jansson M; Ben Azenkoud A; Pimanda JE; Ekwall K; Ungerstedt J; Lehmann S; Hellstrom-Lindberg E, 2014, 'Mutations in Histone Modulators and HOXA5 Methylation Levels Affects Survival in Azacitidine Treated MDS Patients', BLOOD, 124, http://www.bloodjournal.org/content/124/21/4613
    Journal articles | 2014
    Woll PS; Kjaellquist U; Chowdhury O; Doolittle H; Wedge DC; Thongjuea S; Erlandsson R; Ngara M; Anderson K; Deng Q; Mead AJ; Stenson L; Giustacchini A; Duarte S; Giannoulatou E; Taylor S; Karimi M; Scharenberg C; Mortera-Blanco T; Macaulay IC; Clark S-A; Dybedal I; Josefsen D; Fenaux P; Hokland P; Holm MS; Cazzola M; Malcovati L; Tauro S; Bowen D; Boultwood J; Pellagatti A; Pimanda JE; Unnikrishnan A; Vyas P; Goehring G; Schlegelberger B; Tobiasson M; Kvalheim G; Constantinescu SN; Nerlov C; Nilsson L; Campbell PJ; Sandberg R; Papaemmanuil E; Hellstroem-Lindberg E; Linnarsson S; Jacobsen SEW, 2014, 'Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo (vol 25, pg 794, 2014)', CANCER CELL, 25, pp. 861 - 861, http://dx.doi.org/10.1016/j.ccr.2014.05.027
    Journal articles | 2013
    Beck D; Thoms JAI; Perera D; Schütte J; Unnikrishnan A; Knezevic K; Kinston SJ; Wilson NK; O'Brien TA; Göttgens B; Wong JWH; Pimanda JE, 2013, 'Genome-wide analysis of transcriptional regulators in human HSPCs reveals a densely interconnected network of coding and noncoding genes', Blood, 122, pp. e12 - e22, http://dx.doi.org/10.1182/blood-2013-03-490425
    Journal articles | 2013
    Goldberg L; Tijssen MR; Birger Y; Hannah RL; Kinston SJ; Schütte J; Beck D; Knezevic K; Schiby G; Jacob-Hirsch J; Biran A; Kloog Y; Marcucci G; Bloomfield CD; Aplan PD; Pimanda JE; Göttgens B; Izraeli S, 2013, 'Genome-scale expression and transcription factor binding profiles reveal therapeutic targets in transgenic ERG myeloid leukemia', Blood, 122, pp. 2694 - 2703, http://dx.doi.org/10.1182/blood-2013-01-477133
    Journal articles | 2013
    Hesson LB; Patil V; Sloane MA; Nunez AC; Liu J; Pimanda JE; Ward RL, 2013, 'Reassembly of Nucleosomes at the MLH1 Promoter Initiates Resilencing Following Decitabine Exposure', PLoS Genetics, 9, http://dx.doi.org/10.1371/journal.pgen.1003636
    Journal articles | 2013
    Khanna A; Kauko O, Bockelman C, Laine A, Schreck I, Partanen JI, Szwajda A, Bormann S, Bilgen T, Helenius M, Pokharel YR, Pimanda J, Russel MR, Haglund C, Cole KA, Klefstrom J, Aittokallio T, Weiss C, Ristimaki A, Visakorpi T, Westermarck J. , 2013, 'Chk1 targeting reactivates PP2A tumor suppressor activity in cancer cells.', Cancer Research, 73, pp. 6757 - 6769, http://dx.doi.org/10.1158/0008-5472.CAN-13-1002
    Journal articles | 2013
    Khanna A; Pimanda JE; Westermarck J, 2013, 'Cancerous inhibitor of protein phosphatase 2A, an emerging human oncoprotein and a potential cancer therapy target', Cancer Research, 73, pp. 6548 - 6553, http://dx.doi.org/10.1158/0008-5472.CAN-13-1994
    Journal articles | 2013
    Narula J; Williams CJ; Tiwari A; Marks-Bluth J; Pimanda JE; Igoshin OA, 2013, 'Mathematical model of a gene regulatory network reconciles effects of genetic perturbations on hematopoietic stem cell emergence', Developmental Biology, 379, pp. 258 - 269, http://dx.doi.org/10.1016/j.ydbio.2013.04.016
    Journal articles | 2013
    Oram SH; Thoms J; Sive J; Calero-Nieto FJ; Kinston SJ; Schuette J; Knezevic K; Lock RB; Pimanda JE; Gottgens B, 2013, 'Bivalent promoter marks and a latent enhancer may prime the leukaemia oncogene LMO1 for ectopic expression in T-cell leukaemia', Leukemia, 27, pp. 1348 - 1357, http://dx.doi.org/10.1038/leu.2013.2
    Journal articles | 2012
    Beck D; Brandl MB; boelen L; Unnikrishnan A; Pimanda JE; Wong JWH, 2012, 'Signal analysis for genome-wide maps of histone modifications measured by ChIP-seq', Bioinformatics, 28, pp. 1062 - 1069
    Journal articles | 2012
    Hesson LB; Wong JWH; Sloane MA; Pimanda JE; Bourke MJ; Hawkins NJ; Ward RL, 2012, 'Nucleosome occupancy at unmethylated promoter CpG islands represents a novel mechanism of epigenetic gene silencing in cancer', CANCER RESEARCH, 72, http://dx.doi.org/10.1158/1538-7445.AM2012-990
    Journal articles | 2012
    Liu J; Hesson L; Meagher AP; Bourke MJ; Hawkins NJ; Rand KN; Molloy PL; Pimanda JE; Ward RL, 2012, 'Relative distribution of folate species is associated with global DNA methylation in human colorectal mucosa', CANCER PREVENTION RESEARCH, 5, pp. 921 - 929, http://dx.doi.org/10.1158/1940-6207.CAPR-11-0577
    Journal articles | 2012
    Pereira LA; Wong MS; Mossmann AK; Sourris K; Janes ME; Knezevic K; Hirst CE; Lim S; Pimanda JE; Stanley E; Elefanty A, 2012, 'Pdgfrá and Flk1 are direct target genes of Mixl1 in differentiating embryonic stem cells', Steam cell research, 8, pp. 165 - 179, http://dx.doi.org/10.1016/j.scr.2011.09.007
    Journal articles | 2012
    Pimanda JE, 2012, 'Cell signalling pathways that mediate haematopoietic stem cell specification', The International Journal of Biochemistry & Cell Biology, 44, pp. 2175 - 2184
    Journal articles | 2012
    Pimanda JE, 2012, 'Concise Review: Blood Relatives: Formation and Regulation of Hematopoietic Stem Cells by the Basic Helix-Loop-Helix Transcription Factors Stem Cell Leukemia and Lymphoblastic Leukemia-Derived Sequence 1', Stem Cells, 30, pp. 1053 - 1058
    Journal articles | 2011
    Chong J; Chandrakanthan V; Xaymardan M; Asli NS; Li J; Ahmed I; Heffernan C; Menon M; Scarlett C; Rashidianfar A; Biben C; Zoellner H; Colvin EK; Pimanda JE; Biankin AV; Zhou B; Pu WT; Prall OWJ; Harvey RP, 2011, 'Adult cardiac-resident MSC-like stem cells with a proepicardial origin', Cell Stem Cell, 9, pp. 527 - 540, http://dx.doi.org/10.1016/j.stem.2011.10.002
    Journal articles | 2011
    Knezevic K; Wilson N; Bee T; Janes M; Kinston SJ; Polderdijk S; Kolb-Kokocinski A; Ottersbach K; Pencovich N; Groner Y; De bruijn M; Gottgens B; Pimanda JE, 2011, 'A Runx1-Smad6 rheostat controls Runx1 activity during embryonic hematopoiesis', Molecular and Cellular Biology, 31, pp. 2817 - 2826, http://dx.doi.org/10.1128/MCB.01305-10
    Journal articles | 2011
    Liu JJ; Hesson LB; Rand KN; Molloy PL; Pimanda J; Ward RL, 2011, 'Analysis of global and repeat sequence DNA methylation in the blood and normal colonic mucosa of colorectal cancer patients, healthy individuals and patients with folate deficiency', CANCER RESEARCH, 71, http://dx.doi.org/10.1158/1538-7445.AM2011-91
    Journal articles | 2011
    Pimanda J; Thoms J; Birger Y; Foster S; Knezevic K; Kirschenbaum Y; Chandrakanthan V; Lock R; MacKenzie K; Gottgens B; Izraeli S, 2011, 'ERG PROMOTES T-ACUTE LYMPHOBLASTIC LEUKEMIA AND IS TRANSCRIPTIONALLY REGULATED IN LEUKEMIC CELLS BY A STEM CELL ENHANCER', EXPERIMENTAL HEMATOLOGY, 39, pp. S108 - S108, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000293801700179&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2011
    Taoudi S; Bee T; Hilton A; Knezevic K; Scott J; Scott J; Willson TA; Collin C; Thomas T; Voss AK; Kile BT; Alexander WS; Pimanda JE; Hilton DJ, 2011, 'ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification', Genes and Development, 25, pp. 251 - 262
    Journal articles | 2011
    Thoms JAI; Birger Y; Foster S; Knezevic K; Kirshenbaum Y; Chandrakanthan V; Jonquieres G; Spensberger D; Wong JW; Oram SH; Kinston SJ; Groner Y; Lock RB; MacKenzie KL; Gottgens B; Izraeli S; Pimanda JE, 2011, 'ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer', Blood, 117, pp. 7079 - 7089, http://dx.doi.org/10.1182/blood-2010-12-317990
    Journal articles | 2010
    Bachmann PS; Piazza RG; Janes M; Wong NC; Davies C; Mogavero A; Bhadri V; Szymanska B; Geninson G; Magistroni V; Cazaniga G; Biondi A; Miranda-saavedra D; Gottgens B; Saffery R; Craig JM; Marshall GM; Gambacorti-passerini C; Pimanda JE; Lock RB, 2010, 'Epigenetic silencing of BIM in glucocorticoid poor-responsive pediatric acute lymphoblastic leukemia, and its reversal by histone deacetylase inhibition', Blood, 116, pp. 3013 - 3022, http://dx.doi.org/10.1182/blood-2010-05-284968
    Journal articles | 2010
    Oram SH; Thoms JAI; Pridans C; Janes ME; Kinston SJ; Anand S; Landry JR; Lock RB; Jayaraman PS; Huntly BJ; Pimanda JE; Gottgens B, 2010, 'A previously unrecognized promoter of LMO2 forms part of a transcriptional regulatory circuit mediating LMO2 expression in a subset of T-acute lymphoblastic leukaemia patients', Oncogene, 29, pp. 5796 - 5808, http://dx.doi.org/10.1038/onc.2010.320
    Journal articles | 2010
    Pimanda JE; Gottgens B, 2010, 'Gene regulatory networks governing etic stem cell development and identity', International Journal of Developmental Biology, 54, pp. 1201 - 1211, http://dx.doi.org/10.1387/ijdb.093038jp
    Journal articles | 2010
    Wang B; Chen J; Santiago FS; Janes ME; Kavurma MM; Chong BH; Pimanda JE; Khachigian LM, 2010, 'Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription.', Arteriosclerosis, Thrombosis and Vascular Biology, 30, pp. 536 - 545, http://dx.doi.org/10.1161/ATVBAHA.109.193821
    Journal articles | 2010
    Wilson N; Foster S; Wang XL; Knezevic K; Schutte J; Kaimakis P; Chilarska P; Kinston S; Ouwehand AC; Dzierzak E; Pimanda JE; De bruijn M; Gottgens B, 2010, 'Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators.', Cell Stem Cell, 7, pp. 532 - 544
    Journal articles | 2009
    Lock RB; Bachmann PS; Piazza RG; Davies C; James M; Wong NC; Bhadri VA; Mogavero A; Magistroni V; Gambacorti-Passerini C; Saffery R; Craig JM; Pimanda JE; Marshall GM, 2009, 'Epigenetic Silencing of the Pro-Apoptotic Bim Gene in Glucocorticoid Poor-Responsive Pediatric Acute Lymphoblastic Leukemia, and Its Reversal by Histone Deacetylase Inhibition.', Blood, 114, pp. 939 - 939, http://dx.doi.org/10.1182/blood.v114.22.939.939
    Journal articles | 2008
    Landry J; Kinston S; Knezevic K; De bruijn M; Wilson N; Nottingham W; Peitz M; Edenhofer F; Pimanda JE; Ottersbach K; Gottgens B, 2008, 'Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver.', Blood, 111, pp. 3005 - 3014, http://dx.doi.org/10.1182/blood-2007-07-098830
    Journal articles | 2008
    Pimanda JE; Chan W; Wilson N; Smith A; Kinston S; Knezevic K; Janes M; Landry J; Kolb-Kokocinski A; Frampton J; Tannahill D; Ottersbach K; Follows G; Goettgens B; Lacaud G; Kouskoff V, 2008, 'Endoglin expression in blood and endothelium is differentially regulated by modular assembly of the Ets/Gata hemangioblast code', Blood, 112, pp. 4512 - 4522
    Journal articles | 2007
    Chan W; Follows G; Lacaud G; Pimanda JE; Landry J; Kinston S; Knezevic K; Piltz S; Donaldson I; Gambardella L; Sablitzky F; Green AR; Kouskoff V; Gottgens B, 2007, 'The paralogous hematopoietic regulators Lyl1 and Scl are coregulated by Ets and GATA factors, but Lyl1 cannot rescue the early Scl-/- phenotype.', Blood, 109, pp. 1908 - 1916, http://dx.doi.org/10.1182/blood-2006-05-023226
    Journal articles | 2007
    Pimanda JE; Ottersbach K; Knezevic K; Kinston S; Chan W; Wilson N; Landry J; Kolb-Kokocinski A; Green AR; Tannahill D; Gottgens B, 2007, 'The SCL transcriptional network and BMP signaling pathway interact to regulate RUNX1 activity.', Proceedings of the National Academy of Sciences of the United States of America, 104, pp. 840 - 845, http://dx.doi.org/10.1073/pnas.0607196104
    Journal articles | 2007
    Pimanda JE; Ottersbach K; Knezevic K; Kinston S; Chan W; Wilson N; Landry J; Wood A; Kolb-Kokocinski A; Green AR; Tannahill D; Lacaud G; Kouskoff V; Gottgens B, 2007, 'Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development', Proceedings of the National Academy of Sciences of the United States of America, 104, pp. 17692 - 17697
    Journal articles | 2006
    Pimanda JE; Chan W; Donaldson I; Bowen M; Green AR; Gottgens B, 2006, 'Endoglin expression in the endothelium is regulated by Fli-1, Erg, and Elf-1 acting on the promoter and a -8-kb enhancer', Blood, 107, pp. 4737 - 4745
    Journal articles | 2006
    Pimanda JE; Donaldson IJ; Bruijn MF; Kinston SJ; Knezevic K; Huckle L; Piltz S; Landry J-R; Green AR; Tannahill D; Gottgens B, 2006, 'Genome-Wide Computational Screen for Blood Stem Cell Enhancers Integrates RUNX1 and the BMP Signaling Pathway into the SCL Transcriptional Network.', Blood, 108, pp. 4196 - 4196, http://dx.doi.org/10.1182/blood.v108.11.4196.4196
    Journal articles | 2006
    Pimanda JE; Silberstein L; Dominici M; Dekel B; Bowen M; Oldham M; Brandt S; Tannahill D; Gottgens B; Green AR, 2006, 'Transcriptional link between blood and bone: the stem cell leukemia gene and its +19 stem cell enhancer are active in bone cells', Molecular and Cellular Biology, 26, pp. 2615 - 2625, http://dx.doi.org/10.1128/MCB.26.7.2615-2625.2006
    Journal articles | 2006
    Schneppenheim R; Kremer hovinga J; Becker T; Budder U; Karpman D; Brockhaus W; Hrachovinová I; Korczowski B; Oyen F; Rittich S; von Rosen J; Tjønnfjord G; Pimanda JE; Wienker G; Lämmle B, 2006, 'A common origin of the 4143insA ADAMTS13 mutation', Thrombosis and Haemostasis, 96, pp. 3 - 6
    Journal articles | 2005
    Rainis L; Toki T; Pimanda JE; Rosenthal E; Machol E; Strehl S; Gottgens B; Ito E; Izraeli S, 2005, 'The proto-oncogene ERG in megakaryoblastic leukemias.', Cancer research, 65, pp. 7596 - 7602
    Journal articles | 2004
    Pimanda JE; Ganderton TR; Maekawa A; Yap C; Lawler J; Kershaw G; Chesterman CN; Hogg PJ, 2004, 'Role of thrombospondin-1 in control of von Willebrand factor multimer size in mice', The Journal of Biological Chemistry, 279, pp. 21439 - 21448
    Journal articles | 2004
    Pimanda JE; Maekawa A; Wind T; Paxton J; Chesterman CN; Hogg PJ, 2004, 'Congenital thrombotic thrombocytopenic purpura in association with a mutation in the second CUB domain of ADAMTS13', Blood, 103, pp. 627 - 629
    Journal articles | 2003
    Pimanda JE; Chesterman CN; Hogg PJ, 2003, 'A perspective on the measurement of ADAMTS13 in thrombotic thrombocytopaenic purpura', European Journal of Haematology, 70, pp. 257 - 262
    Journal articles | 2003
    Pimanda JE; Lowe HC; Hogg PJ; Chesterman CN; Khachigian LM, 2003, 'Novel and Emerging Therapies in Cardiology and Haematology', Current Drug Targets, 3, pp. 101 - 103
    Journal articles | 2002
    Pimanda JE; Annis D; Raftery M; Mosher D; Chesterman CN; Hogg PJ, 2002, 'The von Willebrand factor-reducing activity of thrombospondin-1 is located in the calcium-binding/C-terminal sequence and requires a free thiol at position 974.', Blood, 100, pp. 2832 - 2838
    Journal articles | 2002
    Pimanda JE; Hogg PJ, 2002, 'Control of von Willebrand factor multimer size and implications for disease', Blood Reviews, 16, pp. 185 - 192
    Journal articles | 2001
    Pimanda JE; Xie LJ; Chesterman CN; Hog PJ, 2001, 'Control of von Willebrand factor multimer size.', BLOOD, 98, pp. 40A - 40A, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000172134100161&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
  • Preprints | 2024
    Thoms JAI; Yan F; Hampton HR; Davidson S; Joshi S; Saw J; Sarowar CH; Lim XY; Nunez AC; Kakadia PM; Bhuyan GS; Zou X; Nguyen M; Ghodousi ES; Koch FC; Vafaee F; Pickford R; Raftery MJ; Hough S; Buckland G; Bailey M; Ghodke Y; Absar N; Vaughan L; Pasalic L; Fong CY; Kenealy M; Hiwase DK; Stoddart RI; Mohammed S; Lee L; Passam FH; Larsen SR; Spring KJ; Skarratt KK; Rebeiro P; Presgrave P; Stevenson WS; Ling S; Tiley C; Fuller SJ; Roncolato F; Enjeti AK; Hoenemann D; Lemech C; Jolly CJ; Bohlander SK; Curtis DJ; Wong JWH; Unnikrishnan A; Hertzberg M; Olivier J; Polizzotto MN; Pimanda JE, 2024, Clinical Response to Azacitidine in Myelodysplastic Neoplasms is Associated with Distinct DNA Methylation Changes in Haematopoietic Stem and Progenitor cellsin vivo, http://dx.doi.org/10.1101/2024.07.19.24310679
    Preprints | 2024
    Truong P; Shen S; Joshi S; Islam MI; Zhong L; Raftery MJ; Afrasiabi A; Alinejad-Rokny H; Nguyen M; Zou X; Bhuyan GS; Sarowar CH; Ghodousi ES; Stonehouse O; Mohamed S; Toscan CE; Connerty P; Kakadia PM; Bohlander SK; Michie KA; Larsson J; Lock RB; Walkley CR; Thoms JAI; Jolly CJ; Pimanda JE, 2024, Genome-Wide CRISPR-Cas9 Screening Identifies a Synergy between Hypomethylating Agents and SUMOylation Blockade in MDS/AML, http://dx.doi.org/10.1101/2024.04.17.589858
    Preprints | 2023
    Subramanian S; Subramanian S; Thoms JAI; Huang Y; Cornejo P; Koch F; Jacquelin S; Shen S; Song E; Joshi S; Brownlee C; Woll P; Fajardo DC; Beck D; Curtis D; Yehson K; Antonenas V; Brien TO; Trickett A; Powell J; Lewis I; Pitson S; Gandhi M; Lane S; Vafaee F; Wong E; Göttgens B; Rokny HA; Wong JWH; Pimanda J, 2023, Cell Type-Specific Regulation by a Heptad of Transcription Factors in Human Hematopoietic Stem and Progenitor Cells, http://dx.doi.org/10.1101/2023.04.18.537282
    Preprints | 2023
    Tan S; Joseph C; Chalk AM; Hendy J; Fabb S; Schleibs K; Lee SC; Tjin G; Grace CS; Madugalle V; Smeets MF; Maluenda AC; Rice KL; Baker EK; Nandurkar H; Slape CI; Parker MW; Unnikrishnan A; Mufti GJ; Tobiasson M; Hellstrom-Lindberg E; Pimanda JE; Gudas LJ; Holien JK; Walkley CR; Wall M; Purton LE, 2023, Dysregulated expression ofHoxa1isoforms in hematopoietic stem and progenitor cells causes myelodysplastic syndromes, , http://dx.doi.org/10.1101/2023.04.24.538176
    Preprints | 2022
    Kugler E; Madiwale S; Yong D; Birger Y; Thoms J; Sykes D; Yassin M; Aqaqe N; Rein A; Fishman H; Geron I; Chen C-W; Raught B; Liu Q; Milyavsky M; Pimanda J; Privé G; Izraeli S, 2022, A single amino acid at PNT domain of ERG mediates its leukemogenic activity through interaction with the NCoR-HDAC3 co-repressor complex, http://dx.doi.org/10.21203/rs.3.rs-1426447/v1
    Preprints | 2022
    Schnegg-Kaufmann A; Thoms J; Bhuyan GS; Hampton H; Vaughan L; Rutherford K; Kakadia P; Johansson E; Failes T; Arndt G; Koval J; Lindeman R; Warburton P; Rodriguez-Meira A; Mead A; Unnikrishnan A; Bohlander S; Papaemmanuil E; Faridani O; Jolly C; Zanini F; Pimanda J, 2022, Single cell genotyping of matched bone marrow and peripheral blood cells in treatment naive and AZA-treated MDS and CMML, http://dx.doi.org/10.1101/2022.01.20.476890
    Conference Papers | 2022
    Schnegg-Kaufmann A; Thoms JA; Bhuyan GS; Hampton HR; Vaughan L; Rutherford K; Kakadia PM; Lee HM; Johansson EM; Failes T; Arndt GM; Koval J; Davidson S; Lindenmann R; Warburton P; Rodriguez-Meira A; Mead AJ; Unnikrishnan A; Hertzberg M; Polizzotto MN; Bohlander SK; Papaemmanuil E; Faridani O; Jolly CJ; Zanini F; Pimanda JE, 2022, 'Single cell genotyping of matched stem/progenitor and mature blood cells in treatment naive and AZA-treated MDS and CMML reveals significant contribution of mutated clones to blood production', in SWISS MEDICAL WEEKLY, E M H SWISS MEDICAL PUBLISHERS LTD, pp. 29S - 29S, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000912385900040&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2022
    Srivastava P; Romanazzo S; Ireland JB; Pimanda JE; Kilian KA, 2022, 'BIOPHYSICAL REGULATION OF IN-VITRO GASTRULATION USING INDUCED PLURIPOTENT STEM CELLS', in TISSUE ENGINEERING PART A, MARY ANN LIEBERT, INC, Vol. 28, pp. S518 - S519, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000821187302276&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2022
    Truong P; Shen S; Joshi S; Afrasiabi A; Zhong L; Raftery MJ; Larsson J; Lock RB; Walkley CR; Rokny HA; Thoms JAI; Jolly CJ; Pimanda JE, 2022, 'Genome-Wide CRISPR-Cas9 Screening Identifies a Synergy between Hypomethylating Agents and Sumoylation Blockade in Myelodysplastic Syndromes and Acute Myeloid Leukemia', in BLOOD, AMER SOC HEMATOLOGY, LA, New Orleans, Vol. 140, presented at 64th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), LA, New Orleans, 10 December 2022 - 13 December 2022, http://dx.doi.org/10.1182/blood-2022-165713
    Preprints | 2021
    Putri GH; Anders S; Pyl PT; Pimanda JE; Zanini F, 2021, Analysing high-throughput sequencing data in Python with HTSeq 2.0, , http://arxiv.org/abs/2112.00939v1
    Preprints | 2021
    Srivastava P; Romanazzo S; Ireland J; Nemec S; Molley T; Jayathilaka P; Pandzic E; Yeola A; Chandrakanthan V; Pimanda J; Kilian K, 2021, Defined microenvironments trigger in vitro gastrulation in human pluripotent stem cells, http://dx.doi.org/10.1101/2021.10.28.466327
    Conference Abstracts | 2020
    Kugler E; Birger Y; Yong D; Thoms J; Rein A; Madiwale S; Pimanda J; Prive G; Izraeli S, 2020, 'AML-079: The PNT Domain of ERG Regulates Hematopoietic Stemness and is Required for the Maintenance of ERG-Induced Leukemia', in Clinical Lymphoma Myeloma and Leukemia, Elsevier BV, Vol. 20, pp. S180 - S181, http://dx.doi.org/10.1016/s2152-2650(20)30713-8
    Conference Abstracts | 2020
    Kugler E; Birger Y; Yong D; Thoms J; Rein A; Madiwale S; Pimanda J; Prive G; Izraeli S, 2020, 'The PNT Domain of ERG Regulates Hematopoietic Stemness and is Required for the Maintenance of ERG-Induced Leukemia', in CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, CIG MEDIA GROUP, LP, Vol. 20, pp. S180 - S181, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000564055100083&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Preprints | 2020
    Liu Y-C; Fabiani E; Kwon J; Gao C; Falconi G; Valentini L; Gurnari C; Liu YV; Jones AI; Yang J; Yang H; Thoms JAI; Unnikrishnan A; Pimanda JE; Pan R; Voso MT; Tenen DG; Chai L, 2020, Demethylation and upregulation of an oncogene post hypomethylating treatment, http://dx.doi.org/10.1101/2020.07.21.20157776
    Conference Abstracts | 2020
    Saini SK; Orskov A; Bjerregaard A-M; Unnikrishnam A; Holmberg-Thyden S; Borch A; Anande G; Bentzen A; Marquard A; Tamhane T; Gang A; Defva I; Szallasi Z; Eklund A; Pimanda J; Gronbaek K; Hadrup S, 2020, 'Human endogenous retroviruses form a reservoir of T cell targets in hematological cancers with low mutational burden', in JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, HI, Honolulu, Vol. 204, presented at Annual Meeting of the American-Association-of-Immunologists - Immunology 2020, HI, Honolulu, 08 May 2020 - 12 May 2020, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000589972403119&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Preprints | 2020
    Yang J; Gao C; Liu M; Chen Z; Liu Y-C; Kwon J; Qi J; Tian X; Stein A; Liu Y; Kong NR; Wu Y; Yin S; Xi JJ; Luo H; Silberstein LE; Thoms JAI; Unnikrishnan A; Pimanda JE; Tenen DG; Chai L, 2020, Induction of a SALL4-dependency for targeted cancer therapy, http://dx.doi.org/10.1101/2020.07.10.197434
    Conference Papers | 2019
    Anande G; Unnikrishnan A; Deshpande N; Mareschal S; Batcha AMN; Herold T; Lehmann S; Wilkins M; Wong J; Pimanda J, 2019, 'Identification of Recurrent Alternative RNA Splicing in Adverse-Risk Acute Myeloid Leukemia', in BLOOD, AMER SOC HEMATOLOGY, FL, Orlando, presented at 61st Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), FL, Orlando, 07 December 2019 - 10 December 2019, http://dx.doi.org/10.1182/blood-2019-129537
    Conference Papers | 2019
    Carmichael C; Wang J; Nguyen T; De Maziere C; Milne A; Goossens S; Davis M; Zadeh S; Vo A; McCormack M; Shields B; Haigh K; Huang Y; Thoms J; Knezevic K; Ritchie M; Berx G; Pimanda J; Kile B; Haigh J, 2019, '2008 - ALTERED EXPRESSION OF EPITHELIAL TO MESENCHYMAL TRANSITION MODULATORS IN ACUTE MYELOID LEUKAEMIA - A MODEL OF LSD1 CORRUPTION', in Experimental Hematology, Elsevier BV, pp. S44 - S44, http://dx.doi.org/10.1016/j.exphem.2019.06.282
    Conference Papers | 2019
    Carmichael C; Wang J; Nguyen T; De Maziere C; Milne A; Goossens S; Davis M; Zadeh S; Vo A; McCormack M; Shields B; Haigh K; Huang Y; Thoms J; Knezevic K; Ritchie M; Berx G; Pimanda J; Kile B; Haigh J, 2019, 'ALTERED EXPRESSION OF EPITHELIAL TO MESENCHYMAL TRANSITION MODULATORS IN ACUTE MYELOID LEUKAEMIA - A MODEL OF LSD1 CORRUPTION', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, pp. S44 - S44, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000844545400062&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2019
    Chacon D; Braytee A; Huang Y; Thoms J; Subramanian S; Sauerland MC; Bohlander SK; Braess J; Woermann BJ; Berdel WE; Hiddemann W; Gabrys B; Metzeler KH; Herold T; Pimanda J; Beck D, 2019, 'Prospective Identification of Acute Myeloid Leukemia Patients Who Benefit from Gene-Expression Based Risk Stratification', in BLOOD, AMER SOC HEMATOLOGY, FL, Orlando, presented at 61st Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), FL, Orlando, 07 December 2019 - 10 December 2019, http://dx.doi.org/10.1182/blood-2019-129519
    Conference Papers | 2019
    Unnikrishnan A; Lim XY; Joshi S; Nunez AC; Vaughan L; Pickford R; Hough S; Davidson S; Fong C; Kenealy M; Hiwase DK; Pasalic L; Mohammed S; Lee L; Passam FH; Spring K; Rebeiro P; Ling S; Fuller S; Presgrave P; Roncolato F; Larsen S; Enjeti AK; Stevenson WS; Tiley C; Campbell PJ; Lemech C; Olivier J; Hertzberg M; Polizzotto MN; Pimanda J, 2019, 'In Vivo Assessment of Intracellular Dynamics Comparing Injection Versus Oral Azacitidine in a Phase IIb Investigator Initiated Clinical Trial', in BLOOD, AMER SOC HEMATOLOGY, FL, Orlando, presented at 61st Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), FL, Orlando, 07 December 2019 - 10 December 2019, http://dx.doi.org/10.1182/blood-2019-123921
    Conference Papers | 2018
    Jing D; Huang Y; Liu X; Sia K; Poulos RC; Span M; Zhang C; Mi J; Wong JWH; Beck D; Pimanda JE; Lock RB, 2018, 'Lymphocyte-specific chromatin accessibility predetermines glucocorticoid resistance in acute lymphoblastic leukemia', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, IL, Chicago, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), IL, Chicago, 14 April 2018 - 18 April 2018, http://dx.doi.org/10.1158/1538-7445.AM2018-3173
    Preprints | 2018
    Poulos R; Perera D; Packham D; Shah A; Janitz C; Pimanda J; Hawkins N; Ward R; Hesson L; Wong JWH, 2018, In search of non-coding driver mutations by deep sequencing of regulatory elements in colorectal cancer, http://dx.doi.org/10.1101/249300
    Conference Papers | 2017
    Ali A; Penneroux J; Dal Bello R; Masse A; Quentin S; Unnikrishnan A; Hernandez L; Raffoux E; Benabelali R; Renneville A; Preudhomme C; Pimanda J; Dombret H; Soulier J; Fenaux P; Clappier E; Ades L; Itzykson R, 2017, 'Granulomonocytic Progenitors (GMPs) Are Key Target Cells of Azacitidine in MDS and AML', in BLOOD, AMER SOC HEMATOLOGY, GA, Atlanta, presented at 59th Annual Meeting of the American-Society-of-Hematology (ASH), GA, Atlanta, 09 December 2017 - 12 December 2017, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000432419401234&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Presentations | 2017
    Chandrakanthan V; Kang YC; Knezevic K; Qiao Q; Oliver R; Unnikrishnan A; Huang Y; Walsh W; Lee B; Lee CB; Power C; Beck D; Taoudi S; Pimanda J, 2017, 'DECLINED PRESENTATION MESENCHYMAL STEM CELL-LIKE CELL MEDIATED HEMATOPOIETIC STEM CELL GENERATION FROM NON-HEMOGENIC ENDOTHELIAL CELLS', https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000972742900274&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Proceedings (Editor of) | 2017
    Chandrakanthan V; Kang YC; Knezevic K; Qiao Q; Oliver RA; Unnikrishnan A; Beck D; Lee B; Brownlee C; Power C; Pimanda JE, 2017, 'Genetic Fate Mapping of Mesenchymal Stem-Like Cells in the Aorta-Gonad Mesonephros (AGM) and Their Contribution to Definitive Hematopoiesis', ELSEVIER SCIENCE BV, SINGAPORE, Natil Univ Singapore, Singapore, Vol. 145, presented at 18th International Congress of Developmental Biology, SINGAPORE, Natil Univ Singapore, Singapore, 18 June 2017 - 22 June 2017, http://dx.doi.org/10.1016/j.mod.2017.04.109
    Conference Papers | 2017
    Kang YC; Glaros E; Thomas S; Qiao Q; Brownlee C; Pimanda J; Chandrakanthan V, 2017, 'Identification of Novel Embryonic Vascular Stem-like cells and their role in Coronary Vasculature development and repair', in MECHANISMS OF DEVELOPMENT, ELSEVIER SCIENCE BV, SINGAPORE, Natil Univ Singapore, Singapore, pp. S48 - S49, presented at 18th International Congress of Developmental Biology, SINGAPORE, Natil Univ Singapore, Singapore, 18 June 2017 - 22 June 2017, http://dx.doi.org/10.1016/j.mod.2017.04.088
    Conference Abstracts | 2017
    Schwarzer A; Emmrich S; Beck D; Schmidt F; Ng M; Adams FF; Witte D; Kaebler S; Wong JWH; Shah A; Jammal R; Maroz A; Reimer C; Pimanda JE; Reinhardt D; Heckl D; Klusmann J-H, 2017, 'Mapping the Lncrna-Landscape of Human Hematopoiesis and Leukemia Reveals Stem Cell Non-Coding Gene Expression Programs', in ANNALS OF HEMATOLOGY, SPRINGER, Vol. 96, pp. S51 - S51, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000394105400047&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2017
    Unnikrishnan A; Quynh AVN; Pickford R; Nunez A; Hesson L; Pimanda J, 2017, 'A NOVEL MASS SPECTROMETRY METHOD REVEALS THE INTRACELLULAR PHARMACOKINETICS OF AZACYTIDINE THERAPY IN VIVO', in HAEMATOLOGICA, FERRATA STORTI FOUNDATION, SPAIN, Madrid, Vol. 102, pp. 258 - 259, presented at 22nd Congress of the European-Hematology-Association, SPAIN, Madrid, 22 June 2017 - 25 June 2017
    Conference Abstracts | 2016
    Beck D; Thoms J; Palu C; Herold T; Shah A; Olivier J; Boelen L; Huang Y; Chacon D; Brown A; Babic M; Hahn C; Perugini M; Zhou X; Huntly B; Berdel W; Woermann B; Buechner T; Hiddemann W; Bohlander S; Scott H; Lewis I; D'Andrea R; Wong J; Pimanda J, 2016, 'INTEGRATIVE ANALYSIS OF LINCRNA EXPRESSION IN 922 ACUTE MYELOID LEUKEMIA PATIENTS REVEALS MULTIPLE PROGNOSTIC GENE SIGNATURES', in HAEMATOLOGICA, FERRATA STORTI FOUNDATION, DENMARK, Copenhagen, Vol. 101, pp. 208 - 209, presented at 21st Congress of the European-Hematology-Association, DENMARK, Copenhagen, 09 June 2016 - 12 June 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000379484600457&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2016
    Chandrakanthan V; Yeola A; Kwan JC; Oliver RA; Qiao Q; Kang YC; Zarzour P; Beck D; Boelen L; Unnikrishnan A; Villanueva JE; Nunez AC; Knezevic K; Palu C; Nasrallah R; Carnell M; Macmillan A; Whan R; Yu Y; Hardy P; Grey ST; Gladbach A; Delerue F; Ittner L; Mobbs R; Walkley CR; Purton LE; Ward RL; Wong JWH; Hesson LB; Walsh W; Pimanda JE, 2016, 'PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells', in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, Vol. 113, pp. E2306 - E2315, http://dx.doi.org/10.1073/pnas.1518244113
    Conference Abstracts | 2016
    Unnikrishnan A; Papaemmanuil E; Beck D; Verma A; Kumari A; Woll P; Richards L; Knezevic K; Chandrakanthan V; Thoms J; Tursky M; Huang Y; Ali Z; Olivier J; Galbraith S; Kulasekararaj A; Tobiasson M; Karimi M; Pellagatti A; Wilson S; Lindeman R; Young B; Ramakrishna R; Arthur C; Stark R; Crispin P; Curnow J; Warburton P; Roncolato F; Boultwood J; Lynch K; Jacobsen S; Mufti G; Hellstrom-Lindberg E; MacKenzie K; Wong J; Campbell P; Pimanda J, 2016, 'INTEGRATIVE GENOMICS IDENTIFIES THE MOLECULAR BASIS OF RESISTANCE TO AZACITIDINE THERAPY IN MYELODYSPLASTIC SYNDROMES', in HAEMATOLOGICA, FERRATA STORTI FOUNDATION, DENMARK, Copenhagen, Vol. 101, pp. 157 - 158, presented at 21st Congress of the European-Hematology-Association, DENMARK, Copenhagen, 09 June 2016 - 12 June 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000379484600349&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2016
    Unnikrishnan A; Papaemmanuil E; Beck D; Verma A; Kumari A; Woll P; Richards L; Knezevic K; Chandrakanthan V; Thoms J; Tursky ML; Huang Y; Ali Z; Olivier S; Galbraith S; Kulasekararaj A; Tobiasson M; Karimi M; Pellagatti A; Wilson S; Lindeman R; Young B; Ramakrishna R; Arthur C; Stark R; Crispin P; Curnow J; Warburton P; Roncolato F; Boultwood J; Lynch K; Jacobsen S; Mufti G; Hellstrom-Lindberg E; MacKenzie K; Wong J; Campbell P; Pimanda J, 2016, 'Integrative genomics identifies the molecular basis of resistance to Azacitidine therapy in Myelodysplastic Syndromes', Ferrata Storti Foundation, Copenhagen, Denmark, pp. 157 - 158, presented at 21st Congress Of The European Hematology Association (EHA), Copenhagen, Denmark, 09 June 2016 - 12 June 2016, https://synapse.mskcc.org/synapse/works/97032
    Conference Papers | 2015
    Avellino R; Havermans M; Erpelinck C; Sanders M; Groeschel S; Vandewerken H; Hoogenboezem RM; Rombouts E; Van Lom K; Van Strien P; De Looper H; Gebhard CC; Rehli M; Beck D; Thoms JAI; Erkeland S; Touw I; Pimanda JE; Bindels EJM; Delwel R, 2015, 'A Tissue-Specific Transcriptional Element for C/ebpa Is Required for HSC Maintenance and Neutrophil Development', in BLOOD, AMER SOC HEMATOLOGY, FL, Orlando, presented at 57th Annual Meeting of the American-Society-of-Hematology, FL, Orlando, 05 December 2015 - 08 December 2015, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000368019001053&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2015
    Chandrakanthan V; Knezevic K; Kang YC; Qiao Q; Pimanda J, 2015, 'GENETIC FATE MAPPING OF MESENCHYMAL STEM-LIKE CELLS IN THE AORTA-GONAD MESONEPHROS (AGM) AND THEIR CONTRIBUTION TO DEVELOPMENTAL HEMATOPMESIS', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, JAPAN, Kyoto, Vol. 43, pp. S46 - S46, presented at 44th Annual Scientific Meeting of the International-Society-for-Experimental-Hematology (ISEH), JAPAN, Kyoto, 17 September 2015 - 19 September 2015, http://dx.doi.org/10.1016/j.exphem.2015.06.054
    Conference Papers | 2015
    Khanna A; Stringer B; Ensbey K; Jahaan Z; Boyd A; McDonald K; Day B; Pimanda J, 2015, 'Clinical relevance of DNA damage modulator checkpoint kinase 1 (CHK1) and cancerous inhibitor of protein phosphatase 2A (CIP2A) in human gliomas', in ANNALS OF ONCOLOGY, OXFORD UNIV PRESS, SINGAPORE, Singapore, pp. 34 - 34, presented at Asia Congress of the European-Society-for-Medical-Oncology (ESMO), SINGAPORE, Singapore, 18 December 2015 - 21 December 2015, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000367158700117&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2015
    Qiao Q; Chandrakanthan V; Pimanda J, 2015, 'CHARACTERISTICS OF STROMAL STEM CELLS IN THE FOETAL LIVER', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, JAPAN, Kyoto, Vol. 43, pp. S90 - S90, presented at 44th Annual Scientific Meeting of the International-Society-for-Experimental-Hematology (ISEH), JAPAN, Kyoto, 17 September 2015 - 19 September 2015, http://dx.doi.org/10.1016/j.exphem.2015.06.234
    Conference Papers | 2015
    Unnikrishnan A; Papaemmanuil E; Beck D; Kumari A, 2015, 'An Integrative Genomics Approach Uncovers the Basis of Resistance to AZA Therapy in MDS and CMML', in An Integrative Genomics Approach Uncovers the Basis of Resistance to, USA, presented at ASH Annual Meeting, USA, 05 December 2015 - 08 December 2015
    Conference Papers | 2014
    Beck D; Palu C; Shah A; Herold T; Olivier J; Valk PJM; Delwel R; Bohlander SK; Wong JW; Pimanda JE, 2014, 'Integrative Analysis of Lincrna Expression and Clinical Annotations Reveals a Signature of 17 Genes with Prognostic Significance in Acute Myeloid Leukemia (AML)', in BLOOD, AMER SOC HEMATOLOGY, CA, San Francisco, presented at 56th Annual Meeting of the American-Society-of-Hematology, CA, San Francisco, 06 December 2014 - 09 December 2014, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000349243503093&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Presentations | 2014
    Khanna A; Stringer B; Day B; Ensbey K; Shen H; Boyd A; McDonald K; Pimanda JE, 2014, 'Keeping glioblastoma (GBM) in check by targeting the CHK1-STAT3-CIP2A axis', presented at 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR), CA, San Diego, 05 April 2014 - 09 April 2014, http://dx.doi.org/10.1158/1538-7445.AM2014-1600
    Conference Abstracts | 2014
    Khanna A; Stringer B; Day B; Ensbey K; Shen H; Boyd A; McDonald KL; Pimanda J, 2014, 'Keeping GBM in check by targeting CHK1-CIP2A axis', in JOURNAL OF CLINICAL ONCOLOGY, LIPPINCOTT WILLIAMS & WILKINS, IL, Chicago, Vol. 32, presented at 50th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), IL, Chicago, 30 May 2014 - 03 June 2014, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000358613202702&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2014
    Unnikrishnan A; Beck D; Verma A; Richards LA; Thoms JAI; Kumari A; Galbraith S; Kulasekararaj A; Tobiasson M; Woll PS; Pellagatti A; Papaemmanuil E; Wilson SR; Lindeman R; Campbell PJ; Boultwood J; Lynch K; Jacobsen SEW; Mufti GJ; Hellstrom-Lindberg E; MacKenzie KL; Wong JWH; Pimanda JE, 2014, 'Identification of a Prognostic Gene Expression Signature for AZA Response in MDS and CMML Patients', in BLOOD, AMER SOC HEMATOLOGY, CA, San Francisco, presented at 56th Annual Meeting of the American-Society-of-Hematology, CA, San Francisco, 06 December 2014 - 09 December 2014, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000349243501166&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2013
    Beck D; Thoms J; Perera D; Unnikrishnan A; Knezevic K; O'Brien T; Gottgens B; Wong J; Pimanda J, 2013, 'GENOME-WIDE ANALYSIS OF TRANSCRIPTIONAL REGULATORS IN HUMAN HSCS REVEALS A DENSELY INTERCONNECTED NETWORK OF CODING AND NON-CODING GENES', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, AUSTRIA, Vienna, pp. S17 - S17, presented at 42nd Annual Scientific Meeting of the International-Society-for-Experimental-Hematology-and-Stem-Cells (ISEH), AUSTRIA, Vienna, 22 August 2013 - 25 August 2013, http://dx.doi.org/10.1016/j.exphem.2013.05.063
    Conference Papers | 2013
    Donald MR; Unnikrishnan A; Pimanda JE; Wilson S, 2013, 'Model Comparisons for RNA-Seq Data', in Proceedings of the 28th International Workshop on Statistical Modelling, Palermo, Italy, pp. 563 - 566, presented at 28th International Workshop on Statistical Modelling, Palermo, Italy, 08 July 2013 - 12 July 2014
    Conference Papers | 2013
    Nasrallah R; Knezevic K; Janes M; Smith A; Gottgens B; Lacaud G; Kouskoff V; Pimanda J, 2013, 'ENRICHING HEMANGIOBLAST AND HEMOGENIC ENDOTHELIAL CELLS USING REGULATORY ELEMENTS OF THE ENDOGLIN GENE', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, AUSTRIA, Vienna, pp. S72 - S72, presented at 42nd Annual Scientific Meeting of the International-Society-for-Experimental-Hematology-and-Stem-Cells (ISEH), AUSTRIA, Vienna, 22 August 2013 - 25 August 2013, http://dx.doi.org/10.1016/j.exphem.2013.05.281
    Conference Presentations | 2012
    Diffner E; Beck D; Gudgin E; Thoms J; Knezevic K; Pridans C; Foster S; Goode D; Lim WK; Boelen L; Metzeler KH; Micklem G; Bohlander SK; Buske C; Burnett AK; Ottersbach K; Vassiliou G; Olivier J; Wong JWH; Gottgens B; Huntly B; Pimanda JE, 2012, 'Activity of a Heptad of Transcription Factors Is Associated with Stem Cell Programs and Clinical Outcome in Acute Myeloid Leukaemia', presented at 54th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), GA, Atlanta, 08 December 2012 - 11 December 2012, http://dx.doi.org/10.1182/blood.V120.21.3525.3525
    Conference Papers | 2012
    Kumari A; Richards LA; Jonquieres G; Knezevic K; O'Brien R; Napier CE; Marks-Bluth J; Pickett H; Pimanda JE; MacKenzie KL, 2012, 'Dyskerin Is Upregulated During Erythroid Differentiation of Human Hematopoietic Progenitor Cells and Hyperactivates Telomerase in Erythroid Precursor Cells', in BLOOD, AMER SOC HEMATOLOGY, GA, Atlanta, presented at 54th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), GA, Atlanta, 08 December 2012 - 11 December 2012, http://dx.doi.org/10.1182/blood.V120.21.980.980
    Conference Abstracts | 2012
    Liu J; Hesson LB; Meagher AP; Bourke MJ; Hawkins NJ; Rand KN; Molloy PL; Pimanda JE; Ward RL, 2012, 'Relative distribution of folate species is associated with global DNA methylation in human colorectal mucosa', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Vol. 72, http://dx.doi.org/10.1158/1538-7445.AM2012-3125
    Conference Papers | 2012
    Sloane M; Hesson L; Wong J; Pimanda J; Bourke M; Hawkins N; Ward R, 2012, 'Inactivation of the deubiquitinase USP44 is an early event in the formation of colorectal cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/1538-7445.AM2012-LB-375
    Conference Abstracts | 2011
    Pimanda J; Thoms J; Birger Y; Foster S; Knezevic K; Kirschenbaum Y; Chandrakanthan V; Lock R; MacKenzie K; Gottgens B; Izraeli S, 2011, 'ERG PROMOTES T-ACUTE LYMPHOBLASTIC LEUKEMIA AND IS TRANSCRIPTIONALLY REGULATED IN LEUKEMIC CELLS BY A STEM CELL ENHANCER', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, Vol. 39, pp. S108 - S108, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000293801700179&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2010
    Pimanda J; Knezevic K; Bee T; Janes M; Thoms J; Wilson N; Kolb-Kokocinski A; Pencovic N; Groner Y; de Bruijn M; Goettgens B, 2010, 'A RUNX1-SMAD6 RHEOSTAT CONTROLS RUNX1 LEVELS AND REGULATES HEMATOPOIESIS IN THE DEVELOPING EMBRYO', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, AUSTRALIA, Melbourne, pp. S17 - S18, presented at 39th Annual Scientific Meeting of the ISEH - Society-for-Hematology-and-Stem-Cells, AUSTRALIA, Melbourne, 15 September 2010 - 18 September 2010, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000281168900035&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2009
    Lock RB; Bachmann PS; Piazza RG; Davies C; James M; Wong NC; Bhadri VA; Mogavero A; Magistroni V; Gambacorti-Passerini C; Saffery R; Craig JM; Pimanda JE; Marshall GM, 2009, 'Epigenetic Silencing of the Pro-Apoptotic Bim Gene in Glucocorticoid Poor-Responsive Pediatric Acute Lymphoblastic Leukemia, and Its Reversal by Histone Deacetylase Inhibition', in BLOOD, AMER SOC HEMATOLOGY, LA, New Orleans, pp. 387 - 388, presented at 51st Annual Meeting of the American-Society-of-Hematology, LA, New Orleans, 05 December 2009 - 08 December 2009, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000272725801119&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2009
    Lock RB; Bachmann PS; Piazza RG; Davies C; James M; Wong NC; Bhadri VA; Mogavero A; Magistroni V; Gambacorti-Passerini C; Saffery R; Craig JM; Pimanda JE; Marshall GM, 2009, 'Epigenetic Silencing of the Pro-Apoptotic Bim Gene in Glucocorticoid Poor-Responsive Pediatric Acute Lymphoblastic Leukemia, and Its Reversal by Histone Deacetylase Inhibition.', in Blood, American Society of Hematology, Vol. 114, pp. 939 - 939, http://dx.doi.org/10.1182/blood.v114.22.939.939
    Conference Papers | 2007
    Pimanda J; Ottersbach K; Knezevic K; Kinston S; Landry J; Wood A; Kolb-Kokocinsky A; Green A; Tannahill D; Gottgens B, 2007, 'GATA2, Fli1 and SCL form a recursively wired gene regulatory circuit in developing blood stem cells', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, GERMANY, Hamburg, pp. 55 - 56, presented at 36th Annual Meeting of the International-Society-for-Experimental-Hematology, GERMANY, Hamburg, 28 September 2007 - 30 September 2007, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000249535200149&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2007
    Pimanda J; Ottersbach K; Knezevic K; Kinston S; Landry T; Wood A; Kolb-Kolocinsky A; Green A; Tannahill D; Gottgens B, 2007, 'GATA2, FLI1 and SCL form a recursively wired gene regulatory circuit in developing blood stem cells', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, GERMANY, Hamburg, pp. 25 - 25, presented at 36th Annual Meeting of the International-Society-for-Experimental-Hematology, GERMANY, Hamburg, 28 September 2007 - 30 September 2007, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000249535200059&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2006
    Pimanda JE; Donaldson IJ; Bruijn MF; Kinston SJ; Knezevic K; Huckle L; Piltz S; Landry J-R; Green AR; Tannahill D; Gottgens B, 2006, 'Genome-wide computational screen for blood stem cell enhancers integrates RUNX1 and the BMP signaling pathway into the SCL transcriptional network.', in BLOOD, AMER SOC HEMATOLOGY, FL, Orlando, pp. 129B - 129B, presented at 48th Annual Meeting of the American-Society-of-Hematology, FL, Orlando, 09 December 2006 - 12 December 2006, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000242440400476&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2006
    Pimanda JE; Donaldson IJ; de Bruijn MFTR; Kinston S; Knezevic K; Huckle L; Piltz S; Landry J-R; Green AR; Tannahill D; Goettgens B, 2006, 'Genome-wide computational screen for bloon stem cell enhancers integrates RUNX1 and the BMP signaling pathway into the SCL transcriptional network', in BLOOD CELLS MOLECULES AND DISEASES, ACADEMIC PRESS INC ELSEVIER SCIENCE, ENGLAND, St Johns Coll, Oxford, pp. 172 - 173, presented at 15th Conference on Hemoglobin Switching, ENGLAND, St Johns Coll, Oxford, 14 September 2006 - 18 September 2006, http://dx.doi.org/10.1016/j.bcmd.2006.10.119
    Conference Papers | 2004
    Silberstein L; Pimanda JE; Piltz S; Delaney L; Oldham S; Kallianpur A; Dominici M; Brandt S; Gottgens B; Green A, 2004, 'A role for SCL in developing bone? the SCL+19 core enhancer targets expression to cells of developing bone, osteocytes, chondrocytes and bone lining cells', in BLOOD, AMER SOC HEMATOLOGY, CA, San Diego, pp. 136B - 136B, presented at 46th Annual Meeting of the American-Society-of-Hematology, CA, San Diego, 04 December 2004 - 07 December 2004, http://dx.doi.org/10.1182/blood.V104.11.4199.4199
    Conference Papers | 2002
    Pimanda JE; Annis DS; Raftery MJ; Mosher DF; Chesterman CN; Hogg PJ, 2002, 'The von Willebrand factor reducing activity of thrombospondin-1 centers around a free thiol at position 974.', in BLOOD, AMER SOC HEMATOLOGY, PENNSYLVANIA, PHILADELPHIA, pp. 257A - 258A, presented at 44th Annual Meeting of the American-Society-of-Hematology, PENNSYLVANIA, PHILADELPHIA, 06 December 2002 - 10 December 2002, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000179184700981&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1