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Dr Gregory Redpath

Lecturer

Ph.D. Medicine Feb 2011- Aug 2015

Department of Child and Adolescent Health, University of Sydney, Sydney, Australia

B.Sc. (Hons.) Biochemistry Feb 2007- Dec 2010

Department of Biochemistry, University of Otago, Dunedin, New Zealand

Medicine & Health

School of Biomedical Sciences

E-mail

g.redpath@unsw.edu.au

Publications
Awards
Research Activities
Engagement
Teaching and Supervision

Journal articles | 2024

Tillu VA; Redpath GMI; Rae J; Ruan J; Yao Y; Cagigas ML; Whan R; Hardeman EC; Gunning PW; Ananthanarayanan V; Parton RG; Ariotti N, 2024, 'Precision in situ cryogenic correlative light and electron microscopy of optogenetically positioned organelles', Journal of Cell Science, 137, http://dx.doi.org/10.1242/jcs.262163

Journal articles | 2024

Tirumala NA; Redpath GMI; Skerhut SV; Dolai P; Kapoor-Kaushik N; Ariotti N; Vijay Kumar K; Ananthanarayanan V, 2024, 'Single-molecule imaging of stochastic interactions that drive dynein activation and cargo movement in cells', Journal of Cell Biology, 223, http://dx.doi.org/10.1083/jcb.202210026

Journal articles | 2023

Redpath GMI; Ananthanarayanan V, 2023, 'Endosomal sorting sorted – motors, adaptors and lessons from in vitro and cellular studies', Journal of Cell Science, 136, http://dx.doi.org/10.1242/jcs.260749

Journal articles | 2023

Siddiqui H; Deo N; Rutledge MT; Williams MJA; Redpath GMI; Mccormick SPA, 2023, 'Plasminogen Receptors Promote Lipoprotein(a) Uptake by Enhancing Surface Binding and Facilitating Macropinocytosis', Arteriosclerosis, Thrombosis, and Vascular Biology, 43, pp. 1851 - 1866, http://dx.doi.org/10.1161/ATVBAHA.123.319344

Journal articles | 2022

Deo N; Redpath G, 2022, 'Serotonin Receptor and Transporter Endocytosis Is an Important Factor in the Cellular Basis of Depression and Anxiety', Frontiers in Cellular Neuroscience, 15, http://dx.doi.org/10.3389/fncel.2021.804592

Journal articles | 2022

Ecker M; Schregle R; Kapoor-Kaushik N; Rossatti P; Betzler VM; Kempe D; Biro M; Ariotti N; Redpath GMI; Rossy J, 2022, 'SNX9-induced membrane tubulation regulates CD28 cluster stability and signalling', eLife, 11, http://dx.doi.org/10.7554/eLife.67550

Journal articles | 2022

Redpath G; Deo N, 2022, 'Serotonin: An overlooked regulator of endocytosis and endosomal sorting?', Biology Open, 11, http://dx.doi.org/10.1242/bio.059057

Journal articles | 2022

Rossatti P; Redpath GMI; Ziegler L; Samson GPB; Clamagirand CD; Legler DF; Rossy J, 2022, 'Rapid increase in transferrin receptor recycling promotes adhesion during T cell activation', BMC Biology, 20, http://dx.doi.org/10.1186/s12915-022-01386-0

Journal articles | 2022

Tirumala NA; Redpath G; Kapoor-Kaushik N; Ariotti N; Dolai P; Kumar KV; Ananthanarayanan V, 2022, 'Single-molecule imaging of cytoplasmic dynein in cellulo reveals the mechanism of motor activation and cargo capture', BIOPHYSICAL JOURNAL, 121, pp. 1 - 1, http://dx.doi.org/10.1016/j.bpj.2021.11.2703

Journal articles | 2022

2022, 'Future leader to watch - Gregory Redpath', BIOLOGY OPEN, 11, http://dx.doi.org/10.1242/bio.059203

Journal articles | 2021

Ecker M; Redpath GMI; Nicovich PR; Rossy J, 2021, 'Quantitative visualization of endocytic trafficking through photoactivation of fluorescent proteins', Molecular Biology of the Cell, 32, pp. 892 - 902, http://dx.doi.org/10.1091/MBC.E20-10-0669

Journal articles | 2021

Redpath GMI; Deo N; Siddiqui H; Madani G; Kapoor-Kaushik N; Ariotti N; Rutledge M; Williams MJA; McCormick SPA, 2021, 'Serotonin and common antidepressants regulate lipoprotein(a) macropinocytosis via enhanced cell surface binding', , http://dx.doi.org/10.1101/2021.03.26.437114

Journal articles | 2021

Tirumala NA; Redpath G; Skerhut SV; Dolai P; Kapoor-Kaushik N; Ariotti N; Kumar V; Ananthanarayanan V, 2021, 'Single-molecule imaging of cytoplasmic dynein in cellulo reveals the mechanism of motor activation and cargo movement', , http://dx.doi.org/10.1101/2021.04.05.438428

Journal articles | 2020

Redpath GMI; Betzler VM; Rossatti P; Rossy J, 2020, 'Membrane Heterogeneity Controls Cellular Endocytic Trafficking', Frontiers in Cell and Developmental Biology, 8, http://dx.doi.org/10.3389/fcell.2020.00757

Journal articles | 2019

Redpath GMI; Ecker M; Kapoor-Kaushik N; Vartoukian H; Carnell M; Kempe D; Biro M; Ariotti N; Rossy J; Kaushik N, 2019, 'Flotillins promote T cell receptor sorting through a fast Rab5–Rab11 endocytic recycling axis', Nature Communications, 10, pp. 4392, http://dx.doi.org/10.1038/s41467-019-12352-w

Journal articles | 2018

Compeer EB; Kraus F; Ecker M; Redpath G; Amiezer M; Rother N; Nicovich PR; Kapoor-Kaushik N; Deng Q; Samson GPB; Yang Z; Lou J; Carnell M; Vartoukian H; Gaus K; Rossy J, 2018, 'A mobile endocytic network connects clathrin-independent receptor endocytosis to recycling and promotes T cell activation', Nature Communications, 9, http://dx.doi.org/10.1038/s41467-018-04088-w

Journal articles | 2017

Piper AK; Ross SE; Redpath GM; Lemckert FA; Woolger N; Bournazos A; Greer PA; Sutton RB; Cooper ST, 2017, 'Enzymatic cleavage of myoferlin releases a dual C2-domain module linked to ERK signalling', Cellular Signalling, 33, pp. 30 - 40, http://dx.doi.org/10.1016/j.cellsig.2017.02.009

Journal articles | 2017

Sharma M; Redpath GM; Williams MJA; McCormick SPA, 2017, 'Recycling of apolipoprotein(a) after PlgRKT-mediated endocytosis of lipoprotein(a)', Circulation Research, 120, pp. 1091 - 1102, http://dx.doi.org/10.1161/CIRCRESAHA.116.310272

Journal articles | 2016

Redpath GMI; Sophocleous RA; Turnbull L; Whitchurch CB; Cooper ST, 2016, 'Ferlins Show Tissue-Specific Expression and Segregate as Plasma Membrane/Late Endosomal or Trans-Golgi/Recycling Ferlins', Traffic, 17, pp. 245 - 266, http://dx.doi.org/10.1111/tra.12370

Journal articles | 2016

Sharma M; Redpath G; McCormick S, 2016, 'Calcium dependent endocytosis and recycling of lipoprotein(a) in HepG2 cells', Atherosclerosis, 252, pp. e244 - e244, http://dx.doi.org/10.1016/j.atherosclerosis.2016.07.038

Journal articles | 2014

Fuson K; Rice A; Mahling R; Snow A; Nayak K; Shanbhogue P; Meyer AG; Redpath GMI; Hinderliter A; Cooper ST; Sutton RB, 2014, 'Alternate splicing of dysferlin C2A confers Ca²⁺-dependent and Ca²⁺-independent binding for membrane repair', Structure, 22, pp. 104 - 115, http://dx.doi.org/10.1016/j.str.2013.10.001

Journal articles | 2014

Redpath GMI; Woolger N; Piper AK; Lemckert FA; Lek A; Greer PA; North KN; Cooper ST, 2014, 'Calpain cleavage within dysferlin exon 40a releases a synaptotagmin-like module for membrane repair', Molecular Biology of the Cell, 25, pp. 3037 - 3048, http://dx.doi.org/10.1091/mbc.E14-04-0947

Journal articles | 2013

Lek A; Evesson FJ; Lemckert FA; Redpath GMI; Lueders AK; Turnbull L; Whitchurch CB; North KN; Cooper ST, 2013, 'Calpains, cleaved mini-dysferlinc72, and L-type channels underpin calcium-dependent muscle membrane repair', Journal of Neuroscience, 33, pp. 5085 - 5094, http://dx.doi.org/10.1523/JNEUROSCI.3560-12.2013
Conference Papers | 2019

Monserrat-Martinez A; Redpath G; Govendir MA; O'Carroll A; Murillo ADA; Sierecki E; Gambin Y, 2019, 'Enteropathogenic E. coli Hijacks Programmed Host-Cell Death Pathways by Interfering with the Higher Order Oligomerization of Immune System Proteins', in FASEB JOURNAL, WILEY, FL, Orlando, presented at Experimental Biology Meeting (EB), FL, Orlando, 06 April 2019 - 09 April 2019, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000495951205245&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

2022	Future Leader to Watch, Biology Open
2018	Runner-up, Best Postdoctoral Presentation, Australia and New Zealand Society for Cell and Development Cell Biology NSW Research Meeting
2014	David Walsh Prize for Best Student Presentation, ComBio 2014
2010	Health Sciences Prestigious Summer Scholarship
2009	Health Research Council Summer Scholarship, Health Research Council of New Zealand

2022

2018

Future Leader to Watch, Biology Open

Runner-up, Best Postdoctoral Presentation, Australia and New Zealand Society for Cell and Development Cell Biology NSW Research Meeting
2022

2014

Future Leader to Watch, Biology Open

David Walsh Prize for Best Student Presentation, ComBio 2014
2022

2010

Future Leader to Watch, Biology Open

Health Sciences Prestigious Summer Scholarship
2022

2009

Future Leader to Watch, Biology Open

Health Research Council Summer Scholarship, Health Research Council of New Zealand

I am a postdoctoral fellow in the Department of Molecular Medicine, University of New South Wales in Sydney, Australia. My research focuses on using live cell imaging to understand how receptor trafficking is regulated and contributes to human diseases and treatments. My work involves investigating how psychedelics act on serotonin receptors at a cellular level, how receptor movement around the cell regulates signalling, and how lipoproteins are cleared from circulation by endocytic processes.

Focal Plane articles: https://focalplane.biologists.com/author/gregredpath/

My Research Supervision

Ph.D. Students

Jack Zhang (2023- current)
David Kim (2023- current)

Previous Supervision

Ph.D. Students

Halima Siddiqui (Advisor, University of Otago, NZ, 2019-2023)
Manuela Ecker (UNSW, 2016-2019)

Honours Students

Shreya Boby (2023-2024)
David Kim (2022-2023)
Sarah Skerhut (2022)
Haig Vartoukian (2017)

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