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Dr Gregory Redpath

Dr Gregory Redpath

Lecturer
  • Ph.D. Medicine                                                                                                              Feb 2011- Aug 2015

Department of Child and Adolescent Health, University of Sydney, Sydney, Australia

  • B.Sc. (Hons.) Biochemistry                                                                                           Feb 2007- Dec 2010

Department of Biochemistry, University of Otago, Dunedin, New Zealand

Medicine & Health
School of Biomedical Sciences
E-mail
g.redpath@unsw.edu.au
  • Journal articles | 2024
    Tillu VA; Redpath GMI; Rae J; Ruan J; Yao Y; Cagigas ML; Whan R; Hardeman EC; Gunning PW; Ananthanarayanan V; Parton RG; Ariotti N, 2024, 'Precision in situ cryogenic correlative light and electron microscopy of optogenetically positioned organelles', Journal of Cell Science, 137, http://dx.doi.org/10.1242/jcs.262163
    Journal articles | 2024
    Tirumala NA; Redpath GMI; Skerhut SV; Dolai P; Kapoor-Kaushik N; Ariotti N; Vijay Kumar K; Ananthanarayanan V, 2024, 'Single-molecule imaging of stochastic interactions that drive dynein activation and cargo movement in cells', Journal of Cell Biology, 223, http://dx.doi.org/10.1083/jcb.202210026
    Journal articles | 2023
    Redpath GMI; Ananthanarayanan V, 2023, 'Endosomal sorting sorted – motors, adaptors and lessons from in vitro and cellular studies', Journal of Cell Science, 136, http://dx.doi.org/10.1242/jcs.260749
    Journal articles | 2023
    Siddiqui H; Deo N; Rutledge MT; Williams MJA; Redpath GMI; Mccormick SPA, 2023, 'Plasminogen Receptors Promote Lipoprotein(a) Uptake by Enhancing Surface Binding and Facilitating Macropinocytosis', Arteriosclerosis, Thrombosis, and Vascular Biology, 43, pp. 1851 - 1866, http://dx.doi.org/10.1161/ATVBAHA.123.319344
    Journal articles | 2022
    Deo N; Redpath G, 2022, 'Serotonin Receptor and Transporter Endocytosis Is an Important Factor in the Cellular Basis of Depression and Anxiety', Frontiers in Cellular Neuroscience, 15, http://dx.doi.org/10.3389/fncel.2021.804592
    Journal articles | 2022
    Ecker M; Schregle R; Kapoor-Kaushik N; Rossatti P; Betzler VM; Kempe D; Biro M; Ariotti N; Redpath GMI; Rossy J, 2022, 'SNX9-induced membrane tubulation regulates CD28 cluster stability and signalling', eLife, 11, http://dx.doi.org/10.7554/eLife.67550
    Journal articles | 2022
    Redpath G; Deo N, 2022, 'Serotonin: An overlooked regulator of endocytosis and endosomal sorting?', Biology Open, 11, http://dx.doi.org/10.1242/bio.059057
    Journal articles | 2022
    Rossatti P; Redpath GMI; Ziegler L; Samson GPB; Clamagirand CD; Legler DF; Rossy J, 2022, 'Rapid increase in transferrin receptor recycling promotes adhesion during T cell activation', BMC Biology, 20, http://dx.doi.org/10.1186/s12915-022-01386-0
    Journal articles | 2022
    Tirumala NA; Redpath G; Kapoor-Kaushik N; Ariotti N; Dolai P; Kumar KV; Ananthanarayanan V, 2022, 'Single-molecule imaging of cytoplasmic dynein in cellulo reveals the mechanism of motor activation and cargo capture', BIOPHYSICAL JOURNAL, 121, pp. 1 - 1, http://dx.doi.org/10.1016/j.bpj.2021.11.2703
    Journal articles | 2022
    2022, 'Future leader to watch - Gregory Redpath', BIOLOGY OPEN, 11, http://dx.doi.org/10.1242/bio.059203
    Journal articles | 2021
    Ecker M; Redpath GMI; Nicovich PR; Rossy J, 2021, 'Quantitative visualization of endocytic trafficking through photoactivation of fluorescent proteins', Molecular Biology of the Cell, 32, pp. 892 - 902, http://dx.doi.org/10.1091/MBC.E20-10-0669
    Journal articles | 2021
    Redpath GMI; Deo N; Siddiqui H; Madani G; Kapoor-Kaushik N; Ariotti N; Rutledge M; Williams MJA; McCormick SPA, 2021, 'Serotonin and common antidepressants regulate lipoprotein(a) macropinocytosis via enhanced cell surface binding', , http://dx.doi.org/10.1101/2021.03.26.437114
    Journal articles | 2021
    Tirumala NA; Redpath G; Skerhut SV; Dolai P; Kapoor-Kaushik N; Ariotti N; Kumar V; Ananthanarayanan V, 2021, 'Single-molecule imaging of cytoplasmic dynein in cellulo reveals the mechanism of motor activation and cargo movement', , http://dx.doi.org/10.1101/2021.04.05.438428
    Journal articles | 2020
    Redpath GMI; Betzler VM; Rossatti P; Rossy J, 2020, 'Membrane Heterogeneity Controls Cellular Endocytic Trafficking', Frontiers in Cell and Developmental Biology, 8, http://dx.doi.org/10.3389/fcell.2020.00757
    Journal articles | 2019
    Redpath GMI; Ecker M; Kapoor-Kaushik N; Vartoukian H; Carnell M; Kempe D; Biro M; Ariotti N; Rossy J; Kaushik N, 2019, 'Flotillins promote T cell receptor sorting through a fast Rab5–Rab11 endocytic recycling axis', Nature Communications, 10, pp. 4392, http://dx.doi.org/10.1038/s41467-019-12352-w
    Journal articles | 2018
    Compeer EB; Kraus F; Ecker M; Redpath G; Amiezer M; Rother N; Nicovich PR; Kapoor-Kaushik N; Deng Q; Samson GPB; Yang Z; Lou J; Carnell M; Vartoukian H; Gaus K; Rossy J, 2018, 'A mobile endocytic network connects clathrin-independent receptor endocytosis to recycling and promotes T cell activation', Nature Communications, 9, http://dx.doi.org/10.1038/s41467-018-04088-w
    Journal articles | 2017
    Piper AK; Ross SE; Redpath GM; Lemckert FA; Woolger N; Bournazos A; Greer PA; Sutton RB; Cooper ST, 2017, 'Enzymatic cleavage of myoferlin releases a dual C2-domain module linked to ERK signalling', Cellular Signalling, 33, pp. 30 - 40, http://dx.doi.org/10.1016/j.cellsig.2017.02.009
    Journal articles | 2017
    Sharma M; Redpath GM; Williams MJA; McCormick SPA, 2017, 'Recycling of apolipoprotein(a) after PlgRKT-mediated endocytosis of lipoprotein(a)', Circulation Research, 120, pp. 1091 - 1102, http://dx.doi.org/10.1161/CIRCRESAHA.116.310272
    Journal articles | 2016
    Redpath GMI; Sophocleous RA; Turnbull L; Whitchurch CB; Cooper ST, 2016, 'Ferlins Show Tissue-Specific Expression and Segregate as Plasma Membrane/Late Endosomal or Trans-Golgi/Recycling Ferlins', Traffic, 17, pp. 245 - 266, http://dx.doi.org/10.1111/tra.12370
    Journal articles | 2016
    Sharma M; Redpath G; McCormick S, 2016, 'Calcium dependent endocytosis and recycling of lipoprotein(a) in HepG2 cells', Atherosclerosis, 252, pp. e244 - e244, http://dx.doi.org/10.1016/j.atherosclerosis.2016.07.038
    Journal articles | 2014
    Fuson K; Rice A; Mahling R; Snow A; Nayak K; Shanbhogue P; Meyer AG; Redpath GMI; Hinderliter A; Cooper ST; Sutton RB, 2014, 'Alternate splicing of dysferlin C2A confers Ca2+-dependent and Ca2+-independent binding for membrane repair', Structure, 22, pp. 104 - 115, http://dx.doi.org/10.1016/j.str.2013.10.001
    Journal articles | 2014
    Redpath GMI; Woolger N; Piper AK; Lemckert FA; Lek A; Greer PA; North KN; Cooper ST, 2014, 'Calpain cleavage within dysferlin exon 40a releases a synaptotagmin-like module for membrane repair', Molecular Biology of the Cell, 25, pp. 3037 - 3048, http://dx.doi.org/10.1091/mbc.E14-04-0947
    Journal articles | 2013
    Lek A; Evesson FJ; Lemckert FA; Redpath GMI; Lueders AK; Turnbull L; Whitchurch CB; North KN; Cooper ST, 2013, 'Calpains, cleaved mini-dysferlinc72, and L-type channels underpin calcium-dependent muscle membrane repair', Journal of Neuroscience, 33, pp. 5085 - 5094, http://dx.doi.org/10.1523/JNEUROSCI.3560-12.2013
  • Conference Papers | 2019
    Monserrat-Martinez A; Redpath G; Govendir MA; O'Carroll A; Murillo ADA; Sierecki E; Gambin Y, 2019, 'Enteropathogenic E. coli Hijacks Programmed Host-Cell Death Pathways by Interfering with the Higher Order Oligomerization of Immune System Proteins', in FASEB JOURNAL, WILEY, FL, Orlando, presented at Experimental Biology Meeting (EB), FL, Orlando, 06 April 2019 - 09 April 2019, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000495951205245&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

2022

Future Leader to Watch, Biology Open

2018

Runner-up, Best Postdoctoral Presentation, Australia and New Zealand Society for Cell and Development Cell Biology NSW Research Meeting

2014

David Walsh Prize for Best Student Presentation, ComBio 2014

2010

Health Sciences Prestigious Summer Scholarship

2009

Health Research Council Summer Scholarship, Health Research Council of New Zealand

I am a postdoctoral fellow in the Department of Molecular Medicine, University of New South Wales in Sydney, Australia. My research focuses on using live cell imaging to understand how receptor trafficking is regulated and contributes to human diseases and treatments. My work involves investigating how psychedelics act on serotonin receptors at a cellular level, how receptor movement around the cell regulates signalling, and how lipoproteins are cleared from circulation by endocytic processes.

Focal Plane Correspondent 2024

https://focalplane.biologists.com/2024/02/01/announcing-the-2024-focalplane-correspondents/

 

 

My Research Supervision

      Ph.D. Students

  • Jack Zhang                                                                                                                   (2023- current)
  • David Kim                                                                                                                     (2023- current)

 

      Honours Students

  • Shreya Boby                                                                                                                  (2023-2024)

 

Previous Supervision

      Ph.D. Students

  • Halima Siddiqui                                                                                                             (Advisor, University of Otago, NZ, 2019-2023)
  • Manuela Ecker                                                                                                              (UNSW, 2016-2019)

 

      Honours Students

  • David Kim                                                                                                                      (2022-2023)
  • Sarah Skerhut                                                                                                                (2022)
  • Haig Vartoukian                                                                                                             (2017)