Sir J. Fraser Stoddart, a giant in the world of modern chemistry, passed away on December 30, 2024, leaving an indelible mark on the scientific world through an extraordinary legacy of innovation, mentorship, and inspiration. We extend our deepest condolences to his family and friends for their loss.

Born on May 24, 1942, in Edinburgh, Scotland, Fraser was raised as an only child on a farm in Carrington, Midlothian.

A Foundation in Education and Partnership

Fraser’s formal education began early, at age 4, at a local village school in Carrington, Midlothian, followed by Melville College in Edinburgh. He went on to earn a BSc (1964), Ph.D. (1966), and D.Sc. (1980) from the University of Edinburgh, where his postgraduate research under Professor Sir Edmund Hirst focused on plant gums. It was during this time that he met his future wife, Norma Scholan, a fellow Edinburgh graduate and accomplished biochemist.

Norma was not only Fraser’s partner in life but also a pivotal collaborator in his work. Described as the “matriarch” of the Stoddart research group, she co-authored numerous scientific papers and played an important role in its success. Together, they raised two daughters, Fiona and Alison, both of whom followed in their parents’ footsteps to earn PhDs in chemistry. Norma’s passing in 2004, after a prolonged battle with breast cancer, was a profound loss.

A Career of Global Influence

Spanning continents and many institutions, Fraser’s career reflected his boundless dedication to advancing science and mentoring the next generation of chemists. From postdoctoral research at Queen’s University in Canada to faculty appointments at Sheffield, Birmingham, UCLA, Northwestern, UNSW, and the University of Hong Kong. Over his career, he mentored more than 400 graduate and postdoctoral researchers, fostering a legacy of scientific excellence.

In 2017, Fraser joined UNSW Sydney to spearhead his “New Chemistry” initiative, focusing on the manipulation of molecules to develop revolutionary devices like switches, sensors, and motors. His time at UNSW further cemented his reputation as an innovator and mentor, sharing his insights with students and colleagues alike.

“Fraser was a force of nature. In addition to his enormous scientific achievements, he inspired and trained a legion of researchers around the world. At UNSW his legacy will live on through the Stoddart Laboratories where his acolytes Albert and DJ continue to advance the frontiers of chemical knowledge.” Professor Timothy Schmidt, Head of the School of Chemistry, UNSW

A Legacy of Innovation

Fraser’s prolific output of over 1,000 journal publications established him as a pioneer in supramolecular chemistry and molecular nanotechnology. His groundbreaking work on mechanical bonds in chemical compounds enabled the creation of nanoscale devices capable of performing tasks like targeted drug delivery, signalling a new era in medicine, materials science and beyond.

He often referred to his approach as "molecular Meccano," a playful description of the methodology that earned him and Professors Ben Feringa and Jean-Pierre Sauvage the 2016 Nobel Prize in Chemistry “for the design and synthesis of molecular machines”.

Recognitions and Personal Impact

Knighted by Queen Elizabeth II in 2007, Fraser received prestigious awards, including the King Faisal International Prize in Science and the Albert Einstein World Award of Science (2007), the Davy Medal of the Royal Society (2008) and a Royal Medal (2010). Days before his passing, he was announced as the 2025 recipient of UCLA’s Glenn T. Seaborg Medal, a testament to his continued influence in the scientific community.

But Fraser’s impact went far beyond accolades. Known for his warmth, humour, and generosity, he was celebrated for his personal qualities as well as his professional achievements. Students and colleagues alike remember him as a storyteller, a problem-solver, and a visionary who encouraged bold thinking and collaboration.

“He was a role model in every sense – someone who inspired others not just through his achievements but through the way he lived, worked, and encouraged those around him to strive for excellence. He was as generous as he was hard-working and visionary, and the impact he made on people’s lives will be passed on for generations.” Dr Albert Fahrenbach and Dr Dong Jun Kim, School of Chemistry, UNSW

A Lasting Legacy

Fraser is survived by his daughters, Fiona McCubbin who lives in Belmont, Massachusetts, and Alison Stoddart based in Cambridge, UK, and five grandchildren.

His legacy lives on not only in the groundbreaking work he pioneered but also in the countless lives he enriched, both professionally and personally - a testament to the power of curiosity, collaboration, and unwavering dedication. Fraser will be remembered as a trailblazer of chemistry and nanotechnology for generations to come.